{"id":"https://openalex.org/W2147019201","doi":"https://doi.org/10.1186/2045-824x-4-10","title":"The angiogenic response is dependent on ultrasound contrast agent concentration","display_name":"The angiogenic response is dependent on ultrasound contrast agent concentration","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2147019201","doi":"https://doi.org/10.1186/2045-824x-4-10","mag":"2147019201","pmid":"https://pubmed.ncbi.nlm.nih.gov/22587914","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3583242"},"language":"en","primary_location":{"id":"doi:10.1186/2045-824x-4-10","doi":"https://doi.org/10.1186/2045-824x-4-10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2045-824x-4-10","pdf_url":"https://vascularcell.com/index.php/vc/article/download/10.1186-2045-824X-4-10/169","source":{"id":"https://openalex.org/S164834453","display_name":"Vascular Cell","issn_l":"2040-2384","issn":["2040-2384","2045-824X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://vascularcell.com/index.php/vc/article/download/10.1186-2045-824X-4-10/169","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074094541","display_name":"Chenara A. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenara A Johnson","raw_affiliation_strings":["Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. wdo@uiuc.edu","Department of Bioengineering / University of Illinois at Urbana-Champaign / 61801 / Urbana / IL / USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. wdo@uiuc.edu","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Bioengineering / University of Illinois at Urbana-Champaign / 61801 / Urbana / IL / USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018653540","display_name":"William D. O\u2019Brien","orcid":"https://orcid.org/0000-0002-9298-7556","observed_orcids":["https://orcid.org/0000-0002-9298-7556"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William D O\u2019Brien","raw_affiliation_strings":["Department of Bioengineering / University of Illinois at Urbana-Champaign / 61801 / Urbana / IL / USA; Department of Electrical and Computer Engineering / University of Illinois at Urbana-Champaign / 61801 / Urbana / IL / USA; Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering / University of Illinois at Urbana-Champaign / 405 N. Mathews / 61801, 217/333-2407 / Urbana / USA;","Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering / University of Illinois at Urbana-Champaign / 405 N. Mathews / 61801, 217/333-2407 / Urbana / USA","Department of Bioengineering / University of Illinois at Urbana-Champaign / 61801 / Urbana / IL / USA","Department of Electrical and Computer Engineering / University of Illinois at Urbana-Champaign / 61801 / Urbana / IL / USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering / University of Illinois at Urbana-Champaign / 61801 / Urbana / IL / USA; Department of Electrical and Computer Engineering / University of Illinois at Urbana-Champaign / 61801 / Urbana / IL / USA; Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering / University of Illinois at Urbana-Champaign / 405 N. Mathews / 61801, 217/333-2407 / Urbana / USA;","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Bioacoustics Research Laboratory, Department of Electrical and Computer Engineering / University of Illinois at Urbana-Champaign / 405 N. Mathews / 61801, 217/333-2407 / Urbana / USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Bioengineering / University of Illinois at Urbana-Champaign / 61801 / Urbana / IL / USA","institution_ids":["https://openalex.org/I157725225"]},{"raw_affiliation_string":"Department of Electrical and Computer Engineering / University of Illinois at Urbana-Champaign / 61801 / Urbana / IL / USA","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018653540"],"corresponding_institution_ids":["https://openalex.org/I157725225"],"apc_list":null,"apc_paid":null,"fwci":0.3643,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.6303433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"4","issue":"1","first_page":"10","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12015","display_name":"Photoacoustic and Ultrasonic Imaging","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultrasound-contrast-agents","display_name":"ultrasound contrast agents","score":0.9950000047683716},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6729999780654907},{"id":"https://openalex.org/keywords/contrast-agent-concentration","display_name":"contrast agent concentration","score":0.8399999737739563},{"id":"https://openalex.org/keywords/ultrasound-bioeffects","display_name":"ultrasound bioeffects","score":0.777999997138977},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.8999999761581421},{"id":"https://openalex.org/keywords/evans-blue","display_name":"Evans blue","score":0.6809999942779541},{"id":"https://openalex.org/keywords/vegf-expression","display_name":"VEGF expression","score":0.984000027179718},{"id":"https://openalex.org/keywords/capillary-density","display_name":"capillary density","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8057520985603333},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.6090476512908936},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.5783004760742188},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3636508584022522},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3596891760826111},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.34829050302505493},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3214169442653656},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3133760690689087},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.15949848294258118},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12611401081085205},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.08541688323020935}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/2045-824x-4-10","doi":"https://doi.org/10.1186/2045-824x-4-10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2045-824x-4-10","pdf_url":"https://vascularcell.com/index.php/vc/article/download/10.1186-2045-824X-4-10/169","source":{"id":"https://openalex.org/S164834453","display_name":"Vascular Cell","issn_l":"2040-2384","issn":["2040-2384","2045-824X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular Cell","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2579935","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3583242","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3583242","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3583242","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vasc Cell","raw_type":"Text"},{"id":"pmid:22587914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22587914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/2045-824x-4-10","doi":"https://doi.org/10.1186/2045-824x-4-10","is_oa":true,"landing_page_url":"https://doi.org/10.1186/2045-824x-4-10","pdf_url":"https://vascularcell.com/index.php/vc/article/download/10.1186-2045-824X-4-10/169","source":{"id":"https://openalex.org/S164834453","display_name":"Vascular Cell","issn_l":"2040-2384","issn":["2040-2384","2045-824X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vascular Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6250795176","display_name":"Ultrasound-induced tissue damage assessment","funder_award_id":"R37EB002641","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000123745","display_name":null,"funder_award_id":"EB002641","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320326972","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147019201.pdf","grobid_xml":"https://content.openalex.org/works/W2147019201.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1953747013","https://openalex.org/W1966541965","https://openalex.org/W1972561586","https://openalex.org/W1981293537","https://openalex.org/W1996742399","https://openalex.org/W1997365698","https://openalex.org/W2006902057","https://openalex.org/W2023321687","https://openalex.org/W2029596036","https://openalex.org/W2030209430","https://openalex.org/W2032261339","https://openalex.org/W2033147508","https://openalex.org/W2037618281","https://openalex.org/W2049334703","https://openalex.org/W2058229385","https://openalex.org/W2059367263","https://openalex.org/W2059460269","https://openalex.org/W2068623366","https://openalex.org/W2068695068","https://openalex.org/W2070101981","https://openalex.org/W2073910638","https://openalex.org/W2080963472","https://openalex.org/W2088053894","https://openalex.org/W2088642020","https://openalex.org/W2103546031","https://openalex.org/W2105998706","https://openalex.org/W2106611655","https://openalex.org/W2128775138","https://openalex.org/W2142500593","https://openalex.org/W2142875026","https://openalex.org/W2155316044","https://openalex.org/W2172148503"],"related_works":["https://openalex.org/W2172148503","https://openalex.org/W2079034479","https://openalex.org/W2088647709","https://openalex.org/W1953747013","https://openalex.org/W2159259004","https://openalex.org/W7099633766","https://openalex.org/W7100304216","https://openalex.org/W1142727298","https://openalex.org/W2008014108","https://openalex.org/W4400183327"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Ultrasound":[1],"(US)":[2],"and":[3,59,100,115,141,178,205,249,260,272],"ultrasound":[4],"contrast":[5],"agents":[6],"(UCAs)":[7],"provide":[8],"a":[9,19,64,92,170,190,223,237,265],"way":[10],"to":[11,36,79,132,149,159,277],"noninvasively":[12],"induce":[13],"targeted":[14],"angiogenesis.":[15],"However,":[16,186],"there":[17],"exists":[18],"lack":[20],"of":[21,26,46,67,84,124,226,243],"understanding":[22],"regarding":[23],"the":[24,38,44,61,81,227,241,270,279],"mechanisms":[25],"this":[27],"process":[28],"that":[29,151,209,234,254],"has":[30],"impeded":[31],"progress.":[32],"This":[33,231],"study":[34,232],"sought":[35],"characterize":[37],"angiogenic":[39,228,245,280],"response,":[40],"by":[41,122],"both":[42,164],"exploring":[43],"role":[45],"UCA":[47],"concentration":[48],"([UCA])":[49],"in":[50,135,240],"bioeffect":[51,62],"induction":[52,242],"at":[53,69,146,163,196,213],"0":[54,197,204,220],"days":[55],"post":[56],"exposure":[57],"(DPE)":[58],"assessing":[60],"as":[63,262],"possible":[65],"potentiator":[66],"angiogenesis":[68,152],"5":[70,89,147,199,206,214],"DPE.":[71,200],"METHODS:":[72],"A":[73],"1-MHz":[74],"ultrasonic":[75],"transducer":[76],"was":[77,130,144,157,169,188,216,236],"used":[78,131,158],"expose":[80],"gracilis":[82],"muscles":[83],"Sprague":[85],"Dawley":[86],"rats":[87],"for":[88,173,184,193],"min":[90],"with":[91,247],"10-\u03bcs":[93],"pulse":[94,97],"duration,":[95],"10-Hz":[96],"repetition":[98],"frequency,":[99],"0.7-MPa":[101],"peak":[102],"rarefactional":[103],"acoustic":[104],"pressure":[105],"(pr).":[106],"Four":[107],"[UCA]s":[108],"were":[109],"tested:":[110],"0x":[111],"(saline),":[112],"1\u00d7,":[113],"5\u00d7,":[114],"10\u00d7,":[116],"where":[117],"1\u00d7":[118],"is":[119],"5%":[120],"Definity":[121],"volume":[123],"solution.":[125],"Evans":[126],"blue":[127],"dye":[128],"(EBD)":[129],"quantify":[133],"changes":[134],"acute":[136],"vascular":[137,273],"permeability":[138],"(0":[139],"DPE),":[140],"VEGF":[142,179],"expression":[143,180],"quantified":[145],"DPE":[148,207,215],"support":[150],"had":[153],"occurred.":[154],"CD31":[155],"staining":[156],"assess":[160],"capillary":[161,194],"density":[162,195],"time":[165],"points.":[166],"RESULTS:":[167],"[UCA]":[168,187,212,224,235],"significant":[171,191,238],"parameter":[172,192,239],"determining":[174],"EBD":[175],"leakage":[176],"(permeability)":[177],"(p":[181],"<":[182],"0.001":[183],"both).":[185],"not":[189],"or":[198],"Multiple":[201],"comparisons":[202],"between":[203,269],"showed":[208],"only":[210],"10\u00d7":[211],"significantly":[217],"different":[218],"than":[219,256],"DPE,":[221],"suggesting":[222],"dependence":[225],"response.":[229,281],"CONCLUSIONS:":[230],"suggests":[233,253],"an":[244],"response":[246],"US":[248,259],"UCAs.":[250],"It":[251],"also":[252],"rather":[255],"damage":[257],"from":[258],"UCAs,":[261],"previously":[263],"speculated,":[264],"nondestructive":[266],"mechanical":[267],"interaction":[268],"UCAs":[271],"endothelium":[274],"induces":[275],"bioeffects":[276],"potentiate":[278]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}