{"id":"https://openalex.org/W2146201166","doi":"https://doi.org/10.1113/jphysiol.1997.sp021843","title":"Properties of cloned ATP\u2010sensitive K+ currents expressed in Xenopus oocytes.","display_name":"Properties of cloned ATP\u2010sensitive K+ currents expressed in Xenopus oocytes.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2146201166","doi":"https://doi.org/10.1113/jphysiol.1997.sp021843","mag":"2146201166","pmid":"https://pubmed.ncbi.nlm.nih.gov/9023770","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1159236"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.1997.sp021843","doi":"https://doi.org/10.1113/jphysiol.1997.sp021843","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1997.sp021843","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2146201166"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1159236/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002740985","display_name":"Fiona Mary Gribble","orcid":"https://orcid.org/0000-0002-4232-2898","observed_orcids":["https://orcid.org/0000-0002-4232-2898"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F M Gribble","raw_affiliation_strings":["University Laboratory of Physiology, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Laboratory of Physiology, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005393076","display_name":"Rebecca Ashfield","orcid":"https://orcid.org/0000-0002-1248-1353","observed_orcids":["https://orcid.org/0000-0002-1248-1353"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R Ashfield","raw_affiliation_strings":["University Laboratory of Physiology, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Laboratory of Physiology, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068116173","display_name":"Carina \u00c4mm\u00e4l\u00e4","orcid":"https://orcid.org/0000-0003-3180-7563","observed_orcids":["https://orcid.org/0000-0003-3180-7563"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C Amm\u00e4l\u00e4","raw_affiliation_strings":["University Laboratory of Physiology, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Laboratory of Physiology, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063776275","display_name":"Frances Mary Ashcroft","orcid":"https://orcid.org/0000-0002-6970-1767","observed_orcids":["https://orcid.org/0000-0002-6970-1767"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"F M Ashcroft","raw_affiliation_strings":["University Laboratory of Physiology, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Laboratory of Physiology, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40120149"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":6.8465,"has_fulltext":false,"cited_by_count":198,"citation_normalized_percentile":{"value":0.9804846,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"498","issue":"1","first_page":"87","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.902999997138977},{"id":"https://openalex.org/keywords/kir6-2","display_name":"Kir6.2","score":0.9150000214576721},{"id":"https://openalex.org/keywords/kir6-1","display_name":"Kir6.1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/kir1-1","display_name":"Kir1.1","score":0.7239999771118164},{"id":"https://openalex.org/keywords/kir2-1","display_name":"Kir2.1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/inwardly-rectifying-potassium-channels","display_name":"inwardly rectifying potassium channels","score":0.8830000162124634},{"id":"https://openalex.org/keywords/atp-sensitivity","display_name":"ATP sensitivity","score":0.6330000162124634},{"id":"https://openalex.org/keywords/metabolic-inhibition","display_name":"metabolic inhibition","score":0.7039999961853027},{"id":"https://openalex.org/keywords/tolbutamide","display_name":"tolbutamide","score":0.8740000128746033},{"id":"https://openalex.org/keywords/glibenclamide","display_name":"glibenclamide","score":0.8840000033378601},{"id":"https://openalex.org/keywords/diazoxide","display_name":"diazoxide","score":0.9300000071525574},{"id":"https://openalex.org/keywords/channel-pharmacology","display_name":"channel pharmacology","score":0.5879999995231628}],"concepts":[{"id":"https://openalex.org/C2777289354","wikidata":"https://www.wikidata.org/wiki/Q14912054","display_name":"Kir6.2","level":4,"score":0.8513106107711792},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.8280931711196899},{"id":"https://openalex.org/C2776054734","wikidata":"https://www.wikidata.org/wiki/Q414275","display_name":"Tolbutamide","level":3,"score":0.7710254192352295},{"id":"https://openalex.org/C2775984225","wikidata":"https://www.wikidata.org/wiki/Q821869","display_name":"Pinacidil","level":4,"score":0.7560864686965942},{"id":"https://openalex.org/C2780561956","wikidata":"https://www.wikidata.org/wiki/Q3698301","display_name":"Cromakalim","level":4,"score":0.7252854704856873},{"id":"https://openalex.org/C2779872217","wikidata":"https://www.wikidata.org/wiki/Q420009","display_name":"Diazoxide","level":3,"score":0.6714181900024414},{"id":"https://openalex.org/C102942909","wikidata":"https://www.wikidata.org/wiki/Q7636212","display_name":"Sulfonylurea receptor","level":4,"score":0.6543787717819214},{"id":"https://openalex.org/C2779768347","wikidata":"https://www.wikidata.org/wiki/Q420626","display_name":"Glibenclamide","level":3,"score":0.6260150074958801},{"id":"https://openalex.org/C94924445","wikidata":"https://www.wikidata.org/wiki/Q841456","display_name":"Inward-rectifier potassium ion channel","level":4,"score":0.5628402233123779},{"id":"https://openalex.org/C2779134199","wikidata":"https://www.wikidata.org/wiki/Q1076381","display_name":"Oligomycin","level":4,"score":0.5247431397438049},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.477535605430603},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42964646220207214},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.4167741537094116},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.41323134303092957},{"id":"https://openalex.org/C83743174","wikidata":"https://www.wikidata.org/wiki/Q423778","display_name":"Potassium channel","level":2,"score":0.41186583042144775},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40850672125816345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36059021949768066},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3333258032798767},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3138985335826874},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28719469904899597},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.2571024000644684},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.13298359513282776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1204197108745575},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.10148593783378601},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09663030505180359},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0667409598827362},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009865","descriptor_name":"Oocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1113/jphysiol.1997.sp021843","doi":"https://doi.org/10.1113/jphysiol.1997.sp021843","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.1997.sp021843","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmid:9023770","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9023770","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1159236","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1159236/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1159236","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1159236/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W119202585","https://openalex.org/W1562579131","https://openalex.org/W1965343672","https://openalex.org/W1974981468","https://openalex.org/W1983011541","https://openalex.org/W1985770721","https://openalex.org/W1986804446","https://openalex.org/W1987759781","https://openalex.org/W1988825124","https://openalex.org/W1991220984","https://openalex.org/W1992045485","https://openalex.org/W1997849672","https://openalex.org/W2010623159","https://openalex.org/W2010693981","https://openalex.org/W2010975803","https://openalex.org/W2022092956","https://openalex.org/W2050342883","https://openalex.org/W2056283223","https://openalex.org/W2074306054","https://openalex.org/W2079031364","https://openalex.org/W2083584165","https://openalex.org/W2108019757","https://openalex.org/W2148959338","https://openalex.org/W2162097287","https://openalex.org/W2170976907","https://openalex.org/W2172079625"],"related_works":["https://openalex.org/W2169038382","https://openalex.org/W2050342883","https://openalex.org/W2016885841","https://openalex.org/W2154081746","https://openalex.org/W4224243782","https://openalex.org/W6999228588","https://openalex.org/W2142746123","https://openalex.org/W1974413979","https://openalex.org/W2122174026","https://openalex.org/W1980051227"],"abstract_inverted_index":{"1.":[0],"We":[1],"have":[2],"studied":[3],"the":[4,58,84,119,219],"electrophysiological":[5],"properties":[6,104],"of":[7,105,110,168,177,182],"cloned":[8,228],"ATP-sensitive":[9,113],"K+":[10,31,49,114],"channels":[11,230],"(KATP":[12,117],"channels)":[13],"heterologously":[14],"expressed":[15],"in":[16,68,72,158,211],"Xenopus":[17,212,220],"oocytes.":[18],"This":[19],"channel":[20,32,99,115],"comprises":[21],"a":[22,166,223],"sulphonylurea":[23,85],"receptor":[24,86],"subunit":[25,33],"(SUR)":[26],"and":[27,40,88,136,148,231],"an":[28,89],"inwardly":[29,47],"rectifying":[30,48],"(Kir).":[34],"2.":[35],"Oocytes":[36],"injected":[37,74],"with":[38,75,165,199],"SUR1":[39,79,196],"either":[41,200],"Kir6.2":[42],"or":[43,62,78,93,132,190,202],"Kir6.1":[44,77],"exhibited":[45],"large":[46],"currents":[50,65,107,116,120,157,172],"when":[51,195],"cytosolic":[52],"ATP":[53,164,183],"levels":[54],"were":[55,66,121,161],"lowered":[56],"by":[57,125,139,144,150,163,237],"metabolic":[59,191,239],"inhibitors":[60],"azide":[61,71],"FCCP.":[63],"No":[64,186],"observed":[67,194],"response":[69],"to":[70,188],"oocytes":[73],"Kir6.2,":[76],"alone,":[80],"indicating":[81],"that":[82,205,218,232],"both":[83],"(SUR1)":[87],"inward":[90],"rectifier":[91],"(Kir6.1":[92],"Kir6.2)":[94],"are":[95],"needed":[96],"for":[97,227],"functional":[98],"activity.":[100],"3.":[101],"The":[102],"pharmacological":[103],"Kir6.2-SUR1":[106,156],"resembled":[108],"those":[109],"native":[111],"beta-cell":[112],"currents):":[118],">":[122],"90%":[123],"blocked":[124],"tolbutamide":[126,189],"(500":[127],"microM),":[128,142],"meglitinide":[129],"(10":[130],"microM)":[131],"glibenclamide":[133],"(100":[134],"nM),":[135],"activated":[137],"1.8-fold":[138],"diazoxide":[140],"(340":[141],"1.4-fold":[143],"pinacidil":[145],"(1":[146],"mM)":[147],"unaffected":[149],"cromakalim":[151],"(0.5":[152],"mM).":[153],"4.":[154],"Macroscopic":[155],"inside-out":[159],"patches":[160],"inhibited":[162],"Ki":[167],"28":[169],"microM.":[170],"Kir6.1-SUR1":[171],"ran":[173],"down":[174],"within":[175],"seconds":[176],"patch":[178],"excision":[179],"preventing":[180],"analysis":[181],"sensitivity.":[184],"5.":[185],"sensitivity":[187],"inhibition":[192],"was":[193,197],"coexpressed":[198],"Kir1.1a":[201],"Kir2.1,":[203],"suggesting":[204],"these":[206],"proteins":[207],"do":[208],"not":[209],"couple":[210],"ocytes.":[213],"6.":[214],"Our":[215],"data":[216],"demonstrate":[217],"oocyte":[221],"constitutes":[222],"good":[224],"expression":[225,233],"system":[226],"KATP":[229],"may":[234],"be":[235],"assayed":[236],"azide-induced":[238],"inhibition.":[240]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}