{"id":"https://openalex.org/W2146186017","doi":"https://doi.org/10.1105/tpc.112.095885","title":"Lysine Decarboxylase Catalyzes the First Step of Quinolizidine Alkaloid Biosynthesis and Coevolved with Alkaloid Production in Leguminosae","display_name":"Lysine Decarboxylase Catalyzes the First Step of Quinolizidine Alkaloid Biosynthesis and Coevolved with Alkaloid Production in Leguminosae","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W2146186017","doi":"https://doi.org/10.1105/tpc.112.095885","mag":"2146186017","pmid":"https://pubmed.ncbi.nlm.nih.gov/22415272","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3336119"},"language":"en","primary_location":{"id":"doi:10.1105/tpc.112.095885","doi":"https://doi.org/10.1105/tpc.112.095885","is_oa":true,"landing_page_url":"https://doi.org/10.1105/tpc.112.095885","pdf_url":"https://academic.oup.com/plcell/article-pdf/24/3/1202/35797505/plcell_v24_3_1202.pdf","source":{"id":"https://openalex.org/S48849333","display_name":"The Plant Cell","issn_l":"1040-4651","issn":["1040-4651","1532-298X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/plcell/article-pdf/24/3/1202/35797505/plcell_v24_3_1202.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054959305","display_name":"Somnuk Bunsupa","orcid":"https://orcid.org/0000-0002-0945-9737","observed_orcids":["https://orcid.org/0000-0002-0945-9737"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Somnuk Bunsupa","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","aGraduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"aGraduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023995404","display_name":"Katayama Kae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kae Katayama","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","aGraduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"aGraduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054172905","display_name":"Emi Ikeura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Emi Ikeura","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","aGraduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"aGraduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064754063","display_name":"Akira Oikawa","orcid":"https://orcid.org/0000-0001-7507-4256","observed_orcids":["https://orcid.org/0000-0001-7507-4256"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akira Oikawa","raw_affiliation_strings":["RIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan","bRIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"bRIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064232992","display_name":"Kiminori Toyooka","orcid":"https://orcid.org/0000-0002-6414-5191","observed_orcids":["https://orcid.org/0000-0002-6414-5191"]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiminori Toyooka","raw_affiliation_strings":["RIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan","bRIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"bRIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052696406","display_name":"Kazuki Saito","orcid":"https://orcid.org/0000-0001-6310-5342","observed_orcids":["https://orcid.org/0000-0001-6310-5342","https://orcid.org/0000-0003-1117-7648","https://orcid.org/0009-0005-5571-884X","https://orcid.org/0000-0001-8590-9800"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuki Saito","raw_affiliation_strings":["Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","RIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan","aGraduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","bRIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"RIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan","institution_ids":["https://openalex.org/I4210110652"]},{"raw_affiliation_string":"aGraduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"bRIKEN Plant Science Center, Tsurumi-ku, Yokohama 230-0045, Japan","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055464615","display_name":"Mami Yamazaki","orcid":"https://orcid.org/0000-0001-6157-5287","observed_orcids":["https://orcid.org/0000-0001-6157-5287"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]},{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mami Yamazaki","raw_affiliation_strings":["Core Research for Evolutional Science and Technology, Japan Science and Technology, Kawaguchi 332-0012, Japan","Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","aGraduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","cCore Research for Evolutional Science and Technology, Japan Science and Technology, Kawaguchi 332-0012, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Core Research for Evolutional Science and Technology, Japan Science and Technology, Kawaguchi 332-0012, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Graduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"aGraduate School of Pharmaceutical Sciences, Chiba University, Chuo-ku, Chiba 260-8675, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"cCore Research for Evolutional Science and Technology, Japan Science and Technology, Kawaguchi 332-0012, Japan","institution_ids":["https://openalex.org/I4210086780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4934,"currency":"USD","value_usd":4934},"apc_paid":{"value":4934,"currency":"USD","value_usd":4934},"fwci":1.9948,"has_fulltext":true,"cited_by_count":153,"citation_normalized_percentile":{"value":0.87312288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"24","issue":"3","first_page":"1202","last_page":"1216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.8564000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11237","display_name":"Plant Gene Expression Analysis","score":0.0575999990105629,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.03840000182390213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lysine-decarboxylase","display_name":"lysine decarboxylase","score":0.996999979019165},{"id":"https://openalex.org/keywords/ornithine-decarboxylase","display_name":"ornithine decarboxylase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/quinolizidine-alkaloids","display_name":"quinolizidine alkaloids","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alkaloid-biosynthesis","display_name":"alkaloid biosynthesis","score":0.9679999947547913},{"id":"https://openalex.org/keywords/lupinus-angustifolius","display_name":"Lupinus angustifolius","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fabaceae","display_name":"Fabaceae","score":0.8270000219345093},{"id":"https://openalex.org/keywords/cadaverine","display_name":"cadaverine","score":0.8700000047683716},{"id":"https://openalex.org/keywords/chloroplast-localization","display_name":"chloroplast localization","score":0.8169999718666077},{"id":"https://openalex.org/keywords/enzyme-evolution","display_name":"enzyme evolution","score":0.531000018119812},{"id":"https://openalex.org/keywords/phylogenetic-analysis","display_name":"phylogenetic analysis","score":0.5929999947547913},{"id":"https://openalex.org/keywords/genetically-modified-plants","display_name":"transgenic plants","score":0.49900001287460327},{"id":"https://openalex.org/keywords/alkaloid-production","display_name":"alkaloid production","score":0.4560000002384186}],"concepts":[{"id":"https://openalex.org/C2779703059","wikidata":"https://www.wikidata.org/wiki/Q3269766","display_name":"Lysine decarboxylase","level":5,"score":0.8877156972885132},{"id":"https://openalex.org/C2776928777","wikidata":"https://www.wikidata.org/wiki/Q161555","display_name":"Cadaverine","level":4,"score":0.8233959674835205},{"id":"https://openalex.org/C2778943457","wikidata":"https://www.wikidata.org/wiki/Q418837","display_name":"Quinolizidine","level":3,"score":0.7180792093276978},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6759375929832458},{"id":"https://openalex.org/C121289238","wikidata":"https://www.wikidata.org/wiki/Q931579","display_name":"Ornithine decarboxylase","level":3,"score":0.6055530309677124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5954346656799316},{"id":"https://openalex.org/C2781205006","wikidata":"https://www.wikidata.org/wiki/Q181095","display_name":"Nicotiana tabacum","level":3,"score":0.5449995994567871},{"id":"https://openalex.org/C2778046504","wikidata":"https://www.wikidata.org/wiki/Q347392","display_name":"Sanguinarine","level":3,"score":0.49146878719329834},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.4873403012752533},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.4667993187904358},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.45434945821762085},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.44047772884368896},{"id":"https://openalex.org/C2779656422","wikidata":"https://www.wikidata.org/wiki/Q2700446","display_name":"Agrobacterium","level":4,"score":0.42745086550712585},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.41428062319755554},{"id":"https://openalex.org/C2777167505","wikidata":"https://www.wikidata.org/wiki/Q410190","display_name":"Putrescine","level":3,"score":0.39948171377182007},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.29556697607040405},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2555469870567322},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.214000403881073},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10090908408164978},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.09922313690185547},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D002103","descriptor_name":"Cadaverine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002262","descriptor_name":"Carboxy-Lyases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002736","descriptor_name":"Chloroplasts","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003653","descriptor_name":"Decarboxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009955","descriptor_name":"Ornithine Decarboxylase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009955","descriptor_name":"Ornithine Decarboxylase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014026","descriptor_name":"Nicotiana","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D031297","descriptor_name":"Lupinus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D031297","descriptor_name":"Lupinus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D031297","descriptor_name":"Lupinus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054837","descriptor_name":"Quinolizidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1105/tpc.112.095885","doi":"https://doi.org/10.1105/tpc.112.095885","is_oa":true,"landing_page_url":"https://doi.org/10.1105/tpc.112.095885","pdf_url":"https://academic.oup.com/plcell/article-pdf/24/3/1202/35797505/plcell_v24_3_1202.pdf","source":{"id":"https://openalex.org/S48849333","display_name":"The Plant Cell","issn_l":"1040-4651","issn":["1040-4651","1532-298X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Cell","raw_type":"journal-article"},{"id":"pmid:22415272","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22415272","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant cell","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3336119","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3336119/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plant Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1105/tpc.112.095885","doi":"https://doi.org/10.1105/tpc.112.095885","is_oa":true,"landing_page_url":"https://doi.org/10.1105/tpc.112.095885","pdf_url":"https://academic.oup.com/plcell/article-pdf/24/3/1202/35797505/plcell_v24_3_1202.pdf","source":{"id":"https://openalex.org/S48849333","display_name":"The Plant Cell","issn_l":"1040-4651","issn":["1040-4651","1532-298X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Plant Cell","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4787627271","display_name":"Regulatory mechanism in metabolic allocation of nitrogen-containing compounds from central metabolisms to specialized metabolisms in plants","funder_award_id":"24570041","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G5654645507","display_name":null,"funder_award_id":"22108008","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6050334762","display_name":"Construction of multi-scale mapping system of plant tissues and cells prepared by high-pressure freezing and TEM techniques","funder_award_id":"24687007","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320322543","display_name":"Shimane University","ror":"https://ror.org/01jaaym28"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320335125","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98"},{"id":"https://openalex.org/F4320338075","display_name":"Core Research for Evolutional Science and Technology","ror":"https://ror.org/00097mb19"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2146186017.pdf","grobid_xml":"https://content.openalex.org/works/W2146186017.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W151156148","https://openalex.org/W601571486","https://openalex.org/W1481566187","https://openalex.org/W1483954000","https://openalex.org/W1488757076","https://openalex.org/W1499366483","https://openalex.org/W1507578651","https://openalex.org/W1517802390","https://openalex.org/W1519731508","https://openalex.org/W1544408548","https://openalex.org/W1575355375","https://openalex.org/W1969151014","https://openalex.org/W1971484621","https://openalex.org/W1973718080","https://openalex.org/W1976995328","https://openalex.org/W1979489154","https://openalex.org/W1981765089","https://openalex.org/W1986060665","https://openalex.org/W1991833944","https://openalex.org/W1992502891","https://openalex.org/W1998053175","https://openalex.org/W1998140558","https://openalex.org/W2011482609","https://openalex.org/W2019419909","https://openalex.org/W2019944037","https://openalex.org/W2022598102","https://openalex.org/W2024556021","https://openalex.org/W2032049916","https://openalex.org/W2033719772","https://openalex.org/W2033760653","https://openalex.org/W2044854256","https://openalex.org/W2045244967","https://openalex.org/W2063665778","https://openalex.org/W2065822440","https://openalex.org/W2067484412","https://openalex.org/W2068713466","https://openalex.org/W2077512489","https://openalex.org/W2077936228","https://openalex.org/W2078313792","https://openalex.org/W2079340318","https://openalex.org/W2082115307","https://openalex.org/W2085611935","https://openalex.org/W2088798172","https://openalex.org/W2089979538","https://openalex.org/W2093695369","https://openalex.org/W2095067772","https://openalex.org/W2098998842","https://openalex.org/W2099396543","https://openalex.org/W2101343618","https://openalex.org/W2103286528","https://openalex.org/W2105925229","https://openalex.org/W2106262929","https://openalex.org/W2107805773","https://openalex.org/W2109385242","https://openalex.org/W2111105530","https://openalex.org/W2116122104","https://openalex.org/W2122442193","https://openalex.org/W2125121305","https://openalex.org/W2134746300","https://openalex.org/W2136170436","https://openalex.org/W2136659052","https://openalex.org/W2137071390","https://openalex.org/W2138511104","https://openalex.org/W2140659155","https://openalex.org/W2143791656","https://openalex.org/W2145985152","https://openalex.org/W2149406735","https://openalex.org/W2149902435","https://openalex.org/W2152301430","https://openalex.org/W2153472178","https://openalex.org/W2155842405","https://openalex.org/W2157827172","https://openalex.org/W2161356660","https://openalex.org/W2163273307","https://openalex.org/W2258351812","https://openalex.org/W2287178437","https://openalex.org/W2429313811","https://openalex.org/W4211259730"],"related_works":["https://openalex.org/W1989683487","https://openalex.org/W2425214437","https://openalex.org/W2591650450","https://openalex.org/W2007484439","https://openalex.org/W2415787454","https://openalex.org/W2770517705","https://openalex.org/W2964820999","https://openalex.org/W2077512489","https://openalex.org/W7123947971","https://openalex.org/W2579518382"],"abstract_inverted_index":{"Lysine":[0],"decarboxylase":[1,27],"(LDC)":[2],"catalyzes":[3],"the":[4,7,70,85,105,116,153,185],"first-step":[5],"in":[6,35,69,100,123,158,184],"biosynthetic":[8],"pathway":[9],"of":[10,20,25,40,72,87,108,112,119,138,150,155,182],"quinolizidine":[11],"alkaloids":[12],"(QAs),":[13],"which":[14],"form":[15,64,162],"a":[16,65,109,171],"distinct,":[17],"large":[18],"family":[19,71],"plant":[21,73],"alkaloids.":[22],"A":[23],"cDNA":[24],"lysine/ornithine":[26],"(L/ODC)":[28],"was":[29,95],"isolated":[30],"by":[31,104],"differential":[32],"transcript":[33],"screening":[34],"QA-producing":[36,51,79,186],"and":[37,59,89,132,141,166],"nonproducing":[38],"cultivars":[39],"Lupinus":[41],"angustifolius.":[42],"We":[43],"also":[44],"obtained":[45],"L/ODC":[46,93,183],"cDNAs":[47],"from":[48,78],"four":[49],"other":[50],"plants,":[52],"Sophora":[53],"flavescens,":[54],"Echinosophora":[55],"koreensis,":[56],"Thermopsis":[57],"chinensis,":[58],"Baptisia":[60],"australis.":[61],"These":[62],"L/ODCs":[63,77],"phylogenetically":[66],"distinct":[67],"subclade":[68],"ornithine":[74],"decarboxylases.":[75],"Recombinant":[76],"plants":[80,144],"preferentially":[81],"or":[82],"equally":[83],"catalyzed":[84],"decarboxylation":[86,160],"L-lysine":[88],"L-ornithine.":[90],"L.":[91],"angustifolius":[92],"(La-L/ODC)":[94,146],"found":[96],"to":[97,115,161],"be":[98],"localized":[99],"chloroplasts,":[101],"as":[102],"suggested":[103],"transient":[106],"expression":[107],"fusion":[110],"protein":[111,122,167],"La-L/ODC":[113],"fused":[114],"N":[117],"terminus":[118],"green":[120],"fluorescent":[121],"Arabidopsis":[124,143],"thaliana.":[125],"Transgenic":[126],"tobacco":[127],"(Nicotiana":[128],"tabacum)":[129],"suspension":[130],"cells":[131],"hairy":[133],"roots":[134],"produced":[135,147],"enhanced":[136,148],"levels":[137,149],"cadaverine-derived":[139],"alkaloids,":[140],"transgenic":[142],"expressing":[145],"cadaverine,":[151],"indicating":[152],"involvement":[154],"this":[156],"enzyme":[157],"lysine":[159],"cadaverine.":[163],"Site-directed":[164],"mutagenesis":[165],"modeling":[168],"studies":[169],"revealed":[170],"structural":[172],"basis":[173],"for":[174],"preferential":[175],"LDC":[176],"activity,":[177],"suggesting":[178],"an":[179],"evolutionary":[180],"implication":[181],"plants.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}