{"id":"https://openalex.org/W2146548469","doi":"https://doi.org/10.1001/archneur.1984.04050170046014","title":"Cholestatic Liver Dysfunction After Long-term Phenytoin Therapy","display_name":"Cholestatic Liver Dysfunction After Long-term Phenytoin Therapy","publication_year":1984,"publication_date":"1984-05-01","ids":{"openalex":"https://openalex.org/W2146548469","doi":"https://doi.org/10.1001/archneur.1984.04050170046014","mag":"2146548469","pmid":"https://pubmed.ncbi.nlm.nih.gov/6721716"},"language":"en","primary_location":{"id":"doi:10.1001/archneur.1984.04050170046014","doi":"https://doi.org/10.1001/archneur.1984.04050170046014","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.1984.04050170046014","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064855876","display_name":"Jerry W. Taylor","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. W. Taylor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062709449","display_name":"M. N. Stein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. N. Stein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"M. J. Murphy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. J. Murphy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091320312","display_name":"Frank A. Mitros","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. A. Mitros","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7733,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.69456965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"41","issue":"5","first_page":"500","last_page":"501"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenytoin","display_name":"phenytoin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.8259999752044678},{"id":"https://openalex.org/keywords/cholestatic-jaundice","display_name":"cholestatic jaundice","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/antiepileptic-drug-side-effects","display_name":"antiepileptic drug adverse effects","score":0.6830000281333923},{"id":"https://openalex.org/keywords/long-term-anticonvulsant-therapy","display_name":"long-term anticonvulsant therapy","score":0.8029999732971191},{"id":"https://openalex.org/keywords/rechallenge","display_name":"drug rechallenge","score":0.7509999871253967},{"id":"https://openalex.org/keywords/biliary-obstruction","display_name":"biliary obstruction","score":0.6610000133514404},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C2778337148","wikidata":"https://www.wikidata.org/wiki/Q410400","display_name":"Phenytoin","level":3,"score":0.9471216201782227},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8080024123191833},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.7984229326248169},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7964588403701782},{"id":"https://openalex.org/C2778456037","wikidata":"https://www.wikidata.org/wiki/Q133244","display_name":"Jaundice","level":2,"score":0.5437626838684082},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5328406095504761},{"id":"https://openalex.org/C2908939727","wikidata":"https://www.wikidata.org/wiki/Q970208","display_name":"Hepatic dysfunction","level":2,"score":0.5326786637306213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45863640308380127},{"id":"https://openalex.org/C2908970061","wikidata":"https://www.wikidata.org/wiki/Q133244","display_name":"Cholestatic Jaundice","level":3,"score":0.4575793147087097},{"id":"https://openalex.org/C2777766500","wikidata":"https://www.wikidata.org/wiki/Q360841","display_name":"Liver biopsy","level":3,"score":0.4323454201221466},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.31817126274108887},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.25852519273757935},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002779","descriptor_name":"Cholestasis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010672","descriptor_name":"Phenytoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1001/archneur.1984.04050170046014","doi":"https://doi.org/10.1001/archneur.1984.04050170046014","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archneur.1984.04050170046014","pdf_url":null,"source":{"id":"https://openalex.org/S4210230857","display_name":"Archives of Neurology","issn_l":"0003-9942","issn":["0003-9942","1538-3687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Neurology","raw_type":"journal-article"},{"id":"pmid:6721716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6721716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of neurology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1517217235","https://openalex.org/W1973148780","https://openalex.org/W1982410352","https://openalex.org/W1984793064","https://openalex.org/W1988270676","https://openalex.org/W1991650314","https://openalex.org/W2006621055","https://openalex.org/W2008824504","https://openalex.org/W2058068726","https://openalex.org/W2064535770","https://openalex.org/W2067252108","https://openalex.org/W2067931578","https://openalex.org/W2080221798","https://openalex.org/W2113684969","https://openalex.org/W2154424029","https://openalex.org/W2325902526","https://openalex.org/W2336128693","https://openalex.org/W2395683607","https://openalex.org/W2401251365","https://openalex.org/W2402194431","https://openalex.org/W2418869689"],"related_works":["https://openalex.org/W2416942408","https://openalex.org/W2042928119","https://openalex.org/W2058068726","https://openalex.org/W1492609260","https://openalex.org/W2087147862","https://openalex.org/W2462879868","https://openalex.org/W2903025378","https://openalex.org/W2867043655","https://openalex.org/W2351941762","https://openalex.org/W2064535770"],"abstract_inverted_index":{"Cholestatic":[0],"jaundice":[1],"developed":[2],"in":[3,22],"a":[4,34],"64-year-old":[5],"woman":[6],"who":[7],"had":[8],"received":[9],"phenytoin":[10,19,89],"sodium":[11],"for":[12],"more":[13],"than":[14],"40":[15],"years.":[16],"Discontinuation":[17],"of":[18,24,48,64],"therapy":[20,41,58],"resulted":[21],"resolution":[23,47],"the":[25,38,49,65],"hepatic":[26,50],"abnormalities,":[27],"which":[28],"recurred":[29],"on":[30],"rechallenge,":[31],"strongly":[32],"suggesting":[33],"causal":[35],"relation":[36],"to":[37,88],"drug.":[39],"Phenytoin":[40],"was":[42,72],"discontinued":[43],"again,":[44],"with":[45,62],"complete":[46],"abnormalities.":[51],"The":[52,75],"liver":[53],"biopsy":[54],"specimen":[55],"obtained":[56],"during":[57],"showed":[59],"cholestasis":[60],"compatible":[61],"obstruction":[63],"biliary":[66],"tree,":[67],"although":[68],"an":[69,85],"obstructive":[70],"process":[71],"never":[73],"demonstrated.":[74],"biochemical":[76],"abnormalities":[77],"and":[78],"histologic":[79],"features":[80],"observed":[81],"most":[82],"likely":[83],"represent":[84],"unusual":[86],"response":[87],"therapy.":[90]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}