{"id":"https://openalex.org/W2146506540","doi":"https://doi.org/10.1517/14622416.5.6.643","title":"Pharmacogenetics of antiretroviral therapy: genetic variation of response and toxicity","display_name":"Pharmacogenetics of antiretroviral therapy: genetic variation of response and toxicity","publication_year":2004,"publication_date":"2004-09-01","ids":{"openalex":"https://openalex.org/W2146506540","doi":"https://doi.org/10.1517/14622416.5.6.643","mag":"2146506540","pmid":"https://pubmed.ncbi.nlm.nih.gov/15335286"},"language":"en","primary_location":{"id":"doi:10.1517/14622416.5.6.643","doi":"https://doi.org/10.1517/14622416.5.6.643","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14622416.5.6.643","pdf_url":null,"source":{"id":"https://openalex.org/S190377370","display_name":"Pharmacogenomics","issn_l":"1462-2416","issn":["1462-2416","1744-8042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109557319","display_name":"Annalise M. Martin","orcid":"https://orcid.org/0000-0002-1399-4310","observed_orcids":["https://orcid.org/0000-0002-1399-4310"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Annalise M Martin","raw_affiliation_strings":["Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia","institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039351765","display_name":"David A Nolan","orcid":"https://orcid.org/0000-0002-0743-8801","observed_orcids":["https://orcid.org/0000-0002-0743-8801"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David Nolan","raw_affiliation_strings":["Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia","institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080161419","display_name":"Silvana Gaudieri","orcid":"https://orcid.org/0000-0001-6873-0198","observed_orcids":["https://orcid.org/0000-0001-6873-0198"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Silvana Gaudieri","raw_affiliation_strings":["Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia","School of Anatomy, Physiology and Human Biology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia","institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"]},{"raw_affiliation_string":"School of Anatomy, Physiology and Human Biology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080985934","display_name":"Elizabeth Jane Phillips","orcid":"https://orcid.org/0000-0002-7623-3383","observed_orcids":["https://orcid.org/0000-0002-7623-3383"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Elizabeth Phillips","raw_affiliation_strings":["Divisions of Clinical Pharmacology & Infectious Diseases, Sunnybrook & Women\u2019s College Health Sciences Centre, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Pharmacology & Infectious Diseases, Sunnybrook & Women\u2019s College Health Sciences Centre, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I1323843004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070165631","display_name":"Simon Alexander Mallal","orcid":"https://orcid.org/0000-0002-7036-1309","observed_orcids":["https://orcid.org/0000-0002-7036-1309"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Simon Mallal","raw_affiliation_strings":["Centre for Clinical Immunology and Biomedical Statistics, Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia. s.mallal@murdoch.edu.au"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Clinical Immunology and Biomedical Statistics, Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Perth, Western Australia. s.mallal@murdoch.edu.au","institution_ids":["https://openalex.org/I176790772","https://openalex.org/I2799740997"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.0904,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.93284809,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"5","issue":"6","first_page":"643","last_page":"655"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9297000169754028,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.06310000270605087,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.9800000190734863},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.8920000195503235},{"id":"https://openalex.org/keywords/drug-response-variability","display_name":"drug response variability","score":0.6389999985694885},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.7369999885559082},{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.902999997138977},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9629999995231628},{"id":"https://openalex.org/keywords/drug-transporters","display_name":"drug transporters","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hiv-protease-inhibitors","display_name":"HIV protease inhibitors","score":0.9900000095367432},{"id":"https://openalex.org/keywords/non-nucleoside-reverse-transcriptase-inhibitors","display_name":"non-nucleoside reverse transcriptase inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/abacavir-hypersensitivity","display_name":"abacavir hypersensitivity","score":0.8479999899864197},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"major histocompatibility complex","score":0.8769999742507935},{"id":"https://openalex.org/keywords/pharmacogenetic-testing","display_name":"pharmacogenetic testing","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.8350241184234619},{"id":"https://openalex.org/C2779465607","wikidata":"https://www.wikidata.org/wiki/Q304330","display_name":"Abacavir","level":5,"score":0.825808048248291},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6137233972549438},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.572127103805542},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.4447654187679291},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42458558082580566},{"id":"https://openalex.org/C2781143361","wikidata":"https://www.wikidata.org/wiki/Q55761529","display_name":"Protease inhibitor (pharmacology)","level":5,"score":0.4199952483177185},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40557220578193665},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28183144330978394},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.23212313652038574},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18227964639663696},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.17981824278831482},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.14569365978240967},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.10026189684867859},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0687413215637207}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D039682","descriptor_name":"HIV-Associated Lipodystrophy Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D039682","descriptor_name":"HIV-Associated Lipodystrophy Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044966","descriptor_name":"Anti-Retroviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1517/14622416.5.6.643","doi":"https://doi.org/10.1517/14622416.5.6.643","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14622416.5.6.643","pdf_url":null,"source":{"id":"https://openalex.org/S190377370","display_name":"Pharmacogenomics","issn_l":"1462-2416","issn":["1462-2416","1744-8042"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321119","host_organization_name":"Future Medicine","host_organization_lineage":["https://openalex.org/P4310321119"],"host_organization_lineage_names":["Future Medicine"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics","raw_type":"journal-article"},{"id":"pmid:15335286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15335286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomics","raw_type":"Journal Article"},{"id":"pmh:oai:alma.61MUN_INST:11136018520007891","doi":null,"is_oa":false,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/journalArticle/Pharmacogenetics-of-antiretroviral-therapy-genetic-variation/991005543319807891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:publications/0b9b36c9-b028-41c8-8adf-f0d8ce0c441b","doi":null,"is_oa":false,"landing_page_url":"https://research-repository.uwa.edu.au/en/publications/0b9b36c9-b028-41c8-8adf-f0d8ce0c441b","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Martin, A M, Nolan, D, Gaudieri, S, Phillips, E & Mallal, S 2004, 'Pharmacogenetics of antiretroviral therapy: genetic variation of response and toxicity', Pharmacogenomics, vol. 5, no. 6, pp. 643-655. https://doi.org/10.1517/14622416.5.6.643","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:researchrepository.murdoch.edu.au:14924","doi":null,"is_oa":false,"landing_page_url":"http://researchrepository.murdoch.edu.au/id/eprint/14924/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W163453395","https://openalex.org/W251742802","https://openalex.org/W1508985588","https://openalex.org/W1569649532","https://openalex.org/W1577781821","https://openalex.org/W1583992601","https://openalex.org/W1853241466","https://openalex.org/W1901840824","https://openalex.org/W1969879564","https://openalex.org/W1979821607","https://openalex.org/W1986044891","https://openalex.org/W1988144987","https://openalex.org/W1995800994","https://openalex.org/W1995968109","https://openalex.org/W1996323553","https://openalex.org/W1996980190","https://openalex.org/W1998388433","https://openalex.org/W2000451387","https://openalex.org/W2003912772","https://openalex.org/W2009104414","https://openalex.org/W2009856823","https://openalex.org/W2013711685","https://openalex.org/W2016380061","https://openalex.org/W2020444154","https://openalex.org/W2020797824","https://openalex.org/W2028725683","https://openalex.org/W2030890271","https://openalex.org/W2035153413","https://openalex.org/W2036030829","https://openalex.org/W2037919740","https://openalex.org/W2039515318","https://openalex.org/W2042511069","https://openalex.org/W2042723151","https://openalex.org/W2043190075","https://openalex.org/W2046283526","https://openalex.org/W2047252585","https://openalex.org/W2049377340","https://openalex.org/W2049902892","https://openalex.org/W2052968172","https://openalex.org/W2053896303","https://openalex.org/W2060382789","https://openalex.org/W2061057762","https://openalex.org/W2063303861","https://openalex.org/W2064733265","https://openalex.org/W2067416157","https://openalex.org/W2073884742","https://openalex.org/W2078387155","https://openalex.org/W2080008894","https://openalex.org/W2081661453","https://openalex.org/W2082335023","https://openalex.org/W2087707746","https://openalex.org/W2089378839","https://openalex.org/W2096051408","https://openalex.org/W2098938825","https://openalex.org/W2100524797","https://openalex.org/W2102545165","https://openalex.org/W2102942667","https://openalex.org/W2106737113","https://openalex.org/W2107227728","https://openalex.org/W2111966641","https://openalex.org/W2114346603","https://openalex.org/W2122329447","https://openalex.org/W2129666171","https://openalex.org/W2136204492","https://openalex.org/W2138345866","https://openalex.org/W2140055542","https://openalex.org/W2141670429","https://openalex.org/W2145378546","https://openalex.org/W2148825772","https://openalex.org/W2152664025","https://openalex.org/W2154374078","https://openalex.org/W2160807401","https://openalex.org/W2163636362","https://openalex.org/W2164327527","https://openalex.org/W2164539379","https://openalex.org/W2164923007","https://openalex.org/W2166901508","https://openalex.org/W2168733361","https://openalex.org/W2171659436","https://openalex.org/W2321248858","https://openalex.org/W2423137336","https://openalex.org/W2434133513"],"related_works":["https://openalex.org/W2090466379","https://openalex.org/W2054989227","https://openalex.org/W2064751972","https://openalex.org/W2044539926","https://openalex.org/W2135826395","https://openalex.org/W2061009479","https://openalex.org/W154452522","https://openalex.org/W2091610996","https://openalex.org/W4200010088","https://openalex.org/W4226271807"],"abstract_inverted_index":{"The":[0,142],"application":[1],"of":[2,55,94,108,127,148],"a":[3,11,123],"pharmacogenetic":[4,149],"approach":[5],"to":[6,90,116,129],"antiretroviral":[7],"drug":[8,20,68,86,131],"therapy":[9],"represents":[10],"significant":[12,26,125],"challenge,":[13],"as":[14,30,32,122],"treatment":[15],"involves":[16],"multiple":[17],"drugs":[18],"and":[19,53,85,98,144],"classes":[21],"with":[22,139],"the":[23,51,61,74,92,106,113],"potential":[24,75,145],"for":[25,76],"variability":[27],"in":[28,45,67,111,151],"drug-host,":[29],"well":[31],"drug-drug,":[33],"interactions.":[34],"However,":[35],"despite":[36],"this":[37,59],"inherent":[38],"complexity,":[39],"considerable":[40],"gains":[41],"have":[42],"been":[43],"made":[44],"understanding":[46],"how":[47],"genetic":[48,65,109],"factors":[49],"influence":[50,91],"efficacy":[52],"toxicity":[54],"HIV":[56,95,152],"therapy.":[57],"In":[58,104],"review":[60],"available":[62],"evidence":[63],"regarding":[64],"variation":[66,110],"disposition":[69,93],"will":[70,119,154],"be":[71,120,156],"examined,":[72],"including":[73],"relatively":[77],"polymorphic":[78],"drug-metabolizing":[79],"enzymes":[80],"(e.g.,":[81,88,133],"cytochrome":[82],"P450":[83],"isoforms)":[84],"transporters":[87],"P-glycoprotein)":[89],"protease":[96],"inhibitor":[97,102],"non-nucleoside":[99],"reverse":[100],"transcriptase":[101],"drugs.":[103],"addition,":[105],"role":[107],"determining":[112],"immune":[114],"response":[115],"drug-specific":[117],"antigens":[118],"considered":[121],"potentially":[124],"determinant":[126],"susceptibility":[128],"idiosyncratic":[130],"reactions":[132],"major":[134],"histocompatibility":[135],"complex":[136],"alleles":[137],"associated":[138],"abacavir":[140],"hypersensitivity).":[141],"current":[143],"clinical":[146],"utility":[147],"testing":[150],"management":[153],"also":[155],"emphasized.":[157]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}