{"id":"https://openalex.org/W214631232","doi":null,"title":"Polymorphisms in the stem cell pathway and esophageal cancer in a Chinese population","display_name":"Polymorphisms in the stem cell pathway and esophageal cancer in a Chinese population","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W214631232","mag":"214631232"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt4vw7s102","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4vw7s102","pdf_url":"https://escholarship.org/uc/item/4vw7s102","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/4vw7s102","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006083415","display_name":"Gina Wallar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Gina Wallar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5006083415"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.7639999985694885},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.6539999842643738},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.7409999966621399},{"id":"https://openalex.org/keywords/wnt2","display_name":"Wnt2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/garlic-consumption","display_name":"garlic consumption","score":0.8190000057220459},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.8349999785423279},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7200000286102295},{"id":"https://openalex.org/keywords/gene-environment-interaction","display_name":"gene-environment interaction","score":0.9020000100135803},{"id":"https://openalex.org/keywords/chinese-population","display_name":"Chinese population","score":0.8510000109672546},{"id":"https://openalex.org/keywords/jiangsu-province","display_name":"Jiangsu Province","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cancer-risk-factors","display_name":"cancer risk factors","score":0.6539999842643738},{"id":"https://openalex.org/keywords/drinking-status","display_name":"drinking status","score":0.41499999165534973},{"id":"https://openalex.org/keywords/smoking-status","display_name":"smoking status","score":0.9350000023841858}],"concepts":[{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.7172294855117798},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5855002403259277},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5681940317153931},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5112831592559814},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5093709230422974},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.47876039147377014},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.47722890973091125},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.4753551185131073},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47310972213745117},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.46318507194519043},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44098618626594543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24982792139053345},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.23215815424919128},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2248266637325287},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22068077325820923},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.20743975043296814}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt4vw7s102","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4vw7s102","pdf_url":"https://escholarship.org/uc/item/4vw7s102","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"mag:214631232","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt4vw7s102/qt4vw7s102.pdf?t=mwmckv","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt4vw7s102","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/4vw7s102","pdf_url":"https://escholarship.org/uc/item/4vw7s102","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308987","display_name":"American Parkinson Disease Association","ror":"https://ror.org/04sedwh45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W214631232.pdf","grobid_xml":"https://content.openalex.org/works/W214631232.grobid-xml"},"referenced_works_count":174,"referenced_works":["https://openalex.org/W8665988","https://openalex.org/W24760097","https://openalex.org/W57303695","https://openalex.org/W144423133","https://openalex.org/W179035579","https://openalex.org/W1525971429","https://openalex.org/W1534431990","https://openalex.org/W1536340771","https://openalex.org/W1537657975","https://openalex.org/W1544046482","https://openalex.org/W1598867832","https://openalex.org/W1619155508","https://openalex.org/W1743302011","https://openalex.org/W1894295571","https://openalex.org/W1897294478","https://openalex.org/W1950889292","https://openalex.org/W1965172023","https://openalex.org/W1966271703","https://openalex.org/W1967658333","https://openalex.org/W1970262077","https://openalex.org/W1971181206","https://openalex.org/W1972755526","https://openalex.org/W1975287575","https://openalex.org/W1975527980","https://openalex.org/W1975970542","https://openalex.org/W1975989949","https://openalex.org/W1980269624","https://openalex.org/W1981989535","https://openalex.org/W1985088074","https://openalex.org/W1988376520","https://openalex.org/W1988399301","https://openalex.org/W1990739275","https://openalex.org/W1992379971","https://openalex.org/W1992828239","https://openalex.org/W1993302385","https://openalex.org/W1993958766","https://openalex.org/W1995496199","https://openalex.org/W1997380392","https://openalex.org/W1999250928","https://openalex.org/W2002341492","https://openalex.org/W2002404925","https://openalex.org/W2006651755","https://openalex.org/W2006907853","https://openalex.org/W2009886857","https://openalex.org/W2012039807","https://openalex.org/W2013315155","https://openalex.org/W2014571900","https://openalex.org/W2016008855","https://openalex.org/W2018348035","https://openalex.org/W2018938350","https://openalex.org/W2019580313","https://openalex.org/W2021140447","https://openalex.org/W2021243192","https://openalex.org/W2024215200","https://openalex.org/W2030607381","https://openalex.org/W2030653144","https://openalex.org/W2033319844","https://openalex.org/W2033364737","https://openalex.org/W2034201179","https://openalex.org/W2038167014","https://openalex.org/W2038321034","https://openalex.org/W2039168588","https://openalex.org/W2040143851","https://openalex.org/W2040153845","https://openalex.org/W2040355283","https://openalex.org/W2040942754","https://openalex.org/W2042099264","https://openalex.org/W2044992780","https://openalex.org/W2047529648","https://openalex.org/W2050415308","https://openalex.org/W2053100259","https://openalex.org/W2053863057","https://openalex.org/W2056302937","https://openalex.org/W2058787857","https://openalex.org/W2059848983","https://openalex.org/W2061901534","https://openalex.org/W2067449053","https://openalex.org/W2067485283","https://openalex.org/W2069505779","https://openalex.org/W2070122773","https://openalex.org/W2072290126","https://openalex.org/W2074210527","https://openalex.org/W2074780268","https://openalex.org/W2079245209","https://openalex.org/W2081623284","https://openalex.org/W2081758458","https://openalex.org/W2083158631","https://openalex.org/W2083605403","https://openalex.org/W2086497168","https://openalex.org/W2088257505","https://openalex.org/W2088681495","https://openalex.org/W2090727140","https://openalex.org/W2091021806","https://openalex.org/W2091605975","https://openalex.org/W2092412751","https://openalex.org/W2094331225","https://openalex.org/W2099193196","https://openalex.org/W2099407632","https://openalex.org/W2100387617","https://openalex.org/W2101341923","https://openalex.org/W2104856383","https://openalex.org/W2105613536","https://openalex.org/W2107648723","https://openalex.org/W2107790330","https://openalex.org/W2109567968","https://openalex.org/W2111566722","https://openalex.org/W2112237505","https://openalex.org/W2112976949","https://openalex.org/W2113263838","https://openalex.org/W2114409847","https://openalex.org/W2114437252","https://openalex.org/W2114499007","https://openalex.org/W2117139716","https://openalex.org/W2117991391","https://openalex.org/W2118039364","https://openalex.org/W2119337308","https://openalex.org/W2123079914","https://openalex.org/W2123680132","https://openalex.org/W2126074499","https://openalex.org/W2129201269","https://openalex.org/W2130979840","https://openalex.org/W2131456432","https://openalex.org/W2133699495","https://openalex.org/W2134406094","https://openalex.org/W2138188114","https://openalex.org/W2139128338","https://openalex.org/W2139385582","https://openalex.org/W2139992910","https://openalex.org/W2141063146","https://openalex.org/W2143343500","https://openalex.org/W2143995836","https://openalex.org/W2144154026","https://openalex.org/W2145187069","https://openalex.org/W2145474622","https://openalex.org/W2146637994","https://openalex.org/W2147765338","https://openalex.org/W2147864074","https://openalex.org/W2148883613","https://openalex.org/W2149497955","https://openalex.org/W2149848115","https://openalex.org/W2151025094","https://openalex.org/W2152194768","https://openalex.org/W2154441109","https://openalex.org/W2154841861","https://openalex.org/W2155011699","https://openalex.org/W2156337099","https://openalex.org/W2158457654","https://openalex.org/W2159537495","https://openalex.org/W2162405663","https://openalex.org/W2163180095","https://openalex.org/W2163199119","https://openalex.org/W2164313608","https://openalex.org/W2164964874","https://openalex.org/W2165019851","https://openalex.org/W2165989705","https://openalex.org/W2167472716","https://openalex.org/W2168818034","https://openalex.org/W2169328918","https://openalex.org/W2170179858","https://openalex.org/W2170956542","https://openalex.org/W2189042664","https://openalex.org/W2256786579","https://openalex.org/W2314540303","https://openalex.org/W2334316724","https://openalex.org/W2337239794","https://openalex.org/W2409477436","https://openalex.org/W2416249814","https://openalex.org/W2419302581","https://openalex.org/W2427387195","https://openalex.org/W2561025267","https://openalex.org/W2916115513","https://openalex.org/W3023299375","https://openalex.org/W3146360245","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W3082907405","https://openalex.org/W2348662860","https://openalex.org/W2005400333","https://openalex.org/W254413634","https://openalex.org/W1981528470","https://openalex.org/W2111203767","https://openalex.org/W2070535583","https://openalex.org/W1897294478","https://openalex.org/W2300448650","https://openalex.org/W2399386838"],"abstract_inverted_index":{"Few":[0],"studies":[1],"have":[2,211,537,620],"explored":[3],"the":[4,29,61,93,151,184,197,226,302,310,329,430,452,542,556,601,622,666,707],"association":[5,163,202,216,231,244,287,304,325,341,362,385,404,427,449,467,499,518,539,567,584,624,634],"between":[6,16,44,63,625,635,646],"stem":[7,30,85],"cell":[8,31],"pathways":[9],"and":[10,13,19,39,47,66,70,88,171,200,265,290,355,366,388,402,407,421,528,554,561,578,592,598,613,628,631,640,649,655,686,704,718],"esophageal":[11,37,64,136,204,246,475,629,641,650,674,693,711],"cancer":[12,38,65,84,137,247,476,630,651,675,712],"potential":[14,90,213,383,497,661],"interactions":[15],"genetic":[17,25,71,647],"markers":[18,27,46,72,648],"environmental":[20,48,68,105,636],"exposures.":[21,49],"We":[22,206,462],"hypothesize":[23],"that":[24,104,154,669,698],"susceptibility":[26],"in":[28,56,150,225,309,328,353,364,405,451,568,676,682,699],"pathway":[32,199,531],"might":[33,41],"be":[34,42,132],"associated":[35,109,134,672,691],"with":[36,110,112,121,135,139,174,203,245,248,272,342,391,429,433,474,477,502,525,673,692],"there":[40,284,359,423,446,515,656],"interaction":[43],"these":[45],"In":[50,99],"a":[51,122,212,242,382,496,549,677,683],"population-based":[52,679],"case-control":[53,680],"study":[54,153,227,544,681],"conducted":[55],"Jiangsu,":[57],"China,":[58],"we":[59,102,380,494,587,619],"evaluate":[60],"associations":[62,82,94,271,645],"various":[67],"factors":[69],"using":[73],"logistic":[74],"regression":[75],"model.":[76],"The":[77,230,643],"focus":[78],"was":[79,108,129,164,285,307,326,360,424,447,516,603],"on":[80,589],"independent":[81],"of":[83,92,95,116,125,143,158,168,178,186,196,217,251,270,305,345,394,411,437,468,481,506,552,660,716,721],"cell-related":[86],"genes":[87],"their":[89],"modification":[91],"known":[96],"risk":[97,138],"factors.":[98],"our":[100],"analysis,":[101],"found":[103,130,207],"tobacco":[106,637,702],"smoking":[107,172,237,492,593,638],"non-smokers":[111,555],"an":[113,140,175,249,339,343,392,425,434,466,478,503,538,565],"adjusted":[114,141,176,435,479,504],"OR":[115,142,177,436,480,505],"1.29":[117],"(95%":[118,145,180,219,253,347,396,413,439,483,508,605],"CI:":[119,146,181,220,254,281,299,318,348,372,397,414,440,457,484,509,606],"1.04-1.59)":[120],"corresponding":[123],"PAR":[124],"11.4%":[126],"(0.90%-21.7%).Garlic":[127],"consumption":[128,157],"to":[131,210,536,701],"inversely":[133,690],"0.67":[144,179],"0.53-0.85)":[147],"for":[148,232,288,313,332,386,558,576,581,611,616,710],"those":[149],"entire":[152,543],"self-reported":[155],"often":[156],"raw":[159,722],"garlic.":[160,723],"This":[161,583,664],"inverse":[162,215,269,303,340,426,498,566],"seen":[165,308],"across":[166],"stratum":[167],"drinking":[169,591],"status":[170,173],"0.48-0.96)":[182],"among":[183,500,520],"group":[185,331,454],"frequent":[187,289,365,406],"drinkers":[188,267,292,357,368,390,409],"who":[189],"were":[190],"ever":[191,596],"smokers.We":[192],"analyzed":[193],"5":[194],"SNPs":[195,532],"Wnt":[198,530],"its":[201],"cancer.":[205,642,694],"rs4730775":[208,274,314,333],"(Wnt2)":[209],"weak":[214,384,654],"0.89":[218],"0.75-1.07":[221],"T/T+C/T":[222,256,320],"vs":[223,276,294,321,351,375,400,417,574,609],"C/C)":[224],"population":[228,685],"overall.":[229],"Wnt2":[233,273,306,563],"(rs4730775)":[234],"varied":[235],"by":[236,261,491],"status;":[238],"never":[239,264,354,387,521],"smokers":[240,501,553,569,597],"had":[241,268,338],"negative":[243],"aOR":[250,344,393,410],"0.72":[252],"0.53-0.98;":[255],"vs.":[257,443,460,487,512],"C/C).":[258],"When":[259,489],"stratified":[260,490,550,588],"alcohol":[262,705],"status,":[263,493],"infrequent":[266,356,389],"(T/T+C/T":[275,293],"C/C":[277,295],"aOR:":[278,296],"0.79":[279],"95%":[280,298,317,371,456,571],"0.62-1.00)":[282],"while":[283,358,445,514],"no":[286,361,403,448,517],"daily":[291,367,408],"1.03":[297],"0.79-1.34).":[300],"Likewise,":[301],"non-smoking/non-drinking":[311],"category":[312],"(aOR:":[315],"0.67,":[316],"0.46-0.98":[319],"C/C,":[322],"respectively).":[323],"No":[324],"observed":[327,363,381,428,450,495,519,632,644],"drinkers/smokers":[330,453],"(Wnt":[334],"2).Similarly,":[335],"rs4835761":[336],"(Wnt8A)":[337],"0.82":[346],"0.64-1.05,":[349],"G/G+A/G":[350,374,399,416,573,608],"A/A)":[352,401],"(aOR":[369],"0.97":[370],"0.74-1.28,":[373],"A/A.":[376],"For":[377,419,595],"rs222851":[378],"(DVL2)":[379],"1.19":[395],"0.93-1.52,":[398],"0.88":[412],"0.74-1.06,":[415],"A/A).":[418],"non-drinkers":[420],"non-smokers,":[422],"rs2241802":[431],"(FZD3)":[432],"0.68":[438],"0.46-1.00;":[441],"G/A+A/A":[442,459],"G/G)":[444],"(aOR=1.00,":[455],"0.82-1.49;":[458],"G/G).":[461],"did":[463,533],"not":[464,534],"observe":[465],"rs2953":[469,526,559,577,612],"miRNA589":[470,527,560],"(CTNNB1":[471],"binding":[472],"site)":[473],"0.95":[482],"0.80-1.13;":[485],"G/T+G/G":[486,511],"T/T).":[488],"0.84":[507],"0.69-1.03;":[510],"T/T)":[513],"smokers.":[522],"Joint":[523],"effects":[524],"other":[529],"appear":[535],"when":[540,547,586],"including":[541],"population.":[545],"However,":[546],"performing":[548],"analysis":[551],"aROR":[557,602],"rs3729629":[562],"demonstrated":[564],"(aROR=0.58,":[570],"CI=0.35-0.96;":[572],"A/A":[575,610],"C/C+G/C":[579,614],"vsG/G":[580,615],"rs3729629).":[582],"remained":[585],"both":[590],"status.":[594],"frequent/daily":[599],"drinkers,":[600],"0.48":[604],"0.26-0.885":[607],"rs3729629).In":[617],"summary,":[618],"identified":[621],"protective":[623],"garlic":[626,687],"intake":[627,688,720],"moderate":[633],"(ETS)":[639],"are":[652,657],"relatively":[653],"some":[658],"indications":[659],"gene-environmental":[662],"interaction.":[663],"is":[665,671,689],"first":[667],"time":[668],"ETS":[670,717],"large":[678],"Chinese":[684],"Our":[695],"observations":[696],"suggest":[697],"addition":[700],"cessation":[703],"control,":[706],"prevention":[708],"strategy":[709],"should":[713],"include":[714],"avoidance":[715],"increasing":[719]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
