{"id":"https://openalex.org/W2146299550","doi":"https://doi.org/10.1016/0922-4106(92)90056-2","title":"The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies","display_name":"The neuroprotective properties of ifenprodil, a novel NMDA receptor antagonist, in neuronal cell culture toxicity studies","publication_year":1992,"publication_date":"1992-08-01","ids":{"openalex":"https://openalex.org/W2146299550","doi":"https://doi.org/10.1016/0922-4106(92)90056-2","mag":"2146299550","pmid":"https://pubmed.ncbi.nlm.nih.gov/1356814"},"language":"en","primary_location":{"id":"doi:10.1016/0922-4106(92)90056-2","doi":"https://doi.org/10.1016/0922-4106(92)90056-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0922-4106(92)90056-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210192051","display_name":"European Journal of Pharmacology Molecular Pharmacology","issn_l":"0922-4106","issn":["0922-4106","1872-8251"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology: Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"David Graham","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Graham","raw_affiliation_strings":["Department of Biology, Synth\u00e9labo Recherche (L.E.R.S.), Bagneux, France","Department of Biology, Synth\u00e9labo Recherche (L.E.R.S.), F-92220 Bagneux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Synth\u00e9labo Recherche (L.E.R.S.), Bagneux, France","institution_ids":[]},{"raw_affiliation_string":"Department of Biology, Synth\u00e9labo Recherche (L.E.R.S.), F-92220 Bagneux, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027258885","display_name":"G\u00e9raldine Darles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G\u00e9raldine Darles","raw_affiliation_strings":["Department of Biology, Synth\u00e9labo Recherche (L.E.R.S.), F-92220 Bagneux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Synth\u00e9labo Recherche (L.E.R.S.), F-92220 Bagneux, France","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109999386","display_name":"Salom\u00f3n Z. Langer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Salomon Z. Langer","raw_affiliation_strings":["Department of Biology, Synth\u00e9labo Recherche (L.E.R.S.), F-92220 Bagneux, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Synth\u00e9labo Recherche (L.E.R.S.), F-92220 Bagneux, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5109999386"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6805,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.66992869,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"226","issue":"4","first_page":"373","last_page":"376"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ifenprodil","display_name":"ifenprodil","score":1.0},{"id":"https://openalex.org/keywords/nmda-receptor-antagonism","display_name":"NMDA receptor antagonism","score":0.9169999957084656},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9940000176429749},{"id":"https://openalex.org/keywords/excitotoxicity","display_name":"excitotoxicity","score":0.8619999885559082},{"id":"https://openalex.org/keywords/glutamate-receptor-agonists","display_name":"glutamate receptor agonists","score":0.8389999866485596},{"id":"https://openalex.org/keywords/nmda","display_name":"NMDA","score":0.6869999766349792},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.9020000100135803},{"id":"https://openalex.org/keywords/kainic-acid","display_name":"kainic acid","score":0.843999981880188},{"id":"https://openalex.org/keywords/quisqualate","display_name":"quisqualate","score":0.9829999804496765},{"id":"https://openalex.org/keywords/sodium-cyanide","display_name":"sodium cyanide","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mk-801","display_name":"MK-801","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cortical-neurons","display_name":"cortical neurons","score":0.6110000014305115},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7289999723434448}],"concepts":[{"id":"https://openalex.org/C2780376555","wikidata":"https://www.wikidata.org/wiki/Q5991156","display_name":"Ifenprodil","level":4,"score":0.9721611738204956},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.825398325920105},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.7688254117965698},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.661443829536438},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5874800086021423},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.48718422651290894},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.449567973613739},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.4432603120803833},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.350547730922699},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.31792715191841125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29745718836784363},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2693595886230469},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12133064866065979}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003485","descriptor_name":"Cyanates","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D005971","descriptor_name":"Glutamates","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D007608","descriptor_name":"Kainic Acid","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016202","descriptor_name":"N-Methylaspartate","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016291","descriptor_name":"Dizocilpine Maleate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016318","descriptor_name":"Quisqualic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0922-4106(92)90056-2","doi":"https://doi.org/10.1016/0922-4106(92)90056-2","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0922-4106(92)90056-2","pdf_url":null,"source":{"id":"https://openalex.org/S4210192051","display_name":"European Journal of Pharmacology Molecular Pharmacology","issn_l":"0922-4106","issn":["0922-4106","1872-8251"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmacology: Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:1356814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1356814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1957958801","https://openalex.org/W1979406476","https://openalex.org/W2003776825","https://openalex.org/W2035750459","https://openalex.org/W2062899329","https://openalex.org/W2064714078","https://openalex.org/W2125440566","https://openalex.org/W2160348025","https://openalex.org/W2229314919"],"related_works":["https://openalex.org/W7100647476","https://openalex.org/W2336180525","https://openalex.org/W7096399867","https://openalex.org/W1999580543","https://openalex.org/W2036058502","https://openalex.org/W2053983542","https://openalex.org/W2059401172","https://openalex.org/W2073171714","https://openalex.org/W2292572876","https://openalex.org/W2042648593"],"abstract_inverted_index":null,"counts_by_year":[{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
