{"id":"https://openalex.org/W2146546754","doi":null,"title":"Apolipoprotein E genotype in matched men and women with coronary heart disease.","display_name":"Apolipoprotein E genotype in matched men and women with coronary heart disease.","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2146546754","mag":"2146546754","pmid":"https://pubmed.ncbi.nlm.nih.gov/16254254"},"language":"en","primary_location":{"id":"pmid:16254254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16254254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and laboratory science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045257830","display_name":"Genovefa D. Kolovou","orcid":"https://orcid.org/0000-0001-8788-4555","observed_orcids":["https://orcid.org/0000-0001-8788-4555"]},"institutions":[{"id":"https://openalex.org/I4210117383","display_name":"Onassis Cardiac Surgery Center","ror":"https://ror.org/02gan0k07","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210117383"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Genovefa D Kolovou","raw_affiliation_strings":["Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece. genkolovou@mail.gr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Onassis Cardiac Surgery Center, 356 Sygrou Ave, 176 74 Athens, Greece. genkolovou@mail.gr","institution_ids":["https://openalex.org/I4210117383"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078627325","display_name":"Katherine K. Anagnostopoulou","orcid":"https://orcid.org/0009-0008-1689-1131","observed_orcids":["https://orcid.org/0009-0008-1689-1131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine K Anagnostopoulou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081993584","display_name":"Klelia D. Salpea","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klelia D Salpea","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085496501","display_name":"Demosthenes B. Panagiotakos","orcid":"https://orcid.org/0000-0001-8583-153X","observed_orcids":["https://orcid.org/0000-0001-8583-153X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Demosthenes B Panagiotakos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046453979","display_name":"Ioannis S. Hoursalas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ioannis S Hoursalas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019040009","display_name":"Marios A. Cariolou","orcid":"https://orcid.org/0000-0002-5882-6935","observed_orcids":["https://orcid.org/0000-0002-5882-6935"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marios A Cariolou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041348540","display_name":"Katerina Koniavitou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katerina Koniavitou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091241266","display_name":"Dennis V. Cokkinos","orcid":"https://orcid.org/0000-0002-3390-4191","observed_orcids":["https://orcid.org/0000-0002-3390-4191"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dennis V Cokkinos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4325,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.68310965,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"35","issue":"4","first_page":"391","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12975","display_name":"Paraoxonase enzyme and polymorphisms","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.984000027179718},{"id":"https://openalex.org/keywords/apoe-polymorphism","display_name":"APOE polymorphism","score":0.7979999780654907},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.9909999966621399},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8339999914169312},{"id":"https://openalex.org/keywords/genotype-distribution","display_name":"genotype distribution","score":0.578000009059906},{"id":"https://openalex.org/keywords/family-history-of-coronary-heart-disease","display_name":"family history of coronary heart disease","score":0.7049999833106995},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.8519999980926514},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.7429999709129333}],"concepts":[{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.8218830227851868},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.7016136646270752},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6963143348693848},{"id":"https://openalex.org/C3018906752","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary heart disease","level":2,"score":0.5853659510612488},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.5660250782966614},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.5598212480545044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5459297299385071},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5275647044181824},{"id":"https://openalex.org/C149737253","wikidata":"https://www.wikidata.org/wiki/Q3240252","display_name":"Polymorphism (computer science)","level":4,"score":0.49209803342819214},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.4674803912639618},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42142394185066223},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.4199608564376831},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.39709243178367615},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3855002522468567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25745922327041626},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20761415362358093},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.18143311142921448},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09870865941047668}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001057","descriptor_name":"Apolipoproteins E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006115","descriptor_name":"Greece","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012737","descriptor_name":"Sex Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017698","descriptor_name":"Postmenopause","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:16254254","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16254254","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of clinical and laboratory science","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.538.2365","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.538.2365","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.annclinlabsci.org/content/35/4/391.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W4166267","https://openalex.org/W147823787","https://openalex.org/W1590095886","https://openalex.org/W1736154854","https://openalex.org/W1920265813","https://openalex.org/W1939948612","https://openalex.org/W1971718473","https://openalex.org/W1984395109","https://openalex.org/W1990207743","https://openalex.org/W1991290354","https://openalex.org/W2001052319","https://openalex.org/W2034968148","https://openalex.org/W2039158755","https://openalex.org/W2040832487","https://openalex.org/W2042199021","https://openalex.org/W2046445606","https://openalex.org/W2051277964","https://openalex.org/W2061571369","https://openalex.org/W2066644955","https://openalex.org/W2070901692","https://openalex.org/W2079413267","https://openalex.org/W2081527646","https://openalex.org/W2082655419","https://openalex.org/W2102949521","https://openalex.org/W2112402451","https://openalex.org/W2114063969","https://openalex.org/W2116404316","https://openalex.org/W2116443347","https://openalex.org/W2116631222","https://openalex.org/W2122643138","https://openalex.org/W2148550388","https://openalex.org/W2151243790","https://openalex.org/W2154797259","https://openalex.org/W2165553239","https://openalex.org/W2166776142","https://openalex.org/W2168723722","https://openalex.org/W2188938709","https://openalex.org/W2347366171","https://openalex.org/W2460968275","https://openalex.org/W4237709179"],"related_works":["https://openalex.org/W2114164652","https://openalex.org/W2016731746","https://openalex.org/W7097114217","https://openalex.org/W2750216034","https://openalex.org/W2137055862","https://openalex.org/W4213391652","https://openalex.org/W2362764139","https://openalex.org/W2406680428","https://openalex.org/W2356245114","https://openalex.org/W2385445129"],"abstract_inverted_index":{"Apolipoprotein":[0],"E":[1,32,85,141,145],"(apo":[2],"E)":[3],"plays":[4],"an":[5],"important":[6],"role":[7],"in":[8,108,123,138],"lipid":[9],"metabolism":[10],"and":[11,55,71,91,118,127,153],"its":[12],"polymorphism":[13,43],"may":[14],"be":[15],"a":[16,27,47,166,169],"risk":[17],"determinant":[18],"of":[19,30,38,41,49,110,129,165,171],"coronary":[20],"heart":[21],"disease":[22],"(CHD).":[23],"Since":[24],"evidence":[25],"suggested":[26],"gender-specific":[28,39],"effect":[29],"apo":[31,140,144],"polymorphism,":[33],"we":[34,63],"studied":[35],"the":[36,42,104,111,130,139,149],"influence":[37],"interaction":[40],"on":[44],"CHD.":[45,156],"From":[46],"total":[48],"463":[50],"Greek":[51,151],"Caucasians":[52],"(314":[53],"men":[54,73,152,159],"149":[56],"postmenopausal":[57],"women)":[58],"with":[59,155,168],"angiographically":[60],"documented":[61],"CHD,":[62,172],"selected":[64],"79":[65,72],"women":[66,154,175],"(68+/-":[67],"9":[68,75],"yr":[69,76],"old)":[70,77],"(66+/-":[74],"who":[78],"were":[79,96,101,136,161],"matched":[80,150],"for":[81],"clinical":[82],"characteristics.":[83],"Apo":[84],"genotyping":[86],"was":[87],"performed":[88],"by":[89,114],"PCR":[90],"RFLP":[92],"analysis.":[93],"Biochemical":[94],"parameters":[95],"also":[97],"measured.":[98],"The":[99,157],"results":[100],"as":[102],"follows:":[103],"E3/3":[105,158],"genotype":[106,146],"occurred":[107,122],"78.5%":[109],"patients,":[112,131],"followed":[113],"E3/4,":[115],"E2/3,":[116],"E2/4,":[117],"E4/4":[119],"genotypes,":[120],"which":[121],"9.5%,":[124,125],"1.9%,":[126],"0.6%":[128],"respectively.":[132],"No":[133],"significant":[134],"differences":[135],"observed":[137],"allele":[142],"or":[143],"distributions":[147],"between":[148],"patients":[160],"more":[162],"frequently":[163],"part":[164],"family":[167],"history":[170],"compared":[173],"to":[174],"(p=0.035).":[176]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}