{"id":"https://openalex.org/W2146038779","doi":null,"title":"Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma.","display_name":"Loss of imprinting and elevated expression of wild-type p73 in human gastric adenocarcinoma.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2146038779","mag":"2146038779","pmid":"https://pubmed.ncbi.nlm.nih.gov/10815895"},"language":"en","primary_location":{"id":"pmid:10815895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10815895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073039727","display_name":"Min Ju Kang","orcid":"https://orcid.org/0000-0001-5040-1388","observed_orcids":["https://orcid.org/0000-0001-5040-1388"]},"institutions":[{"id":"https://openalex.org/I35928602","display_name":"Kyung Hee University","ror":"https://ror.org/01zqcg218","country_code":"KR","type":"education","lineage":["https://openalex.org/I35928602"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"M J Kang","raw_affiliation_strings":["Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. sgchi@nms.kyunghee.ac.Kr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. sgchi@nms.kyunghee.ac.Kr","institution_ids":["https://openalex.org/I35928602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069665291","display_name":"Bum-Joon Park","orcid":"https://orcid.org/0000-0002-6037-7219","observed_orcids":["https://orcid.org/0000-0002-6037-7219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B J Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111890638","display_name":"Do-Sun Byun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D S Byun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029966999","display_name":"Jae\u2010Il Park","orcid":"https://orcid.org/0000-0002-0737-2654","observed_orcids":["https://orcid.org/0000-0002-0737-2654"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J I Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046710765","display_name":"Heung\u2010Joong Kim","orcid":"https://orcid.org/0000-0003-1636-3669","observed_orcids":["https://orcid.org/0000-0003-1636-3669"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H J Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029214767","display_name":"Jae\u2010Hak Park","orcid":"https://orcid.org/0000-0002-4971-4640","observed_orcids":["https://orcid.org/0000-0002-4971-4640"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110249914","display_name":"S G Chi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S G Chi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7727,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.9068204,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"6","issue":"5","first_page":"1767","last_page":"71"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.5083000063896179,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.4496999979019165,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p73","display_name":"p73","score":0.9480000138282776},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.871999979019165},{"id":"https://openalex.org/keywords/genomic-imprinting","display_name":"genomic imprinting","score":0.8629999756813049},{"id":"https://openalex.org/keywords/loss-of-imprinting","display_name":"loss of imprinting","score":0.9049999713897705},{"id":"https://openalex.org/keywords/allelotype","display_name":"allelotype","score":0.5400000214576721},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":0.8740000128746033},{"id":"https://openalex.org/keywords/serum-deprivation","display_name":"serum deprivation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-hypoxia","display_name":"tumor hypoxia","score":0.6349999904632568},{"id":"https://openalex.org/keywords/nutrient-starvation","display_name":"nutrient deprivation","score":0.8650000095367432},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.722000002861023},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9200000166893005},{"id":"https://openalex.org/keywords/gastric-carcinogenesis","display_name":"gastric carcinogenesis","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7968755960464478},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.723864734172821},{"id":"https://openalex.org/C200544954","wikidata":"https://www.wikidata.org/wiki/Q516389","display_name":"Penetrance","level":4,"score":0.6763899326324463},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6553480625152588},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5557102560997009},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5175249576568604},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.5078125596046448},{"id":"https://openalex.org/C201492766","wikidata":"https://www.wikidata.org/wiki/Q84087","display_name":"Genomic imprinting","level":5,"score":0.5064119100570679},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.43912574648857117},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3708410859107971},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3205256760120392},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.12791302800178528},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.11931955814361572}],"mesh":[{"descriptor_ui":"D000072160","descriptor_name":"Tumor Protein p73","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077209","descriptor_name":"Decitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018392","descriptor_name":"Genomic Imprinting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018807","descriptor_name":"Polymorphism, Single-Stranded Conformational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020298","descriptor_name":"U937 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10815895","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10815895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2146038779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10815895","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1528203329","https://openalex.org/W1548270835","https://openalex.org/W1577731619","https://openalex.org/W1600735289","https://openalex.org/W1675096266","https://openalex.org/W1939117974","https://openalex.org/W1943845680","https://openalex.org/W1981548290","https://openalex.org/W1985064409","https://openalex.org/W2020408434","https://openalex.org/W2075621444","https://openalex.org/W2112410112","https://openalex.org/W2118102989","https://openalex.org/W2118815793","https://openalex.org/W2126787895","https://openalex.org/W2164712283","https://openalex.org/W2274359797","https://openalex.org/W2312368952","https://openalex.org/W2333707271"],"related_works":["https://openalex.org/W2375516016","https://openalex.org/W1964620315","https://openalex.org/W2378405996","https://openalex.org/W2352663596","https://openalex.org/W2035764656","https://openalex.org/W2351082606","https://openalex.org/W2014614848","https://openalex.org/W2362482741","https://openalex.org/W2028469579","https://openalex.org/W2367838011"],"abstract_inverted_index":{"The":[0],"p73":[1,20,32,45,64,79,112,184,204,220],"gene":[2,176],"located":[3],"at":[4],"1p36.3":[5],"encodes":[6],"for":[7],"a":[8,60,75,92,119,123,150,154,207],"protein":[9],"with":[10,147,153,186,228],"significant":[11,61],"similarity":[12],"to":[13],"p53.":[14],"To":[15],"investigate":[16],"the":[17,26,115,128,144,162,168,175,187],"penetrance":[18],"of":[19,31,44,56,63,69,78,84,100,107,118,125,130,143,157,167,174,183,190,194,209,219,230],"in":[21,33,49,67,82,122,212],"gastric":[22,52,213],"carcinogenesis,":[23],"we":[24],"analyzed":[25],"expression,":[27],"allelotype,":[28],"and":[29,37,54,165,180,215],"mutation":[30,173],"five":[34,57],"cell":[35,58],"lines":[36],"75":[38],"tissues.":[39,73],"Although":[40],"extremely":[41],"low":[42],"levels":[43],"expression":[46,185,193],"were":[47],"observed":[48],"all":[50],"noncancerous":[51,109],"tissues":[53],"four":[55],"lines,":[59],"elevation":[62],"was":[65,80,134,177,196],"detected":[66],"37":[68],"39":[70],"(94.9%)":[71],"carcinoma":[72],"Furthermore,":[74],"tumor-specific":[76],"increase":[77],"identified":[81],"14":[83],"16":[85],"(87.5%)":[86],"matched":[87],"sets.":[88],"Allelotyping":[89],"analysis":[90],"using":[91],"StyI":[93],"or":[94,140,172,192,235],"BanI":[95],"polymorphism":[96],"revealed":[97],"that":[98,203,217],"5":[99],"21":[101],"(23.8%)":[102],"informative":[103],"carcinomas,":[104],"but":[105],"none":[106],"19":[108],"cases,":[110],"express":[111],"biallelically,":[113],"suggesting":[114],"transcriptional":[116],"activation":[117],"silent":[120,151],"allele":[121,133,152],"subset":[124],"cancers.":[126],"Whereas":[127],"transcription":[129],"an":[131,158],"active":[132,159],"markedly":[135],"induced":[136],"by":[137,224],"serum":[138],"starvation":[139],"clump":[141],"formation":[142],"cells,":[145],"treatment":[146],"5-aza-2'deoxycytidine":[148],"activated":[149],"subsequent":[155],"up-regulation":[156],"allele,":[160],"supporting":[161],"genomic":[163],"imprinting":[164],"autoregulation":[166],"gene.":[169],"Allelic":[170],"deletion":[171],"not":[178,206],"found,":[179],"no":[181],"association":[182],"mutational":[188],"status":[189],"p53":[191],"p21Waf1":[195],"recognized.":[197],"Taken":[198],"together,":[199],"this":[200],"study":[201],"argues":[202],"is":[205],"target":[208],"genetic":[210],"alteration":[211],"carcinogenesis":[214],"suggests":[216],"overexpression":[218],"might":[221],"be":[222],"triggered":[223],"physiological":[225],"stresses":[226],"accompanied":[227],"outgrowth":[229],"tumors,":[231],"such":[232],"as":[233],"hypoxia":[234],"nutrient":[236],"deprivation.":[237]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
