{"id":"https://openalex.org/W214633216","doi":null,"title":"UFT plus calcium folinate vs 5-FU plus calcium folinate in colon cancer.","display_name":"UFT plus calcium folinate vs 5-FU plus calcium folinate in colon cancer.","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W214633216","mag":"214633216","pmid":"https://pubmed.ncbi.nlm.nih.gov/10442360"},"language":"en","primary_location":{"id":"pmid:10442360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10442360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101590686","display_name":"Rebecca L. Smith","orcid":"https://orcid.org/0000-0002-8033-0848","observed_orcids":["https://orcid.org/0000-0002-8033-0848"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Smith","raw_affiliation_strings":["National Surgical Adjuvant Breast and Bowel Project Operations Center, Allegheny University of Health Sciences, Pittsburgh, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Surgical Adjuvant Breast and Bowel Project Operations Center, Allegheny University of Health Sciences, Pittsburgh, Pennsylvania, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073338995","display_name":"Donald Lawrence Wickerham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D L Wickerham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081334147","display_name":"Harry S. Wieand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H S Wieand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047355804","display_name":"Linda H. Colangelo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Colangelo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113641337","display_name":"E.P. Mamounas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E P Mamounas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8683,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.72068653,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"13","issue":"7 Suppl 3","first_page":"44","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9682999849319458,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.030300000682473183,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9010000228881836},{"id":"https://openalex.org/keywords/adjuvant-chemotherapy","display_name":"adjuvant chemotherapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/uft","display_name":"UFT","score":0.8410000205039978},{"id":"https://openalex.org/keywords/tegafur-uracil","display_name":"tegafur-uracil","score":0.9580000042915344},{"id":"https://openalex.org/keywords/leucovorin","display_name":"leucovorin","score":0.9300000071525574},{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9900000095367432},{"id":"https://openalex.org/keywords/levamisole","display_name":"levamisole","score":0.9860000014305115},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.8880000114440918},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9940000176429749},{"id":"https://openalex.org/keywords/toxicity-profile","display_name":"toxicity profile","score":0.5960000157356262}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7202062606811523},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.6685521602630615},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.6427620649337769},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.631906270980835},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5873693227767944},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5599939227104187},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5079846978187561},{"id":"https://openalex.org/C2780456651","wikidata":"https://www.wikidata.org/wiki/Q238512","display_name":"Fluorouracil","level":3,"score":0.46871891617774963},{"id":"https://openalex.org/C2777299880","wikidata":"https://www.wikidata.org/wiki/Q413370","display_name":"Tegafur","level":3,"score":0.44945186376571655},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.43220147490501404},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.383791983127594},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3821970820426941}],"mesh":[{"descriptor_ui":"D000964","descriptor_name":"Antimetabolites, Antineoplastic","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002955","descriptor_name":"Leucovorin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005472","descriptor_name":"Fluorouracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005641","descriptor_name":"Tegafur","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014498","descriptor_name":"Uracil","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10442360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10442360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncology (Williston Park, N.Y.)","raw_type":"Clinical Trial"},{"id":"mag:214633216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10442360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W172055697","https://openalex.org/W1515227788","https://openalex.org/W2047516847","https://openalex.org/W2416435070"],"related_works":["https://openalex.org/W104046904","https://openalex.org/W2474393237","https://openalex.org/W1975257373","https://openalex.org/W3159747767","https://openalex.org/W2422265363","https://openalex.org/W2168600267","https://openalex.org/W2398581533","https://openalex.org/W1999326227","https://openalex.org/W2017000486","https://openalex.org/W2394638627"],"abstract_inverted_index":{"Adjuvant":[0,97],"chemotherapy":[1],"has":[2],"been":[3,27],"shown":[4],"to":[5,29],"alter":[6],"the":[7,88,109,144,155,165,170],"natural":[8],"history":[9],"of":[10,41,91,108,112,123,194],"resected":[11],"colon":[12,92,195],"cancer.":[13,93,196],"Two":[14],"regimens":[15,44,133],"(5-fluorouracil":[16],"[5-FU]":[17],"plus":[18,23,48,68,117,149,180],"calcium":[19,49,70,119,151,182],"folinate":[20,50,71,114,152,167,183],"and":[21,33,57,66,77,99,137,169],"5-FU":[22,47],"levamisole":[24],"[Ergamisol])":[25],"have":[26,138],"found":[28],"prolong":[30],"disease-free":[31,55,159],"survival":[32,35,56,59,146,160,163],"overall":[34,58,162],"in":[36,143],"affected":[37],"patients.":[38],"Previous":[39],"comparisons":[40],"these":[42],"two":[43],"indicate":[45],"that":[46,63,131,178],"may":[51],"offer":[52],"a":[53,84,105,188],"small":[54],"advantage.":[60],"The":[61,94],"demonstration":[62],"UFT":[64,116,148,179],"(uracil":[65],"tegafur)":[67],"oral":[69,118,150,181],"(Orzel)":[72],"offers":[73],"significant":[74],"antitumor":[75],"activity":[76],"an":[78],"acceptable":[79],"toxicity":[80,124,140,171],"profile":[81],"makes":[82],"this":[83],"logical":[85],"formulation":[86],"for":[87,191],"adjuvant":[89,192],"treatment":[90,153,168,193],"National":[95],"Surgical":[96],"Breast":[98],"Bowel":[100],"Project":[101],"Protocol":[102],"C-06":[103],"is":[104,176],"randomized":[106],"comparison":[107],"relative":[110],"efficacies":[111],"5-FU/calcium":[113,166],"vs":[115],"folinate.":[120],"Preliminary":[121],"analysis":[122],"findings":[125],"among":[126],"473":[127],"evaluable":[128],"patients":[129],"indicates":[130],"both":[132],"are":[134],"well":[135],"tolerated":[136],"similar":[139],"profiles.":[141],"If,":[142],"final":[145],"analysis,":[147],"yields":[154],"same":[156],"or":[157],"better":[158],"and/or":[161],"as":[164,187],"profiles":[172],"remain":[173],"similar,":[174],"it":[175],"likely":[177],"will":[184],"be":[185],"accepted":[186],"new":[189],"standard":[190]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
