{"id":"https://openalex.org/W2147012305","doi":null,"title":"Central nucleus of the amygdala in descending control of pain-related behavior","display_name":"Central nucleus of the amygdala in descending control of pain-related behavior","publication_year":2015,"publication_date":"2015-08-11","ids":{"openalex":"https://openalex.org/W2147012305","mag":"2147012305"},"language":"en","primary_location":{"id":"pmh:oai:helda.helsinki.fi:10138/155702","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/155702","pdf_url":"http://hdl.handle.net/10138/155702","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10138/155702","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086153860","display_name":"Nora Bourbia","orcid":"https://orcid.org/0000-0001-8006-823X","observed_orcids":["https://orcid.org/0000-0001-8006-823X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Nora Bourbia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086153860"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/central-nucleus-of-the-amygdala","display_name":"central amygdala","score":0.9079999923706055},{"id":"https://openalex.org/keywords/descending-pain-modulation","display_name":"descending pain modulation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/chronic-neuropathic-pain","display_name":"chronic neuropathic pain","score":0.9100000262260437},{"id":"https://openalex.org/keywords/spared-nerve-injury","display_name":"spared nerve injury","score":0.9399999976158142},{"id":"https://openalex.org/keywords/corticotropin-releasing-factor","display_name":"corticotropin-releasing factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/group-i-metabotropic-glutamate-receptors","display_name":"group I metabotropic glutamate receptors","score":0.8560000061988831},{"id":"https://openalex.org/keywords/mglur1","display_name":"mGluR1","score":0.9240000247955322},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.6330000162124634},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.6669999957084656},{"id":"https://openalex.org/keywords/periaqueductal-gray","display_name":"periaqueductal gray","score":0.8730000257492065},{"id":"https://openalex.org/keywords/sensory-discriminative-pain","display_name":"sensory-discriminative pain","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.7172161340713501},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.5313369035720825},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5123854279518127},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4626079499721527},{"id":"https://openalex.org/C2777426569","wikidata":"https://www.wikidata.org/wiki/Q5062126","display_name":"Central nucleus of the amygdala","level":3,"score":0.4511309862136841}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:helda.helsinki.fi:10138/155702","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/155702","pdf_url":"http://hdl.handle.net/10138/155702","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.978.5478","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.978.5478","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://helda.helsinki.fi/bitstream/handle/10138/155702/centraln.pdf%3Bjsessionid%3DA0A11832C894169F5B633D8C8EE24D09?sequence%3D1","raw_type":"text"},{"id":"mag:2147012305","doi":null,"is_oa":false,"landing_page_url":"https://helda.helsinki.fi/bitstream/10138/155702/1/centraln.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:helda.helsinki.fi:10138/155702","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/155702","pdf_url":"http://hdl.handle.net/10138/155702","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["ddh","jufo-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoralThesis"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320322754","display_name":"Kansainv\u00e4lisen Liikkuvuuden ja Yhteisty\u00f6n Keskus","ror":"https://ror.org/00wj0f678"},{"id":"https://openalex.org/F4320322861","display_name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/005rt3g54"},{"id":"https://openalex.org/F4320323760","display_name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00ckakm23"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2147012305.pdf","grobid_xml":"https://content.openalex.org/works/W2147012305.grobid-xml"},"referenced_works_count":209,"referenced_works":["https://openalex.org/W47887686","https://openalex.org/W1506802847","https://openalex.org/W1567484043","https://openalex.org/W1577753627","https://openalex.org/W1582090951","https://openalex.org/W1584138169","https://openalex.org/W1601053906","https://openalex.org/W1602500275","https://openalex.org/W1604789895","https://openalex.org/W1608318158","https://openalex.org/W1738778520","https://openalex.org/W1769392980","https://openalex.org/W1817626063","https://openalex.org/W1862521538","https://openalex.org/W1862698768","https://openalex.org/W1883044208","https://openalex.org/W1944937124","https://openalex.org/W1959439884","https://openalex.org/W1963819476","https://openalex.org/W1965066118","https://openalex.org/W1966681494","https://openalex.org/W1967677380","https://openalex.org/W1971046211","https://openalex.org/W1972087800","https://openalex.org/W1972308065","https://openalex.org/W1973345654","https://openalex.org/W1974720828","https://openalex.org/W1974936571","https://openalex.org/W1976569881","https://openalex.org/W1978647782","https://openalex.org/W1978754919","https://openalex.org/W1978896524","https://openalex.org/W1978926613","https://openalex.org/W1979514882","https://openalex.org/W1979809234","https://openalex.org/W1980499237","https://openalex.org/W1980899076","https://openalex.org/W1982324570","https://openalex.org/W1985150351","https://openalex.org/W1985387196","https://openalex.org/W1985748807","https://openalex.org/W1985956463","https://openalex.org/W1986079135","https://openalex.org/W1988520394","https://openalex.org/W1988677318","https://openalex.org/W1990014844","https://openalex.org/W1990126819","https://openalex.org/W1993267237","https://openalex.org/W1995465610","https://openalex.org/W1998026463","https://openalex.org/W1998634228","https://openalex.org/W1999968276","https://openalex.org/W2001537848","https://openalex.org/W2002664363","https://openalex.org/W2003400289","https://openalex.org/W2004901620","https://openalex.org/W2005129085","https://openalex.org/W2006132476","https://openalex.org/W2008106418","https://openalex.org/W2008785662","https://openalex.org/W2009073501","https://openalex.org/W2009374031","https://openalex.org/W2010589854","https://openalex.org/W2011590385","https://openalex.org/W2013728417","https://openalex.org/W2013830361","https://openalex.org/W2013885507","https://openalex.org/W2013914537","https://openalex.org/W2013924802","https://openalex.org/W2015473510","https://openalex.org/W2015641096","https://openalex.org/W2018368852","https://openalex.org/W2018645868","https://openalex.org/W2019794987","https://openalex.org/W2019821941","https://openalex.org/W2020839318","https://openalex.org/W2022248485","https://openalex.org/W2022835494","https://openalex.org/W2022862310","https://openalex.org/W2023908259","https://openalex.org/W2024136403","https://openalex.org/W2026072615","https://openalex.org/W2026829647","https://openalex.org/W2027072793","https://openalex.org/W2027523863","https://openalex.org/W2027584400","https://openalex.org/W2028934136","https://openalex.org/W2029348535","https://openalex.org/W2029389427","https://openalex.org/W2032052087","https://openalex.org/W2032480075","https://openalex.org/W2033824845","https://openalex.org/W2034709588","https://openalex.org/W2035015555","https://openalex.org/W2036062643","https://openalex.org/W2037366172","https://openalex.org/W2040213978","https://openalex.org/W2040443501","https://openalex.org/W2040509064","https://openalex.org/W2040540166","https://openalex.org/W2043051277","https://openalex.org/W2043487642","https://openalex.org/W2043915483","https://openalex.org/W2044860425","https://openalex.org/W2044873841","https://openalex.org/W2045979887","https://openalex.org/W2046013541","https://openalex.org/W2047010161","https://openalex.org/W2048220035","https://openalex.org/W2048701325","https://openalex.org/W2049511526","https://openalex.org/W2050066016","https://openalex.org/W2050251142","https://openalex.org/W2050750919","https://openalex.org/W2053047652","https://openalex.org/W2053986765","https://openalex.org/W2054221346","https://openalex.org/W2059074079","https://openalex.org/W2060350676","https://openalex.org/W2061404967","https://openalex.org/W2061600370","https://openalex.org/W2062700118","https://openalex.org/W2063246027","https://openalex.org/W2064698198","https://openalex.org/W2066837200","https://openalex.org/W2067988122","https://openalex.org/W2073035767","https://openalex.org/W2073356650","https://openalex.org/W2073430759","https://openalex.org/W2073844986","https://openalex.org/W2075253677","https://openalex.org/W2075312117","https://openalex.org/W2079403841","https://openalex.org/W2079909627","https://openalex.org/W2080084877","https://openalex.org/W2080603742","https://openalex.org/W2081085930","https://openalex.org/W2081308078","https://openalex.org/W2082215577","https://openalex.org/W2085286930","https://openalex.org/W2086659083","https://openalex.org/W2087472973","https://openalex.org/W2090283458","https://openalex.org/W2091034155","https://openalex.org/W2091172151","https://openalex.org/W2091282711","https://openalex.org/W2092767025","https://openalex.org/W2092929554","https://openalex.org/W2093500809","https://openalex.org/W2099082558","https://openalex.org/W2103249556","https://openalex.org/W2104089244","https://openalex.org/W2104851682","https://openalex.org/W2106571496","https://openalex.org/W2107001816","https://openalex.org/W2111544318","https://openalex.org/W2114501436","https://openalex.org/W2115393043","https://openalex.org/W2116635659","https://openalex.org/W2117457874","https://openalex.org/W2121214651","https://openalex.org/W2121366273","https://openalex.org/W2122163450","https://openalex.org/W2122654901","https://openalex.org/W2123258170","https://openalex.org/W2123488301","https://openalex.org/W2124550844","https://openalex.org/W2125028680","https://openalex.org/W2127894556","https://openalex.org/W2128574573","https://openalex.org/W2129239485","https://openalex.org/W2131695915","https://openalex.org/W2135923112","https://openalex.org/W2136408513","https://openalex.org/W2136876344","https://openalex.org/W2141005071","https://openalex.org/W2141901630","https://openalex.org/W2142628949","https://openalex.org/W2144358297","https://openalex.org/W2144395351","https://openalex.org/W2144933081","https://openalex.org/W2145062794","https://openalex.org/W2147948348","https://openalex.org/W2151292425","https://openalex.org/W2151678102","https://openalex.org/W2153898363","https://openalex.org/W2154546113","https://openalex.org/W2155926670","https://openalex.org/W2157473071","https://openalex.org/W2159259673","https://openalex.org/W2161464817","https://openalex.org/W2161998020","https://openalex.org/W2163986606","https://openalex.org/W2166523893","https://openalex.org/W2169949212","https://openalex.org/W2171037951","https://openalex.org/W2171952745","https://openalex.org/W2172166988","https://openalex.org/W2217896758","https://openalex.org/W2224771370","https://openalex.org/W2243322739","https://openalex.org/W2246441098","https://openalex.org/W2331665880","https://openalex.org/W2341656352","https://openalex.org/W2390431606","https://openalex.org/W2412953837","https://openalex.org/W2419628133","https://openalex.org/W2477022270","https://openalex.org/W4406058850"],"related_works":["https://openalex.org/W2163986606","https://openalex.org/W2037366172","https://openalex.org/W2972014858","https://openalex.org/W4220992912","https://openalex.org/W2315645997","https://openalex.org/W2749657464","https://openalex.org/W2125028680","https://openalex.org/W2954427034","https://openalex.org/W2015641096","https://openalex.org/W4281749770"],"abstract_inverted_index":{"The":[0,30,164,226,314,355],"central":[1],"nucleus":[2],"of":[3,24,32,40,50,66,77,142,147,169,176,186,201,205,223,232,238,254,258,280,311,319,322,329,360,367,375,389,399,421,434,446],"amygdala":[4],"(CeA)":[5],"is":[6,27,244,342,382],"known":[7],"to":[8,36,112,308],"be":[9],"involved":[10,126],"in":[11,21,53,57,62,127,134,172,178,216,241,246,271,290,304,327,335,363,372,385,406,410,428,436],"pain":[12,54,69,78,82,148,177,233],"and":[13,46,55,61,92,102,118,136,145,156,184,195,249,301,349,440,448,456],"nociception,":[14,450],"but":[15,273],"the":[16,38,41,47,51,88,98,103,109,119,132,143,167,170,173,187,198,217,220,229,242,302,305,309,317,323,340,353,358,361,364,373,380,386,396,400,418,422,438],"mechanisms":[17],"or":[18],"its":[19],"role":[20,168,318,359],"descending":[22,295,347,365,387,414],"control":[23,59,138,248,366,388],"pain-related":[25],"behavior":[26,83],"poorly":[28],"understood.":[29],"aim":[31],"this":[33],"study":[34],"was":[35,84,94,266,408],"investigate":[37],"involvement":[39],"neuropeptide":[42],"corticotropin-releasing":[43],"factor":[44],"(CRF)":[45],"glutamatergic":[48,212,419],"system":[49,420],"CeA":[52,133,144,171,218,243,252,306,374,423,442],"nociception":[56,331,368,390],"healthy":[58,137,272,376,429],"animals":[60],"an":[63,236],"animal":[64],"model":[65],"chronic":[67],"neuropathic":[68,224,312],"induced":[70,130,297,369,391,416,443],"by":[71,86,96,131,268,287,298,332,370,392,403,417],"spared-nerve":[72],"injury":[73],"(SNI).":[74],"Two":[75],"aspects":[76],"were":[79,111,125,150,159],"studied:":[80],"emotional-like":[81,174],"assessed":[85,95],"using":[87],"aversive":[89,199,221],"place-avoidance":[90],"paradigm":[91],"sensory-discriminative":[93,230],"determining":[97],"mechanical":[99,262,447],"limb-withdrawal":[100,106],"threshold":[101],"thermal":[104,449],"(heat)":[105],"latency.":[107],"Moreover,":[108],"aims":[110],"determine":[113],"whether":[114],"medullospinal":[115],"serotoninergic":[116],"pathways":[117],"midbrain":[120],"periaqueductal":[121],"grey":[122],"(PAG),":[123],"respectively,":[124,197,454],"relaying":[128],"pain-modulation":[129],"SNI":[135,179,250,275,291,336,411],"animals.":[139],"Additionally,":[140],"hemisphere":[141],"submodality":[146],"stimulus":[149],"among":[151],"studied":[152],"parameters.":[153],"Surgical":[154],"procedures":[155],"electrophysiological":[157],"recordings":[158],"performed":[160],"under":[161],"general":[162],"anesthesia.":[163],"studies":[165,227],"on":[166,228,316,357],"aspect":[175,200,222,231],"rats":[180,337,377],"revealed":[181,234],"that":[182,235,265,339,379],"activation":[183],"blocking":[185,211],"group":[188],"I":[189],"metabotropic":[190],"glutamate":[191,259,281,334,371,435],"receptors":[192,215,270,289,300],"(mGluRs)":[193],"facilitates":[194],"inhibits,":[196],"pain.":[202,225],"Furthermore,":[203,293,395],"increase":[204,237],"endogenous":[206,239],"CRF":[207,240,405],"as":[208,210],"well":[209],"N-methyl-D-aspartate":[213],"(NMDA)":[214],"reduced":[219],"pronociceptive":[245,284,401],"both":[247,346,437],"rats.":[251,276,292,412],"injection":[253],"a":[255,261,283,343,383,431],"high":[256,432],"dose":[257,279,433],"had":[260,282],"antinociceptive":[263,350],"effect":[264,285,402],"mediated":[267,286],"NMDA":[269,288,299],"not":[274],"A":[277],"low":[278],"tonic":[294],"pronociception":[296],"mGluR1":[303],"contributes":[307],"maintenance":[310],"hypersensitivity.":[313],"investigation":[315,356],"serotonergic":[320],"neurons":[321],"rostroventromedial":[324],"medulla":[325],"(RVM)":[326],"modulation":[328],"spinal":[330],"amygdaloid":[333,393,404],"indicated":[338,378],"RVM":[341],"relay":[344,384],"for":[345],"pro-":[348],"effects":[351,452],"from":[352],"CeA.":[354],"PAG":[362,381],"glutamate.":[394],"right-hemispheric":[397],"lateralization":[398,427],"controls":[407],"lost":[409],"However,":[413],"antinociception":[415],"showed":[424],"no":[425],"hemispheric":[426],"controls;":[430],"left":[439],"right":[441],"equal":[444],"attenuations":[445],"which":[451],"were,":[453],"NMDA-dependent":[455],"NDMA-independent.":[457]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
