{"id":"https://openalex.org/W2145997121","doi":"https://doi.org/10.1371/journal.pone.0069223","title":"Deep Tissue Injury in Development of Pressure Ulcers: A Decrease of Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load","display_name":"Deep Tissue Injury in Development of Pressure Ulcers: A Decrease of Inflammasome Activation and Changes in Human Skin Morphology in Response to Aging and Mechanical Load","publication_year":2013,"publication_date":"2013-08-14","ids":{"openalex":"https://openalex.org/W2145997121","doi":"https://doi.org/10.1371/journal.pone.0069223","mag":"2145997121","pmid":"https://pubmed.ncbi.nlm.nih.gov/23967056","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3743891"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0069223","doi":"https://doi.org/10.1371/journal.pone.0069223","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0069223","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0069223&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0069223&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055229535","display_name":"Olivera Stojadinovi\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210101935","display_name":"University of Miami Health System","ror":"https://ror.org/00zw9nc64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivera Stojadinovic","raw_affiliation_strings":["Department of Dermatology & Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller Medical School, Miami, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology & Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller Medical School, Miami, Florida, United States of America","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005037375","display_name":"Julia Minkiewicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Minkiewicz","raw_affiliation_strings":["Department of Physiology & Biophysics, University of Miami Miller Medical School, Miami, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology & Biophysics, University of Miami Miller Medical School, Miami, Florida, United States of America","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012558330","display_name":"Andrew Phillip Sawaya","orcid":"https://orcid.org/0000-0002-4675-3919","observed_orcids":["https://orcid.org/0000-0002-4675-3919"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210101935","display_name":"University of Miami Health System","ror":"https://ror.org/00zw9nc64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Sawaya","raw_affiliation_strings":["Department of Dermatology & Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller Medical School, Miami, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology & Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller Medical School, Miami, Florida, United States of America","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073586417","display_name":"Jonathan W. Bourne","orcid":"https://orcid.org/0000-0003-3297-0135","observed_orcids":["https://orcid.org/0000-0003-3297-0135"]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan W. Bourne","raw_affiliation_strings":["Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, New York, United States of America","institution_ids":["https://openalex.org/I1281539108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001897843","display_name":"Peter A. Torzilli","orcid":"https://orcid.org/0000-0003-2054-8332","observed_orcids":["https://orcid.org/0000-0003-2054-8332"]},"institutions":[{"id":"https://openalex.org/I1281539108","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1281539108"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Torzilli","raw_affiliation_strings":["Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, New York, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York, New York, United States of America","institution_ids":["https://openalex.org/I1281539108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065360220","display_name":"Juan Pablo de Rivero Vaccari","orcid":"https://orcid.org/0000-0002-5460-8834","observed_orcids":["https://orcid.org/0000-0002-5460-8834"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Pablo de Rivero Vaccari","raw_affiliation_strings":["Departments of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011373172","display_name":"W. Dalton Dietrich","orcid":"https://orcid.org/0000-0002-8732-4942","observed_orcids":["https://orcid.org/0000-0002-8732-4942"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Dalton Dietrich","raw_affiliation_strings":["Departments of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurological Surgery, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida, United States of America","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045688399","display_name":"Robert W. Keane","orcid":"https://orcid.org/0000-0003-4068-9511","observed_orcids":["https://orcid.org/0000-0003-4068-9511"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Keane","raw_affiliation_strings":["Department of Physiology & Biophysics, University of Miami Miller Medical School, Miami, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology & Biophysics, University of Miami Miller Medical School, Miami, Florida, United States of America","institution_ids":["https://openalex.org/I145608581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068471387","display_name":"Marjana Tomic\u2010Canic","orcid":"https://orcid.org/0000-0002-9341-0193","observed_orcids":["https://orcid.org/0000-0002-9341-0193"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I4210101935","display_name":"University of Miami Health System","ror":"https://ror.org/00zw9nc64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marjana Tomic-Canic","raw_affiliation_strings":["Department of Dermatology & Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller Medical School, Miami, Florida, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology & Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller Medical School, Miami, Florida, United States of America","institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210101935"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068471387"],"corresponding_institution_ids":["https://openalex.org/I145608581","https://openalex.org/I4210101935"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":7.3934,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.97756543,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"8","first_page":"e69223","last_page":"e69223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11670","display_name":"Pressure Ulcer Prevention and Management","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11670","display_name":"Pressure Ulcer Prevention and Management","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pressure-ulcers","display_name":"pressure ulcers","score":0.972000002861023},{"id":"https://openalex.org/keywords/deep-tissue-injury","display_name":"deep tissue injury","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.949999988079071},{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.8510000109672546},{"id":"https://openalex.org/keywords/mechanical-loading","display_name":"mechanical loading","score":0.5540000200271606},{"id":"https://openalex.org/keywords/collagen-fiber-orientation","display_name":"collagen fiber orientation","score":0.8230000138282776},{"id":"https://openalex.org/keywords/skin-ischemia","display_name":"skin ischemia","score":0.7620000243186951},{"id":"https://openalex.org/keywords/biomechanical-modeling","display_name":"biomechanical modeling","score":0.6309999823570251},{"id":"https://openalex.org/keywords/skin-morphology","display_name":"skin morphology","score":0.3100000023841858}],"concepts":[{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.9384979009628296},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5690897107124329},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.524185836315155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4894525110721588},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.47069549560546875},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.43237417936325073},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3810538053512573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2685583829879761},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24910637736320496},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071199","descriptor_name":"NLR Family, Pyrin Domain-Containing 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003668","descriptor_name":"Pressure Ulcer","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003668","descriptor_name":"Pressure Ulcer","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003668","descriptor_name":"Pressure Ulcer","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D020405","descriptor_name":"Dermis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0069223","doi":"https://doi.org/10.1371/journal.pone.0069223","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0069223","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0069223&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2739680","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3743891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3743891","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3743891","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:23967056","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23967056","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.794.9330","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.794.9330","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/89/d1/pone.0069223.PMC3743891.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:080f8f4474f94f69a578cd5543efdf59","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/080f8f4474f94f69a578cd5543efdf59","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 8, p e69223 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0069223","doi":"https://doi.org/10.1371/journal.pone.0069223","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0069223","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0069223&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1579509143","display_name":"The Role of Statins in Cutaneous Wound Healing","funder_award_id":"R21AR060562","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G3548137065","display_name":"Development of the Cellular Biomarker for Diabetic Foot Ulcers","funder_award_id":"RC1DK086364","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3888152444","display_name":"Clinical and Translational Science Center","funder_award_id":"TL1TR000459","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G641913881","display_name":"Inflammasome regulation after spinal cord injury","funder_award_id":"R01NS059836","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7225957187","display_name":"Clinical and Translational Science Center","funder_award_id":"UL1TR000457","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8468887574","display_name":"Clinical and Translational Science Center (TL1)","funder_award_id":"TL1RR024998","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G8677239873","display_name":"Experimental Model For Pressure Ulcers In Human Skin: The Role of Aging and ECM","funder_award_id":"R21AG030673","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320313999","display_name":"Hospital for Special Surgery","ror":"https://ror.org/03zjqec80"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145997121.pdf","grobid_xml":"https://content.openalex.org/works/W2145997121.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W44581492","https://openalex.org/W116014723","https://openalex.org/W127240344","https://openalex.org/W157368067","https://openalex.org/W169725593","https://openalex.org/W206358843","https://openalex.org/W649833424","https://openalex.org/W1500073316","https://openalex.org/W1506247747","https://openalex.org/W1521386149","https://openalex.org/W1533217355","https://openalex.org/W1707913463","https://openalex.org/W1836110191","https://openalex.org/W1885912605","https://openalex.org/W1896340865","https://openalex.org/W1923932430","https://openalex.org/W1963874353","https://openalex.org/W1964066419","https://openalex.org/W1965707131","https://openalex.org/W1969410217","https://openalex.org/W1969993314","https://openalex.org/W1970345379","https://openalex.org/W1977859556","https://openalex.org/W1985982440","https://openalex.org/W1997511379","https://openalex.org/W1998607883","https://openalex.org/W1999276471","https://openalex.org/W1999500173","https://openalex.org/W2004797008","https://openalex.org/W2012789061","https://openalex.org/W2014820886","https://openalex.org/W2015619467","https://openalex.org/W2020527684","https://openalex.org/W2027849929","https://openalex.org/W2027957579","https://openalex.org/W2028545985","https://openalex.org/W2029610098","https://openalex.org/W2037478167","https://openalex.org/W2042117992","https://openalex.org/W2043430870","https://openalex.org/W2050662961","https://openalex.org/W2053527010","https://openalex.org/W2059032249","https://openalex.org/W2059422618","https://openalex.org/W2061581542","https://openalex.org/W2062985572","https://openalex.org/W2064208931","https://openalex.org/W2064512362","https://openalex.org/W2065403797","https://openalex.org/W2067374467","https://openalex.org/W2069948647","https://openalex.org/W2071534864","https://openalex.org/W2074657339","https://openalex.org/W2080660266","https://openalex.org/W2085461280","https://openalex.org/W2086919198","https://openalex.org/W2094787046","https://openalex.org/W2096558846","https://openalex.org/W2102620217","https://openalex.org/W2104896257","https://openalex.org/W2109260655","https://openalex.org/W2111340005","https://openalex.org/W2120989266","https://openalex.org/W2121560754","https://openalex.org/W2127814906","https://openalex.org/W2137500094","https://openalex.org/W2141980196","https://openalex.org/W2145395614","https://openalex.org/W2151820612","https://openalex.org/W2151843453","https://openalex.org/W2154637073","https://openalex.org/W2171766571","https://openalex.org/W2415303526","https://openalex.org/W4210987759"],"related_works":["https://openalex.org/W7099846062","https://openalex.org/W169725593","https://openalex.org/W2098988268","https://openalex.org/W7171416656","https://openalex.org/W1596989578","https://openalex.org/W1511544947","https://openalex.org/W2025347083","https://openalex.org/W2987170845","https://openalex.org/W7095864378","https://openalex.org/W1987188142"],"abstract_inverted_index":{"Molecular":[0],"mechanisms":[1,234],"leading":[2],"to":[3,70,175,186,203],"pressure":[4,18,48,82,204,245],"ulcer":[5,49,205],"development":[6,243],"are":[7],"scarce":[8],"in":[9,47,60,88,114,131,143,158,167,181,184,193,198,231],"spite":[10],"of":[11,14,17,77,85,126,146,235,244],"high":[12],"mortality":[13],"patients.":[15],"Development":[16],"ulcers":[19],"that":[20,32,172,190,211,239],"is":[21,28],"initially":[22],"observed":[23,130],"as":[24],"deep":[25,236],"tissue":[26,187,212,237],"injury":[27,238],"multifactorial.":[29],"We":[30,170],"postulate":[31],"biomechanical":[33],"forces":[34],"and":[35,41,64,116,123,179],"inflammasome":[36,103,118,148,155,182],"activation,":[37],"together":[38],"with":[39],"ischemia":[40],"aging,":[42],"may":[43,216,227,240],"play":[44],"a":[45,56,71,86,89,191],"role":[46],"development.":[50],"To":[51],"test":[52],"this":[53],"we":[54],"used":[55],"newly-developed":[57],"bio-mechanical":[58],"model":[59,224],"which":[61],"ischemic":[62],"young":[63,168],"aged":[65,132,159],"human":[66],"skin":[67,110,133,139,200],"was":[68,97],"subjected":[69],"constant":[72],"physiological":[73],"compressive":[74],"stress":[75],"(load)":[76],"300":[78],"kPa":[79],"(determined":[80],"by":[81,107],"plate":[83],"analyses":[84],"person":[87],"reclining":[90],"position)":[91],"for":[92],"0.5-4":[93],"hours.":[94],"Collagen":[95],"orientation":[96,125],"assessed":[98],"using":[99],"polarized":[100],"light,":[101],"whereas":[102,161],"proteins":[104,156,183],"were":[105,129],"quantified":[106],"immunoblotting.":[108],"Loaded":[109],"showed":[111,140],"marked":[112],"changes":[113,178,209],"morphology":[115],"NLRP3":[117,147,154],"protein":[119],"expression.":[120],"Sub-epidermal":[121],"separations":[122],"altered":[124],"collagen":[127],"fibers":[128],"at":[134],"earlier":[135],"time":[136],"points.":[137],"Aged":[138],"significant":[141],"decreases":[142],"the":[144,194,233],"levels":[145,166],"proteins.":[149],"Loading":[150],"did":[151],"not":[152,217],"alter":[153],"expression":[157],"skin,":[160],"it":[162],"significantly":[163],"increased":[164],"their":[165],"skin.":[169],"conclude":[171],"aging":[173],"contributes":[174],"rapid":[176],"morphological":[177,208],"decrease":[180],"response":[185,197],"damage,":[188],"suggesting":[189],"decline":[192],"innate":[195],"inflammatory":[196],"elderly":[199],"could":[201],"contribute":[202],"pathogenesis.":[206],"Observed":[207],"suggest":[210],"damage":[213],"upon":[214],"loading":[215],"be":[218,228],"entirely":[219],"preventable.":[220],"Furthermore,":[221],"newly":[222],"developed":[223],"described":[225],"here":[226],"very":[229],"useful":[230],"understanding":[232],"lead":[241],"towards":[242],"ulcers.":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}