{"id":"https://openalex.org/W2147000688","doi":"https://doi.org/10.1093/genetics/153.3.1091","title":"Activation of the Saccharomyces cerevisiae Filamentation/Invasion Pathway by Osmotic Stress in High-Osmolarity Glycogen Pathway Mutants","display_name":"Activation of the Saccharomyces cerevisiae Filamentation/Invasion Pathway by Osmotic Stress in High-Osmolarity Glycogen Pathway Mutants","publication_year":1999,"publication_date":"1999-11-01","ids":{"openalex":"https://openalex.org/W2147000688","doi":"https://doi.org/10.1093/genetics/153.3.1091","mag":"2147000688","pmid":"https://pubmed.ncbi.nlm.nih.gov/10545444","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1460814"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/153.3.1091","doi":"https://doi.org/10.1093/genetics/153.3.1091","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/153.3.1091","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111959519","display_name":"Kenneth Davenport","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K D Davenport","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005-1892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005-1892","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057754874","display_name":"Kim E. Williams","orcid":"https://orcid.org/0000-0002-9379-8917","observed_orcids":["https://orcid.org/0000-0002-9379-8917"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K E Williams","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005-1892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005-1892","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030049361","display_name":"Breanna Diane Ullmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B D Ullmann","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005-1892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005-1892","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042023011","display_name":"Michael C. Gustin","orcid":"https://orcid.org/0000-0003-0097-9194","observed_orcids":["https://orcid.org/0000-0003-0097-9194"]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M C Gustin","raw_affiliation_strings":["Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005-1892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005-1892","institution_ids":["https://openalex.org/I74775410"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042023011"],"corresponding_institution_ids":["https://openalex.org/I74775410"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":1.8196,"has_fulltext":true,"cited_by_count":78,"citation_normalized_percentile":{"value":0.85197545,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"153","issue":"3","first_page":"1091","last_page":"1103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hog-pathway","display_name":"HOG pathway","score":0.8360000252723694},{"id":"https://openalex.org/keywords/osmotic-stress","display_name":"osmotic stress","score":0.8159999847412109},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7590000033378601},{"id":"https://openalex.org/keywords/dual-specificity-phosphatase","display_name":"dual-specificity phosphatase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/tec1","display_name":"Tec1","score":0.7620000243186951},{"id":"https://openalex.org/keywords/ste7","display_name":"Ste7","score":0.8370000123977661},{"id":"https://openalex.org/keywords/osmosensitivity","display_name":"osmosensitivity","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8081935048103333},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.6998831629753113},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.65028315782547},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6342891454696655},{"id":"https://openalex.org/C4907923","wikidata":"https://www.wikidata.org/wiki/Q5448273","display_name":"Filamentation","level":3,"score":0.6036783456802368},{"id":"https://openalex.org/C168529131","wikidata":"https://www.wikidata.org/wiki/Q13656562","display_name":"Osmotic shock","level":3,"score":0.5897927284240723},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5488623976707458},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5148472189903259},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.48842138051986694},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.4524742662906647},{"id":"https://openalex.org/C129900496","wikidata":"https://www.wikidata.org/wiki/Q643555","display_name":"Osmotic concentration","level":2,"score":0.43462836742401123},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.4258330464363098},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3229061961174011},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26871705055236816},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20495766401290894},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C520434653","wikidata":"https://www.wikidata.org/wiki/Q38867","display_name":"Laser","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005990","descriptor_name":"Glycerol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006003","descriptor_name":"Glycogen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013012","descriptor_name":"Sorbitol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013489","descriptor_name":"Suppression, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/genetics/153.3.1091","doi":"https://doi.org/10.1093/genetics/153.3.1091","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/153.3.1091","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmid:10545444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10545444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G5072236891","display_name":null,"funder_award_id":"GMO-83262-7","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W9946280","https://openalex.org/W1501659119","https://openalex.org/W1526043578","https://openalex.org/W1531194664","https://openalex.org/W1573821584","https://openalex.org/W1588192538","https://openalex.org/W1600400967","https://openalex.org/W1600651336","https://openalex.org/W1806143782","https://openalex.org/W1857242751","https://openalex.org/W1898443428","https://openalex.org/W1944234208","https://openalex.org/W1965833684","https://openalex.org/W1971453983","https://openalex.org/W1977667188","https://openalex.org/W1981249926","https://openalex.org/W1983482381","https://openalex.org/W1985891609","https://openalex.org/W1992016289","https://openalex.org/W1994478080","https://openalex.org/W1998871484","https://openalex.org/W1999157780","https://openalex.org/W1999340863","https://openalex.org/W2002141062","https://openalex.org/W2006733565","https://openalex.org/W2007555056","https://openalex.org/W2020679798","https://openalex.org/W2022200993","https://openalex.org/W2029086616","https://openalex.org/W2035797493","https://openalex.org/W2037221816","https://openalex.org/W2039839254","https://openalex.org/W2051538397","https://openalex.org/W2056178963","https://openalex.org/W2057126981","https://openalex.org/W2066955442","https://openalex.org/W2075104267","https://openalex.org/W2077339073","https://openalex.org/W2079588007","https://openalex.org/W2083076387","https://openalex.org/W2084737875","https://openalex.org/W2084952038","https://openalex.org/W2091512138","https://openalex.org/W2093070862","https://openalex.org/W2094498131","https://openalex.org/W2097283846","https://openalex.org/W2099221935","https://openalex.org/W2108053853","https://openalex.org/W2110330905","https://openalex.org/W2136623592","https://openalex.org/W2136891997","https://openalex.org/W2144634347","https://openalex.org/W2144784260","https://openalex.org/W2148665155","https://openalex.org/W2162929432","https://openalex.org/W2165310182","https://openalex.org/W2314225431","https://openalex.org/W6683579831","https://openalex.org/W6815745757"],"related_works":["https://openalex.org/W2585653632","https://openalex.org/W2110852847","https://openalex.org/W2792808883","https://openalex.org/W2117466701","https://openalex.org/W2021674453","https://openalex.org/W2144368255","https://openalex.org/W2141879066","https://openalex.org/W2145757787","https://openalex.org/W7135620648","https://openalex.org/W2079588007"],"abstract_inverted_index":{"Mitogen-activated":[0],"protein":[1],"kinase":[2],"(MAPK)":[3],"cascades":[4,17],"are":[5,133,161],"frequently":[6],"used":[7],"signal":[8],"transduction":[9],"mechanisms":[10],"in":[11,18,41,46,84,106,111,117,122,135,145,163],"eukaryotes.":[12],"Of":[13],"the":[14,21,42,88,99,150,173,181],"five":[15],"MAPK":[16,90],"Saccharomyces":[19],"cerevisiae,":[20],"high-osmolarity":[22,58],"glycerol":[23],"response":[24,107],"(HOG)":[25],"pathway":[26,141,177],"functions":[27],"to":[28,32,51,81,108,180],"sense":[29],"and":[30,70,130],"respond":[31],"hypertonic":[33],"stress.":[34],"We":[35],"utilized":[36],"a":[37,47,74,112,118,123,138,146,155],"partial":[38],"loss-of-function":[39],"mutant":[40,157,183],"HOG":[43,140,182],"pathway,":[44],"pbs2-3,":[45],"high-copy":[48,61],"suppressor":[49],"screen":[50],"identify":[52],"proteins":[53],"that":[54,77,95,172],"modulate":[55],"growth":[56],"on":[57,158],"media.":[59],"Three":[60],"suppressors":[62],"of":[63,87,92,101,175],"pbs2-3":[64,113,124,156],"osmosensitivity":[65,100],"were":[66],"identified:":[67],"MSG5,":[68],"CAK1,":[69],"TRX1.":[71],"Msg5p":[72,93],"is":[73,104],"dual-specificity":[75],"phosphatase":[76],"was":[78],"previously":[79],"demonstrated":[80],"dephosphorylate":[82],"MAPKs":[83],"yeast.":[85],"Deletions":[86],"putative":[89],"targets":[91],"revealed":[94],"kss1delta":[96],"could":[97],"suppress":[98],"pbs2-3.":[102],"Kss1p":[103],"phosphorylated":[105],"hyperosmotic":[109],"shock":[110],"strain,":[114],"but":[115],"not":[116],"wild-type":[119],"strain":[120,125],"nor":[121],"overexpressing":[126],"MSG5.":[127],"Both":[128],"TEC1":[129],"FRE::lacZ":[131],"expressions":[132],"activated":[134],"strains":[136,164],"lacking":[137,165],"functional":[139],"during":[142],"osmotic":[143],"stress":[144],"filamentation/invasion-pathway-dependent":[147],"manner.":[148],"Additionally,":[149],"cellular":[151],"projections":[152],"formed":[153],"by":[154],"high":[159],"osmolarity":[160],"absent":[162],"KSS1":[166],"or":[167],"STE7.":[168],"These":[169],"data":[170],"suggest":[171],"loss":[174],"filamentation/invasion":[176],"repression":[178],"contributes":[179],"phenotype.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}