{"id":"https://openalex.org/W2147142136","doi":"https://doi.org/10.3233/jad-2011-101848","title":"Genetic Association of Sequence Variants Near AGER/NOTCH4 and Dementia","display_name":"Genetic Association of Sequence Variants Near AGER/NOTCH4 and Dementia","publication_year":2011,"publication_date":"2011-05-10","ids":{"openalex":"https://openalex.org/W2147142136","doi":"https://doi.org/10.3233/jad-2011-101848","mag":"2147142136","pmid":"https://pubmed.ncbi.nlm.nih.gov/21297263","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3477600"},"language":"en","primary_location":{"id":"doi:10.3233/jad-2011-101848","doi":"https://doi.org/10.3233/jad-2011-101848","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-2011-101848","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3477600","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082785548","display_name":"Anna M. Bennet","orcid":"https://orcid.org/0000-0003-2704-2625","observed_orcids":["https://orcid.org/0000-0003-2704-2625"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anna M. Bennet","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","#N# Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"#N# Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042706889","display_name":"Chandra A. Reynolds","orcid":"https://orcid.org/0000-0001-6502-7173","observed_orcids":["https://orcid.org/0000-0001-6502-7173"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chandra A. Reynolds","raw_affiliation_strings":["Department of Psychology, University of California at Riverside, Riverside, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of California at Riverside, Riverside, CA, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111864240","display_name":"Ulrika K. Eriksson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Ulrika K. Eriksson","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","#N# Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"#N# Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110578571","display_name":"Mun\u2010Gwan Hong","orcid":"https://orcid.org/0000-0001-8603-8293","observed_orcids":["https://orcid.org/0000-0001-8603-8293","https://orcid.org/0000-0001-8808-7128"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Mun-Gwan Hong","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","#N# Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"#N# Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025313057","display_name":"Kaj Blennow","orcid":"https://orcid.org/0000-0002-1890-4193","observed_orcids":["https://orcid.org/0000-0002-1890-4193"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Kaj Blennow","raw_affiliation_strings":["Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063732312","display_name":"Margaret Gatz","orcid":"https://orcid.org/0000-0002-1071-9970","observed_orcids":["https://orcid.org/0000-0002-1071-9970"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Margaret Gatz","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","Department of Psychology, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Psychology, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039580759","display_name":"Andrey Alexeyenko","orcid":"https://orcid.org/0000-0001-8812-6481","observed_orcids":["https://orcid.org/0000-0001-8812-6481"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andrey Alexeyenko","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","#N# Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"#N# Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011350655","display_name":"Nancy L. Pedersen","orcid":"https://orcid.org/0000-0001-8057-3543","observed_orcids":["https://orcid.org/0000-0001-8057-3543"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Nancy L. Pedersen","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","Department of Psychology, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Psychology, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004064960","display_name":"Jonathan A. Prince","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Jonathan A. Prince","raw_affiliation_strings":["Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","#N# Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"#N# Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5004064960"],"corresponding_institution_ids":["https://openalex.org/I28166907"],"apc_list":null,"apc_paid":null,"fwci":0.4366,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.69138612,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"24","issue":"3","first_page":"475","last_page":"484"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.8568999767303467,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.12080000340938568,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dementia","display_name":"dementia","score":0.6729999780654907},{"id":"https://openalex.org/keywords/ager","display_name":"AGER","score":0.8009999990463257}],"concepts":[{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6602357029914856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6513715386390686},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5705206394195557},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5257799625396729},{"id":"https://openalex.org/C2776485563","wikidata":"https://www.wikidata.org/wiki/Q18253272","display_name":"PSEN1","level":5,"score":0.5014100074768066},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.4777611792087555},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4550101161003113},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4433252811431885},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.4289109408855438},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.31297236680984497},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2584362030029297},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.2295350432395935},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.21121546626091003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1772729456424713},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.13102364540100098},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12657582759857178},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067759","descriptor_name":"Receptor for Advanced Glycation End Products","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074562","descriptor_name":"Receptor, Notch4","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002896","descriptor_name":"Chromosomes, Human, Pair 6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003704","descriptor_name":"Dementia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011971","descriptor_name":"Receptors, Immunologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018709","descriptor_name":"Statistics, Nonparametric","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3233/jad-2011-101848","doi":"https://doi.org/10.3233/jad-2011-101848","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-2011-101848","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:21297263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21297263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2469887","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3477600","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3477600","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3477600","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Alzheimers Dis","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2469887","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3477600","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1543456837","display_name":"GENETIC AND ENVIRONMENTAL INFLUENCES IN BEHAVIORAL AGING","funder_award_id":"R01AG004563","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1567932728","display_name":null,"funder_award_id":"AG-10175","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2338584565","display_name":null,"funder_award_id":"AG04563","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G364899994","display_name":null,"funder_award_id":"AG 08724","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3919405917","display_name":null,"funder_award_id":"AG028555","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4075787065","display_name":"Cholesterol metabolism pathway: Cognitive change and Alzheimer's disease risk","funder_award_id":"R01AG028555","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5862741731","display_name":null,"funder_award_id":"AG 08861","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5968098363","display_name":"Genetic & Environmental Influences-Biobehavioral Aging","funder_award_id":"R01AG010175","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G7352717633","display_name":"DEMENTIA IN SWEDISH TWINS","funder_award_id":"R01AG008724","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320324119","display_name":"Uppsala Universitet","ror":"https://ror.org/048a87296"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W195933567","https://openalex.org/W1491174923","https://openalex.org/W1543029084","https://openalex.org/W1812789667","https://openalex.org/W1969672258","https://openalex.org/W1995618284","https://openalex.org/W2001688761","https://openalex.org/W2010390315","https://openalex.org/W2017079501","https://openalex.org/W2020592632","https://openalex.org/W2030137882","https://openalex.org/W2030657258","https://openalex.org/W2036735444","https://openalex.org/W2039214602","https://openalex.org/W2040575803","https://openalex.org/W2041378923","https://openalex.org/W2042734169","https://openalex.org/W2045153164","https://openalex.org/W2046006229","https://openalex.org/W2046209489","https://openalex.org/W2058723245","https://openalex.org/W2059742736","https://openalex.org/W2070137740","https://openalex.org/W2080949377","https://openalex.org/W2083045667","https://openalex.org/W2085851888","https://openalex.org/W2100245721","https://openalex.org/W2121820194","https://openalex.org/W2124481332","https://openalex.org/W2130153674","https://openalex.org/W2132314391","https://openalex.org/W2148568069","https://openalex.org/W2149791927","https://openalex.org/W2150671144","https://openalex.org/W2152119060","https://openalex.org/W2156737316","https://openalex.org/W2161633633","https://openalex.org/W2162530578","https://openalex.org/W2287355387","https://openalex.org/W2482979027","https://openalex.org/W4211161847"],"related_works":["https://openalex.org/W4385566539","https://openalex.org/W2095929608","https://openalex.org/W2141412509","https://openalex.org/W2104960549","https://openalex.org/W4224142722","https://openalex.org/W4406209952","https://openalex.org/W2897857720","https://openalex.org/W1994778639","https://openalex.org/W170042837","https://openalex.org/W2470626250"],"abstract_inverted_index":{"We":[0],"performed":[1],"a":[2,8,39,51,112,188],"survey":[3],"of":[4,10,31,41,82,95,120],"sequence":[5],"variation":[6],"in":[7,14,22,29,159,172],"series":[9],"20":[11],"genes":[12,125],"involved":[13],"inflammation-related":[15],"pathways":[16],"for":[17,115],"association":[18],"with":[19,60,147,175],"dementia":[20,34,131],"risk":[21,132],"twin":[23],"and":[24,55,65,139],"unrelated":[25],"case-control":[26],"samples":[27,64],"consisting":[28],"total":[30,40],"1462":[32],"Swedish":[33],"casesand":[35],"1929":[36],"controls.":[37],"For":[38],"218":[42],"tested":[43],"genetic":[44],"markers,":[45],"strong":[46,142,173],"evidence":[47],"was":[48],"obtained":[49],"implicating":[50],"region":[52,102,157],"near":[53,92],"AGER":[54,96,110],"NOTCH4":[56],"on":[57,164],"chromosome":[58,165],"6p":[59],"replication":[61],"across":[62],"both":[63],"maximum":[66],"combined":[67],"significance":[68],"at":[69],"marker":[70],"rs1800625":[71],"(OR":[72],"=":[73,79,98],"1.37,":[74],"95%":[75],"CI":[76],"1.19\u20131.56,":[77],"p":[78],"1.36\u00d710(\u20136)).":[80],"Imputation":[81],"the":[83,93,152,160],"associated":[84,101,168],"genomic":[85],"interval":[86],"provided":[87],"an":[88,118],"improved":[89],"signal":[90,189],"atrs8365,":[91],"3UTR":[94],"(p":[97],"7.34\u00d710(\u20137)).":[99],"The":[100,155],"extends":[103],"120":[104],"kb":[105],"encompassing":[106],"11":[107],"candidate":[108],"genes.While":[109],"encodes":[111],"key":[113],"receptor":[114],"amyloid-\u03b2":[116],"protein,":[117],"analysis":[119],"network":[121],"context":[122],"based":[123],"upon":[124],"now":[126],"confirmed":[127],"to":[128,130,145,151],"contribute":[129],"(A\u03b2PP,":[133],"PSEN1,":[134],"PSEN2,":[135],"CR1,":[136],"CLU,":[137],"PICALM,":[138],"APOE)":[140],"suggested":[141],"functional":[143],"coupling":[144,150],"NOTCH4,":[146],"no":[148],"significant":[149],"remaining":[153],"candidates.":[154],"implicated":[156],"occurs":[158],"broad":[161],"HLA":[162,180],"locus":[163],"6p,":[166],"but":[167],"markers":[169],"were":[170],"not":[171],"LD":[174],"known":[176],"variants":[177],"that":[178,184],"regulate":[179],"gene":[181],"function,":[182],"suggesting":[183],"this":[185],"may":[186],"represent":[187],"distinct":[190],"from":[191],"immune-system":[192],"pathways.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}