{"id":"https://openalex.org/W2147024375","doi":"https://doi.org/10.1002/mas.20064","title":"Hydrogen exchange mass spectrometry for the analysis of protein dynamics","display_name":"Hydrogen exchange mass spectrometry for the analysis of protein dynamics","publication_year":2005,"publication_date":"2005-10-05","ids":{"openalex":"https://openalex.org/W2147024375","doi":"https://doi.org/10.1002/mas.20064","mag":"2147024375","pmid":"https://pubmed.ncbi.nlm.nih.gov/16208684"},"language":"en","primary_location":{"id":"doi:10.1002/mas.20064","doi":"https://doi.org/10.1002/mas.20064","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mas.20064","pdf_url":null,"source":{"id":"https://openalex.org/S69764086","display_name":"Mass Spectrometry Reviews","issn_l":"0277-7037","issn":["0277-7037","1098-2787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mass Spectrometry Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071831434","display_name":"Thomas E. Wales","orcid":"https://orcid.org/0000-0001-6133-5689","observed_orcids":["https://orcid.org/0000-0001-6133-5689"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas E. Wales","raw_affiliation_strings":["Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131-0001, USA","Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131-0001, USA","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082763070","display_name":"John R. Engen","orcid":"https://orcid.org/0000-0002-6918-9476","observed_orcids":["https://orcid.org/0000-0002-6918-9476"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John R. Engen","raw_affiliation_strings":["Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131","institution_ids":["https://openalex.org/I169521973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082763070"],"corresponding_institution_ids":["https://openalex.org/I169521973"],"apc_list":{"value":5230,"currency":"USD","value_usd":5230},"apc_paid":null,"fwci":3.7476,"has_fulltext":false,"cited_by_count":865,"citation_normalized_percentile":{"value":0.97209302,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"25","issue":"1","first_page":"158","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.008200000040233135,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydrogen-deuterium-exchange-mass-spectrometry","display_name":"hydrogen-deuterium exchange mass spectrometry","score":0.9810000061988831},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"protein dynamics","score":0.9929999709129333},{"id":"https://openalex.org/keywords/deuterium-incorporation","display_name":"deuterium incorporation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.824999988079071},{"id":"https://openalex.org/keywords/enzyme-activation","display_name":"enzyme activation","score":0.8700000047683716},{"id":"https://openalex.org/keywords/protein-ligand-binding","display_name":"protein-ligand binding","score":0.8619999885559082},{"id":"https://openalex.org/keywords/protein-function","display_name":"protein function","score":0.44999998807907104}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.932415246963501},{"id":"https://openalex.org/C2775981520","wikidata":"https://www.wikidata.org/wiki/Q17156992","display_name":"Protein dynamics","level":3,"score":0.7582584619522095},{"id":"https://openalex.org/C167569220","wikidata":"https://www.wikidata.org/wiki/Q5954985","display_name":"Hydrogen\u2013deuterium exchange","level":3,"score":0.7447161674499512},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.741996705532074},{"id":"https://openalex.org/C58364064","wikidata":"https://www.wikidata.org/wiki/Q102296","display_name":"Deuterium","level":2,"score":0.7198021411895752},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.5282365679740906},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.44648411870002747},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.41789400577545166},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.35359886288642883},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.32379716634750366},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.29783040285110474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1977803111076355},{"id":"https://openalex.org/C184779094","wikidata":"https://www.wikidata.org/wiki/Q26383","display_name":"Atomic physics","level":1,"score":0.10096040368080139},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003903","descriptor_name":"Deuterium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D021241","descriptor_name":"Spectrometry, Mass, Electrospray Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D041961","descriptor_name":"Deuterium Exchange Measurement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mas.20064","doi":"https://doi.org/10.1002/mas.20064","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mas.20064","pdf_url":null,"source":{"id":"https://openalex.org/S69764086","display_name":"Mass Spectrometry Reviews","issn_l":"0277-7037","issn":["0277-7037","1098-2787"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mass Spectrometry Reviews","raw_type":"journal-article"},{"id":"pmid:16208684","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16208684","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mass spectrometry reviews","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3829057187","display_name":"FUNCTIONAL PROTEIN ANALYSIS--A SHARED RESOURCE FOR UNM","funder_award_id":"R24CA088339","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4952656899","display_name":"New Mexico IDeA Networks of Biomedical Research Excellence (INBRE) [P20]","funder_award_id":"P20RR016480","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G622866585","display_name":"Arrestin activation probed with mass spectrometry","funder_award_id":"R01GM068901","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8872309832","display_name":"Structural Dynamics of Src-Family Kinase Activation","funder_award_id":"R01GM070590","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":91,"referenced_works":["https://openalex.org/W301254211","https://openalex.org/W1490851253","https://openalex.org/W1495926848","https://openalex.org/W1499408335","https://openalex.org/W1502960349","https://openalex.org/W1592588142","https://openalex.org/W1964461510","https://openalex.org/W1966510993","https://openalex.org/W1966603445","https://openalex.org/W1968718594","https://openalex.org/W1969249762","https://openalex.org/W1969875263","https://openalex.org/W1973622698","https://openalex.org/W1973992005","https://openalex.org/W1975340554","https://openalex.org/W1979819780","https://openalex.org/W1982063067","https://openalex.org/W1983502971","https://openalex.org/W1985681568","https://openalex.org/W1988624456","https://openalex.org/W1991485090","https://openalex.org/W1994201946","https://openalex.org/W1994228342","https://openalex.org/W1994477349","https://openalex.org/W1994530375","https://openalex.org/W1996826403","https://openalex.org/W1999689666","https://openalex.org/W2000415868","https://openalex.org/W2001488748","https://openalex.org/W2003544835","https://openalex.org/W2003607269","https://openalex.org/W2005834965","https://openalex.org/W2008818819","https://openalex.org/W2015381090","https://openalex.org/W2015529752","https://openalex.org/W2020513008","https://openalex.org/W2021297680","https://openalex.org/W2025648143","https://openalex.org/W2030142197","https://openalex.org/W2030362421","https://openalex.org/W2031399393","https://openalex.org/W2033300775","https://openalex.org/W2040199505","https://openalex.org/W2048087151","https://openalex.org/W2049709989","https://openalex.org/W2051606841","https://openalex.org/W2052829813","https://openalex.org/W2056540478","https://openalex.org/W2058674139","https://openalex.org/W2058880472","https://openalex.org/W2060528711","https://openalex.org/W2062551574","https://openalex.org/W2062972508","https://openalex.org/W2063811186","https://openalex.org/W2068043800","https://openalex.org/W2071068229","https://openalex.org/W2071228911","https://openalex.org/W2075331260","https://openalex.org/W2075741153","https://openalex.org/W2075885329","https://openalex.org/W2077045440","https://openalex.org/W2077659509","https://openalex.org/W2077907343","https://openalex.org/W2081133134","https://openalex.org/W2083897259","https://openalex.org/W2084619201","https://openalex.org/W2085983316","https://openalex.org/W2086024800","https://openalex.org/W2086884857","https://openalex.org/W2088473552","https://openalex.org/W2089840592","https://openalex.org/W2098999612","https://openalex.org/W2099157701","https://openalex.org/W2100678278","https://openalex.org/W2112381187","https://openalex.org/W2114320763","https://openalex.org/W2115463031","https://openalex.org/W2117360121","https://openalex.org/W2121612064","https://openalex.org/W2123218964","https://openalex.org/W2131741443","https://openalex.org/W2131918208","https://openalex.org/W2134892295","https://openalex.org/W2135309948","https://openalex.org/W2141980994","https://openalex.org/W2147654333","https://openalex.org/W2157005876","https://openalex.org/W2167810265","https://openalex.org/W2297748357","https://openalex.org/W2395369082","https://openalex.org/W2474650212"],"related_works":["https://openalex.org/W2410118221","https://openalex.org/W2076150935","https://openalex.org/W84215808","https://openalex.org/W1580673954","https://openalex.org/W1480417691","https://openalex.org/W2151586694","https://openalex.org/W2319885547","https://openalex.org/W2157005876","https://openalex.org/W4366822184","https://openalex.org/W1702911555"],"abstract_inverted_index":{"Hydrogen":[0],"exchange":[1,77],"coupled":[2],"to":[3,48],"mass":[4,95],"spectrometry":[5],"(MS)":[6],"has":[7],"become":[8],"a":[9,30,74,87],"valuable":[10],"analytical":[11],"tool":[12],"for":[13],"the":[14,82,106,122,131,135,138,142,160],"study":[15],"of":[16,34,105,134,149],"protein":[17,23,35,43,50,60,75,83,94,150],"dynamics.":[18],"By":[19],"combining":[20],"information":[21],"about":[22],"dynamics":[24,44],"with":[25,78,100],"more":[26,31],"classical":[27],"functional":[28],"data,":[29],"thorough":[32],"understanding":[33],"function":[36],"can":[37],"be":[38],"obtained.":[39],"In":[40,125],"many":[41],"cases,":[42],"are":[45,119],"directly":[46],"related":[47],"specific":[49],"functions":[51],"such":[52],"as":[53],"conformational":[54],"changes":[55],"during":[56,62],"enzyme":[57],"activation":[58],"or":[59],"movements":[61],"binding.":[63],"The":[64,90,103],"method":[65],"is":[66,84,98,109],"made":[67],"possible":[68],"because":[69],"labile":[70],"backbone":[71],"hydrogens":[72],"in":[73,86,93,115,159],"will":[76,129],"deuterium":[79,107,113],"atoms":[80],"when":[81],"placed":[85],"D2O":[88],"solution.":[89],"subsequent":[91],"increase":[92],"over":[96],"time":[97],"measured":[99],"high-resolution":[101],"MS.":[102],"location":[104],"incorporation":[108,114],"determined":[110],"by":[111],"monitoring":[112],"peptic":[116],"fragments":[117],"that":[118,145],"produced":[120],"after":[121],"labeling":[123],"reaction.":[124],"this":[126],"review,":[127],"we":[128],"summarize":[130],"general":[132],"principles":[133],"method,":[136],"discuss":[137],"latest":[139],"variations":[140],"on":[141],"experimental":[143],"protocol":[144],"probe":[146],"different":[147],"types":[148],"movements,":[151],"and":[152,157],"review":[153],"other":[154],"recent":[155],"work":[156],"improvements":[158],"field.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":24},{"year":2024,"cited_by_count":25},{"year":2023,"cited_by_count":30},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":38},{"year":2020,"cited_by_count":37},{"year":2019,"cited_by_count":53},{"year":2018,"cited_by_count":37},{"year":2017,"cited_by_count":55},{"year":2016,"cited_by_count":54},{"year":2015,"cited_by_count":53},{"year":2014,"cited_by_count":61},{"year":2013,"cited_by_count":58},{"year":2012,"cited_by_count":53}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
