{"id":"https://openalex.org/W2146397488","doi":"https://doi.org/10.1136/adc.2009.176768","title":"Question 2 Which medications effectively reduce pubertal gynaecomastia?","display_name":"Question 2 Which medications effectively reduce pubertal gynaecomastia?","publication_year":2010,"publication_date":"2010-03-01","ids":{"openalex":"https://openalex.org/W2146397488","doi":"https://doi.org/10.1136/adc.2009.176768","mag":"2146397488","pmid":"https://pubmed.ncbi.nlm.nih.gov/20308342"},"language":"en","primary_location":{"id":"doi:10.1136/adc.2009.176768","doi":"https://doi.org/10.1136/adc.2009.176768","is_oa":false,"landing_page_url":"https://doi.org/10.1136/adc.2009.176768","pdf_url":null,"source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081351913","display_name":"Stephen L Maidment","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800290887","display_name":"Peterborough City Hospital","ror":"https://ror.org/02q69x434","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800290887","https://openalex.org/I4210158470"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"S. L Maidment","raw_affiliation_strings":["Paediatrics, Peterborough District Hospital, UK. smaidment@doctors.org.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Paediatrics, Peterborough District Hospital, UK. smaidment@doctors.org.uk","institution_ids":["https://openalex.org/I2800290887"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081351913"],"corresponding_institution_ids":["https://openalex.org/I2800290887"],"apc_list":null,"apc_paid":null,"fwci":0.8119,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.74904436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"95","issue":"3","first_page":"237","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13097","display_name":"Male Breast Health Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13097","display_name":"Male Breast Health Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anastrozole","display_name":"anastrozole","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tamoxifen","display_name":"tamoxifen","score":1.0},{"id":"https://openalex.org/keywords/antiestrogens","display_name":"antiestrogens","score":0.8399999737739563},{"id":"https://openalex.org/keywords/aromatase-inhibitors","display_name":"aromatase inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/puberty","display_name":"puberty","score":0.6200000047683716},{"id":"https://openalex.org/keywords/treatment-efficacy","display_name":"treatment efficacy","score":0.43299999833106995}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9718701839447021},{"id":"https://openalex.org/C2777691561","wikidata":"https://www.wikidata.org/wiki/Q339221","display_name":"Gynecomastia","level":2,"score":0.6063928604125977},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.42465782165527344},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4181234836578369},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.34494471549987793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2032935619354248},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077384","descriptor_name":"Anastrozole","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004965","descriptor_name":"Estrogen Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006177","descriptor_name":"Gynecomastia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009570","descriptor_name":"Nitriles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011627","descriptor_name":"Puberty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013629","descriptor_name":"Tamoxifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014230","descriptor_name":"Triazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1136/adc.2009.176768","doi":"https://doi.org/10.1136/adc.2009.176768","is_oa":false,"landing_page_url":"https://doi.org/10.1136/adc.2009.176768","pdf_url":null,"source":{"id":"https://openalex.org/S207294652","display_name":"Archives of Disease in Childhood","issn_l":"0003-9888","issn":["0003-9888","1468-2044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Disease in Childhood","raw_type":"journal-article"},{"id":"pmid:20308342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20308342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of disease in childhood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1982106451","https://openalex.org/W1999272049","https://openalex.org/W2023008880","https://openalex.org/W2024362401","https://openalex.org/W2031876175","https://openalex.org/W2117785194","https://openalex.org/W2279061913","https://openalex.org/W2335679897"],"related_works":["https://openalex.org/W2024362401","https://openalex.org/W2023008880","https://openalex.org/W2202747862","https://openalex.org/W2335679897","https://openalex.org/W2279061913","https://openalex.org/W4406016833","https://openalex.org/W2117785194","https://openalex.org/W1980858876","https://openalex.org/W2998066751","https://openalex.org/W2015371121"],"abstract_inverted_index":{"Tom":[0,88,123],"is":[1,15,89,162,176],"a":[2,8,75,153],"12-year-old":[3],"boy":[4],"who":[5],"presents":[6],"with":[7,158],"6-month":[9],"history":[10],"of":[11,21,49,127,134,144,180],"breast":[12,56,171],"enlargement.":[13],"He":[14,38,58,73],"extremely":[16],"embarrassed":[17],"about":[18],"the":[19,47,70,85,142,204],"size":[20,48,143],"his":[22,50,63,79,145],"breasts":[23],"and":[24,62,65,78,108,174],"avoids":[25],"sport":[26],"because":[27],"he":[28],"does":[29],"not":[30],"want":[31],"to":[32,45,97,117,141],"be":[33,43,98,115,152],"seen":[34],"while":[35],"getting":[36],"changed.":[37],"wonders":[39],"if":[40],"anything":[41],"can":[42,114],"done":[44],"reduce":[46,194],"breasts.\n\nTom":[51],"has":[52,59,74,137],"Tanner":[53],"stage":[54],"III":[55],"development.":[57],"entered":[60],"puberty":[61],"height":[64],"weight":[66],"are":[67,82,183],"both":[68],"on":[69,124],"99th":[71],"centile.":[72],"male":[76],"karyotype":[77],"hormone":[80],"levels":[81],"all":[83],"within":[84],"normal":[86],"range.\n\nAs":[87],"so":[90],"distressed,":[91],"you":[92],"decide":[93],"that":[94,103],"something":[95],"needs":[96],"done.":[99],"You":[100,121,147],"have":[101],"heard":[102],"anti-oestrogens,":[104],"such":[105,111],"as":[106,112],"tamoxifen,":[107],"aromatase":[109],"inhibitors,":[110],"anastrozole,":[113],"used":[116],"treat":[118],"pubertal":[119,159,195],"gynaecomastia.":[120],"start":[122],"10":[125],"mg":[126],"tamoxifen":[128,166],"daily,":[129],"but":[130],"after":[131],"6":[132],"months":[133],"treatment":[135],"this":[136,188],"made":[138],"little":[139],"difference":[140],"breasts.":[146],"wonder":[148],"whether":[149],"anastrozole":[150,163],"would":[151],"more":[154,177],"effective":[155,168,178],"therapy.\n\nIn":[156],"boys":[157],"gynaecomastia":[160],"[patient],":[161],"[treatment]":[164,167],"or":[165],"in":[169,185],"reducing":[170],"tissue":[172],"[outcome]":[173],"which":[175],"[comparison]?\n\nDetails":[179],"relevant":[181],"papers":[182],"summarised":[184],"table":[186],"2.\n\nView":[187],"table:\n\nTable":[189],"2":[190],"\nWhich":[191],"medications":[192],"effectively":[193],"gynaecomastia?\n\n\n\n###":[196],"Primary":[197],"sources\n\nThe":[198],"primary":[199],"source":[200],"was":[201],"PubMed,":[202],"using":[203],"search":[205],"\u2026":[206]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}