{"id":"https://openalex.org/W2146499272","doi":null,"title":"Design and Synthesis of HIV-1 Protease Inhibitors","display_name":"Design and Synthesis of HIV-1 Protease Inhibitors","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W2146499272","mag":"2146499272"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-571","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-571","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-571","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110028978","display_name":"Mathias Alterman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mathias Alterman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5110028978"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-protease-inhibitors","display_name":"HIV-1 protease inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tetrazole-synthesis","display_name":"tetrazole synthesis","score":0.777999997138977},{"id":"https://openalex.org/keywords/surface-plasmon-resonance-biosensor","display_name":"surface plasmon resonance biosensor","score":0.7929999828338623},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.7350000143051147},{"id":"https://openalex.org/keywords/x-ray-crystal-structure","display_name":"X-ray crystal structure","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.6339992880821228},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4948422312736511},{"id":"https://openalex.org/C2777583353","wikidata":"https://www.wikidata.org/wiki/Q410261","display_name":"HIV-1 protease","level":4,"score":0.4362650513648987},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.42950135469436646},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.382604718208313},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35185980796813965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34494343400001526},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20850780606269836},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17583706974983215}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-571","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-571","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2146499272","doi":null,"is_oa":false,"landing_page_url":"https://uu.diva-portal.org/smash/get/diva2:166067/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-571","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-571","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":199,"referenced_works":["https://openalex.org/W49920453","https://openalex.org/W82820957","https://openalex.org/W136988059","https://openalex.org/W161489366","https://openalex.org/W578064583","https://openalex.org/W1133356780","https://openalex.org/W1480478945","https://openalex.org/W1502533956","https://openalex.org/W1510136884","https://openalex.org/W1528522073","https://openalex.org/W1548955637","https://openalex.org/W1598953054","https://openalex.org/W1605828942","https://openalex.org/W1625094297","https://openalex.org/W1637218542","https://openalex.org/W1775967318","https://openalex.org/W1888137339","https://openalex.org/W1916636794","https://openalex.org/W1921702285","https://openalex.org/W1964041012","https://openalex.org/W1964916693","https://openalex.org/W1965825835","https://openalex.org/W1965920593","https://openalex.org/W1966625144","https://openalex.org/W1966966267","https://openalex.org/W1967682764","https://openalex.org/W1967769136","https://openalex.org/W1967994100","https://openalex.org/W1968873679","https://openalex.org/W1970511538","https://openalex.org/W1970540146","https://openalex.org/W1973485456","https://openalex.org/W1974066556","https://openalex.org/W1974224443","https://openalex.org/W1976683819","https://openalex.org/W1977081895","https://openalex.org/W1977282539","https://openalex.org/W1978507884","https://openalex.org/W1980438105","https://openalex.org/W1981164507","https://openalex.org/W1981754097","https://openalex.org/W1982512475","https://openalex.org/W1983467229","https://openalex.org/W1985469117","https://openalex.org/W1985535752","https://openalex.org/W1987362380","https://openalex.org/W1989475707","https://openalex.org/W1989906248","https://openalex.org/W1990224503","https://openalex.org/W1992850824","https://openalex.org/W1993377322","https://openalex.org/W1995215826","https://openalex.org/W1995396220","https://openalex.org/W1996024432","https://openalex.org/W1996634009","https://openalex.org/W1997844736","https://openalex.org/W2000960726","https://openalex.org/W2002030293","https://openalex.org/W2002625833","https://openalex.org/W2002783186","https://openalex.org/W2003027607","https://openalex.org/W2004391976","https://openalex.org/W2005288968","https://openalex.org/W2006973067","https://openalex.org/W2008791719","https://openalex.org/W2008972159","https://openalex.org/W2010183118","https://openalex.org/W2010503625","https://openalex.org/W2012108232","https://openalex.org/W2015559549","https://openalex.org/W2015625581","https://openalex.org/W2016069268","https://openalex.org/W2016323479","https://openalex.org/W2017178255","https://openalex.org/W2017609395","https://openalex.org/W2018155545","https://openalex.org/W2018653074","https://openalex.org/W2019261111","https://openalex.org/W2019508559","https://openalex.org/W2022926519","https://openalex.org/W2023690185","https://openalex.org/W2027095884","https://openalex.org/W2027477912","https://openalex.org/W2029815870","https://openalex.org/W2030402747","https://openalex.org/W2030676469","https://openalex.org/W2030936820","https://openalex.org/W2031095951","https://openalex.org/W2032026161","https://openalex.org/W2033272342","https://openalex.org/W2034209707","https://openalex.org/W2034660792","https://openalex.org/W2035341183","https://openalex.org/W2036840512","https://openalex.org/W2037692933","https://openalex.org/W2039127550","https://openalex.org/W2042695720","https://openalex.org/W2046382666","https://openalex.org/W2046854154","https://openalex.org/W2047732345","https://openalex.org/W2049841556","https://openalex.org/W2050805406","https://openalex.org/W2051903773","https://openalex.org/W2054468412","https://openalex.org/W2055763988","https://openalex.org/W2056213705","https://openalex.org/W2056633621","https://openalex.org/W2056640340","https://openalex.org/W2057647173","https://openalex.org/W2058841922","https://openalex.org/W2060210361","https://openalex.org/W2060740730","https://openalex.org/W2060751102","https://openalex.org/W2062293412","https://openalex.org/W2063291686","https://openalex.org/W2063491230","https://openalex.org/W2063785972","https://openalex.org/W2064635496","https://openalex.org/W2064737932","https://openalex.org/W2065114401","https://openalex.org/W2065631521","https://openalex.org/W2065649191","https://openalex.org/W2065740427","https://openalex.org/W2067393428","https://openalex.org/W2069366448","https://openalex.org/W2070368233","https://openalex.org/W2071380584","https://openalex.org/W2075987068","https://openalex.org/W2077430714","https://openalex.org/W2078701683","https://openalex.org/W2085318243","https://openalex.org/W2086003834","https://openalex.org/W2086020611","https://openalex.org/W2086186867","https://openalex.org/W2087876594","https://openalex.org/W2088351021","https://openalex.org/W2090126383","https://openalex.org/W2090178505","https://openalex.org/W2092915302","https://openalex.org/W2093800350","https://openalex.org/W2095011753","https://openalex.org/W2099313905","https://openalex.org/W2105535972","https://openalex.org/W2107118006","https://openalex.org/W2112362416","https://openalex.org/W2112857740","https://openalex.org/W2113282092","https://openalex.org/W2119520241","https://openalex.org/W2122167307","https://openalex.org/W2122204312","https://openalex.org/W2125143013","https://openalex.org/W2130082288","https://openalex.org/W2130741230","https://openalex.org/W2131376910","https://openalex.org/W2132666819","https://openalex.org/W2134293108","https://openalex.org/W2140382609","https://openalex.org/W2142144836","https://openalex.org/W2149996025","https://openalex.org/W2150412246","https://openalex.org/W2154963941","https://openalex.org/W2155898968","https://openalex.org/W2156590690","https://openalex.org/W2160276605","https://openalex.org/W2161558889","https://openalex.org/W2162250498","https://openalex.org/W2162705413","https://openalex.org/W2163676940","https://openalex.org/W2164021685","https://openalex.org/W2164929179","https://openalex.org/W2165429130","https://openalex.org/W2165732545","https://openalex.org/W2166782710","https://openalex.org/W2167442923","https://openalex.org/W2169655668","https://openalex.org/W2170424911","https://openalex.org/W2171316918","https://openalex.org/W2175970307","https://openalex.org/W2268964075","https://openalex.org/W2324473093","https://openalex.org/W2331925431","https://openalex.org/W2333399282","https://openalex.org/W2334860476","https://openalex.org/W2339006876","https://openalex.org/W2395363633","https://openalex.org/W2413729856","https://openalex.org/W2431570982","https://openalex.org/W2621219747","https://openalex.org/W2906748080","https://openalex.org/W2949872882","https://openalex.org/W2949998689","https://openalex.org/W2950124641","https://openalex.org/W2950534783","https://openalex.org/W2950636979","https://openalex.org/W2951411853","https://openalex.org/W2951524779","https://openalex.org/W2953334945","https://openalex.org/W3026032990","https://openalex.org/W3083783902"],"related_works":["https://openalex.org/W2090178505","https://openalex.org/W1984355694","https://openalex.org/W620227209","https://openalex.org/W2016371679","https://openalex.org/W334846575","https://openalex.org/W2949354251","https://openalex.org/W939140767","https://openalex.org/W2483319390","https://openalex.org/W2952495186","https://openalex.org/W1992437543"],"abstract_inverted_index":{"Human":[0],"Immunodeficiency":[1],"Virus":[2],"(HIV)":[3],"is":[4,18,61],"the":[5,21,27,30,88,129,134,141,148,151,160,163,178,182,190,219,227,252],"causative":[6],"agent":[7],"of":[8,20,29,34,47,50,100,133,138,140,154,162,172,181,189,210,223,231,238,254],"Acquired":[9],"Immune":[10],"Deficiency":[11],"Syndrome":[12],"(AIDS).":[13],"The":[14],"C2-symmetric":[15],"HIV-1":[16,35,54,113,117,123,194,259],"protease":[17,36,55,114,124,260],"one":[19,232],"prime":[22],"targets":[23],"for":[24,208],"chemotherapy":[25],"in":[26,63,116,159,177,185,242],"treatment":[28],"HIV":[31],"infection.":[32],"Inhibition":[33],"leads":[37],"to":[38,91,212,226,236],"immature":[39],"and":[40,45,57,107,115,201,216],"non-infectious":[41],"viral":[42],"particles.":[43],"Design":[44],"synthesis":[46,206],"a":[48,76,98,186,198],"number":[49],"C2-symmetrical":[51],"C-terminal":[52],"duplicated":[53],"inhibitors":[56,86,104,125,183],"subsequent":[58],"biological":[59],"evaluation":[60,253],"presented":[62],"this":[64,95],"thesis.":[65],"A":[66],"versatile":[67],"three":[68],"step":[69],"synthetic":[70],"route":[71],"has":[72],"been":[73],"developed":[74,215],"using":[75],"carbohydrate":[77],"as":[78,145,258],"an":[79],"inexpensive":[80],"chiral":[81],"starting":[82],"material":[83],"thus":[84],"allowing":[85],"with":[87,147],"desired":[89],"stereochemistry":[90],"be":[92],"obtained.":[93],"By":[94],"efficient":[96],"method":[97],"series":[99],"tailor-made":[101],"P2/P2'":[102],"modified":[103],"were":[105,109,126,167],"synthesized,":[106],"these":[108],"evaluated":[110],"on":[111,193,218],"purified":[112],"infected":[118,195],"cell":[119],"assays.":[120,247],"Highly":[121],"active":[122,143],"identified":[127],"among":[128],"tested":[130],"compounds.":[131],"Analyses":[132],"X-ray":[135],"crystal":[136],"structures":[137],"two":[139],"most":[142],"compounds,":[144],"complexes":[146],"protease,":[149],"guided":[150],"further":[152],"design":[153],"P1/P1'":[155,164,179,228],"elongated":[156],"inhibitors.":[157,261],"Substitutions":[158],"para-position":[161],"benzyl":[165,229],"groups":[166,230],"promoted":[168],"efficiently":[169],"by":[170],"microwave-irradiated":[171],"palladium-catalyzed":[173],"reactions.":[174],"Particular":[175],"modifications":[176],"region":[180],"resulted":[184],"40-fold":[187],"increase":[188],"anti-viral":[191],"activity":[192],"cells.":[196],"Furthermore,":[197],"fast,":[199],"efficient,":[200],"general":[202],"one-pot":[203],"microwave":[204],"enhanced":[205],"protocol":[207],"transformations":[209],"organo-bromides":[211],"tetrazoles":[213],"was":[214,234],"applied":[217],"inhibitor":[220,233],"scaffold.":[221],"Attachment":[222],"linker":[224],"molecules":[225],"used":[235],"develop":[237],"sensitivity":[239],"enhancer":[240],"tools":[241],"surface":[243],"plasmon":[244],"resonance":[245],"biosensor":[246],"These":[248],"new":[249],"assays":[250],"enable":[251],"low-molecular":[255],"weight":[256],"compounds":[257]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}