{"id":"https://openalex.org/W2146333376","doi":"https://doi.org/10.1210/en.2003-0323","title":"Glucagon-Like Peptide 1 Inhibits Cell Apoptosis and Improves Glucose Responsiveness of Freshly Isolated Human Islets","display_name":"Glucagon-Like Peptide 1 Inhibits Cell Apoptosis and Improves Glucose Responsiveness of Freshly Isolated Human Islets","publication_year":2003,"publication_date":"2003-09-02","ids":{"openalex":"https://openalex.org/W2146333376","doi":"https://doi.org/10.1210/en.2003-0323","mag":"2146333376","pmid":"https://pubmed.ncbi.nlm.nih.gov/12960095"},"language":"en","primary_location":{"id":"doi:10.1210/en.2003-0323","doi":"https://doi.org/10.1210/en.2003-0323","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2003-0323","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002815019","display_name":"Loredana Farilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loredana Farilla","raw_affiliation_strings":["Division of Endocrinology and Diabetes and Metabolism, Cedars-Sinai Medical Center, 8723 Alden Drive, SSB #290, Los Angeles, California 90048, USA. perfettir@cshs.org","Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048","University of California Los Angeles (L.F., C.B., R.P.), Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Diabetes and Metabolism, Cedars-Sinai Medical Center, 8723 Alden Drive, SSB #290, Los Angeles, California 90048, USA. perfettir@cshs.org","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"University of California Los Angeles (L.F., C.B., R.P.), Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018642610","display_name":"Angela Bulotta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Bulotta","raw_affiliation_strings":["Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072950568","display_name":"Boaz Hirshberg","orcid":"https://orcid.org/0000-0003-2829-3602","observed_orcids":["https://orcid.org/0000-0003-2829-3602"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boaz Hirshberg","raw_affiliation_strings":["National Institutes of Health (B.H., D.M.H.), Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health (B.H., D.M.H.), Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045419036","display_name":"Sergio Li Calzi","orcid":"https://orcid.org/0000-0001-8963-1519","observed_orcids":["https://orcid.org/0000-0001-8963-1519"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergio Li Calzi","raw_affiliation_strings":["Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081560169","display_name":"Nasif Khoury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nasif Khoury","raw_affiliation_strings":["Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078471371","display_name":"Houtan Noushmehr","orcid":"https://orcid.org/0000-0003-4051-8114","observed_orcids":["https://orcid.org/0000-0003-4051-8114"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Houtan Noushmehr","raw_affiliation_strings":["Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048","institution_ids":["https://openalex.org/I1282927834"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cristina Bertolotto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cristina Bertolotto","raw_affiliation_strings":["Division of Neonatology (C.B.), Cedars-Sinai Medical Center, Los Angeles, California","University of California Los Angeles (L.F., C.B., R.P.), Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neonatology (C.B.), Cedars-Sinai Medical Center, Los Angeles, California","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"University of California Los Angeles (L.F., C.B., R.P.), Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056539409","display_name":"Umberto Di Mario","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Umberto Di Mario","raw_affiliation_strings":["Department of Clinical Sciences (U.D.M.), University \u201cLa Sapienza,\u201d Rome 00161, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Sciences (U.D.M.), University \u201cLa Sapienza,\u201d Rome 00161, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055271857","display_name":"David M. Harlan","orcid":"https://orcid.org/0000-0002-6938-8109","observed_orcids":["https://orcid.org/0000-0002-6938-8109"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Harlan","raw_affiliation_strings":["National Institutes of Health (B.H., D.M.H.), Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health (B.H., D.M.H.), Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008946836","display_name":"Riccardo Perfetti","orcid":"https://orcid.org/0000-0002-0545-8964","observed_orcids":["https://orcid.org/0000-0002-0545-8964"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Riccardo Perfetti","raw_affiliation_strings":["Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048","University of California Los Angeles (L.F., C.B., R.P.), Los Angeles, California 90095"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology (L.F., A.B., S.L.C., N.K., H.N., R.P.), Cedars-Sinai Medical Center, Los Angeles, California 90048","institution_ids":["https://openalex.org/I1282927834"]},{"raw_affiliation_string":"University of California Los Angeles (L.F., C.B., R.P.), Los Angeles, California 90095","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5008946836"],"corresponding_institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I161318765"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":11.7733,"has_fulltext":false,"cited_by_count":671,"citation_normalized_percentile":{"value":0.99091758,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"144","issue":"12","first_page":"5149","last_page":"5158"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glucagon-like-peptide-1","display_name":"glucagon-like peptide-1","score":1.0},{"id":"https://openalex.org/keywords/beta-cell-apoptosis","display_name":"beta-cell apoptosis","score":0.8500000238418579},{"id":"https://openalex.org/keywords/human-pancreatic-islets","display_name":"human pancreatic islets","score":0.8740000128746033},{"id":"https://openalex.org/keywords/glucose-dependent-insulin-secretion","display_name":"glucose-dependent insulin secretion","score":0.8130000233650208},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9599999785423279},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.9800000190734863},{"id":"https://openalex.org/keywords/islet-viability","display_name":"islet viability","score":0.6330000162124634},{"id":"https://openalex.org/keywords/islet-morphology","display_name":"islet morphology","score":0.6179999709129333},{"id":"https://openalex.org/keywords/insulin-content","display_name":"insulin content","score":0.7149999737739563},{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.4399999976158142},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.3140000104904175}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8290190696716309},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.8269585371017456},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8098663091659546},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7638388872146606},{"id":"https://openalex.org/C2776398474","wikidata":"https://www.wikidata.org/wiki/Q424611","display_name":"Glucagon-like peptide-1","level":4,"score":0.6911613345146179},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6802879571914673},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5896081328392029},{"id":"https://openalex.org/C2778563252","wikidata":"https://www.wikidata.org/wiki/Q170617","display_name":"Glucagon","level":3,"score":0.5636721253395081},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5405797362327576},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.47235071659088135},{"id":"https://openalex.org/C2776828364","wikidata":"https://www.wikidata.org/wiki/Q1767180","display_name":"Beta cell","level":4,"score":0.46270301938056946},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.28257688879966736},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.23338288068771362},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21201860904693604},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.15999311208724976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15371569991111755},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10851225256919861}],"mesh":[{"descriptor_ui":"D000078790","descriptor_name":"Insulin Secretion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005934","descriptor_name":"Glucagon","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007515","descriptor_name":"Islets of Langerhans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1210/en.2003-0323","doi":"https://doi.org/10.1210/en.2003-0323","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.2003-0323","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:12960095","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12960095","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.320.3558","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.320.3558","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://endo.endojournals.org/content/144/12/5149.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.910.458","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.910.458","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://dojindo.cn/uploads/UploadFile/Glucagon-Like%20Peptide%201%20Inhibits%20Cell%20Apoptosis%20and.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1994754052","https://openalex.org/W2019099090","https://openalex.org/W2021338058","https://openalex.org/W2025162869","https://openalex.org/W2026348270","https://openalex.org/W2036386129","https://openalex.org/W2063291578","https://openalex.org/W2063693981","https://openalex.org/W2069288695","https://openalex.org/W2082604269","https://openalex.org/W2095130937","https://openalex.org/W2103961634","https://openalex.org/W2106709311","https://openalex.org/W2107076497","https://openalex.org/W2109069837","https://openalex.org/W2111947641","https://openalex.org/W2112773576","https://openalex.org/W2113520782","https://openalex.org/W2118889627","https://openalex.org/W2127409471","https://openalex.org/W2128095876","https://openalex.org/W2141160128","https://openalex.org/W2143847100","https://openalex.org/W2144803025","https://openalex.org/W2147679298","https://openalex.org/W2149502431","https://openalex.org/W2152039827","https://openalex.org/W2153361294","https://openalex.org/W2156959752","https://openalex.org/W2160757033","https://openalex.org/W2169760435","https://openalex.org/W2169938583","https://openalex.org/W2328786770","https://openalex.org/W2394846572"],"related_works":["https://openalex.org/W7099938821","https://openalex.org/W2351095822","https://openalex.org/W2026348270","https://openalex.org/W2045326048","https://openalex.org/W2063693981","https://openalex.org/W2134022031","https://openalex.org/W4394936508","https://openalex.org/W1969752909","https://openalex.org/W7096592251","https://openalex.org/W2066487478"],"abstract_inverted_index":{"The":[0,32,117,157,181],"peptide":[1,4],"hormone,":[2],"glucagon-like":[3],"1":[5],"(GLP-1),":[6],"has":[7],"been":[8],"shown":[9],"to":[10,39,250],"increase":[11],"glucose-dependent":[12,90,228],"insulin":[13,16,91,202,229],"secretion,":[14],"enhance":[15],"gene":[17],"transcription,":[18],"expand":[19],"islet":[20,97],"cell":[21,111,261],"mass,":[22],"and":[23,46,74,78,83,147,173,191,198,220,257,259],"inhibit":[24,47],"beta-cell":[25],"apoptosis":[26,48],"in":[27,49,61,99,119,125,137,142,207],"animal":[28],"models":[29],"of":[30,34,66,80,110,122,160,167,176,183,189,227],"diabetes.":[31],"aim":[33],"the":[35,62,100,120,165,174,186,196],"present":[36],"study":[37],"was":[38,113,128,162,193,204,222],"evaluate":[40],"whether":[41],"GLP-1":[42,67,161,184,211,248],"could":[43],"improve":[44],"function":[45,258],"freshly":[50,251],"isolated":[51,252],"human":[52,253],"islets.":[53],"Human":[54],"islets":[55,127,208,254],"were":[56],"cultured":[57,209],"for":[58,76],"5":[59,150],"d":[60,132,149,218,235,241],"presence,":[63],"or":[64],"absence,":[65],"(10":[68],"nm,":[69],"added":[70,249],"every":[71],"12":[72],"h)":[73],"studied":[75],"viability":[77],"expression":[79],"proapoptotic":[81],"(caspase-3)":[82],"antiapoptotic":[84,158],"factors":[85],"(bcl-2)":[86],"as":[87,89],"well":[88],"production.":[92],"We":[93],"observed":[94,194],"better-preserved":[95],"three-dimensional":[96],"morphology":[98,256],"GLP-1-treated":[101,126],"islets,":[102],"compared":[103],"with":[104,164,210],"controls.":[105],"Nuclear":[106],"condensation,":[107],"a":[108,223],"feature":[109],"apoptosis,":[112],"inhibited":[114],"by":[115],"GLP-1.":[116],"reduction":[118],"number":[121],"apoptotic":[123,135],"cells":[124],"particularly":[129],"evident":[130],"at":[131,148,195,217,234,240],"3":[133],"(6.1%":[134],"nuclei":[136],"treated":[138],"cultures":[139],"vs.":[140,152,212],"15.5%":[141],"controls;":[143],"P":[144,154,237],"<":[145,155,171,179,215,232,238],"0.01)":[146],"(8.9":[151],"18.9%;":[153],"0.01).":[156,180],"effect":[159,182],"associated":[163],"down-regulation":[166],"active":[168],"caspase-3":[169,192],"(P":[170,178,214,231],"0.001)":[172],"up-regulation":[175],"bcl-2":[177,190],"on":[185],"intracellular":[187],"levels":[188],"mRNA":[197],"protein":[199],"levels.":[200],"Intracellular":[201],"content":[203],"markedly":[205],"enhanced":[206],"control":[213],"0.001,":[216],"5),":[219],"there":[221],"parallel":[224],"GLP-1-dependent":[225],"potentiation":[226],"secretion":[230],"0.01":[233],"3;":[236],"0.05":[239],"5).":[242],"Our":[243],"findings":[244],"provide":[245],"evidence":[246],"that":[247],"preserves":[255],"inhibits":[260],"apoptosis.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":26},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":32},{"year":2015,"cited_by_count":28},{"year":2014,"cited_by_count":36},{"year":2013,"cited_by_count":49},{"year":2012,"cited_by_count":40}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}