{"id":"https://openalex.org/W2146770372","doi":null,"title":"Hormonal interactions in progesterone regulation of gonadotropin gene expression","display_name":"Hormonal interactions in progesterone regulation of gonadotropin gene expression","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2146770372","mag":"2146770372"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt7gk123xr","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7gk123xr","pdf_url":"https://escholarship.org/uc/item/7gk123xr","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/7gk123xr","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011998776","display_name":"Yasmin Ghochani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yasmin Ghochani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5011998776"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gonadotropin-gene-expression","display_name":"gonadotropin gene expression","score":0.8679999709129333},{"id":"https://openalex.org/keywords/fsh-beta-subunit","display_name":"FSH beta subunit","score":0.7239999771118164},{"id":"https://openalex.org/keywords/lh-beta-subunit","display_name":"LH beta subunit","score":1.0},{"id":"https://openalex.org/keywords/gonadotrophs","display_name":"gonadotrophs","score":0.8379999995231628},{"id":"https://openalex.org/keywords/foxl2","display_name":"FOXL2","score":0.6610000133514404},{"id":"https://openalex.org/keywords/smad","display_name":"Smad","score":0.6790000200271606},{"id":"https://openalex.org/keywords/gonadotropin-surge","display_name":"gonadotropin surge","score":0.8809999823570251},{"id":"https://openalex.org/keywords/gonadal-steroid-feedback","display_name":"gonadal steroid feedback","score":0.7120000123977661},{"id":"https://openalex.org/keywords/gonadotropin-releasing-hormone","display_name":"gonadotropin-releasing hormone","score":0.6740000247955322},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.6950080394744873},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6557361483573914},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6527048349380493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6403855085372925},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5262517333030701},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.5248746275901794},{"id":"https://openalex.org/C197012351","wikidata":"https://www.wikidata.org/wiki/Q3099316","display_name":"Gonadotropic cell","level":4,"score":0.4523910880088806},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.3764355182647705},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2918185591697693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0912090539932251},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt7gk123xr","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7gk123xr","pdf_url":"https://escholarship.org/uc/item/7gk123xr","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:2146770372","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt7gk123xr/qt7gk123xr.pdf?t=lq6fn3","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt7gk123xr","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/7gk123xr","pdf_url":"https://escholarship.org/uc/item/7gk123xr","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2146770372.pdf","grobid_xml":"https://content.openalex.org/works/W2146770372.grobid-xml"},"referenced_works_count":156,"referenced_works":["https://openalex.org/W97536107","https://openalex.org/W645375282","https://openalex.org/W1513897826","https://openalex.org/W1542467604","https://openalex.org/W1549730489","https://openalex.org/W1551136566","https://openalex.org/W1562153609","https://openalex.org/W1607158610","https://openalex.org/W1736447480","https://openalex.org/W1927347481","https://openalex.org/W1964388570","https://openalex.org/W1964512812","https://openalex.org/W1966169469","https://openalex.org/W1967174959","https://openalex.org/W1970336036","https://openalex.org/W1971274261","https://openalex.org/W1972810033","https://openalex.org/W1973113277","https://openalex.org/W1974593629","https://openalex.org/W1976676739","https://openalex.org/W1976918496","https://openalex.org/W1977357672","https://openalex.org/W1979688291","https://openalex.org/W1984134696","https://openalex.org/W1984795474","https://openalex.org/W1987417875","https://openalex.org/W1987968238","https://openalex.org/W1989478369","https://openalex.org/W1990225079","https://openalex.org/W1991565704","https://openalex.org/W1992462878","https://openalex.org/W1994665476","https://openalex.org/W1994738588","https://openalex.org/W1995498585","https://openalex.org/W1997510672","https://openalex.org/W1999627315","https://openalex.org/W2004248502","https://openalex.org/W2006636734","https://openalex.org/W2007210832","https://openalex.org/W2007220451","https://openalex.org/W2008493497","https://openalex.org/W2009038754","https://openalex.org/W2011585740","https://openalex.org/W2011775394","https://openalex.org/W2012765360","https://openalex.org/W2013303140","https://openalex.org/W2014889798","https://openalex.org/W2015462373","https://openalex.org/W2016843227","https://openalex.org/W2017177010","https://openalex.org/W2019251281","https://openalex.org/W2020189783","https://openalex.org/W2022233058","https://openalex.org/W2022975112","https://openalex.org/W2024584207","https://openalex.org/W2025995094","https://openalex.org/W2026237709","https://openalex.org/W2027549819","https://openalex.org/W2029464736","https://openalex.org/W2029477181","https://openalex.org/W2029800597","https://openalex.org/W2030914006","https://openalex.org/W2034512494","https://openalex.org/W2035000884","https://openalex.org/W2036423270","https://openalex.org/W2037655256","https://openalex.org/W2041653433","https://openalex.org/W2044213109","https://openalex.org/W2047119340","https://openalex.org/W2049686120","https://openalex.org/W2049971061","https://openalex.org/W2051697611","https://openalex.org/W2051804947","https://openalex.org/W2052224954","https://openalex.org/W2056362365","https://openalex.org/W2056635197","https://openalex.org/W2056835256","https://openalex.org/W2057313063","https://openalex.org/W2057782871","https://openalex.org/W2057848210","https://openalex.org/W2059792018","https://openalex.org/W2060088323","https://openalex.org/W2060903877","https://openalex.org/W2061099010","https://openalex.org/W2062372161","https://openalex.org/W2063645101","https://openalex.org/W2066951718","https://openalex.org/W2068113812","https://openalex.org/W2070625108","https://openalex.org/W2070931346","https://openalex.org/W2071458975","https://openalex.org/W2071792035","https://openalex.org/W2072551067","https://openalex.org/W2074821975","https://openalex.org/W2074989385","https://openalex.org/W2075894485","https://openalex.org/W2076023323","https://openalex.org/W2078874543","https://openalex.org/W2080182601","https://openalex.org/W2081567987","https://openalex.org/W2081901226","https://openalex.org/W2082559087","https://openalex.org/W2083590043","https://openalex.org/W2084525029","https://openalex.org/W2085124463","https://openalex.org/W2085403222","https://openalex.org/W2087728475","https://openalex.org/W2088617710","https://openalex.org/W2090011325","https://openalex.org/W2091095324","https://openalex.org/W2092224562","https://openalex.org/W2093963412","https://openalex.org/W2094517790","https://openalex.org/W2100192487","https://openalex.org/W2101178259","https://openalex.org/W2102868284","https://openalex.org/W2103031848","https://openalex.org/W2103143130","https://openalex.org/W2105698692","https://openalex.org/W2107180907","https://openalex.org/W2109133691","https://openalex.org/W2112912949","https://openalex.org/W2112924154","https://openalex.org/W2116949924","https://openalex.org/W2118037914","https://openalex.org/W2122250093","https://openalex.org/W2127309304","https://openalex.org/W2127624529","https://openalex.org/W2128840922","https://openalex.org/W2131226468","https://openalex.org/W2132562148","https://openalex.org/W2133657460","https://openalex.org/W2136211439","https://openalex.org/W2137676124","https://openalex.org/W2140486768","https://openalex.org/W2143133954","https://openalex.org/W2143411872","https://openalex.org/W2143572454","https://openalex.org/W2146242428","https://openalex.org/W2146258274","https://openalex.org/W2146853018","https://openalex.org/W2148119988","https://openalex.org/W2148378944","https://openalex.org/W2152038391","https://openalex.org/W2159744955","https://openalex.org/W2161966432","https://openalex.org/W2164612855","https://openalex.org/W2165762583","https://openalex.org/W2166188229","https://openalex.org/W2167303818","https://openalex.org/W2167627996","https://openalex.org/W2171312408","https://openalex.org/W2172256092","https://openalex.org/W2315037039","https://openalex.org/W2410181866","https://openalex.org/W2792786100"],"related_works":["https://openalex.org/W2766221126","https://openalex.org/W1964388570","https://openalex.org/W2016878897","https://openalex.org/W2007565466","https://openalex.org/W2050682157","https://openalex.org/W2313472017","https://openalex.org/W1963617861","https://openalex.org/W2133494354","https://openalex.org/W2119416730","https://openalex.org/W2071458975"],"abstract_inverted_index":{"The":[0],"differential":[1],"regulation":[2,15,88,183],"of":[3,18,36,53,56,67,86,89,127,156,159,175,184,210,235,244],"gonadotropin":[4,39,57,91],"secretion":[5,17],"is":[6,49],"integral":[7],"to":[8,140,153,179,214],"a":[9,50,102,108,168,193],"properly":[10],"functioning":[11],"reproductive":[12,229],"system.":[13],"Transcriptional":[14],"and":[16,26,63,107,118,122,161,237],"the":[19,34,37,54,60,71,76,84,90,94,125,128,136,172,176,181,197],"two":[20],"gonadotropins":[21],"diverge":[22],"during":[23],"late":[24],"proestrus":[25],"early":[27],"estrus":[28],"when":[29],"LH":[30],"levels":[31,243],"decline":[32],"with":[33],"termination":[35],"preovulatory":[38],"surge,":[40],"while":[41],"FSH":[42,73],"remains":[43],"elevated.":[44],"Gonadal":[45],"steroid":[46],"hormone":[47],"feedback":[48,182],"crucial":[51],"component":[52],"control":[55],"synthesis":[58],"in":[59,186,189],"pituitary":[61],"gonadotrope,":[62],"progestins":[64],"may":[65],"be":[66],"particular":[68],"importance":[69],"for":[70,114],"secondary":[72],"surge.":[74],"In":[75,124],"current":[77],"study,":[78],"we":[79,133,151,191],"have":[80],"focused":[81],"on":[82],"delineating":[83],"mechanisms":[85],"progestin":[87,116],"\\\\[Beta\\\\]-subunits.":[92],"Within":[93],"murine":[95],"FSH\\\\[Beta\\\\]":[96],"promoter,":[97,132],"our":[98,202],"studies":[99,203],"demonstrated":[100],"that":[101,135],"FOXL2":[103],"element":[104],"at":[105,171],"-350":[106],"nearby":[109],"Smad":[110],"half-site":[111],"are":[112],"necessary":[113],"both":[115],"responsiveness":[117],"synergy":[119],"between":[120],"activin":[121],"progestin.":[123],"context":[126],"-300":[129],"rat":[130],"LH\\\\[Beta\\\\]":[131,163],"found":[134],"-200/-150bp":[137],"region":[138,174],"contributes":[139],"basal":[141,160],"gene":[142,164],"expression,":[143],"most":[144],"likely":[145],"by":[146,166],"binding":[147],"transcriptional":[148],"activators.":[149],"Additionally,":[150],"contributed":[152],"finer":[154],"mapping":[155],"progesterone":[157,185],"suppression":[158],"GnRH-induced":[162],"expression":[165],"identifying":[167],"critical":[169],"segment":[170],"-300/-280bp":[173],"promoter.":[177],"Finally,":[178],"study":[180],"gonadotrope":[187],"cells":[188],"vivo,":[190],"created":[192],"gonadotrope-":[194],"specific":[195],"PRKO:":[196],"PRKOLacZ/Flox/LH\\\\[Beta\\\\]-Cre":[198],"mouse":[199],"line.":[200],"Though,":[201],"did":[204],"not":[205],"show":[206],"any":[207],"significant":[208],"impairment":[209],"fertility,":[211],"possibly":[212],"due":[213],"genetic":[215],"penetrance":[216],"or":[217],"mosaicism":[218],"issues,":[219],"they":[220],"serve":[221],"as":[222,232,239,241],"preliminary":[223],"data":[224],"indicating":[225],"trends":[226],"towards":[227],"lower":[228,233,242],"function,":[230],"such":[231],"number":[234],"litters":[236],"pups,":[238],"well":[240],"circulating":[245],"hormones.":[246]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}