{"id":"https://openalex.org/W2146166364","doi":"https://doi.org/10.1080/10601329409349743","title":"Release Behavior of 5-Fluorouracil from Chitosan-Gel Nanospheres Immobilizing 5-Fluorouracil Coated with Polysaccharides and Their Cell Specific Cytotoxicity","display_name":"Release Behavior of 5-Fluorouracil from Chitosan-Gel Nanospheres Immobilizing 5-Fluorouracil Coated with Polysaccharides and Their Cell Specific Cytotoxicity","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2146166364","doi":"https://doi.org/10.1080/10601329409349743","mag":"2146166364"},"language":"en","primary_location":{"id":"doi:10.1080/10601329409349743","doi":"https://doi.org/10.1080/10601329409349743","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10601329409349743","pdf_url":null,"source":{"id":"https://openalex.org/S4210184698","display_name":"Journal of Macromolecular Science Part A","issn_l":"1060-1325","issn":["1060-1325","1520-5738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Macromolecular Science, Part A","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2146166364"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011399496","display_name":"Yuichi Ohya","orcid":"https://orcid.org/0000-0002-8862-850X","observed_orcids":["https://orcid.org/0000-0002-8862-850X"]},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuichi Ohya","raw_affiliation_strings":["Department of Applied Chemistry Faculty of Engineering , Kansai University Suita , Osaka, 564, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry Faculty of Engineering , Kansai University Suita , Osaka, 564, Japan","institution_ids":["https://openalex.org/I56624758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042061168","display_name":"Masahiro Shiratani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiro Shiratani","raw_affiliation_strings":["Department of Applied Chemistry Faculty of Engineering , Kansai University Suita , Osaka, 564, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry Faculty of Engineering , Kansai University Suita , Osaka, 564, Japan","institution_ids":["https://openalex.org/I56624758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110406785","display_name":"Hironao Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hironao Kobayashi","raw_affiliation_strings":["Department of Applied Chemistry Faculty of Engineering , Kansai University Suita , Osaka, 564, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry Faculty of Engineering , Kansai University Suita , Osaka, 564, Japan","institution_ids":["https://openalex.org/I56624758"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110233259","display_name":"Tatsuro Ouchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56624758","display_name":"Kansai University","ror":"https://ror.org/03xg1f311","country_code":"JP","type":"education","lineage":["https://openalex.org/I56624758"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tatsuro Ouchi","raw_affiliation_strings":["Department of Applied Chemistry Faculty of Engineering , Kansai University Suita , Osaka, 564, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry Faculty of Engineering , Kansai University Suita , Osaka, 564, Japan","institution_ids":["https://openalex.org/I56624758"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I56624758"],"apc_list":null,"apc_paid":null,"fwci":1.5593,"has_fulltext":false,"cited_by_count":202,"citation_normalized_percentile":{"value":0.75191257,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"31","issue":"5","first_page":"629","last_page":"642"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.923799991607666,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.06920000165700912,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-fluorouracil","display_name":"5-fluorouracil","score":0.9570000171661377},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.8349999785423279},{"id":"https://openalex.org/keywords/polysaccharide-coatings","display_name":"polysaccharide coatings","score":0.7200000286102295},{"id":"https://openalex.org/keywords/sodium-hyaluronate","display_name":"sodium hyaluronate","score":0.7770000100135803},{"id":"https://openalex.org/keywords/glutaraldehyde-crosslinking","display_name":"glutaraldehyde crosslinking","score":0.9110000133514404},{"id":"https://openalex.org/keywords/hepatocyte-targeting","display_name":"hepatocyte targeting","score":0.7559999823570251},{"id":"https://openalex.org/keywords/galactosamine","display_name":"galactosamine","score":0.7429999709129333},{"id":"https://openalex.org/keywords/human-hepatoma-cells","display_name":"human hepatoma cells","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C2777529624","wikidata":"https://www.wikidata.org/wiki/Q416475","display_name":"Glutaraldehyde","level":2,"score":0.8597833514213562},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.8418364524841309},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.7297618985176086},{"id":"https://openalex.org/C2781088250","wikidata":"https://www.wikidata.org/wiki/Q161219","display_name":"Chitin","level":3,"score":0.6704255938529968},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5507742166519165},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5122250914573669},{"id":"https://openalex.org/C153356533","wikidata":"https://www.wikidata.org/wiki/Q901016","display_name":"Polyelectrolyte","level":3,"score":0.508655846118927},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.43894559144973755},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.43657582998275757},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.41445720195770264},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32117384672164917},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.17819783091545105},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/10601329409349743","doi":"https://doi.org/10.1080/10601329409349743","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10601329409349743","pdf_url":null,"source":{"id":"https://openalex.org/S4210184698","display_name":"Journal of Macromolecular Science Part A","issn_l":"1060-1325","issn":["1060-1325","1520-5738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Macromolecular Science, Part A","raw_type":"journal-article"},{"id":"doi:10.1080/10601329408545334","doi":"https://doi.org/10.1080/10601329408545334","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10601329408545334","pdf_url":null,"source":{"id":"https://openalex.org/S4210184698","display_name":"Journal of Macromolecular Science Part A","issn_l":"1060-1325","issn":["1060-1325","1520-5738"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Macromolecular Science, Part A","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1496677692","https://openalex.org/W1500048896","https://openalex.org/W1516811814","https://openalex.org/W1558104881","https://openalex.org/W1565909178","https://openalex.org/W1658581991","https://openalex.org/W1966596114","https://openalex.org/W1973840814","https://openalex.org/W1982611833","https://openalex.org/W1989971319","https://openalex.org/W2008014078","https://openalex.org/W2018276955","https://openalex.org/W2049353143","https://openalex.org/W2068566312","https://openalex.org/W2085634338","https://openalex.org/W2098865263","https://openalex.org/W2101086611","https://openalex.org/W2151043432","https://openalex.org/W2165157870","https://openalex.org/W2314011505"],"related_works":["https://openalex.org/W2101086611","https://openalex.org/W2107143012","https://openalex.org/W2056300960","https://openalex.org/W3017019992","https://openalex.org/W871257650","https://openalex.org/W1600620287","https://openalex.org/W2141318937","https://openalex.org/W2377298211","https://openalex.org/W7162878555"],"abstract_inverted_index":{"Small-sized":[0],"chitosan-gel":[1],"nanospheres,":[2],"CNSs":[3,42,50,108],"(average":[4],"diameter":[5],"250":[6],"nm),":[7],"containing":[8],"5-fluorouracil":[9],"(5FU)":[10],"or":[11,16],"immobilizing":[12],"5FU":[13,36,97,105],"derivatives":[14,37],"(aminopentyl-carbamoyl-5FU":[15],"aminopentyl-ester-methylene-5FU)":[17],"were":[18,38,51],"prepared":[19],"by":[20,43,98,112,167],"the":[21,26,90,99,107,142,146,155,163,168,176,181],"glutaraldehyde":[22],"crosslinking":[23],"technique":[24],"and":[25,62,78,93,122,186],"emulsion":[27],"method.":[28],"When":[29],"chitosan":[30,120],"was":[31,86],"crosslinked":[32],"with":[33,53,124,138],"glutaraldehyde,":[34],"these":[35],"simultaneously":[39],"immobilized":[40],"to":[41,72,88,133,136,152],"means":[44],"of":[45,67,84,96,104,114,117,119,148,170,184],"Schiff's":[46],"base":[47],"formation.":[48],"The":[49,81,101,160],"coated":[52],"anionic":[54],"polysaccharides,":[55],"such":[56],"as":[57,154],"6-O-carboxymethyl-N-acetyl-\u03b1-l,4-polygalactosamine/Na":[58],"(CM-NAPGA/Na),":[59],"6-O-carboxymethyl-chitin/Na":[60],"(CM-chitin/Na),":[61],"sodium":[63],"hyaluronate,":[64],"through":[65],"formation":[66],"a":[68],"polyelectrolyte":[69,82],"complex":[70,83],"membrane":[71],"give":[73],"CNS/polyanion,":[74],"i.e.,":[75],"CNS/G,":[76],"CNS/C,":[77],"CNS/H,":[79],"respectively.":[80],"polysaccharide":[85],"employed":[87],"achieve":[89],"controlled":[91,111],"release":[92,102],"effective":[94],"targeting":[95,156],"CNSs.":[100],"rate":[103],"from":[106],"could":[109],"be":[110,134],"immobilization":[113],"5FU,":[115],"degree":[116],"deacetylation":[118],"used":[121],"coating":[123],"polysaccharides.":[125],"Since":[126],"very":[127],"few":[128],"galactosamine":[129,143],"residues":[130,144],"are":[131,150],"known":[132],"able":[135],"cross-react":[137],"ligands":[139],"for":[140,158],"galactose,":[141],"on":[145],"surface":[147],"CNS/Gs":[149],"expected":[151],"act":[153],"moieties":[157],"hepatocyte.":[159],"CNS/G":[161,174],"showed":[162],"lectinmediated":[164],"aggregation":[165],"phenomenon":[166],"addition":[169],"APA":[171],"lectin.":[172],"Moreover,":[173],"had":[175],"highest":[177],"cytotoxic":[178],"activity":[179],"among":[180],"three":[182],"kinds":[183],"CNS/polyanion":[185],"CNS":[187],"in":[188,195],"HLE":[189],"human":[190],"hepatoma":[191],"cell":[192],"culture":[193],"system":[194],"vitro.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
