{"id":"https://openalex.org/W2146229280","doi":"https://doi.org/10.1042/bj20101895","title":"Flexibility of the Ure2 prion domain is important for amyloid fibril formation","display_name":"Flexibility of the Ure2 prion domain is important for amyloid fibril formation","publication_year":2011,"publication_date":"2011-01-27","ids":{"openalex":"https://openalex.org/W2146229280","doi":"https://doi.org/10.1042/bj20101895","mag":"2146229280","pmid":"https://pubmed.ncbi.nlm.nih.gov/21091436"},"language":"en","primary_location":{"id":"doi:10.1042/bj20101895","doi":"https://doi.org/10.1042/bj20101895","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20101895","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Yong Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Yu","raw_affiliation_strings":["Graduate University of the Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan District, Beijing 100049, China","National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate University of the Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan District, Beijing 100049, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101764240","display_name":"Haiyan Wang","orcid":"https://orcid.org/0000-0002-5759-4183","observed_orcids":["https://orcid.org/0000-0002-5759-4183"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai-Yan Wang","raw_affiliation_strings":["Graduate University of the Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan District, Beijing 100049, China","National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate University of the Chinese Academy of Sciences, 19 Yuquan Road, Shijingshan District, Beijing 100049, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ming Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Bai","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058049092","display_name":"Sarah Perrett","orcid":"https://orcid.org/0000-0003-0137-0997","observed_orcids":["https://orcid.org/0000-0003-0137-0997"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Sarah Perrett","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058049092"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540","https://openalex.org/I4210165038"],"apc_list":null,"apc_paid":null,"fwci":0.3656,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.58328096,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"434","issue":"1","first_page":"143","last_page":"151"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ure2","display_name":"Ure2","score":0.972000002861023},{"id":"https://openalex.org/keywords/ure3-prion","display_name":"[URE3] prion","score":0.9240000247955322},{"id":"https://openalex.org/keywords/prion-domain","display_name":"prion domain","score":0.7599999904632568},{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"intrinsically disordered proteins","score":0.8090000152587891},{"id":"https://openalex.org/keywords/protein-flexibility","display_name":"protein flexibility","score":0.7950000166893005},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.996999979019165},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.6259999871253967},{"id":"https://openalex.org/keywords/cross-seeding","display_name":"cross-seeding","score":0.7369999885559082},{"id":"https://openalex.org/keywords/guanidine-hydrochloride","display_name":"guanidine hydrochloride","score":0.8999999761581421},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.47999998927116394},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9359999895095825}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4835743308067322},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.45374637842178345},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42715752124786377},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.42413175106048584},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3929540812969208},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.1059650182723999}],"mesh":[{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011328","descriptor_name":"Prions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1042/bj20101895","doi":"https://doi.org/10.1042/bj20101895","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20101895","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:21091436","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21091436","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1521448744","https://openalex.org/W1546592314","https://openalex.org/W1880600007","https://openalex.org/W1905296056","https://openalex.org/W1967581734","https://openalex.org/W1969006061","https://openalex.org/W1978130423","https://openalex.org/W1981704126","https://openalex.org/W1994321237","https://openalex.org/W1998535995","https://openalex.org/W2007372833","https://openalex.org/W2016983199","https://openalex.org/W2019205978","https://openalex.org/W2025211528","https://openalex.org/W2032015542","https://openalex.org/W2033507186","https://openalex.org/W2034170455","https://openalex.org/W2041973951","https://openalex.org/W2046445620","https://openalex.org/W2047544531","https://openalex.org/W2047706498","https://openalex.org/W2052540870","https://openalex.org/W2057833016","https://openalex.org/W2059821314","https://openalex.org/W2063688094","https://openalex.org/W2073675629","https://openalex.org/W2079902305","https://openalex.org/W2087654804","https://openalex.org/W2089410077","https://openalex.org/W2090590635","https://openalex.org/W2094956744","https://openalex.org/W2104491557","https://openalex.org/W2105740620","https://openalex.org/W2106899110","https://openalex.org/W2110690773","https://openalex.org/W2116953763","https://openalex.org/W2118878821","https://openalex.org/W2126251089","https://openalex.org/W2150784670","https://openalex.org/W2165186407","https://openalex.org/W2172165761","https://openalex.org/W4251149346","https://openalex.org/W6639829338"],"related_works":["https://openalex.org/W2090590635","https://openalex.org/W1998535995","https://openalex.org/W1994373083","https://openalex.org/W2047544531","https://openalex.org/W1965212214","https://openalex.org/W2042879628","https://openalex.org/W2163348104","https://openalex.org/W2007372833","https://openalex.org/W2110690773","https://openalex.org/W2106899110"],"abstract_inverted_index":{"Ure2,":[0,81,143],"the":[1,5,29,38,43,46,60,74,77,111,119,159,164,167,177,190,193,197],"protein":[2],"determinant":[3],"of":[4,45,73,135,151,158,163,172,192,199],"Saccharomyces":[6],"cerevisiae":[7],"prion":[8,20,194],"[URE3],":[9],"has":[10,32],"a":[11,33,102],"natively":[12],"disordered":[13],"N-terminal":[14],"domain":[15,195],"that":[16,189],"is":[17],"important":[18],"for":[19,141],"formation":[21,26],"in":[22,27,149],"vivo":[23],"and":[24,48,64,71,90,110,153,174],"amyloid":[25],"vitro;":[28],"globular":[30],"C-domain":[31],"glutathione":[34],"transferase-like":[35],"fold.":[36],"In":[37],"present":[39],"study,":[40],"we":[41],"swapped":[42],"position":[44,191],"N-":[47],"C-terminal":[49],"regions,":[50],"with":[51,101,156],"or":[52],"without":[53],"an":[54],"intervening":[55],"peptide":[56],"linker,":[57],"to":[58,96,116,126,201,206],"create":[59],"Ure2":[61,200],"variants":[62,75],"CLN-Ure2":[63,93,152,173],"CN-Ure2":[65,122,175],"respectively.":[66],"The":[67,186],"native":[68],"structural":[69],"content":[70],"stability":[72],"were":[76,114],"same":[78,120,178],"as":[79,82,183],"wild-type":[80,108,142,184],"indicated":[83],"by":[84],"enzymatic":[85],"activity,":[86],"far-UV":[87],"CD":[88],"analysis":[89],"equilibrium":[91],"denaturation.":[92],"was":[94,131,147],"able":[95],"form":[97,127,202],"amyloid-like":[98],"fibrils,":[99,128],"but":[100,129],"significantly":[103],"longer":[104],"lag":[105],"time":[106],"than":[107],"Ure2;":[109],"two":[112],"proteins":[113],"unable":[115],"cross-seed.":[117],"Under":[118],"conditions,":[121],"showed":[123,176],"limited":[124],"ability":[125,198],"this":[130],"improved":[132],"after":[133],"addition":[134],"0.03":[136],"M":[137],"guanidinium":[138],"chloride.":[139],"As":[140],"allosteric":[144],"enzyme":[145],"activity":[146],"observed":[148],"fibrils":[150,171,203],"CN-Ure2,":[154],"consistent":[155],"retention":[157],"native-like":[160],"dimeric":[161],"structure":[162],"C-domains":[165],"within":[166],"fibrils.":[168],"Proteolytically":[169],"digested":[170],"residual":[179],"fibril":[180],"core":[181],"morphology":[182],"Ure2.":[185],"results":[187],"suggest":[188],"affects":[196],"primarily":[204],"due":[205],"effects":[207],"on":[208],"its":[209],"flexibility.":[210]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
