{"id":"https://openalex.org/W2145876349","doi":"https://doi.org/10.1016/j.ccr.2012.11.013","title":"Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer","display_name":"Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer","publication_year":2012,"publication_date":"2012-12-27","ids":{"openalex":"https://openalex.org/W2145876349","doi":"https://doi.org/10.1016/j.ccr.2012.11.013","mag":"2145876349","pmid":"https://pubmed.ncbi.nlm.nih.gov/23273921","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3578577"},"language":"en","primary_location":{"id":"doi:10.1016/j.ccr.2012.11.013","doi":"https://doi.org/10.1016/j.ccr.2012.11.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ccr.2012.11.013","pdf_url":"http://www.cell.com/article/S1535610812004928/pdf","source":{"id":"https://openalex.org/S25671836","display_name":"Cancer Cell","issn_l":"1535-6108","issn":["1535-6108","1878-3686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1535610812004928/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108447612","display_name":"Jie Liang","orcid":"https://orcid.org/0000-0003-1145-0210","observed_orcids":["https://orcid.org/0000-0003-1145-0210"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Liang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056655144","display_name":"Masayuki Nagahashi","orcid":"https://orcid.org/0000-0002-9308-448X","observed_orcids":["https://orcid.org/0000-0002-9308-448X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masayuki Nagahashi","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]},{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081708169","display_name":"Eugene Y. Kim","orcid":"https://orcid.org/0000-0002-9276-7238","observed_orcids":["https://orcid.org/0000-0002-9276-7238"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eugene\u00a0Y. Kim","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039357128","display_name":"Kuzhuvelil B. Harikumar","orcid":"https://orcid.org/0000-0002-1763-4179","observed_orcids":["https://orcid.org/0000-0002-1763-4179"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuzhuvelil\u00a0B. Harikumar","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075614575","display_name":"Akimitsu Yamada","orcid":"https://orcid.org/0000-0003-3006-0648","observed_orcids":["https://orcid.org/0000-0003-3006-0648"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akimitsu Yamada","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]},{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086647934","display_name":"Wei\u2010Ching Huang","orcid":"https://orcid.org/0000-0003-1255-2067","observed_orcids":["https://orcid.org/0000-0003-1255-2067"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-Ching Huang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026510433","display_name":"Nitai C. Hait","orcid":"https://orcid.org/0000-0001-7707-425X","observed_orcids":["https://orcid.org/0000-0001-7707-425X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nitai\u00a0C. Hait","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059559405","display_name":"Jeremy C. Allegood","orcid":"https://orcid.org/0009-0007-1741-9923","observed_orcids":["https://orcid.org/0009-0007-1741-9923"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy\u00a0C. Allegood","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046132594","display_name":"Megan M. Price","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan\u00a0M. Price","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071351984","display_name":"Dorit Avni","orcid":"https://orcid.org/0000-0002-0444-881X","observed_orcids":["https://orcid.org/0000-0002-0444-881X","https://orcid.org/0000-0003-3126-9320"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dorit Avni","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057255416","display_name":"Kazuaki Takabe","orcid":"https://orcid.org/0000-0002-6435-4241","observed_orcids":["https://orcid.org/0000-0002-6435-4241"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]},{"id":"https://openalex.org/I72019824","display_name":"Virginia Commonwealth University Medical Center","ror":"https://ror.org/057xmsr27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I72019824"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazuaki Takabe","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]},{"raw_affiliation_string":"Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I72019824"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047515959","display_name":"Tomasz Kordula","orcid":"https://orcid.org/0000-0003-1141-0331","observed_orcids":["https://orcid.org/0000-0003-1141-0331"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomasz Kordula","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011102538","display_name":"Sheldon Milstien","orcid":"https://orcid.org/0000-0003-0728-837X","observed_orcids":["https://orcid.org/0000-0003-0728-837X"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheldon Milstien","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014072958","display_name":"Sarah Spiegel","orcid":"https://orcid.org/0000-0003-0751-2634","observed_orcids":["https://orcid.org/0000-0003-0751-2634"]},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]},{"id":"https://openalex.org/I4390039382","display_name":"VCU Massey Comprehensive Cancer Center","ror":"https://ror.org/0173y3036","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sarah Spiegel","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology and the Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA","institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014072958"],"corresponding_institution_ids":["https://openalex.org/I184840846","https://openalex.org/I4390039382"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":12.9137,"has_fulltext":false,"cited_by_count":584,"citation_normalized_percentile":{"value":0.99434846,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"23","issue":"1","first_page":"107","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sphingosine-1-phosphate","display_name":"sphingosine-1-phosphate","score":1.0},{"id":"https://openalex.org/keywords/sphingosine-kinase-1","display_name":"sphingosine kinase 1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/sphingosine-kinase-2","display_name":"sphingosine kinase 2","score":0.9179999828338623},{"id":"https://openalex.org/keywords/s1pr1","display_name":"S1PR1","score":0.7519999742507935},{"id":"https://openalex.org/keywords/stat3-activation","display_name":"STAT3 activation","score":0.8930000066757202},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.8970000147819519},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9710000157356262},{"id":"https://openalex.org/keywords/colitis-associated-cancer","display_name":"colitis-associated colorectal cancer","score":0.7950000166893005},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.9150000214576721},{"id":"https://openalex.org/keywords/ulcerative-colitis","display_name":"ulcerative colitis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.921999990940094},{"id":"https://openalex.org/keywords/chronic-intestinal-inflammation","display_name":"chronic intestinal inflammation","score":0.9010000228881836},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C140800825","wikidata":"https://www.wikidata.org/wiki/Q17915625","display_name":"S1PR1","level":5,"score":0.785647988319397},{"id":"https://openalex.org/C2777700496","wikidata":"https://www.wikidata.org/wiki/Q7576797","display_name":"Sphingosine kinase","level":5,"score":0.6216629147529602},{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.6083539128303528},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.5994755029678345},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5712920427322388},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5688055157661438},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5494399666786194},{"id":"https://openalex.org/C2778703144","wikidata":"https://www.wikidata.org/wiki/Q46298","display_name":"Sphingosine","level":3,"score":0.5322579741477966},{"id":"https://openalex.org/C2776596873","wikidata":"https://www.wikidata.org/wiki/Q418267","display_name":"Sphingosine-1-phosphate","level":4,"score":0.5316425561904907},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.4905073046684265},{"id":"https://openalex.org/C2777550365","wikidata":"https://www.wikidata.org/wiki/Q14913834","display_name":"Sphingosine kinase 1","level":5,"score":0.4553107023239136},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.4508294463157654},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44355759024620056},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4371393918991089},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4354250729084015},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3708704710006714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26821398735046387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24751073122024536},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19787278771400452},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17568457126617432},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.11844673752784729},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.11400532722473145},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08622300624847412},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.08482033014297485},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06284204125404358},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068876","descriptor_name":"Fingolimod Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099157","descriptor_name":"Sphingosine Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003092","descriptor_name":"Colitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008246","descriptor_name":"Lysophospholipids","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011409","descriptor_name":"Propylene Glycols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011409","descriptor_name":"Propylene Glycols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017853","descriptor_name":"Phosphotransferases (Alcohol Group Acceptor)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ccr.2012.11.013","doi":"https://doi.org/10.1016/j.ccr.2012.11.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ccr.2012.11.013","pdf_url":"http://www.cell.com/article/S1535610812004928/pdf","source":{"id":"https://openalex.org/S25671836","display_name":"Cancer Cell","issn_l":"1535-6108","issn":["1535-6108","1878-3686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell","raw_type":"journal-article"},{"id":"pmid:23273921","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23273921","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer cell","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2874757","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3578577","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3578577","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3578577/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cancer Cell","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.ccr.2012.11.013","doi":"https://doi.org/10.1016/j.ccr.2012.11.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ccr.2012.11.013","pdf_url":"http://www.cell.com/article/S1535610812004928/pdf","source":{"id":"https://openalex.org/S25671836","display_name":"Cancer Cell","issn_l":"1535-6108","issn":["1535-6108","1878-3686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3841059082","display_name":"VCU Neuroscience Center Core Grant","funder_award_id":"P30NS047463","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3957918773","display_name":"Cellular & Inflammatory Pathways in Ashtma & Allergic Diseases: From IgE to Cells","funder_award_id":"U19AI077435","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G398677862","display_name":"Sphingosine-1 Phosphate in Breast Cancer Progression and Lymphangiogenesis","funder_award_id":"R01CA160688","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4829253442","display_name":"Sphingosine kinases in cancer cell signaling","funder_award_id":"R01CA061774","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5009838213","display_name":"VCU Building Interdisciplinary Research Careers in Women's Health","funder_award_id":"K12HD055881","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6349314010","display_name":"Roles of sphingosine-1 phosphate phosphohydrolase","funder_award_id":"R37GM043880","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G819540347","display_name":"Training In Functional Lipidomics In Cardiovascular & Respiratory Diseases","funder_award_id":"T32HL094290","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000888536","display_name":"Massey Cancer Center -\u00a0Cancer Center Support Grant","funder_award_id":"P30CA016059","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320311413","display_name":"Susan G. Komen","ror":"https://ror.org/02nadbe75"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145876349.pdf"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W78483733","https://openalex.org/W1533021978","https://openalex.org/W1904767156","https://openalex.org/W1973573934","https://openalex.org/W1975993695","https://openalex.org/W1979992629","https://openalex.org/W1982334431","https://openalex.org/W1983079076","https://openalex.org/W1987352835","https://openalex.org/W1987375206","https://openalex.org/W1987543885","https://openalex.org/W1988139137","https://openalex.org/W1991115604","https://openalex.org/W1995391501","https://openalex.org/W1995753003","https://openalex.org/W1996605319","https://openalex.org/W1997458456","https://openalex.org/W2005271761","https://openalex.org/W2006881062","https://openalex.org/W2007606465","https://openalex.org/W2013494956","https://openalex.org/W2015336843","https://openalex.org/W2015354948","https://openalex.org/W2018146992","https://openalex.org/W2028956758","https://openalex.org/W2031268426","https://openalex.org/W2032674547","https://openalex.org/W2034371280","https://openalex.org/W2044227662","https://openalex.org/W2047607345","https://openalex.org/W2051686420","https://openalex.org/W2052788204","https://openalex.org/W2066717022","https://openalex.org/W2076519131","https://openalex.org/W2076738925","https://openalex.org/W2077827642","https://openalex.org/W2078730804","https://openalex.org/W2078794107","https://openalex.org/W2082626794","https://openalex.org/W2087314408","https://openalex.org/W2088514755","https://openalex.org/W2101229561","https://openalex.org/W2105269215","https://openalex.org/W2105702970","https://openalex.org/W2111942396","https://openalex.org/W2118278569","https://openalex.org/W2124076790","https://openalex.org/W2129363220","https://openalex.org/W2130614040","https://openalex.org/W2132805096","https://openalex.org/W2135575116","https://openalex.org/W2136662222","https://openalex.org/W2144994796","https://openalex.org/W2149441416","https://openalex.org/W2151217876","https://openalex.org/W2151535044","https://openalex.org/W2156263183","https://openalex.org/W2164422031","https://openalex.org/W2167876561","https://openalex.org/W2168478794","https://openalex.org/W4232654765","https://openalex.org/W6652268416"],"related_works":["https://openalex.org/W1967943715","https://openalex.org/W1975941604","https://openalex.org/W2507425343","https://openalex.org/W2056697413","https://openalex.org/W2330626735","https://openalex.org/W2810739650","https://openalex.org/W1778175015","https://openalex.org/W1980524113","https://openalex.org/W2069369799","https://openalex.org/W2991248756"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":36},{"year":2023,"cited_by_count":22},{"year":2022,"cited_by_count":37},{"year":2021,"cited_by_count":47},{"year":2020,"cited_by_count":52},{"year":2019,"cited_by_count":44},{"year":2018,"cited_by_count":44},{"year":2017,"cited_by_count":57},{"year":2016,"cited_by_count":65},{"year":2015,"cited_by_count":51},{"year":2014,"cited_by_count":48},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
