{"id":"https://openalex.org/W2146776384","doi":"https://doi.org/10.1086/373993","title":"Susceptibility of Herpes Simplex Virus Isolates to Nucleoside Analogues and the Proportion of Nucleoside\u2010Resistant Variants after Repeated Topical Application of Penciclovir to Recurrent Herpes Labialis","display_name":"Susceptibility of Herpes Simplex Virus Isolates to Nucleoside Analogues and the Proportion of Nucleoside\u2010Resistant Variants after Repeated Topical Application of Penciclovir to Recurrent Herpes Labialis","publication_year":2003,"publication_date":"2003-04-15","ids":{"openalex":"https://openalex.org/W2146776384","doi":"https://doi.org/10.1086/373993","mag":"2146776384","pmid":"https://pubmed.ncbi.nlm.nih.gov/12696003"},"language":"en","primary_location":{"id":"doi:10.1086/373993","doi":"https://doi.org/10.1086/373993","is_oa":false,"landing_page_url":"https://doi.org/10.1086/373993","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047959344","display_name":"Young Kyoo Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["KR","US"],"is_corresponding":false,"raw_author_name":"Young\u00a0Kyoo Shin","raw_affiliation_strings":["Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver, Colorado, USA","Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea","Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver, Colorado, USA","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Pediatrics, College of Medicine, Korea University, Seoul, Korea","institution_ids":["https://openalex.org/I197347611"]},{"raw_affiliation_string":"Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079455826","display_name":"Adriana Weinberg","orcid":"https://orcid.org/0000-0001-6920-0623","observed_orcids":["https://orcid.org/0000-0001-6920-0623"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana Weinberg","raw_affiliation_strings":["Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113609107","display_name":"Spotswood L. Spruance","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Spotswood Spruance","raw_affiliation_strings":["University of Utah School of Medicine, Salt Lake City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Utah School of Medicine, Salt Lake City","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040462090","display_name":"Mariann Bernard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariann Bernard","raw_affiliation_strings":["Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110570310","display_name":"Teresa H. Bacon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Teresa\u00a0H. Bacon","raw_affiliation_strings":["Department of Internal Medicine (Infectious Diseases), GlaxoSmithKline Consumer Healthcare, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (Infectious Diseases), GlaxoSmithKline Consumer Healthcare, Surrey, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109110769","display_name":"Ron J. Boon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ron\u00a0J. Boon","raw_affiliation_strings":["Department of Internal Medicine (Infectious Diseases), GlaxoSmithKline Consumer Healthcare, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine (Infectious Diseases), GlaxoSmithKline Consumer Healthcare, Surrey, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051264386","display_name":"Myron J. Levin","orcid":"https://orcid.org/0000-0002-7468-106X","observed_orcids":["https://orcid.org/0000-0002-7468-106X"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myron\u00a0J. Levin","raw_affiliation_strings":["Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pediatric Infectious Diseases, School of Medicine, University of Colorado, Denver","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":0.9682,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.78114558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"187","issue":"8","first_page":"1241","last_page":"1245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11826","display_name":"Ocular Infections and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus","display_name":"herpes simplex virus","score":0.9100000262260437},{"id":"https://openalex.org/keywords/recurrent-herpes-labialis","display_name":"recurrent herpes labialis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/penciclovir","display_name":"penciclovir","score":0.9900000095367432},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.8629999756813049},{"id":"https://openalex.org/keywords/antiviral-resistance","display_name":"antiviral resistance","score":0.9049999713897705},{"id":"https://openalex.org/keywords/topical-antiviral-therapy","display_name":"topical antiviral therapy","score":0.9750000238418579},{"id":"https://openalex.org/keywords/sensory-ganglia","display_name":"sensory ganglia","score":0.7310000061988831},{"id":"https://openalex.org/keywords/plaque-reduction-assay","display_name":"plaque reduction assay","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C2780796145","wikidata":"https://www.wikidata.org/wiki/Q420364","display_name":"Penciclovir","level":4,"score":0.9881190061569214},{"id":"https://openalex.org/C2776723293","wikidata":"https://www.wikidata.org/wiki/Q420186","display_name":"Famciclovir","level":3,"score":0.8810691833496094},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.7894753813743591},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.6916413903236389},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.6719708442687988},{"id":"https://openalex.org/C2777333352","wikidata":"https://www.wikidata.org/wiki/Q2689559","display_name":"Nucleoside analogue","level":3,"score":0.5511602163314819},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5413309335708618},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5304968357086182},{"id":"https://openalex.org/C2911196830","wikidata":"https://www.wikidata.org/wiki/Q2364836","display_name":"Herpes Labialis","level":4,"score":0.48311591148376465},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.45017409324645996},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.34117424488067627},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006560","descriptor_name":"Herpes Labialis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010948","descriptor_name":"Viral Plaque Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1086/373993","doi":"https://doi.org/10.1086/373993","is_oa":false,"landing_page_url":"https://doi.org/10.1086/373993","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:12696003","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12696003","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306085","display_name":"U.S. Department of Health and Human Services","ror":"https://ror.org/033jnv181"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1572040339","https://openalex.org/W1585389173","https://openalex.org/W1970118148","https://openalex.org/W1983142184","https://openalex.org/W1993942283","https://openalex.org/W1997962853","https://openalex.org/W2021769481","https://openalex.org/W2041703498","https://openalex.org/W2073213251","https://openalex.org/W2112266191","https://openalex.org/W2134538961","https://openalex.org/W2147053153","https://openalex.org/W2162317223","https://openalex.org/W2164424385"],"related_works":["https://openalex.org/W2164424385","https://openalex.org/W2134538961","https://openalex.org/W2162317223","https://openalex.org/W2136151488","https://openalex.org/W2043837454","https://openalex.org/W7096325697","https://openalex.org/W2467052564","https://openalex.org/W2028094086","https://openalex.org/W1998362201","https://openalex.org/W2044587079"],"abstract_inverted_index":{"Subjects":[0],"received":[1],"topical":[2],"penciclovir":[3,39],"for":[4],"4":[5],"days":[6],"during":[7,55],"successive":[8,61,93,104],"episodes":[9,105],"of":[10,15,27,33,65,72,87,115,141,147],"recurrent":[11],"herpes":[12,16],"labialis.":[13],"Isolation":[14],"simplex":[17],"virus":[18],"(HSV)":[19],"was":[20,49,75],"attempted":[21],"from":[22,103,131],"lesions":[23],"obtained":[24,106],"before":[25,107],"initiation":[26],"treatment":[28,57,108],"and":[29,47],"on":[30,92],"each":[31],"day":[32],"therapy.":[34],"Isolates":[35],"remained":[36,97],"sensitive":[37],"to":[38],"when":[40],"tested":[41],"by":[42],"a":[43,70,79,98],"plaque":[44],"reduction":[45],"assay,":[46],"there":[48],"no":[50,110],"significant":[51],"change":[52,111],"in":[53,112,128,137],"sensitivity":[54],"any":[56],"course":[58],"or":[59],"between":[60],"treatments.":[62],"The":[63],"proportion":[64,86,114],"nucleoside-resistant":[66],"variants":[67,90],"present":[68],"within":[69],"subset":[71],"these":[73],"isolates":[74,102,130],"further":[76],"investigated":[77],"using":[78],"more-sensitive":[80],"plating":[81],"efficiency":[82],"assay.":[83],"Although":[84],"the":[85,113,138],"antiviral-resistant":[88,122],"HSV":[89,117,129],"increased":[91],"days,":[94],"it":[95],"invariably":[96],"minor":[99],"subpopulation.":[100],"Moreover,":[101],"showed":[109],"resistant":[116],"variants.":[118],"We":[119],"conclude":[120],"that":[121],"variants,":[123],"which":[124],"are":[125],"readily":[126],"detected":[127],"peripheral":[132],"lesions,":[133],"do":[134],"not":[135],"accumulate":[136],"sensory":[139],"ganglia":[140],"immunocompetent":[142],"patients":[143],"receiving":[144],"multiple":[145],"courses":[146],"nucleoside":[148],"analogues.":[149]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
