{"id":"https://openalex.org/W2145924416","doi":"https://doi.org/10.1126/science.275.5302.993","title":"Regulation of Replicon Size in Xenopus Egg Extracts","display_name":"Regulation of Replicon Size in Xenopus Egg Extracts","publication_year":1997,"publication_date":"1997-02-14","ids":{"openalex":"https://openalex.org/W2145924416","doi":"https://doi.org/10.1126/science.275.5302.993","mag":"2145924416","pmid":"https://pubmed.ncbi.nlm.nih.gov/9020085"},"language":"en","primary_location":{"id":"doi:10.1126/science.275.5302.993","doi":"https://doi.org/10.1126/science.275.5302.993","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.275.5302.993","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080203458","display_name":"Johannes C. Walter","orcid":"https://orcid.org/0000-0002-4186-7570","observed_orcids":["https://orcid.org/0000-0002-4186-7570"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johannes Walter","raw_affiliation_strings":["Department of Biology, University of California, San Diego, La Jolla, CA 92093-0347, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of California, San Diego, La Jolla, CA 92093-0347, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018892772","display_name":"John W. Newport","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John W. Newport","raw_affiliation_strings":["Department of Biology, University of California, San Diego, La Jolla, CA 92093-0347, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of California, San Diego, La Jolla, CA 92093-0347, USA","institution_ids":["https://openalex.org/I36258959"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018892772"],"corresponding_institution_ids":["https://openalex.org/I36258959"],"apc_list":null,"apc_paid":null,"fwci":3.6713,"has_fulltext":false,"cited_by_count":170,"citation_normalized_percentile":{"value":0.94537941,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"275","issue":"5302","first_page":"993","last_page":"995"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.16349999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.02410000003874302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/replicon-size","display_name":"replicon size","score":0.972000002861023},{"id":"https://openalex.org/keywords/dna-replication-initiation","display_name":"DNA replication initiation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/origin-recognition-complex","display_name":"origin recognition complex","score":0.9449999928474426},{"id":"https://openalex.org/keywords/xenopus-egg-extracts","display_name":"Xenopus egg extracts","score":0.9079999923706055},{"id":"https://openalex.org/keywords/s-phase","display_name":"S phase","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.49300000071525574},{"id":"https://openalex.org/keywords/early-embryonic-development","display_name":"early embryonic development","score":0.6740000247955322},{"id":"https://openalex.org/keywords/xenopus-laevis","display_name":"Xenopus laevis","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C18103114","wikidata":"https://www.wikidata.org/wiki/Q1720369","display_name":"Replicon","level":4,"score":0.9744069576263428},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.948392927646637},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.753929615020752},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5906475186347961},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.5639927387237549},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.4949426054954529},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49344220757484436},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4636363387107849},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.44644874334335327},{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.4175562858581543},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36467593908309937},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3359628915786743},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.28731340169906616},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08477663993835449},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.060927510261535645}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010063","descriptor_name":"Ovum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012093","descriptor_name":"Replicon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014982","descriptor_name":"Xenopus laevis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016196","descriptor_name":"S Phase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018741","descriptor_name":"Replication Origin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051738","descriptor_name":"Origin Recognition Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.275.5302.993","doi":"https://doi.org/10.1126/science.275.5302.993","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.275.5302.993","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:9020085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9020085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2806130466","display_name":null,"funder_award_id":"R01FM44656","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G5848104107","display_name":null,"funder_award_id":"1F32FM17980-01","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1420696562","https://openalex.org/W1942821452","https://openalex.org/W1965895804","https://openalex.org/W1988254015","https://openalex.org/W1989909507","https://openalex.org/W2001095597","https://openalex.org/W2005021182","https://openalex.org/W2018782003","https://openalex.org/W2030923676","https://openalex.org/W2045515164","https://openalex.org/W2059594509","https://openalex.org/W2085666970","https://openalex.org/W2097043033","https://openalex.org/W2105656306","https://openalex.org/W2107332774","https://openalex.org/W2114840814","https://openalex.org/W2161533283"],"related_works":["https://openalex.org/W2161533283","https://openalex.org/W2102148937","https://openalex.org/W2085266985","https://openalex.org/W2011737256","https://openalex.org/W1988254015","https://openalex.org/W2167369910","https://openalex.org/W116768201","https://openalex.org/W2083771066","https://openalex.org/W2140178583","https://openalex.org/W2069915673"],"abstract_inverted_index":{"Once":[0],"a":[1,48],"specific":[2],"number":[3],"of":[4,21,40,69,76],"cells":[5],"have":[6],"been":[7],"produced":[8],"in":[9,33,42,83],"the":[10,18,22,38,54],"early":[11,84],"Xenopus":[12,44],"laevis":[13],"embryo,":[14],"replicon":[15,34,77],"size":[16,35],"during":[17],"S":[19],"phase":[20],"cell":[23],"cycle":[24],"increases.":[25],"Here,":[26],"it":[27],"is":[28],"reported":[29],"that":[30,82],"similar":[31,67],"increase":[32],"occurred":[36],"when":[37],"concentration":[39],"nuclei":[41],"replication-competent":[43],"egg":[45],"extracts":[46],"exceeded":[47],"critical":[49],"threshold.":[50],"In":[51],"this":[52,70],"system,":[53],"origin":[55],"recognition":[56],"complex":[57,71],"(ORC)":[58],"did":[59],"not":[60],"become":[61],"stoichiometrically":[62],"limiting":[63],"for":[64],"initiation,":[65],"and":[66],"amounts":[68],"bound":[72],"to":[73],"chromatin":[74],"regardless":[75],"size.":[78],"These":[79],"data":[80],"suggest":[81],"development,":[85],"an":[86],"unidentified":[87],"factor":[88],"controls":[89],"how":[90],"many":[91],"preformed":[92],"ORC-DNA":[93],"complexes":[94],"initiate":[95],"DNA":[96],"replication.":[97]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
