{"id":"https://openalex.org/W2146016509","doi":"https://doi.org/10.1158/0008-5472.can-12-3175","title":"A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation","display_name":"A Novel Inhibitor of STAT3 Homodimerization Selectively Suppresses STAT3 Activity and Malignant Transformation","publication_year":2013,"publication_date":"2013-01-16","ids":{"openalex":"https://openalex.org/W2146016509","doi":"https://doi.org/10.1158/0008-5472.can-12-3175","mag":"2146016509","pmid":"https://pubmed.ncbi.nlm.nih.gov/23322008","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4030628"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.can-12-3175","doi":"https://doi.org/10.1158/0008-5472.can-12-3175","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-12-3175","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC4030628","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061809819","display_name":"Xiaolei Zhang","orcid":"https://orcid.org/0000-0003-2395-2453","observed_orcids":["https://orcid.org/0000-0003-2395-2453"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaolei Zhang","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031793941","display_name":"Ying Sun","orcid":"https://orcid.org/0000-0002-1720-8540","observed_orcids":["https://orcid.org/0000-0002-1720-8540"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Sun","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000278449","display_name":"Roberta Pireddu","orcid":"https://orcid.org/0000-0003-2322-2346","observed_orcids":["https://orcid.org/0000-0003-2322-2346"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberta Pireddu","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076875770","display_name":"Hua Yang","orcid":"https://orcid.org/0000-0003-1833-9515","observed_orcids":["https://orcid.org/0000-0003-1833-9515"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hua Yang","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005785768","display_name":"Murali K. Urlam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Murali K. Urlam","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057921101","display_name":"Harshani R. Lawrence","orcid":"https://orcid.org/0000-0002-9263-7775","observed_orcids":["https://orcid.org/0000-0002-9263-7775"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harshani R. Lawrence","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061379138","display_name":"Wayne C. Guida","orcid":"https://orcid.org/0000-0003-3353-4853","observed_orcids":["https://orcid.org/0000-0003-3353-4853"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wayne C. Guida","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027503793","display_name":"Nicholas J. Lawrence","orcid":"https://orcid.org/0000-0003-1129-2558","observed_orcids":["https://orcid.org/0000-0003-1129-2558"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas J. Lawrence","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103060677","display_name":"Sa\u0131\u0308d M. Sebti","orcid":"https://orcid.org/0000-0001-5163-1038","observed_orcids":["https://orcid.org/0000-0001-5163-1038"]},"institutions":[{"id":"https://openalex.org/I2613432","display_name":"University of South Florida","ror":"https://ror.org/032db5x82","country_code":"US","type":"education","lineage":["https://openalex.org/I2613432"]},{"id":"https://openalex.org/I3019308854","display_name":"Moffitt Cancer Center","ror":"https://ror.org/01xf75524","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I3019308854"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sa\u00efd M. Sebti","raw_affiliation_strings":["Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Department of Drug Discovery, H. Lee Moffitt Cancer Center and Research Institute; Departments of 2Oncologic Sciences, 3Molecular Medicine, and 4Chemistry, University of South Florida, Tampa, Florida","institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5103060677"],"corresponding_institution_ids":["https://openalex.org/I2613432","https://openalex.org/I3019308854"],"apc_list":null,"apc_paid":null,"fwci":6.4786,"has_fulltext":false,"cited_by_count":146,"citation_normalized_percentile":{"value":0.97395163,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"73","issue":"6","first_page":"1922","last_page":"1933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9459999799728394},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.8379999995231628},{"id":"https://openalex.org/keywords/tyrosine-705-phosphorylation","display_name":"tyrosine 705 phosphorylation","score":0.8370000123977661},{"id":"https://openalex.org/keywords/sh2-domain","display_name":"SH2 domain","score":0.9210000038146973},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/egfr-binding","display_name":"EGFR binding","score":0.6759999990463257},{"id":"https://openalex.org/keywords/stat3-target-genes","display_name":"STAT3 target genes","score":0.6230000257492065},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.8619999885559082},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.7480000257492065},{"id":"https://openalex.org/keywords/cancer-cell-growth","display_name":"cancer cell growth","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5372197031974792},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5361888408660889},{"id":"https://openalex.org/C199835354","wikidata":"https://www.wikidata.org/wiki/Q15311861","display_name":"Cyclin D1","level":4,"score":0.5046981573104858},{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.4969501793384552},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.4325949251651764},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4265597462654114},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4190783202648163},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.410235196352005},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3562108874320984},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34955355525016785},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22457268834114075},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1887529194355011},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.14187902212142944}],"mesh":[{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005454","descriptor_name":"Fluorescence Polarization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1158/0008-5472.can-12-3175","doi":"https://doi.org/10.1158/0008-5472.can-12-3175","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.can-12-3175","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},{"id":"pmid:23322008","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23322008","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3005382","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4030628","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4030628","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4030628","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3005382","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC4030628","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7014006031","display_name":"Targeting STAT3 as a novel approach to cancer therapy","funder_award_id":"R01CA140681","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7584671513","display_name":"TARGETED INTERVENTION OF BREAST ONCOGENIC PATHWAYS","funder_award_id":"R01CA098473","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000876523","display_name":"Moffitt Cancer Center Support Grant","funder_award_id":"P30CA076292","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1495457417","https://openalex.org/W1548640328","https://openalex.org/W1553166169","https://openalex.org/W1917630072","https://openalex.org/W1981799488","https://openalex.org/W1986283895","https://openalex.org/W1987487419","https://openalex.org/W2004029306","https://openalex.org/W2007840001","https://openalex.org/W2010169031","https://openalex.org/W2016135485","https://openalex.org/W2029275361","https://openalex.org/W2029638319","https://openalex.org/W2032674547","https://openalex.org/W2033768738","https://openalex.org/W2044227662","https://openalex.org/W2046265191","https://openalex.org/W2058792197","https://openalex.org/W2068406274","https://openalex.org/W2074356752","https://openalex.org/W2085007453","https://openalex.org/W2087173163","https://openalex.org/W2097565074","https://openalex.org/W2117525838","https://openalex.org/W2139520473","https://openalex.org/W2152637502","https://openalex.org/W2799941631","https://openalex.org/W6633190146","https://openalex.org/W6639763190","https://openalex.org/W6646816969"],"related_works":["https://openalex.org/W1997814360","https://openalex.org/W2130644579","https://openalex.org/W2980903182","https://openalex.org/W7043522003","https://openalex.org/W2029638319","https://openalex.org/W6996862497","https://openalex.org/W7052980668","https://openalex.org/W2230354098","https://openalex.org/W2117525838","https://openalex.org/W2223029608"],"abstract_inverted_index":{"STAT3-STAT3":[0,39,214],"dimerization,":[1,40],"which":[2,116,181],"involves":[3],"reciprocal":[4],"binding":[5,71,98],"of":[6,25,37,103,126,135,147,177,191,204,218],"the":[7,57,61,124,144,202],"STAT3-SH2":[8],"domain":[9,63],"to":[10,72],"phosphorylated":[11],"tyrosine-705":[12],"(Y-705),":[13],"is":[14],"required":[15],"for":[16],"STAT3":[17,78,81,92,120,127,148,192,221],"nuclear":[18,133],"translocation,":[19],"DNA":[20],"binding,":[21,138],"and":[22,42,49,64,79,82,86,94,130,139,142,160,171,175,222],"transcriptional":[23,140],"regulation":[24],"downstream":[26],"target":[27,149],"genes.":[28],"Here,":[29],"we":[30,208],"describe":[31],"a":[32,111,187,195,213],"small":[33],"molecule":[34],"S3I-1757":[35,54,90,108,205,211],"capable":[36,217],"disrupting":[38],"activation,":[41],"malignant":[43,224],"transforming":[44],"activity.":[45],"Fluorescence":[46],"polarization":[47],"assay":[48],"molecular":[50],"modeling":[51],"suggest":[52],"that":[53,89,193,230],"interacts":[55],"with":[56,107],"phospho-Y-705-binding":[58],"site":[59],"in":[60,99,226],"SH2":[62],"displaces":[65],"fluorescein-labeled":[66],"GpYLPQTV":[67],"phosphotyrosine":[68],"peptide":[69],"from":[70,201],"STAT3.":[73,184,233],"We":[74],"generated":[75],"hemagglutinin":[76],"(HA)-tagged":[77],"FLAG-tagged":[80],"showed":[83],"using":[84],"coimmunoprecipitation":[85],"colocalization":[87],"studies":[88],"inhibits":[91,122,169],"dimerization":[93,215],"STAT3-EGF":[95],"receptor":[96],"(EGFR)":[97],"intact":[100],"cells.":[101],"Treatment":[102],"human":[104,178,227],"cancer":[105,179,228],"cells":[106,200,229],"(but":[109],"not":[110,118,167],"closely":[112],"related":[113],"analog,":[114],"S3I-1756,":[115,168],"does":[117],"inhibit":[119],"dimerization),":[121],"selectively":[123],"phosphorylation":[125],"over":[128],"AKT1":[129],"ERK1/2":[131],"(MAPK3/1),":[132],"accumulation":[134],"P-Y705-STAT3,":[136],"STAT3-DNA":[137],"activation":[141],"suppresses":[143],"expression":[145],"levels":[146],"genes,":[150],"such":[151],"as":[152,212],"Bcl-xL":[153],"(BCL2L1),":[154],"survivin":[155],"(BIRC5),":[156],"cyclin":[157],"D1":[158],"(CCND1),":[159],"matrix":[161],"metalloproteinase":[162],"(MMP)-9.":[163],"Furthermore,":[164],"S3I-1757,":[165],"but":[166],"anchorage-dependent":[170],"-independent":[172],"growth,":[173],"migration,":[174],"invasion":[176],"cells,":[180],"depend":[182,231],"on":[183,232],"Finally,":[185],"STAT3-C,":[186],"genetically":[188],"engineered":[189],"mutant":[190],"forms":[194],"constitutively":[196],"dimerized":[197],"STAT3,":[198],"rescues":[199],"effects":[203],"inhibition.":[206],"Thus,":[207],"have":[209],"developed":[210],"inhibitor":[216],"blocking":[219],"hyperactivated":[220],"suppressing":[223],"transformation":[225]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}