{"id":"https://openalex.org/W2146832801","doi":"https://doi.org/10.1002/cbf.1119","title":"Oxidative stress and serum paraoxonase activity in experimental hypothyroidism: effect of vitamin E supplementation","display_name":"Oxidative stress and serum paraoxonase activity in experimental hypothyroidism: effect of vitamin E supplementation","publication_year":2004,"publication_date":"2004-06-21","ids":{"openalex":"https://openalex.org/W2146832801","doi":"https://doi.org/10.1002/cbf.1119","mag":"2146832801","pmid":"https://pubmed.ncbi.nlm.nih.gov/15386442"},"language":"en","primary_location":{"id":"doi:10.1002/cbf.1119","doi":"https://doi.org/10.1002/cbf.1119","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbf.1119","pdf_url":null,"source":{"id":"https://openalex.org/S960618578","display_name":"Cell Biochemistry and Function","issn_l":"0263-6484","issn":["0263-6484","1099-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Function","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029531704","display_name":"Emre Sarand\u00f6l","orcid":"https://orcid.org/0000-0002-2593-7196","observed_orcids":["https://orcid.org/0000-0002-2593-7196"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Emre Sarand\u00f6l","raw_affiliation_strings":["Department of Biochemistry, Uludag University Medical Faculty, Bursa, Turkey. sarandol@uludag.edu.tr","Department of Biochemistry, Uludag University, Medical Faculty, Bursa, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Uludag University Medical Faculty, Bursa, Turkey. sarandol@uludag.edu.tr","institution_ids":["https://openalex.org/I131835042"]},{"raw_affiliation_string":"Department of Biochemistry, Uludag University, Medical Faculty, Bursa, Turkey","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115686579","display_name":"Sibel Ta\u015f","orcid":"https://orcid.org/0000-0001-8880-0771","observed_orcids":["https://orcid.org/0000-0001-8880-0771","https://orcid.org/0000-0001-6225-774X"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sibel Ta\u015f","raw_affiliation_strings":["Department of Biology, Uludag University Science and Literature Faculty, Bursa, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Uludag University Science and Literature Faculty, Bursa, Turkey","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007229234","display_name":"Melahat Dirican","orcid":"https://orcid.org/0000-0002-4956-5278","observed_orcids":["https://orcid.org/0000-0002-4956-5278"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Melahat Dirican","raw_affiliation_strings":["Department of Biochemistry, Uludag University, Medical Faculty, Bursa, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Uludag University, Medical Faculty, Bursa, Turkey","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045650375","display_name":"Zehra Serdar","orcid":"https://orcid.org/0000-0001-6844-2460","observed_orcids":["https://orcid.org/0000-0001-6844-2460"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Zehra Serdar","raw_affiliation_strings":["Department of Biochemistry, Uludag University, Medical Faculty, Bursa, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Uludag University, Medical Faculty, Bursa, Turkey","institution_ids":["https://openalex.org/I131835042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029531704"],"corresponding_institution_ids":["https://openalex.org/I131835042"],"apc_list":{"value":4220,"currency":"USD","value_usd":4220},"apc_paid":null,"fwci":3.363,"has_fulltext":false,"cited_by_count":121,"citation_normalized_percentile":{"value":0.91340782,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"23","issue":"1","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.8740000128746033,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.09210000187158585,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.029999999329447746,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":0.972000002861023},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9940000176429749},{"id":"https://openalex.org/keywords/paraoxonase","display_name":"paraoxonase","score":0.7599999904632568},{"id":"https://openalex.org/keywords/arylesterase","display_name":"arylesterase","score":0.972000002861023},{"id":"https://openalex.org/keywords/vitamin-e-supplementation","display_name":"vitamin E supplementation","score":0.9959999918937683},{"id":"https://openalex.org/keywords/propylthiouracil","display_name":"propylthiouracil","score":0.9340000152587891},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9629999995231628},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9210000038146973},{"id":"https://openalex.org/keywords/antioxidant-status","display_name":"antioxidant status","score":0.75},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.902999997138977}],"concepts":[{"id":"https://openalex.org/C2775960720","wikidata":"https://www.wikidata.org/wiki/Q377342","display_name":"Propylthiouracil","level":3,"score":0.9586554169654846},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8208376169204712},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8185185790061951},{"id":"https://openalex.org/C2781389560","wikidata":"https://www.wikidata.org/wiki/Q4802704","display_name":"Arylesterase","level":5,"score":0.6906899213790894},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6789315342903137},{"id":"https://openalex.org/C2777551382","wikidata":"https://www.wikidata.org/wiki/Q141180","display_name":"Vitamin E","level":3,"score":0.6107967495918274},{"id":"https://openalex.org/C2776509667","wikidata":"https://www.wikidata.org/wiki/Q7135605","display_name":"Paraoxonase","level":3,"score":0.5889872312545776},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.5085400342941284},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.4188621938228607},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34907472133636475},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3296319246292114},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.32309389114379883},{"id":"https://openalex.org/C37501387","wikidata":"https://www.wikidata.org/wiki/Q18030661","display_name":"PON1","level":4,"score":0.17689213156700134},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12005037069320679},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011441","descriptor_name":"Propylthiouracil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014810","descriptor_name":"Vitamin E","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043303","descriptor_name":"Aryldialkylphosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D043303","descriptor_name":"Aryldialkylphosphatase","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D043303","descriptor_name":"Aryldialkylphosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/cbf.1119","doi":"https://doi.org/10.1002/cbf.1119","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cbf.1119","pdf_url":null,"source":{"id":"https://openalex.org/S960618578","display_name":"Cell Biochemistry and Function","issn_l":"0263-6484","issn":["0263-6484","1099-0844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biochemistry and Function","raw_type":"journal-article"},{"id":"pmid:15386442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15386442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell biochemistry and function","raw_type":"Comparative Study"},{"id":"pmh:d5a36c54-eccf-4713-b26c-fae29abfbc67","doi":null,"is_oa":false,"landing_page_url":"https://avesis.uludag.edu.tr/publication/details/d5a36c54-eccf-4713-b26c-fae29abfbc67/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055210","display_name":"Bursa Uludag University - AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W51173725","https://openalex.org/W104178420","https://openalex.org/W985753769","https://openalex.org/W1487463077","https://openalex.org/W1625479408","https://openalex.org/W1775749144","https://openalex.org/W1916733258","https://openalex.org/W1940016704","https://openalex.org/W1970431838","https://openalex.org/W1970709107","https://openalex.org/W1971343760","https://openalex.org/W1971751503","https://openalex.org/W1982248018","https://openalex.org/W1983310681","https://openalex.org/W1998927777","https://openalex.org/W2004022011","https://openalex.org/W2009399687","https://openalex.org/W2012318339","https://openalex.org/W2025679035","https://openalex.org/W2032699068","https://openalex.org/W2040504119","https://openalex.org/W2042203706","https://openalex.org/W2044360953","https://openalex.org/W2048607595","https://openalex.org/W2058630246","https://openalex.org/W2063576996","https://openalex.org/W2069460849","https://openalex.org/W2080996575","https://openalex.org/W2087975771","https://openalex.org/W2088720117","https://openalex.org/W2088826552","https://openalex.org/W2089431180","https://openalex.org/W2093022509","https://openalex.org/W2094597272","https://openalex.org/W2111998516","https://openalex.org/W2112181382","https://openalex.org/W2114158288","https://openalex.org/W2122751858","https://openalex.org/W2125513677","https://openalex.org/W2130021528","https://openalex.org/W2136863520","https://openalex.org/W2136995454","https://openalex.org/W2138328421","https://openalex.org/W2142296338","https://openalex.org/W2145729118","https://openalex.org/W2172351553","https://openalex.org/W2254923557","https://openalex.org/W2409579179","https://openalex.org/W3022864527","https://openalex.org/W4298009682","https://openalex.org/W6661797303"],"related_works":["https://openalex.org/W2032699068","https://openalex.org/W2773416664","https://openalex.org/W2012352015","https://openalex.org/W2128851665","https://openalex.org/W2016154039","https://openalex.org/W2081653686","https://openalex.org/W2604619708","https://openalex.org/W2587357251","https://openalex.org/W2158507333","https://openalex.org/W2035634745"],"abstract_inverted_index":{"Thyroid":[0],"hormones":[1],"are":[2,21],"associated":[3],"with":[4,98,112,155,166],"the":[5,11,16,27,41,94,99,113,156],"oxidative":[6,17,168],"and":[7,23,29,32,39,86,102,123,134,143,170],"antioxidative":[8],"status":[9,18,31],"of":[10,19,43],"organism.":[12],"Since":[13],"data":[14],"on":[15,47,177],"hypothyroidism":[20,38,163],"limited":[22],"controversial,":[24],"we":[25],"investigated":[26],"oxidant":[28],"antioxidant":[30],"serum":[33,151],"paraoxonase/arylesterase":[34],"activities":[35,136],"in":[36,93,105,128,139,150],"propylthiouracil-induced":[37],"examined":[40],"effect":[42],"vitamin":[44,69,78,108,144,171],"E":[45,109,117,145,172],"supplementation":[46,118,146,173],"this":[48,178],"experimental":[49],"model.":[50],"Forty":[51],"male":[52],"Sprague":[53],"Dawley":[54],"rats":[55,101],"were":[56,91,103,137],"randomly":[57],"divided":[58],"into":[59],"four":[60],"groups":[61],"(group":[62],"1,":[63],"control;":[64],"group":[65,71,74,96,110,142],"2,":[66],"control":[67,100],"+":[68,77,107],"E;":[70],"3,":[72],"propylthiouracil;":[73],"4,":[75],"propylthiouracil":[76,106,129,140],"E).":[79],"Plasma,":[80],"red":[81],"blood":[82],"cell,":[83],"liver,":[84],"heart":[85],"skeletal":[87],"muscle":[88],"malondialdehyde":[89],"levels":[90,127],"increased":[92,121,167],"propylthiouracil-treated":[95,114,157],"compared":[97,111,154],"decreased":[104,138],"group.":[115],"Vitamin":[116],"also":[119],"significantly":[120],"liver":[122],"kidney":[124],"reduced":[125],"glutathione":[126],"treated":[130,141],"animals.":[131],"Serum":[132],"paraoxonase":[133,152],"arylesterase":[135],"caused":[147],"significant":[148],"increase":[149],"activity":[153],"rats.":[158],"These":[159],"findings":[160],"suggest":[161],"that":[162],"is":[164],"accompanied":[165],"stress":[169],"exerts":[174],"beneficial":[175],"effects":[176],"situation.":[179]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}