{"id":"https://openalex.org/W2146362299","doi":null,"title":"Viscoelastic haemostatic assays and fibrinogen concentration tests during haemodilution: The effects of fibrinogen and factor XIII","display_name":"Viscoelastic haemostatic assays and fibrinogen concentration tests during haemodilution: The effects of fibrinogen and factor XIII","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2146362299","mag":"2146362299"},"language":"en","primary_location":{"id":"pmh:oai:lup.lub.lu.se:db66db0d-21f5-4867-aaa9-3cd967c746ca","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/4813146","pdf_url":"https://lup.lub.lu.se/record/4813146","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://lup.lub.lu.se/record/4813146","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043768244","display_name":"Dag Winstedt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Winstedt, Dag","raw_affiliation_strings":["Anesthesiology and Intensive Care"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology and Intensive Care","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5043768244"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11116","display_name":"Trauma, Hemostasis, Coagulopathy, Resuscitation","score":0.7157999873161316,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.257099986076355,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.0203000009059906,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hemodilution","display_name":"hemodilution","score":0.9200000166893005},{"id":"https://openalex.org/keywords/fibrinogen","display_name":"fibrinogen","score":0.8510000109672546},{"id":"https://openalex.org/keywords/factor-xiii","display_name":"factor XIII","score":0.9950000047683716},{"id":"https://openalex.org/keywords/fibrinogen-concentrate","display_name":"fibrinogen concentrate","score":0.6579999923706055},{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.6840000152587891},{"id":"https://openalex.org/keywords/rotational-thromboelastometry","display_name":"rotational thromboelastometry","score":0.7910000085830688},{"id":"https://openalex.org/keywords/clauss-fibrinogen-assay","display_name":"Clauss fibrinogen assay","score":0.8270000219345093},{"id":"https://openalex.org/keywords/hydroxyethyl-starch","display_name":"hydroxyethyl starch","score":0.8339999914169312},{"id":"https://openalex.org/keywords/dextran","display_name":"dextran","score":0.9200000166893005},{"id":"https://openalex.org/keywords/human-serum-albumin","display_name":"human serum albumin","score":0.843999981880188},{"id":"https://openalex.org/keywords/crystalloids","display_name":"crystalloids","score":0.6179999709129333},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.6240000128746033},{"id":"https://openalex.org/keywords/cardiac-surgery","display_name":"cardiac surgery","score":0.7200000286102295},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.8840000033378601},{"id":"https://openalex.org/keywords/clot-strength","display_name":"clot strength","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C26809991","wikidata":"https://www.wikidata.org/wiki/Q1678517","display_name":"Thromboelastometry","level":3,"score":0.9223238229751587},{"id":"https://openalex.org/C2779036427","wikidata":"https://www.wikidata.org/wiki/Q381899","display_name":"Fibrinogen","level":2,"score":0.9154188632965088},{"id":"https://openalex.org/C2779412105","wikidata":"https://www.wikidata.org/wiki/Q415775","display_name":"Hydroxyethyl starch","level":2,"score":0.8031628131866455},{"id":"https://openalex.org/C2910686401","wikidata":"https://www.wikidata.org/wiki/Q4463725","display_name":"Thrombelastography","level":3,"score":0.7102636098861694},{"id":"https://openalex.org/C2777664302","wikidata":"https://www.wikidata.org/wiki/Q4463725","display_name":"Thromboelastography","level":3,"score":0.6863706707954407},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.654206395149231},{"id":"https://openalex.org/C2779672106","wikidata":"https://www.wikidata.org/wiki/Q423712","display_name":"Factor XIII","level":3,"score":0.5897078514099121},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5661834478378296},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4971502125263214},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.4175725281238556},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2687395513057709},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25745081901550293}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:lup.lub.lu.se:db66db0d-21f5-4867-aaa9-3cd967c746ca","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/4813146","pdf_url":"https://lup.lub.lu.se/record/4813146","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"}],"best_oa_location":{"id":"pmh:oai:lup.lub.lu.se:db66db0d-21f5-4867-aaa9-3cd967c746ca","doi":null,"is_oa":true,"landing_page_url":"https://lup.lub.lu.se/record/4813146","pdf_url":"https://lup.lub.lu.se/record/4813146","source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1652-8220","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2146362299.pdf","grobid_xml":"https://content.openalex.org/works/W2146362299.grobid-xml"},"referenced_works_count":190,"referenced_works":["https://openalex.org/W77958472","https://openalex.org/W294546078","https://openalex.org/W1482813609","https://openalex.org/W1484119264","https://openalex.org/W1505442646","https://openalex.org/W1522316610","https://openalex.org/W1551426461","https://openalex.org/W1570398861","https://openalex.org/W1573687947","https://openalex.org/W1598742325","https://openalex.org/W1642214441","https://openalex.org/W1757052311","https://openalex.org/W1835416951","https://openalex.org/W1835760130","https://openalex.org/W1862124182","https://openalex.org/W1872336636","https://openalex.org/W1873771693","https://openalex.org/W1891869308","https://openalex.org/W1907544254","https://openalex.org/W1959659843","https://openalex.org/W1966383370","https://openalex.org/W1967391155","https://openalex.org/W1967433109","https://openalex.org/W1969720423","https://openalex.org/W1970976986","https://openalex.org/W1971800005","https://openalex.org/W1974157302","https://openalex.org/W1974693697","https://openalex.org/W1975630534","https://openalex.org/W1976408668","https://openalex.org/W1977564719","https://openalex.org/W1978039741","https://openalex.org/W1983760732","https://openalex.org/W1984117630","https://openalex.org/W1985622962","https://openalex.org/W1988094450","https://openalex.org/W1989317042","https://openalex.org/W1989528047","https://openalex.org/W1992034786","https://openalex.org/W1993947427","https://openalex.org/W1995576073","https://openalex.org/W1995955953","https://openalex.org/W1997145995","https://openalex.org/W1997234893","https://openalex.org/W1999666547","https://openalex.org/W2000140744","https://openalex.org/W2000869723","https://openalex.org/W2000942655","https://openalex.org/W2001571740","https://openalex.org/W2002971616","https://openalex.org/W2005292580","https://openalex.org/W2011356417","https://openalex.org/W2012863747","https://openalex.org/W2013856778","https://openalex.org/W2018688990","https://openalex.org/W2019202692","https://openalex.org/W2019560744","https://openalex.org/W2020450390","https://openalex.org/W2025778465","https://openalex.org/W2025896600","https://openalex.org/W2026966694","https://openalex.org/W2027895493","https://openalex.org/W2028417314","https://openalex.org/W2030577502","https://openalex.org/W2031831303","https://openalex.org/W2032300812","https://openalex.org/W2033169931","https://openalex.org/W2033421420","https://openalex.org/W2035950674","https://openalex.org/W2035956989","https://openalex.org/W2037413510","https://openalex.org/W2037685794","https://openalex.org/W2040423276","https://openalex.org/W2042851569","https://openalex.org/W2042893845","https://openalex.org/W2047835029","https://openalex.org/W2048020487","https://openalex.org/W2048933053","https://openalex.org/W2050544261","https://openalex.org/W2053986303","https://openalex.org/W2055354058","https://openalex.org/W2057283407","https://openalex.org/W2057902900","https://openalex.org/W2058563954","https://openalex.org/W2059103024","https://openalex.org/W2060879244","https://openalex.org/W2061665783","https://openalex.org/W2061786051","https://openalex.org/W2061817066","https://openalex.org/W2064521505","https://openalex.org/W2066545175","https://openalex.org/W2067456929","https://openalex.org/W2070316667","https://openalex.org/W2071984687","https://openalex.org/W2072112773","https://openalex.org/W2072634400","https://openalex.org/W2073188716","https://openalex.org/W2074678811","https://openalex.org/W2079715879","https://openalex.org/W2080347790","https://openalex.org/W2081532052","https://openalex.org/W2084280207","https://openalex.org/W2085277127","https://openalex.org/W2085317365","https://openalex.org/W2085678187","https://openalex.org/W2086081842","https://openalex.org/W2087077586","https://openalex.org/W2087591091","https://openalex.org/W2088106697","https://openalex.org/W2088970589","https://openalex.org/W2090488720","https://openalex.org/W2091470148","https://openalex.org/W2091685079","https://openalex.org/W2092918979","https://openalex.org/W2093351031","https://openalex.org/W2094588855","https://openalex.org/W2095270829","https://openalex.org/W2096615409","https://openalex.org/W2098948149","https://openalex.org/W2101567488","https://openalex.org/W2103935614","https://openalex.org/W2105947477","https://openalex.org/W2106323705","https://openalex.org/W2108048196","https://openalex.org/W2108261788","https://openalex.org/W2109027708","https://openalex.org/W2111374185","https://openalex.org/W2112577081","https://openalex.org/W2113298224","https://openalex.org/W2114180453","https://openalex.org/W2115301416","https://openalex.org/W2115587613","https://openalex.org/W2116850529","https://openalex.org/W2117801227","https://openalex.org/W2117953661","https://openalex.org/W2119820222","https://openalex.org/W2121864664","https://openalex.org/W2123061949","https://openalex.org/W2125877520","https://openalex.org/W2126420535","https://openalex.org/W2127414127","https://openalex.org/W2127445047","https://openalex.org/W2127912237","https://openalex.org/W2127988410","https://openalex.org/W2128009068","https://openalex.org/W2128082929","https://openalex.org/W2128128223","https://openalex.org/W2128879892","https://openalex.org/W2133274714","https://openalex.org/W2134104280","https://openalex.org/W2134816037","https://openalex.org/W2134913308","https://openalex.org/W2134921235","https://openalex.org/W2135860345","https://openalex.org/W2135878370","https://openalex.org/W2136243936","https://openalex.org/W2136753338","https://openalex.org/W2138199266","https://openalex.org/W2138702609","https://openalex.org/W2140068452","https://openalex.org/W2143432233","https://openalex.org/W2146106384","https://openalex.org/W2148706741","https://openalex.org/W2150017313","https://openalex.org/W2150762619","https://openalex.org/W2151601292","https://openalex.org/W2152723000","https://openalex.org/W2154400398","https://openalex.org/W2154587132","https://openalex.org/W2156287593","https://openalex.org/W2156773861","https://openalex.org/W2158818146","https://openalex.org/W2159483735","https://openalex.org/W2160950641","https://openalex.org/W2162062485","https://openalex.org/W2162573377","https://openalex.org/W2163497519","https://openalex.org/W2164738897","https://openalex.org/W2165111558","https://openalex.org/W2166423559","https://openalex.org/W2169416224","https://openalex.org/W2171732914","https://openalex.org/W2174057956","https://openalex.org/W2213866923","https://openalex.org/W2230985493","https://openalex.org/W2414825422","https://openalex.org/W2415542966","https://openalex.org/W2415658791","https://openalex.org/W2417501014","https://openalex.org/W4317929363"],"related_works":["https://openalex.org/W1843883841","https://openalex.org/W2140068452","https://openalex.org/W2108261788","https://openalex.org/W294546078","https://openalex.org/W2049170872","https://openalex.org/W2395427806","https://openalex.org/W7162875074","https://openalex.org/W1981004445","https://openalex.org/W2585256530","https://openalex.org/W2052055236"],"abstract_inverted_index":{"Background:":[0],"The":[1],"efficacy":[2],"of":[3,5,90,138,187,194,197,293,341,355],"concentrates":[4],"fibrinogen":[6,45,91,93,119,139,201,328,342,362],"and":[7,12,43,148,167,180,207,218,257,296],"factor":[8],"XIII":[9,126],"in":[10,41,48,313,359],"hypothermia":[11],"haemodilution":[13,101,116,149,271,297,316],"has":[14],"not":[15,23,153,318],"yet":[16],"been":[17,25],"completely":[18],"investigated.":[19],"Clauss":[20,205,236,310,330,361],"methods":[21,47,206,237,311,331,363],"have":[22],"previously":[24],"evaluated":[26],"perioperatively.":[27],"Methods:":[28],"Coagulation":[29],"was":[30,243,248,262],"assessed":[31],"with":[32,53,78,102,113,117,150,162,171,203,272,279,298,346],"rotational":[33],"thromboelastometry":[34],"(ROTEM)":[35],"or":[36,73,84,111,175,190,280],"free":[37],"oscillation":[38],"rheometry":[39],"(FOR)":[40],"vitro":[42],"different":[44,235],"measurement":[46],"observational":[49],"studies.":[50],"Results:":[51],"Haemodilution":[52],"human":[54],"albumin":[55],"(HA)":[56],"impaired":[57],"clot":[58,63,95,141,159,168,222,323],"strength":[59,96,160,223,324],"(EXTEM":[60],"MCF,":[61],"maximal":[62],"formation)":[64],"less":[65,109,281],"than":[66,104,110,274,282,327],"the":[67,213,339,353],"synthetic":[68,105,275],"colloids":[69,106],"hydroxyethyl":[70],"starch":[71],"(HES)":[72],"dextran":[74],"(p<0.001),":[75,107,166],"but":[76,108,132,152,245,277,351],"equal":[77,112,278],"crystalloid":[79,284],"fluids":[80],"(normal":[81],"saline,":[82],"NA,":[83],"Ringer\u2019s":[85],"acetated":[86],"solution,":[87],"RA).":[88],"Addition":[89],"improved":[92,120,184,267,305],"dependent":[94],"(FIBTEM":[97],"MCF)":[98,226],"better":[99,269],"after":[100,270,283,312,344],"HA":[103,273],"crystalloids.":[114],"In":[115],"HA,":[118,347],"ROTEM":[121,176],"parameters":[122],"dose-dependently":[123],"(p<0.001).":[124],"Factor":[125],"(FXIII)":[127],"had":[128,287],"no":[129],"effect":[130,135,290],"alone,":[131],"an":[133,288],"additional":[134,289],"to":[136,156,199,212,291,301,365],"that":[137,292],"on":[140],"strength,":[142],"FIBTEM-MCF":[143],"(p<0.02).":[144],"Hypothermia":[145,295],"at":[146,308,349],"33\u00b0C":[147],"HES,":[151,358],"RA,":[154],"interacted":[155,300],"impair":[157,302],"fibrinogen-dependent":[158,221,322],"measured":[161,170,202],"FOR":[163,172],"Fibscreen2":[164],"G\u2032max":[165],"velocity":[169],"Fibscreen1":[173],"COT2":[174],"EXTEM":[177],"CFT":[178],"(p=0.035":[179],"p<0.001).":[181],"Fibrinogen":[182,265],"(+/-FXIII)":[183],"coagulation":[185,268,306],"independently":[186],"temperature":[188],"(33\u00b0":[189],"37\u00b0C).":[191],"After":[192],"infusion":[193],"1000":[195],"ml":[196],"HES":[198,299,315],"patients,":[200],"two":[204],"one":[208],"immunological":[209],"method":[210],"decreased":[211,227,325],"same":[214],"extent":[215],"(29,":[216],"27,":[217],"31%),":[219],"whereas":[220],"(ROTEM":[224],"FIBTEM":[225],"more":[228,326],"(44%,":[229],"p>0.001).":[230],"Finally,":[231],"when":[232],"comparing":[233],"seven":[234],"during":[238],"cardiac":[239],"surgery,":[240],"within-method":[241],"variability":[242,247],"low,":[244],"between-method":[246],"high":[249],"(mean":[250],"difference":[251],">0.5":[252],"g/l).No":[253],"differences":[254],"between":[255,334],"pre-":[256],"post-weaning":[258],"from":[259],"cardiopulmonary":[260],"by-pass":[261],"seen.":[263],"Conclusion:":[264],"concentrate":[266,343],"colloids,":[276,356],"haemodilution.":[285],"FXIII":[286],"fibrinogen.":[294],"coagulation.":[303],"Fibrinogen+/-FXIII":[304],"also":[307,348],"33\u00b0C.":[309],"vivo":[314],"did":[317],"overestimate":[319],"fibrinogen;":[320],"however,":[321],"concentration.":[329],"varied":[332],"considerably":[333],"methods.":[335],"These":[336],"findings":[337],"support":[338],"use":[340,354],"resuscitation":[345],"hypothermia,":[350],"question":[352],"especially":[357],"resuscitation.":[360],"need":[364],"improve.":[366]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
