{"id":"https://openalex.org/W2146994571","doi":"https://doi.org/10.1172/jci113650","title":"A common neoepitope is created when the reactive center of C1-inhibitor is cleaved by plasma kallikrein, activated factor XII fragment, C1 esterase, or neutrophil elastase.","display_name":"A common neoepitope is created when the reactive center of C1-inhibitor is cleaved by plasma kallikrein, activated factor XII fragment, C1 esterase, or neutrophil elastase.","publication_year":1988,"publication_date":"1988-08-01","ids":{"openalex":"https://openalex.org/W2146994571","doi":"https://doi.org/10.1172/jci113650","mag":"2146994571","pmid":"https://pubmed.ncbi.nlm.nih.gov/2457036","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/303566"},"language":"en","primary_location":{"id":"doi:10.1172/jci113650","doi":"https://doi.org/10.1172/jci113650","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci113650","pdf_url":"http://www.jci.org/articles/view/113650/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/113650/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084649088","display_name":"Ariane I. de Agostini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A de Agostini","raw_affiliation_strings":["Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Vanderbilt University, Nashville, Tennessee 37232","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113762236","display_name":"P A Patston","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P A Patston","raw_affiliation_strings":["Rheumatology Division , H6pital Cantonal Universitaire , 1211 Geneve 4 , Switzerland ;","Bioengineering"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Division , H6pital Cantonal Universitaire , 1211 Geneve 4 , Switzerland ;","institution_ids":[]},{"raw_affiliation_string":"Bioengineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028051869","display_name":"V Marottoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V Marottoli","raw_affiliation_strings":["Rheumatology Division , H6pital Cantonal Universitaire , 1211 Geneve 4 , Switzerland ;","Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rheumatology Division , H6pital Cantonal Universitaire , 1211 Geneve 4 , Switzerland ;","institution_ids":[]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086515743","display_name":"S Carrel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Carrel","raw_affiliation_strings":["Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108359656","display_name":"P C Harpel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P C Harpel","raw_affiliation_strings":["Hemostasis and Thrombosis Laboratory , Departments ofPathology and Medicine , Vanderbilt University , Nashville , Tennessee 37232 ;","Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemostasis and Thrombosis Laboratory , Departments ofPathology and Medicine , Vanderbilt University , Nashville , Tennessee 37232 ;","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008948102","display_name":"Marc Schapira","orcid":"https://orcid.org/0000-0003-0384-0075","observed_orcids":["https://orcid.org/0000-0003-0384-0075"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Schapira","raw_affiliation_strings":["Hemostasis and Thrombosis Laboratory , Departments ofPathology and Medicine , Vanderbilt University , Nashville , Tennessee 37232 ;","Vanderbilt University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hemostasis and Thrombosis Laboratory , Departments ofPathology and Medicine , Vanderbilt University , Nashville , Tennessee 37232 ;","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Vanderbilt University","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":2.1712,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.88025336,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"82","issue":"2","first_page":"700","last_page":"705"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c1-inhibitor","display_name":"C1 inhibitor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/reactive-center-loop","display_name":"reactive center loop","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neoantigens","display_name":"neoantigens","score":0.9229999780654907},{"id":"https://openalex.org/keywords/plasma-kallikrein","display_name":"plasma kallikrein","score":0.9869999885559082},{"id":"https://openalex.org/keywords/factor-xiia","display_name":"factor XIIa","score":0.8669999837875366},{"id":"https://openalex.org/keywords/neutrophil-elastase","display_name":"neutrophil elastase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.7350000143051147},{"id":"https://openalex.org/keywords/epitope-mapping","display_name":"epitope mapping","score":0.5839999914169312},{"id":"https://openalex.org/keywords/protein-conformational-change","display_name":"protein conformational change","score":0.6069999933242798}],"concepts":[{"id":"https://openalex.org/C52853521","wikidata":"https://www.wikidata.org/wiki/Q423285","display_name":"Kallikrein","level":3,"score":0.8982629179954529},{"id":"https://openalex.org/C2778965386","wikidata":"https://www.wikidata.org/wiki/Q420068","display_name":"Serpin","level":3,"score":0.8269376754760742},{"id":"https://openalex.org/C2776317360","wikidata":"https://www.wikidata.org/wiki/Q14905648","display_name":"Neutrophil elastase","level":3,"score":0.7029139399528503},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.6951138973236084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6580952405929565},{"id":"https://openalex.org/C2779931649","wikidata":"https://www.wikidata.org/wiki/Q416510","display_name":"C1-inhibitor","level":3,"score":0.5563691854476929},{"id":"https://openalex.org/C2781044401","wikidata":"https://www.wikidata.org/wiki/Q418897","display_name":"Elastase","level":3,"score":0.4844198524951935},{"id":"https://openalex.org/C2777167447","wikidata":"https://www.wikidata.org/wiki/Q339499","display_name":"Factor XII","level":3,"score":0.471407413482666},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.4557878077030182},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4406474232673645},{"id":"https://openalex.org/C182220744","wikidata":"https://www.wikidata.org/wiki/Q7251226","display_name":"Proteases","level":3,"score":0.4361109435558319},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.4247957468032837},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4235178828239441},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2458065152168274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2384982407093048},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.226408451795578},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12971988320350647},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07639467716217041},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06852293014526367},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C2777995640","wikidata":"https://www.wikidata.org/wiki/Q1129007","display_name":"Angioedema","level":2,"score":0.0},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.0},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D003166","descriptor_name":"Complement Activating Enzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003173","descriptor_name":"Complement C1s","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003173","descriptor_name":"Complement C1s","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003174","descriptor_name":"Complement C1 Inactivator Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003174","descriptor_name":"Complement C1 Inactivator Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005174","descriptor_name":"Factor XII","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005174","descriptor_name":"Factor XII","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007118","descriptor_name":"Immunoassay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007610","descriptor_name":"Kallikreins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010196","descriptor_name":"Pancreatic Elastase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015956","descriptor_name":"Factor XIIa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1172/jci113650","doi":"https://doi.org/10.1172/jci113650","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci113650","pdf_url":"http://www.jci.org/articles/view/113650/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:303566","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/303566","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:2457036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2457036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/89997","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/89997","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:serval.unil.ch:BIB_1CC03D8800FF","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_1CC03D8800FF","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Investigation, vol. 82, no. 2, pp. 700-5","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1172/jci113650","doi":"https://doi.org/10.1172/jci113650","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci113650","pdf_url":"http://www.jci.org/articles/view/113650/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1201819638","display_name":null,"funder_award_id":"RR-05424","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320323831","display_name":"Universit\u00e9 de Lausanne","ror":"https://ror.org/019whta54"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2146994571.pdf","grobid_xml":"https://content.openalex.org/works/W2146994571.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W15795119","https://openalex.org/W178665079","https://openalex.org/W330357786","https://openalex.org/W1497409606","https://openalex.org/W1522956225","https://openalex.org/W1541482973","https://openalex.org/W1565281311","https://openalex.org/W1632246081","https://openalex.org/W1889077695","https://openalex.org/W1974121285","https://openalex.org/W1977069525","https://openalex.org/W1980337146","https://openalex.org/W1999681026","https://openalex.org/W2008405604","https://openalex.org/W2018050263","https://openalex.org/W2018289835","https://openalex.org/W2042708260","https://openalex.org/W2065141688","https://openalex.org/W2075057874","https://openalex.org/W2081217040","https://openalex.org/W2083679654","https://openalex.org/W2084465075","https://openalex.org/W2091437216","https://openalex.org/W2091849415","https://openalex.org/W2093523386","https://openalex.org/W2093869678","https://openalex.org/W2100837269","https://openalex.org/W2101108802","https://openalex.org/W2102613564","https://openalex.org/W2107873069","https://openalex.org/W2158396300","https://openalex.org/W2158623312","https://openalex.org/W2214005498","https://openalex.org/W2269405856","https://openalex.org/W2403672035","https://openalex.org/W2404599160","https://openalex.org/W2412176855","https://openalex.org/W2414194330","https://openalex.org/W2417762343","https://openalex.org/W2613467369","https://openalex.org/W6639751288"],"related_works":["https://openalex.org/W2252063895","https://openalex.org/W2410956791","https://openalex.org/W2158396300","https://openalex.org/W2888963816","https://openalex.org/W2056744126","https://openalex.org/W2027807255","https://openalex.org/W1963949013","https://openalex.org/W1565281311","https://openalex.org/W1541482973","https://openalex.org/W92317621"],"abstract_inverted_index":{"The":[0],"reactive":[1,40],"center":[2],"of":[3,99,124],"C1-inhibitor,":[4],"a":[5,18],"plasma":[6,29,129],"protease":[7],"inhibitor":[8],"that":[9,88,113],"belongs":[10],"to":[11,25],"the":[12,39,77,83,97,100,104,122],"serpin":[13],"superfamily,":[14],"is":[15,22,62,67,74,117],"located":[16],"on":[17,119],"peptide":[19],"loop":[20,127],"which":[21,86],"highly":[23],"susceptible":[24],"proteolytic":[26],"cleavage.":[27],"With":[28],"kallikrein,":[30,130],"C1s":[31],"and":[32,64,96,134],"beta-Factor":[33,132],"XIIa,":[34,133],"this":[35],"cleavage":[36,123],"occurs":[37],"at":[38,54],"site":[41],"residue":[42,55],"P1":[43],"(Arg444);":[44],"with":[45],"neutrophil":[46,136],"elastase,":[47],"it":[48],"takes":[49],"place":[50],"near":[51],"P1,":[52],"probably":[53],"P3":[56],"(Val442).":[57],"After":[58],"these":[59],"cleavages,":[60],"C1-inhibitor":[61,73,120],"inactivated":[63],"its":[65,125],"conformation":[66],"modified.":[68],"Moreover,":[69],"in":[70],"vivo,":[71],"cleaved":[72,101],"removed":[75],"from":[76],"blood":[78],"stream":[79],"more":[80],"rapidly":[81],"than":[82],"intact":[84],"serpin,":[85],"suggests":[87],"proteolysis":[89],"unmasks":[90],"sites":[91],"responsible":[92],"for":[93],"cellular":[94],"recognition":[95],"uptake":[98],"inhibitor.":[102],"In":[103],"study":[105],"reported":[106],"here,":[107],"we":[108],"show,":[109],"using":[110],"an":[111,114],"MAb,":[112],"identical":[115],"neoepitope":[116],"created":[118],"after":[121],"exposed":[126],"by":[128,135],"C1s,":[131],"elastase.":[137]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}