{"id":"https://openalex.org/W2147002124","doi":"https://doi.org/10.1093/jat/10.2.46","title":"LC/MS Determination of Bromazepam, Clopenthixol, and Reserpine in Serum of a Non-Fatal Case of Intoxication","display_name":"LC/MS Determination of Bromazepam, Clopenthixol, and Reserpine in Serum of a Non-Fatal Case of Intoxication","publication_year":1986,"publication_date":"1986-03-01","ids":{"openalex":"https://openalex.org/W2147002124","doi":"https://doi.org/10.1093/jat/10.2.46","mag":"2147002124","pmid":"https://pubmed.ncbi.nlm.nih.gov/2871228"},"language":"en","primary_location":{"id":"doi:10.1093/jat/10.2.46","doi":"https://doi.org/10.1093/jat/10.2.46","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jat/10.2.46","pdf_url":null,"source":{"id":"https://openalex.org/S140972820","display_name":"Journal of Analytical Toxicology","issn_l":"0146-4760","issn":["0146-4760","1945-2403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037559677","display_name":"A.C. Tas","orcid":"https://orcid.org/0000-0003-2991-6322","observed_orcids":["https://orcid.org/0000-0003-2991-6322"]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. C. Tas","raw_affiliation_strings":["TNO-CIVO Institutes, P.O. Box 360, 3700 AJ Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO-CIVO Institutes, P.O. Box 360, 3700 AJ Zeist, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038766778","display_name":"J. van der Greef","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. van der Greef","raw_affiliation_strings":["TNO-CIVO Institutes, P.O. Box 360, 3700 AJ Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO-CIVO Institutes, P.O. Box 360, 3700 AJ Zeist, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078828848","display_name":"M.C. ten Noever de Brauw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148297040","display_name":"Netherlands Organisation for Applied Scientific Research","ror":"https://ror.org/01bnjb948","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I148297040"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. C. ten Noever de Brauw","raw_affiliation_strings":["TNO-CIVO Institutes, P.O. Box 360, 3700 AJ Zeist, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TNO-CIVO Institutes, P.O. Box 360, 3700 AJ Zeist, The Netherlands","institution_ids":["https://openalex.org/I148297040"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110021595","display_name":"Th. A. Plomp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"T. A. Plomp","raw_affiliation_strings":["University of Utrecht, Centre for Human Toxicology, Vondellaan 14, 3521 GE Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utrecht, Centre for Human Toxicology, Vondellaan 14, 3521 GE Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113608977","display_name":"R. A. A. Maes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"R. A. A. Maes","raw_affiliation_strings":["University of Utrecht, Centre for Human Toxicology, Vondellaan 14, 3521 GE Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utrecht, Centre for Human Toxicology, Vondellaan 14, 3521 GE Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040953536","display_name":"M. H\u00f6hn","orcid":"https://orcid.org/0000-0002-7555-4580","observed_orcids":["https://orcid.org/0000-0002-7555-4580"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Hohn","raw_affiliation_strings":["Finnigan MAT, Barkenhausenstrasse 2, 2800 Bremen 14, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Finnigan MAT, Barkenhausenstrasse 2, 2800 Bremen 14, Federal Republic of Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011684246","display_name":"Uwe Rapp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"U. Rapp","raw_affiliation_strings":["Finnigan MAT, Barkenhausenstrasse 2, 2800 Bremen 14, Federal Republic of Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Finnigan MAT, Barkenhausenstrasse 2, 2800 Bremen 14, Federal Republic of Germany","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113608977"],"corresponding_institution_ids":["https://openalex.org/I193662353"],"apc_list":{"value":4823,"currency":"USD","value_usd":4823},"apc_paid":null,"fwci":4.5927,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.94714329,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"10","issue":"2","first_page":"46","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11423","display_name":"Pesticide Residue Analysis and Safety","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bromazepam","display_name":"bromazepam","score":1.0},{"id":"https://openalex.org/keywords/clopenthixol","display_name":"clopenthixol","score":0.9990000128746033},{"id":"https://openalex.org/keywords/reserpine","display_name":"reserpine","score":1.0},{"id":"https://openalex.org/keywords/serum-drug-determination","display_name":"serum drug determination","score":0.6549999713897705},{"id":"https://openalex.org/keywords/drug-poisoning","display_name":"drug poisoning","score":0.6430000066757202},{"id":"https://openalex.org/keywords/lc-ms","display_name":"LC-MS","score":0.5090000033378601},{"id":"https://openalex.org/keywords/memory-effects","display_name":"memory effects","score":0.503000020980835},{"id":"https://openalex.org/keywords/detection-limit","display_name":"detection limit","score":0.46700000762939453},{"id":"https://openalex.org/keywords/forensic-toxicology","display_name":"forensic toxicology","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C2778519950","wikidata":"https://www.wikidata.org/wiki/Q422435","display_name":"Bromazepam","level":4,"score":0.7703887224197388},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.5808385610580444},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42055660486221313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18965986371040344},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.15126526355743408},{"id":"https://openalex.org/C2778173252","wikidata":"https://www.wikidata.org/wiki/Q83871","display_name":"Benzodiazepine","level":3,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001960","descriptor_name":"Bromazepam","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001960","descriptor_name":"Bromazepam","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003006","descriptor_name":"Clopenthixol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003006","descriptor_name":"Clopenthixol","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012110","descriptor_name":"Reserpine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D012110","descriptor_name":"Reserpine","qualifier_ui":"Q000506","qualifier_name":"poisoning","is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013892","descriptor_name":"Thioxanthenes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/jat/10.2.46","doi":"https://doi.org/10.1093/jat/10.2.46","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jat/10.2.46","pdf_url":null,"source":{"id":"https://openalex.org/S140972820","display_name":"Journal of Analytical Toxicology","issn_l":"0146-4760","issn":["0146-4760","1945-2403"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Analytical Toxicology","raw_type":"journal-article"},{"id":"pmid:2871228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2871228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of analytical toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.836.4422","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.836.4422","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jat.oxfordjournals.org/content/10/2/46.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8263999819755554,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1974847149","https://openalex.org/W1975846004","https://openalex.org/W1977945080","https://openalex.org/W1982109841","https://openalex.org/W1990174181","https://openalex.org/W2012287059","https://openalex.org/W2012671639","https://openalex.org/W2020729534","https://openalex.org/W2029527804","https://openalex.org/W2036317320","https://openalex.org/W2036784207","https://openalex.org/W2039604560","https://openalex.org/W2051120301","https://openalex.org/W2052848611","https://openalex.org/W2055639263","https://openalex.org/W2062164584","https://openalex.org/W2080077667","https://openalex.org/W2146602224"],"related_works":["https://openalex.org/W7097181355","https://openalex.org/W2080462862","https://openalex.org/W2304227193","https://openalex.org/W2082065775","https://openalex.org/W1987657867","https://openalex.org/W2379850575","https://openalex.org/W4413440500","https://openalex.org/W2014064219","https://openalex.org/W2825225819","https://openalex.org/W2146287947"],"abstract_inverted_index":{"Combined":[0],"liquid":[1],"chromatography":[2],"and":[3,25,97,112],"mass":[4,89],"spectrometry":[5],"(LC/MS)":[6],"with":[7,36],"a":[8,16,76,87],"moving":[9],"belt":[10,104,120],"interface":[11],"can":[12],"be":[13,66],"used":[14],"as":[15],"rapid":[17],"method":[18],"for":[19,49,61,91],"the":[20,50,58,103,115,119],"determination":[21],"of":[22,33,38,95,102,118,125],"bromazepam,":[23],"clopenthixol,":[24,98],"reserpine":[26],"in":[27,54,75],"serum":[28,77],"samples":[29],"obtained":[30,74],"from":[31],"cases":[32],"acute":[34],"overdoses":[35],"combinations":[37],"these":[39],"drugs.":[40],"Low":[41],"resolution":[42,56],"detection":[43,59],"limits":[44],"are":[45],"about":[46,92],"100":[47],"pg":[48],"three":[51],"drugs,":[52],"while":[53],"high":[55,83],"mode":[57],"limit":[60],"bromazepam":[62,96],"is":[63],"shown":[64,106],"to":[65,107,113,122],"at":[67],"least":[68],"35":[69],"pg.":[70],"Accurate":[71],"masses":[72],"were":[73],"sample":[78],"within":[79],"5":[80],"ppm":[81],"using":[82],"voltage":[84],"scanning":[85],"over":[86],"narrow":[88],"range":[90],"10":[93],"ng":[94],"respectively.":[99],"Chemical":[100],"deactivation":[101],"was":[105],"effectively":[108],"reduce":[109],"memory":[110],"effects":[111],"improve":[114],"desorption":[116],"characteristics":[117],"leading":[121],"higher":[123],"yields":[124],"evaporated":[126],"intact":[127],"molecules.":[128]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
