{"id":"https://openalex.org/W2145962902","doi":"https://doi.org/10.1002/stem.1029","title":"Intratumoral Heterogeneity in the Self\u2010Renewal and Tumorigenic Differentiation of Ovarian Cancer","display_name":"Intratumoral Heterogeneity in the Self\u2010Renewal and Tumorigenic Differentiation of Ovarian Cancer","publication_year":2012,"publication_date":"2012-01-20","ids":{"openalex":"https://openalex.org/W2145962902","doi":"https://doi.org/10.1002/stem.1029","mag":"2145962902","pmid":"https://pubmed.ncbi.nlm.nih.gov/22267284"},"language":"en","primary_location":{"id":"doi:10.1002/stem.1029","doi":"https://doi.org/10.1002/stem.1029","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.1029","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001693435","display_name":"Sagi Abelson","orcid":"https://orcid.org/0000-0003-1747-3819","observed_orcids":["https://orcid.org/0000-0003-1747-3819"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Sagi Abelson","raw_affiliation_strings":["Rappaport Faculty of Medicine and Research Institute, Technion\u2010Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rappaport Faculty of Medicine and Research Institute, Technion\u2010Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077957086","display_name":"Yeela Shamai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Yeela Shamai","raw_affiliation_strings":["Rappaport Faculty of Medicine and Research Institute, Technion\u2010Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rappaport Faculty of Medicine and Research Institute, Technion\u2010Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014182533","display_name":"Liron Berger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Liron Berger","raw_affiliation_strings":["Rappaport Faculty of Medicine and Research Institute, Technion\u2010Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rappaport Faculty of Medicine and Research Institute, Technion\u2010Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033851673","display_name":"Roni Shouval","orcid":"https://orcid.org/0000-0001-9827-8032","observed_orcids":["https://orcid.org/0000-0001-9827-8032"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Roni Shouval","raw_affiliation_strings":["Rappaport Faculty of Medicine and Research Institute, Technion\u2010Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rappaport Faculty of Medicine and Research Institute, Technion\u2010Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089625707","display_name":"Karl L. Skorecki","orcid":"https://orcid.org/0000-0002-0900-3406","observed_orcids":["https://orcid.org/0000-0002-0900-3406"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Karl Skorecki","raw_affiliation_strings":["Rambam Medical Center, Technion\u2010Israel Institute of Technology, Haifa, Israel","Rappaport Faculty of Medicine and Research Institute, Technion\u2010Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rambam Medical Center, Technion\u2010Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]},{"raw_affiliation_string":"Rappaport Faculty of Medicine and Research Institute, Technion\u2010Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039064154","display_name":"Maty Tzukerman","orcid":"https://orcid.org/0000-0002-9080-2511","observed_orcids":["https://orcid.org/0000-0002-9080-2511"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Maty Tzukerman","raw_affiliation_strings":["Rambam Medical Center, Technion\u2010Israel Institute of Technology, Haifa, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rambam Medical Center, Technion\u2010Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039064154","https://openalex.org/A5089625707"],"corresponding_institution_ids":["https://openalex.org/I174306211"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":3.1612,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.92684325,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"3","first_page":"415","last_page":"424"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-clear-cell-carcinoma","display_name":"ovarian clear cell carcinoma","score":0.8820000290870667},{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.996999979019165},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.9559999704360962},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.8669999837875366},{"id":"https://openalex.org/keywords/aldehyde-dehydrogenase","display_name":"aldehyde dehydrogenase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7360000014305115},{"id":"https://openalex.org/keywords/tumor-plasticity","display_name":"tumor plasticity","score":0.621999979019165},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8354264497756958},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.750991702079773},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6855353116989136},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6104239821434021},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5650936365127563},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.47820377349853516},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4765351712703705},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.47292807698249817},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4708050489425659},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.4421050548553467},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4150558114051819},{"id":"https://openalex.org/C2779982571","wikidata":"https://www.wikidata.org/wiki/Q25098780","display_name":"Differentiation therapy","level":5,"score":0.41042810678482056},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37949338555336},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3134136199951172},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.30762529373168945},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.21682971715927124},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17374581098556519},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12490099668502808},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.10094252228736877},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.0},{"id":"https://openalex.org/C2776601000","wikidata":"https://www.wikidata.org/wiki/Q612108","display_name":"Acute promyelocytic leukemia","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018960","descriptor_name":"Hyaluronan Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055153","descriptor_name":"Stem Cell Niche","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/stem.1029","doi":"https://doi.org/10.1002/stem.1029","is_oa":false,"landing_page_url":"https://doi.org/10.1002/stem.1029","pdf_url":null,"source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"STEM CELLS","raw_type":"journal-article"},{"id":"pmid:22267284","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22267284","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309524","display_name":"Skirball Foundation","ror":"https://ror.org/00wwe9h57"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1965281877","https://openalex.org/W1975468172","https://openalex.org/W1978773985","https://openalex.org/W1992676863","https://openalex.org/W1993685841","https://openalex.org/W1998706588","https://openalex.org/W1999356404","https://openalex.org/W2019264784","https://openalex.org/W2019865561","https://openalex.org/W2020131167","https://openalex.org/W2023316892","https://openalex.org/W2023427658","https://openalex.org/W2023457181","https://openalex.org/W2029012555","https://openalex.org/W2034269086","https://openalex.org/W2038873665","https://openalex.org/W2046788126","https://openalex.org/W2046925061","https://openalex.org/W2049883475","https://openalex.org/W2056025993","https://openalex.org/W2056564024","https://openalex.org/W2066646758","https://openalex.org/W2067256262","https://openalex.org/W2070901986","https://openalex.org/W2081447858","https://openalex.org/W2082823320","https://openalex.org/W2087272148","https://openalex.org/W2090853702","https://openalex.org/W2100625749","https://openalex.org/W2104666893","https://openalex.org/W2104879427","https://openalex.org/W2114503960","https://openalex.org/W2122147062","https://openalex.org/W2132672784","https://openalex.org/W2135231064","https://openalex.org/W2137715553","https://openalex.org/W2138274847","https://openalex.org/W2138784667","https://openalex.org/W2142159058","https://openalex.org/W2146267383","https://openalex.org/W2151948621","https://openalex.org/W2155464942"],"related_works":["https://openalex.org/W1971900889","https://openalex.org/W1981205172","https://openalex.org/W2064781703","https://openalex.org/W2598963892","https://openalex.org/W1978773985","https://openalex.org/W2965245113","https://openalex.org/W2027848801","https://openalex.org/W2301789486","https://openalex.org/W2155464942","https://openalex.org/W2139028067"],"abstract_inverted_index":{"Resistance":[0],"to":[1,7,17,88,161,194,233],"anticancer":[2,195,239],"therapy":[3,240],"has":[4],"been":[5],"attributed":[6],"interindividual":[8],"differences":[9],"in":[10,44,63,120,191,220,226],"gene":[11],"expression":[12],"pathways":[13],"among":[14],"tumors,":[15],"and":[16,115,164,170,181,229],"the":[18,36,70,99,121,159,173,176,192,198,227],"existence":[19],"within":[20],"tumors":[21],"of":[22,50,84,104,113,126,132,142,175,179,200,213],"cancer":[23],"stem":[24,39],"cells":[25,55,134,154],"with":[26,158,197],"self-renewal":[27,163,180,228],"capacity.":[28],"In":[29,69],"previous":[30],"studies,":[31],"we":[32,73],"have":[33],"demonstrated":[34],"that":[35,56,94,135,185],"human":[37],"embryonic":[38],"cell":[40,82],"(hESC)-derived":[41],"cellular":[42],"microenvironment":[43,123],"immunocompromised":[45],"mice":[46],"enables":[47],"functional":[48],"distinction":[49],"heterogeneous":[51],"tumor":[52,62,66,100,137,215],"cells,":[53],"including":[54],"do":[57],"not":[58],"grow":[59],"into":[60,145,204],"a":[61,85,110,140,186,205],"conventional":[64],"direct":[65],"xenograft":[67],"platform.":[68],"current":[71],"study,":[72],"use":[74],"clonally":[75,106],"expanded":[76,107],"subpopulations":[77,108],"derived":[78],"from":[79],"ovarian":[80],"clear":[81],"carcinoma":[83],"single":[86],"tumor,":[87],"demonstrate":[89],"striking":[90],"intratumoral":[91,168,224],"phenotypic":[92],"heterogeneity":[93,169,225],"is":[95,189],"dynamically":[96],"dependent":[97],"on":[98,210],"growth":[101,119,125,138,203,216],"microenvironment.":[102],"Each":[103],"six":[105],"displays":[109],"different":[111],"level":[112,174],"morphologic":[114],"tumorigenic":[116,143,182,230],"differentiation,":[117],"wherein":[118],"hESC-derived":[122],"favors":[124],"CD44+":[127],"aldehyde":[128,147],"dehydrogenase":[129,148],"positive":[130],"pockets":[131],"self-renewing":[133],"sustain":[136],"through":[139],"process":[141],"differentiation":[144,183,231],"CD44-":[146],"negative":[149],"derivatives.":[150],"Strikingly,":[151],"these":[152,214],"derivative":[153],"display":[155],"microenvironment-dependent":[156],"plasticity":[157,171],"capacity":[160],"restore":[162],"CD44":[165],"expression.":[166],"Such":[167],"at":[172],"key":[177],"properties":[178],"suggests":[184],"paradigm":[187],"shift":[188],"needed":[190],"approach":[193],"therapy,":[196],"aim":[199],"turning":[201],"malignant":[202],"chronic":[206],"manageable":[207],"disorder,":[208],"based":[209],"continual":[211],"monitoring":[212],"properties.":[217],"The":[218],"hESC-based":[219],"vivo":[221],"model":[222],"renders":[223],"amenable":[232],"biological":[234],"analysis":[235],"as":[236,238],"well":[237],"testing.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}