{"id":"https://openalex.org/W2146807385","doi":null,"title":"Expression of thymidine phosphorylase is associated with a poor prognosis in patients with ductal adenocarcinoma of the pancreas.","display_name":"Expression of thymidine phosphorylase is associated with a poor prognosis in patients with ductal adenocarcinoma of the pancreas.","publication_year":1998,"publication_date":"1998-07-01","ids":{"openalex":"https://openalex.org/W2146807385","mag":"2146807385","pmid":"https://pubmed.ncbi.nlm.nih.gov/9676835"},"language":"en","primary_location":{"id":"pmid:9676835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9676835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113604948","display_name":"Sonshin Takao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107139324","display_name":"Kagoshima University","ror":"https://ror.org/03ss88z23","country_code":"JP","type":"education","lineage":["https://openalex.org/I107139324"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S Takao","raw_affiliation_strings":["First Department of Surgery, Institute for Cancer Research, Kagoshima University School of Medicine, Sakuragaoka, Japan. sonshin@med6.kufm.kagoshima-u.ac.jp"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Department of Surgery, Institute for Cancer Research, Kagoshima University School of Medicine, Sakuragaoka, Japan. sonshin@med6.kufm.kagoshima-u.ac.jp","institution_ids":["https://openalex.org/I107139324"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012359351","display_name":"Yuji Takebayashi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Takebayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088595151","display_name":"Xiaofang Che","orcid":"https://orcid.org/0000-0002-9087-1007","observed_orcids":["https://orcid.org/0000-0002-9087-1007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Che","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072871817","display_name":"Hiroyuki Shinchi","orcid":"https://orcid.org/0000-0001-6207-2737","observed_orcids":["https://orcid.org/0000-0001-6207-2737"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Shinchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110043316","display_name":"Shoji Natsugoe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Natsugoe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063302620","display_name":"Kazutaka Miyadera","orcid":"https://orcid.org/0009-0003-4284-9803","observed_orcids":["https://orcid.org/0009-0003-4284-9803"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Miyadera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066192865","display_name":"Yuji Yamada","orcid":"https://orcid.org/0000-0003-2338-6906","observed_orcids":["https://orcid.org/0000-0003-2338-6906"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Yamada","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007803029","display_name":"S Akiyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Akiyama","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111968750","display_name":"Takashi Aikou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Aikou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0712,"has_fulltext":false,"cited_by_count":61,"citation_normalized_percentile":{"value":0.94511739,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"4","issue":"7","first_page":"1619","last_page":"24"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.006399999838322401,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thymidine-phosphorylase","display_name":"thymidine phosphorylase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9829999804496765},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5460000038146973},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.8880000114440918},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/microvessel-count","display_name":"microvessel count","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C2776735402","wikidata":"https://www.wikidata.org/wiki/Q22038268","display_name":"Thymidine phosphorylase","level":3,"score":0.941391110420227},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5875116586685181},{"id":"https://openalex.org/C2776436680","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microvessel","level":3,"score":0.5856020450592041},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5683411955833435},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5436472296714783},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5326789021492004},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5318799614906311},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5080342292785645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44991326332092285},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3812267780303955},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36882922053337097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3668956160545349},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.31806468963623047}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010183","descriptor_name":"Pancreatic Ducts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013939","descriptor_name":"Thymidine Phosphorylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:9676835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9676835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2146807385","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9676835","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W29671035","https://openalex.org/W70975532","https://openalex.org/W153934429","https://openalex.org/W200461205","https://openalex.org/W1503054422","https://openalex.org/W1536690700","https://openalex.org/W1537668772","https://openalex.org/W1537854451","https://openalex.org/W1586102570","https://openalex.org/W1603098046","https://openalex.org/W1655483869","https://openalex.org/W1969560479","https://openalex.org/W1971389573","https://openalex.org/W1974384202","https://openalex.org/W1978347107","https://openalex.org/W2003497133","https://openalex.org/W2005177011","https://openalex.org/W2021948632","https://openalex.org/W2026255963","https://openalex.org/W2033158086","https://openalex.org/W2043213673","https://openalex.org/W2046170187","https://openalex.org/W2055218751","https://openalex.org/W2064276205","https://openalex.org/W2074070420","https://openalex.org/W2080734791","https://openalex.org/W2080881382","https://openalex.org/W2085328261","https://openalex.org/W2094810573","https://openalex.org/W2096918975","https://openalex.org/W2113550611","https://openalex.org/W2129941826","https://openalex.org/W2131535006","https://openalex.org/W2158743409","https://openalex.org/W2159699022","https://openalex.org/W2161182938","https://openalex.org/W2162907832","https://openalex.org/W2171515720","https://openalex.org/W2254121776","https://openalex.org/W2319962899","https://openalex.org/W2414962566","https://openalex.org/W2612574275"],"related_works":["https://openalex.org/W2401837959","https://openalex.org/W7042558981","https://openalex.org/W2443144594","https://openalex.org/W2411628238","https://openalex.org/W2026255963","https://openalex.org/W2069517601","https://openalex.org/W2410531856","https://openalex.org/W2160640244","https://openalex.org/W1971389573","https://openalex.org/W2410980330"],"abstract_inverted_index":{"Thymidine":[0],"phosphorylase":[1],"(dThdPase)":[2],"is":[3],"identical":[4],"to":[5],"platelet-derived":[6],"endothelial":[7],"cell":[8],"growth":[9],"factor":[10],"and":[11,30,37,40,81,86,94],"has":[12],"angiogenic":[13,134],"activity.":[14],"In":[15],"this":[16],"study,":[17],"we":[18],"investigated":[19],"the":[20,28,32,50,58,87,125],"expression":[21,36,44,63,80,120],"of":[22,27,52,57,64,89,127],"dThdPase":[23,35,43,65,79,119],"in":[24,49,55,101,109,121],"ductal":[25],"adenocarcinoma":[26,123],"pancreas":[29],"examined":[31],"correlation":[33],"between":[34,78],"clinicopathological":[38],"factors":[39],"clinical":[41],"outcome.":[42],"was":[45,104],"demonstrated":[46],"by":[47],"immunohistochemistry":[48],"cytoplasm":[51],"tumor":[53,128],"cells":[54],"59%":[56],"54":[59],"patients":[60],"studied.":[61],"The":[62,97],"correlated":[66],"significantly":[67,105],"with":[68],"a":[69],"poor":[70],"prognosis":[71],"(P=0.013).":[72],"Significant":[73],"correlations":[74],"were":[75],"also":[76],"observed":[77],"extrapancreatic":[82],"neural":[83],"plexus":[84],"invasion":[85,129],"presence":[88],"postoperative":[90],"hepatic":[91],"metastases":[92],"(P=0.05":[93],"0.03,":[95],"respectively).":[96],"average":[98],"microvessel":[99],"count":[100],"dThdPase-positive":[102],"tumors":[103,111],"higher":[106],"than":[107],"that":[108,118],"dThdPase-negative":[110],"(P":[112],"<":[113],"0.0001).":[114],"These":[115],"findings":[116],"suggest":[117],"pancreatic":[122],"enhances":[124],"abilities":[126],"and/or":[130],"metastasis":[131],"through":[132],"its":[133],"properties.":[135]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
