{"id":"https://openalex.org/W2146772089","doi":"https://doi.org/10.1158/1078-0432.ccr-13-1746","title":"BRAF Fusions Define a Distinct Molecular Subset of Melanomas with Potential Sensitivity to MEK Inhibition","display_name":"BRAF Fusions Define a Distinct Molecular Subset of Melanomas with Potential Sensitivity to MEK Inhibition","publication_year":2013,"publication_date":"2013-12-15","ids":{"openalex":"https://openalex.org/W2146772089","doi":"https://doi.org/10.1158/1078-0432.ccr-13-1746","mag":"2146772089","pmid":"https://pubmed.ncbi.nlm.nih.gov/24345920","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3880773"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-13-1746","doi":"https://doi.org/10.1158/1078-0432.ccr-13-1746","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-13-1746","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3880773","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088553415","display_name":"Katherine E. Hutchinson","orcid":"https://orcid.org/0000-0002-4660-3523","observed_orcids":["https://orcid.org/0000-0002-4660-3523"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine E. Hutchinson","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029183165","display_name":"Doron Lipson","orcid":"https://orcid.org/0009-0004-2738-5702","observed_orcids":["https://orcid.org/0009-0004-2738-5702"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Doron Lipson","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113642947","display_name":"Philip J. Stephens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Philip J. Stephens","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066068230","display_name":"Geoff A. Otto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Geoff Otto","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072853514","display_name":"Brian David Lehmann","orcid":"https://orcid.org/0000-0003-0407-5248","observed_orcids":["https://orcid.org/0000-0003-0407-5248","https://orcid.org/0000-0002-4269-2274"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian D. Lehmann","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044228225","display_name":"Pamela L. Lyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pamela L. Lyle","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025331447","display_name":"Cindy L. Vnencak\u2010Jones","orcid":"https://orcid.org/0000-0002-9204-3061","observed_orcids":["https://orcid.org/0000-0002-9204-3061"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cindy L. Vnencak-Jones","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088559019","display_name":"Jeffrey S. Ross","orcid":"https://orcid.org/0000-0001-8494-2596","observed_orcids":["https://orcid.org/0000-0001-8494-2596"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey S. Ross","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032756469","display_name":"Jennifer A. Pietenpol","orcid":"https://orcid.org/0000-0001-6268-6798","observed_orcids":["https://orcid.org/0000-0001-6268-6798"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer A. Pietenpol","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075566772","display_name":"Jeffrey Alan Sosman","orcid":"https://orcid.org/0000-0002-0650-9698","observed_orcids":["https://orcid.org/0000-0002-0650-9698"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey A. Sosman","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049243227","display_name":"Igor J. Puzanov","orcid":"https://orcid.org/0000-0002-9803-3497","observed_orcids":["https://orcid.org/0000-0002-9803-3497"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor Puzanov","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111578811","display_name":"Vincent A. Miller","orcid":"https://orcid.org/0000-0003-1667-3771","observed_orcids":["https://orcid.org/0000-0003-1667-3771"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vincent A. Miller","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062616992","display_name":"William J. Pao","orcid":"https://orcid.org/0000-0002-9888-0733","observed_orcids":["https://orcid.org/0000-0002-9888-0733"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I4390039299","display_name":"Vanderbilt-Ingram Cancer Center","ror":"https://ror.org/02rjj2m04","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I4390039299","https://openalex.org/I901861585"]},{"id":"https://openalex.org/I4405260259","display_name":"Albany Medical College","ror":"https://ror.org/03g66yt05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4405259726","https://openalex.org/I4405260259"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Pao","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Cancer Biology, 2Biochemistry, Vanderbilt-Ingram Cancer Center; Departments of 3Pathology, Microbiology, and Immunology, 4Medicine, Division of Hematology-Oncology, Vanderbilt University School of Medicine; 5Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee; 6Foundation Medicine, Inc., Cambridge, Massachusetts; and 7Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I4390039299","https://openalex.org/I4405260259","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.0311,"has_fulltext":false,"cited_by_count":183,"citation_normalized_percentile":{"value":0.98274275,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"19","issue":"24","first_page":"6696","last_page":"6702"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/braf-fusion","display_name":"BRAF fusion","score":0.9039999842643738},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9739999771118164},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.878000020980835},{"id":"https://openalex.org/keywords/driver-mutations","display_name":"driver mutations","score":0.5789999961853027},{"id":"https://openalex.org/keywords/targeted-therapy-selection","display_name":"targeted therapy selection","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2779176653","wikidata":"https://www.wikidata.org/wiki/Q18026236","display_name":"GNAQ","level":4,"score":0.9277907609939575},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.8550504446029663},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8337606191635132},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.7544219493865967},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.6994563341140747},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6937483549118042},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5929133892059326},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.5170567631721497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4958723485469818},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.42145484685897827},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.41774439811706543},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41043201088905334},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4051142930984497},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37560561299324036},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.242662250995636},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22489869594573975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20709756016731262},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.08003023266792297}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013430","descriptor_name":"Sulfate Adenylyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/1078-0432.ccr-13-1746","doi":"https://doi.org/10.1158/1078-0432.ccr-13-1746","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-13-1746","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:24345920","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24345920","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3233349","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3880773","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3880773","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3880773","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3233349","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3880773","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2201323934","display_name":"Clinical Investigation in Tumor Immunotherapy","funder_award_id":"K24CA097588","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2321428606","display_name":null,"funder_award_id":"CA98131","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3680935081","display_name":"Overcoming acquired resistance to EGFR inhibitors in lung cancer","funder_award_id":"R01CA121210","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7248731751","display_name":"SPORE in Breast Cancer","funder_award_id":"P50CA098131","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000880732","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA068485","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W90339236","https://openalex.org/W1988372189","https://openalex.org/W1995889524","https://openalex.org/W2017090190","https://openalex.org/W2018336040","https://openalex.org/W2020672661","https://openalex.org/W2029575024","https://openalex.org/W2037942882","https://openalex.org/W2043058822","https://openalex.org/W2054839838","https://openalex.org/W2055560959","https://openalex.org/W2064553999","https://openalex.org/W2065155886","https://openalex.org/W2068310793","https://openalex.org/W2075608121","https://openalex.org/W2081295565","https://openalex.org/W2085573901","https://openalex.org/W2095288784","https://openalex.org/W2107712702","https://openalex.org/W2125333956","https://openalex.org/W2128327828","https://openalex.org/W2136474966","https://openalex.org/W2160402926","https://openalex.org/W2169438753"],"related_works":["https://openalex.org/W2095529752","https://openalex.org/W2894448865","https://openalex.org/W4281736002","https://openalex.org/W2571705501","https://openalex.org/W4391645047","https://openalex.org/W1979730673","https://openalex.org/W2972321788","https://openalex.org/W3134943966","https://openalex.org/W1982615769","https://openalex.org/W7082639400"],"abstract_inverted_index":{"PURPOSE:":[0],"Recurrent":[1],"\"driver\"":[2],"mutations":[3],"at":[4],"specific":[5],"loci":[6],"in":[7,38,61,87,101,118,130,164,192,229],"BRAF,":[8],"NRAS,":[9],"KIT,":[10],"GNAQ,":[11],"and":[12,51,83],"GNA11":[13],"define":[14,200],"clinically":[15],"relevant":[16],"molecular":[17,110,203],"subsets":[18],"of":[19,98,108,115,123,135,154,205,212],"melanoma,":[20,206],"but":[21,146],"more":[22],"than":[23],"30%":[24],"are":[25],"\"pan-negative\"":[26,39,63,166,195,213],"for":[27,232],"these":[28],"recurrent":[29],"mutations.":[30],"We":[31,65,103],"sought":[32],"to":[33,93,210,223],"identify":[34],"additional":[35,72,156],"potential":[36,96,189],"drivers":[37],"melanoma.":[40,64,102],"EXPERIMENTAL":[41],"DESIGN:":[42],"Using":[43],"a":[44,57,62,159,165,201],"targeted":[45,52],"next-generation":[46],"sequencing":[47,85],"(NGS)":[48],"assay":[49],"(FoundationOne\u2122)":[50],"RNA":[53],"sequencing,":[54],"we":[55,185],"identified":[56,187],"novel":[58],"PAPSS1-BRAF":[59,136],"fusion":[60,162],"then":[66],"analyzed":[67],"NGS":[68,151],"data":[69,86,152],"from":[70],"51":[71,155],"melanomas":[73,157],"genotyped":[74],"by":[75,112,132,139,148,171],"FoundationOne\u2122,":[76],"as":[77,79],"well":[78],"melanoma":[80,183],"RNA,":[81],"whole-genome":[82],"whole-exome":[84],"The":[88],"Cancer":[89],"Genome":[90],"Atlas":[91],"(TCGA),":[92],"determine":[94],"the":[95,105,124],"frequency":[97],"BRAF":[99,149,161,190,198],"fusions":[100,191,199],"characterized":[104],"signaling":[106,169],"properties":[107],"confirmed":[109],"alterations":[111],"ectopic":[113,133],"expression":[114,134],"engineered":[116],"cDNAs":[117],"293H":[119],"cells.":[120],"RESULTS:":[121],"Activation":[122],"mitogen-activated":[125,140],"protein":[126,141],"kinase":[127,142,143],"(MAPK)":[128],"pathway":[129],"cells":[131],"was":[137,173],"abrogated":[138],"(MEK)":[144],"inhibition":[145],"not":[147],"inhibition.":[150],"analysis":[153],"revealed":[158],"second":[160],"(TRIM24-BRAF)":[163],"sample;":[167],"MAPK":[168],"induced":[170],"TRIM24-BRAF":[172],"also":[174],"MEK":[175,224],"inhibitor":[176,225],"sensitive.":[177],"Through":[178],"mining":[179],"TCGA":[180],"skin":[181],"cutaneous":[182],"dataset,":[184],"further":[186],"two":[188],"another":[193],"49":[194],"cases.":[196,214],"CONCLUSIONS:":[197],"new":[202],"subset":[204],"potentially":[207],"comprising":[208],"4%":[209],"8%":[211],"Their":[215],"presence":[216],"may":[217],"explain":[218],"an":[219],"unexpected":[220],"clinical":[221],"response":[222],"therapy":[226],"or":[227],"assist":[228],"selecting":[230],"patients":[231],"MEK-directed":[233],"therapy.":[234]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":20},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":19}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}