{"id":"https://openalex.org/W2147035002","doi":null,"title":"Biological and biochemical differences between tubercidin (7-deazaadenosine) and its 5'-phosphate methyl ester.","display_name":"Biological and biochemical differences between tubercidin (7-deazaadenosine) and its 5'-phosphate methyl ester.","publication_year":1971,"publication_date":"1971-12-01","ids":{"openalex":"https://openalex.org/W2147035002","mag":"2147035002","pmid":"https://pubmed.ncbi.nlm.nih.gov/5120290"},"language":"en","primary_location":{"id":"pmid:5120290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5120290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111920957","display_name":"Bijoy K. Bhuyan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B K Bhuyan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108486115","display_name":"GARY L. NEIL","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G L Neil","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102920608","display_name":"Charles G. Smith","orcid":"https://orcid.org/0000-0002-5743-5860","observed_orcids":["https://orcid.org/0000-0002-5743-5860"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C G Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011238252","display_name":"E J Olin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E J Olin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5082005204","display_name":"L. H. Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L H Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1573,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.35012077,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"12","first_page":"1923","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9721999764442444,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tubercidin","display_name":"tubercidin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/7-deazaadenosine","display_name":"7-deazaadenosine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.8519999980926514},{"id":"https://openalex.org/keywords/kb-cells","display_name":"KB cells","score":0.7549999952316284},{"id":"https://openalex.org/keywords/l1210-cells","display_name":"L1210 leukemia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/dna-synthesis-inhibition","display_name":"DNA synthesis inhibition","score":0.925000011920929},{"id":"https://openalex.org/keywords/hydrolysis","display_name":"hydrolysis","score":0.6190000176429749},{"id":"https://openalex.org/keywords/rna-incorporation","display_name":"RNA incorporation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/dna-incorporation","display_name":"DNA incorporation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/antituberculosis-drugs","display_name":"antitubercular agents","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.8421441316604614},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6734228134155273},{"id":"https://openalex.org/C2780017796","wikidata":"https://www.wikidata.org/wiki/Q6456824","display_name":"L1210 cells","level":4,"score":0.6582460999488831},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6129109859466553},{"id":"https://openalex.org/C2777132085","wikidata":"https://www.wikidata.org/wiki/Q46220103","display_name":"Phosphate","level":2,"score":0.597526490688324},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5939050912857056},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.5395660996437073},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5074507594108582},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.48211169242858887},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3398006558418274}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001769","descriptor_name":"Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002854","descriptor_name":"Chromatography, Paper","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003864","descriptor_name":"Depression, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007939","descriptor_name":"Leukemia L1210","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009062","descriptor_name":"Mouth Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009705","descriptor_name":"Nucleosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013936","descriptor_name":"Thymidine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:5120290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5120290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:mouseion.jax.org:ssbb1971-2253","doi":null,"is_oa":false,"landing_page_url":"https://mouseion.jax.org/ssbb1971/1254","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Subject Strain Bibliography 1971","raw_type":"text"},{"id":"mag:2147035002","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/5120290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W112185069","https://openalex.org/W166402193","https://openalex.org/W1547916312","https://openalex.org/W1558079879","https://openalex.org/W1592815109","https://openalex.org/W1604914977","https://openalex.org/W1906197854","https://openalex.org/W1963822247","https://openalex.org/W2016866166","https://openalex.org/W2019391401","https://openalex.org/W2030095340","https://openalex.org/W2074927849","https://openalex.org/W2091609058","https://openalex.org/W2151961990","https://openalex.org/W2434062470"],"related_works":["https://openalex.org/W2030095340","https://openalex.org/W1999559505","https://openalex.org/W2100190827","https://openalex.org/W1909710140","https://openalex.org/W1535869422","https://openalex.org/W1604914977","https://openalex.org/W2124180162","https://openalex.org/W2082870442","https://openalex.org/W2409528257","https://openalex.org/W2777791865"],"abstract_inverted_index":{"On":[0],"a":[1,187],"molar":[2],"basis,":[3],"tubercidin":[4,17],"(Tu)":[5],"was":[6,51,62,82,100,141,153],"about":[7,36],"20":[8],"times":[9],"more":[10],"cytotoxic":[11],"than":[12],"the":[13,26,33,54,60,70,73,86,98,105,156,174],"methyl":[14],"ester":[15],"of":[16,56,69,77,89,91,104,120,122,126,146,158,160],"5\u2032-phosphate":[18],"(MepTu)":[19],"when":[20,38,53],"KB":[21,109],"cells":[22,44,71,81,110,113,152],"were":[23,35,40,171,181],"exposed":[24],"to":[25,85,93,155,162,169,186],"drugs":[27,34,61],"for":[28,45,102],"1":[29],"hr.":[30,47],"In":[31],"contrast,":[32],"equitoxic":[37],"they":[39],"in":[41,97,173],"contact":[42,68],"with":[43,72],"72":[46],"The":[48,95,144],"same":[49],"relationship":[50],"seen":[52],"inhibition":[55],"DNA":[57],"synthesis":[58],"by":[59,124,150],"compared":[63],"after":[64],"short-":[65],"and":[66,111,165,180,185],"long-term":[67],"drugs.\n\nThe":[74],"delayed":[75],"cytotoxicity":[76],"MepTu":[78,92,123,147,161,166],"toward":[79],"mammalian":[80],"mostly":[83],"due":[84],"slow":[87],"rate":[88],"hydrolysis":[90,106,121,159,168],"Tu.":[94],"serum":[96,125,133,140],"medium":[99],"responsible":[101],"most":[103],"while":[107,138],"intact":[108],"L1210":[112],"themselves":[114],"had":[115,134],"less":[116],"hydrolytic":[117,136],"activity.\n\nThe":[118],"rates":[119],"different":[127],"animal":[128],"species":[129],"are":[130],"described.":[131],"Human":[132],"low":[135],"capacity":[137],"mouse":[139],"highly":[142],"active.":[143],"amount":[145],"taken":[148],"up":[149],"blood":[151],"proportional":[154],"percentage":[157],"Tu.\n\nBoth":[163],"Tu":[164,178],"(after":[167],"Tu)":[170],"present":[172],"acid-soluble":[175],"pool":[176],"as":[177],"phosphates":[179],"incorporated":[182],"into":[183,191],"RNA":[184],"much":[188],"lesser":[189],"extent":[190],"DNA.":[192]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}