{"id":"https://openalex.org/W2146094598","doi":"https://doi.org/10.1158/1535-7163.mct-11-0490","title":"Cooperation between c-Met and Focal Adhesion Kinase Family Members in Medulloblastoma and Implications for Therapy","display_name":"Cooperation between c-Met and Focal Adhesion Kinase Family Members in Medulloblastoma and Implications for Therapy","publication_year":2011,"publication_date":"2011-12-21","ids":{"openalex":"https://openalex.org/W2146094598","doi":"https://doi.org/10.1158/1535-7163.mct-11-0490","mag":"2146094598","pmid":"https://pubmed.ncbi.nlm.nih.gov/22188814","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3277676"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.mct-11-0490","doi":"https://doi.org/10.1158/1535-7163.mct-11-0490","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-11-0490","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3277676","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012671751","display_name":"Fadila Guessous","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fadila Guessous","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","Pfizer Oncology Research Unit, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080914162","display_name":"Yanzhi Yang","orcid":"https://orcid.org/0000-0001-5128-7054","observed_orcids":["https://orcid.org/0000-0001-5128-7054"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanzhi Yang","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","Pfizer Oncology Research Unit, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032019716","display_name":"Elizabeth K. Johnson","orcid":"https://orcid.org/0009-0003-1216-9110","observed_orcids":["https://orcid.org/0009-0003-1216-9110"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Johnson","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","Pfizer Oncology Research Unit, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091073839","display_name":"Lukasz Marcinkiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lukasz Marcinkiewicz","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","Pfizer Oncology Research Unit, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105784284","display_name":"Matthew R. Smith","orcid":"https://orcid.org/0009-0003-9463-0010","observed_orcids":["https://orcid.org/0009-0003-9463-0010"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Smith","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","Pfizer Oncology Research Unit, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100386105","display_name":"Ying Zhang","orcid":"https://orcid.org/0000-0002-2675-9213","observed_orcids":["https://orcid.org/0000-0002-2675-9213"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","Pfizer Oncology Research Unit, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075504455","display_name":"Alexander V. Kofman","orcid":"https://orcid.org/0000-0002-8491-2407","observed_orcids":["https://orcid.org/0000-0002-8491-2407"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Kofman","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","Pfizer Oncology Research Unit, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023905352","display_name":"David Schiff","orcid":"https://orcid.org/0000-0002-1896-2502","observed_orcids":["https://orcid.org/0000-0002-1896-2502","https://orcid.org/0000-0003-1561-9220"]},"institutions":[{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Schiff","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074923974","display_name":"James G. Christensen","orcid":"https://orcid.org/0000-0003-1835-0335","observed_orcids":["https://orcid.org/0000-0003-1835-0335"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Christensen","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","Pfizer Oncology Research Unit, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]},{"raw_affiliation_string":"Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044442671","display_name":"Roger Abounader","orcid":"https://orcid.org/0000-0003-4075-9460","observed_orcids":["https://orcid.org/0000-0003-4075-9460"]},"institutions":[{"id":"https://openalex.org/I4390039272","display_name":"University of Virginia Cancer Center","ror":"https://ror.org/04w75nz84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039272"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Roger Abounader","raw_affiliation_strings":["Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations: Departments of 1Microbiology and 2Neurology, 3Cancer Center, University of Virginia, Charlottesville, Virginia; and 4Pfizer Oncology Research Unit, La Jolla, California","institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5044442671"],"corresponding_institution_ids":["https://openalex.org/I4390039272","https://openalex.org/I51556381"],"apc_list":null,"apc_paid":null,"fwci":0.4916,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.6908467,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"11","issue":"2","first_page":"288","last_page":"297"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.02930000051856041,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.8519999980926514},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pyk2","display_name":"Pyk2","score":0.984000027179718},{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.6690000295639038},{"id":"https://openalex.org/keywords/kinase-inhibitor-combination-therapy","display_name":"kinase inhibitor combination therapy","score":0.722000002861023},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.49799999594688416},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6899999976158142},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.671999990940094},{"id":"https://openalex.org/keywords/non-receptor-tyrosine-kinase","display_name":"non-receptor tyrosine kinase","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.9810076951980591},{"id":"https://openalex.org/C151166631","wikidata":"https://www.wikidata.org/wiki/Q904514","display_name":"Focal adhesion","level":3,"score":0.7617491483688354},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7053148746490479},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.6783427596092224},{"id":"https://openalex.org/C108391706","wikidata":"https://www.wikidata.org/wiki/Q15333532","display_name":"PTK2","level":5,"score":0.5278727412223816},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4735126793384552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3971810042858124},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.3543711304664612},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34857693314552307},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2481546700000763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2464596927165985},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16520962119102478},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.07897302508354187},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000077547","descriptor_name":"Crizotinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008527","descriptor_name":"Medulloblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015363","descriptor_name":"Quinolones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040081","descriptor_name":"Protein Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051417","descriptor_name":"Focal Adhesion Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051418","descriptor_name":"Focal Adhesion Kinase 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051418","descriptor_name":"Focal Adhesion Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051418","descriptor_name":"Focal Adhesion Kinase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1158/1535-7163.mct-11-0490","doi":"https://doi.org/10.1158/1535-7163.mct-11-0490","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.mct-11-0490","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},{"id":"pmid:22188814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22188814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2558063","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3277676","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3277676","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3277676","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Mol Cancer Ther","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2558063","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3277676","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1539784606","display_name":"Molecular interactions and restoration strategies of PTEN and p53 in gliomas","funder_award_id":"R01CA134843","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1989192761","display_name":"Novel RTK Targeting Strategies in Glioblastoma","funder_award_id":"R01NS045209","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W71738449","https://openalex.org/W145615813","https://openalex.org/W1520567777","https://openalex.org/W1979108161","https://openalex.org/W1996679013","https://openalex.org/W1996816252","https://openalex.org/W2012498136","https://openalex.org/W2014238399","https://openalex.org/W2018956956","https://openalex.org/W2023894531","https://openalex.org/W2025880272","https://openalex.org/W2025920788","https://openalex.org/W2034246730","https://openalex.org/W2038056960","https://openalex.org/W2047198790","https://openalex.org/W2065088072","https://openalex.org/W2076022561","https://openalex.org/W2077403190","https://openalex.org/W2080664438","https://openalex.org/W2085442006","https://openalex.org/W2088626912","https://openalex.org/W2092777351","https://openalex.org/W2096844786","https://openalex.org/W2117293305","https://openalex.org/W2126890008","https://openalex.org/W2136390065","https://openalex.org/W2140506935","https://openalex.org/W2143445068","https://openalex.org/W2147674012","https://openalex.org/W2158196548","https://openalex.org/W2158769524","https://openalex.org/W2166927748","https://openalex.org/W2171179595","https://openalex.org/W2314640709"],"related_works":["https://openalex.org/W2328598650","https://openalex.org/W2046755327","https://openalex.org/W3203437735","https://openalex.org/W2997598382","https://openalex.org/W4402838030","https://openalex.org/W7095927206","https://openalex.org/W7044689647","https://openalex.org/W4407254041","https://openalex.org/W2310066925","https://openalex.org/W2012498136"],"abstract_inverted_index":{"We":[0,63,78,91,162],"previously":[1],"showed":[2],"the":[3,6,28,66,99,112,130,141,168,246],"involvement":[4],"of":[5,30,102,114,132,147,152,171,197],"tyrosine":[7,16],"kinase":[8,20,160],"receptor":[9],"c-Met":[10,54,69,81,103,121,156,195,210,240],"in":[11,27,36,60,86,167,204,233],"medulloblastoma":[12,37,61,76,88,105,133,144,153,175,200,221,234,259],"malignancy.":[13,134],"The":[14],"nonreceptor":[15],"kinases":[17],"focal":[18],"adhesion":[19],"(FAK)":[21],"and":[22,57,70,72,84,96,109,122,157,178,231,241,243,251],"Pyk2":[23,58,85,97,232],"are":[24],"key":[25],"players":[26],"progression":[29],"different":[31],"cancers.":[32],"However,":[33],"their":[34,73],"role":[35,228],"malignancy":[38,145],"is":[39],"not":[40],"well":[41],"understood.":[42],"In":[43,189],"this":[44,137],"study,":[45],"using":[46],"a":[47,164,216,227,255],"protein":[48],"array":[49],"approach,":[50],"we":[51,117,139],"found":[52,79,93,163],"that":[53,80,94,119],"induces":[55],"FAK":[56,83,95,123,158,213,230],"phosphorylation":[59],"cells.":[62],"therefore":[64],"studied":[65],"interactions":[67,238],"between":[68,239],"FAK/Pyk2":[71],"implications":[74],"for":[75,220,229,245,258],"therapy.":[77,222,260],"activates":[82],"several":[87],"cell":[89,106,176,179],"lines.":[90],"also":[92],"mediate":[98],"malignant":[100],"effects":[101,128,142],"on":[104,129,143,174],"proliferation,":[107],"migration,":[108],"invasion.":[110],"On":[111],"basis":[113],"these":[115],"findings,":[116],"hypothesized":[118],"combined":[120,150],"inhibitions":[124,185],"would":[125],"have":[126],"additive":[127],"inhibition":[131],"To":[135],"test":[136],"hypothesis,":[138],"assessed":[140],"parameters":[146],"single":[148,184],"or":[149],"treatments":[151],"cells":[154],"with":[155,183,194,212],"small-molecule":[159],"inhibitors.":[161],"significant":[165],"increase":[166],"inhibitory":[169],"effect":[170],"both":[172],"inhibitors":[173,211,214,253],"migration":[177],"invasion":[180],"as":[181,254],"compared":[182],"(P":[186],"<":[187],"0.05).":[188],"addition,":[190],"oral":[191],"gavage":[192],"treatment":[193],"inhibitor":[196],"mice":[198],"bearing":[199],"xenografts":[201],"significantly":[202],"reduced":[203],"vivo":[205],"tumor":[206],"growth.":[207],"Therefore,":[208],"combining":[209,249],"constitutes":[215],"new":[217,237,256],"potential":[218],"strategy":[219,257],"Altogether,":[223],"our":[224],"study":[225],"describes":[226],"malignancy,":[235],"uncovers":[236],"FAK/Pyk2,":[242],"proposes":[244],"first":[247],"time":[248],"anti-c-Met":[250],"anti-FAK":[252]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}