{"id":"https://openalex.org/W2145824104","doi":"https://doi.org/10.1186/1476-4598-9-75","title":"Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy","display_name":"Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy","publication_year":2010,"publication_date":"2010-04-12","ids":{"openalex":"https://openalex.org/W2145824104","doi":"https://doi.org/10.1186/1476-4598-9-75","mag":"2145824104","pmid":"https://pubmed.ncbi.nlm.nih.gov/20385023","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2864216"},"language":"en","primary_location":{"id":"doi:10.1186/1476-4598-9-75","doi":"https://doi.org/10.1186/1476-4598-9-75","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-4598-9-75","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-9-75","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-9-75","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014651791","display_name":"Jose Rafael Sierra","orcid":"https://orcid.org/0000-0002-8903-5845","observed_orcids":["https://orcid.org/0000-0002-8903-5845"]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["CA","IT"],"is_corresponding":false,"raw_author_name":"J. Rafael Sierra","raw_affiliation_strings":["Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo (Torino), Italy","Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo (Torino), Italy","Present address: University Health Network, Ontario Cancer Institute and Princess Margaret Hospital, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo (Torino), Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo (Torino), Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Present address: University Health Network, Ontario Cancer Institute and Princess Margaret Hospital, Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074944902","display_name":"Virna Cepero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["CA","IT"],"is_corresponding":false,"raw_author_name":"Virna Cepero","raw_affiliation_strings":["Institute for Cancer Research and Treatment, University of Torino Medical School, 10060, Candiolo (Torino), Italy","Present address: University Health Network, Ontario Cancer Institute and Princess Margaret Hospital, Toronto, ON, M5G 2M9, Canada","Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo (Torino), Italy","Present address: University Health Network, Ontario Cancer Institute and Princess Margaret Hospital, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Research and Treatment, University of Torino Medical School, 10060, Candiolo (Torino), Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Present address: University Health Network, Ontario Cancer Institute and Princess Margaret Hospital, Toronto, ON, M5G 2M9, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"raw_affiliation_string":"Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo (Torino), Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Present address: University Health Network, Ontario Cancer Institute and Princess Margaret Hospital, Toronto, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059509038","display_name":"Silvia Giordano","orcid":"https://orcid.org/0000-0003-1854-1086","observed_orcids":["https://orcid.org/0000-0003-1854-1086"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Silvia Giordano","raw_affiliation_strings":["Institute for Cancer Research and Treatment, University of Torino Medical School, 10060, Candiolo (Torino), Italy","Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Torino Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Cancer Research and Treatment, University of Torino Medical School, 10060, Candiolo (Torino), Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Torino Italy","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5059509038"],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":{"value":5090,"currency":"USD","value_usd":5090},"fwci":13.4166,"has_fulltext":true,"cited_by_count":234,"citation_normalized_percentile":{"value":0.99159269,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"75","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.042100001126527786,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.03579999879002571,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.9819999933242798},{"id":"https://openalex.org/keywords/molecular-mechanisms-of-resistance","display_name":"molecular mechanisms of resistance","score":0.9240000247955322},{"id":"https://openalex.org/keywords/small-molecule-tyrosine-kinase-inhibitors","display_name":"small-molecule tyrosine kinase inhibitors","score":0.8140000104904175},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7549999952316284},{"id":"https://openalex.org/keywords/resistance-reversal-strategies","display_name":"resistance reversal strategies","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.7249263525009155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6444895267486572},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6156185269355774},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.6052614450454712},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5870683193206787},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.567601203918457},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5666380524635315},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5305165648460388},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5182440280914307},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.5139312148094177},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.42452266812324524},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3052145838737488},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27507632970809937},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.19635820388793945},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18015596270561218},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07401275634765625}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1476-4598-9-75","doi":"https://doi.org/10.1186/1476-4598-9-75","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-4598-9-75","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-9-75","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},{"id":"pmid:20385023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20385023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2864216","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2864216/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cancer","raw_type":"Text"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/84805","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/84805","pdf_url":"https://utoronto.scholaris.ca/bitstreams/7f837a66-09d6-45e4-ba99-b8e04164c9c2/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:69091294c5644137866e49b18f1d2d8a","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/69091294c5644137866e49b18f1d2d8a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Cancer, Vol 9, Iss 1, p 75 (2010)","raw_type":"article"},{"id":"pmh:oai:iris.unito.it:2318/107556","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/107556","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2323661500","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1186/1476-4598-9-75.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1186/1476-4598-9-75","doi":"https://doi.org/10.1186/1476-4598-9-75","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1476-4598-9-75","pdf_url":"https://molecular-cancer.biomedcentral.com/counter/pdf/10.1186/1476-4598-9-75","source":{"id":"https://openalex.org/S132829192","display_name":"Molecular Cancer","issn_l":"1476-4598","issn":["1476-4598"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145824104.pdf","grobid_xml":"https://content.openalex.org/works/W2145824104.grobid-xml"},"referenced_works_count":179,"referenced_works":["https://openalex.org/W53566393","https://openalex.org/W108519829","https://openalex.org/W1556788203","https://openalex.org/W1679250118","https://openalex.org/W1890809256","https://openalex.org/W1964762450","https://openalex.org/W1966828606","https://openalex.org/W1966973502","https://openalex.org/W1967920366","https://openalex.org/W1968892414","https://openalex.org/W1969075054","https://openalex.org/W1971845675","https://openalex.org/W1972304655","https://openalex.org/W1975939084","https://openalex.org/W1977183039","https://openalex.org/W1977889545","https://openalex.org/W1977999028","https://openalex.org/W1982720580","https://openalex.org/W1983673751","https://openalex.org/W1985264867","https://openalex.org/W1988869660","https://openalex.org/W1992892839","https://openalex.org/W1996180238","https://openalex.org/W1997261348","https://openalex.org/W1998971866","https://openalex.org/W1999250974","https://openalex.org/W1999614615","https://openalex.org/W2001298924","https://openalex.org/W2001447115","https://openalex.org/W2002937040","https://openalex.org/W2003514175","https://openalex.org/W2003631713","https://openalex.org/W2003632995","https://openalex.org/W2004439203","https://openalex.org/W2005631145","https://openalex.org/W2008345619","https://openalex.org/W2010022150","https://openalex.org/W2011905613","https://openalex.org/W2011906439","https://openalex.org/W2013678879","https://openalex.org/W2014390504","https://openalex.org/W2015713305","https://openalex.org/W2019439252","https://openalex.org/W2020372547","https://openalex.org/W2025201739","https://openalex.org/W2026389791","https://openalex.org/W2027684043","https://openalex.org/W2030440427","https://openalex.org/W2031981310","https://openalex.org/W2031998778","https://openalex.org/W2033151149","https://openalex.org/W2033595975","https://openalex.org/W2034269086","https://openalex.org/W2037011799","https://openalex.org/W2037602001","https://openalex.org/W2037602803","https://openalex.org/W2040575339","https://openalex.org/W2040827891","https://openalex.org/W2042327295","https://openalex.org/W2043696829","https://openalex.org/W2044565900","https://openalex.org/W2045842462","https://openalex.org/W2047549748","https://openalex.org/W2048634696","https://openalex.org/W2050338667","https://openalex.org/W2050825441","https://openalex.org/W2053415059","https://openalex.org/W2054431600","https://openalex.org/W2054633892","https://openalex.org/W2055262054","https://openalex.org/W2057335049","https://openalex.org/W2057623977","https://openalex.org/W2058743530","https://openalex.org/W2058762693","https://openalex.org/W2059411043","https://openalex.org/W2061161052","https://openalex.org/W2061860992","https://openalex.org/W2062609883","https://openalex.org/W2062706311","https://openalex.org/W2063749929","https://openalex.org/W2064283997","https://openalex.org/W2065725840","https://openalex.org/W2067135009","https://openalex.org/W2068244265","https://openalex.org/W2069273600","https://openalex.org/W2071863102","https://openalex.org/W2072847374","https://openalex.org/W2073051869","https://openalex.org/W2074781545","https://openalex.org/W2074854146","https://openalex.org/W2075790568","https://openalex.org/W2076704022","https://openalex.org/W2076736727","https://openalex.org/W2077804275","https://openalex.org/W2080251370","https://openalex.org/W2080732293","https://openalex.org/W2081087531","https://openalex.org/W2086224272","https://openalex.org/W2090648424","https://openalex.org/W2093613683","https://openalex.org/W2096418206","https://openalex.org/W2097732752","https://openalex.org/W2097946794","https://openalex.org/W2098223440","https://openalex.org/W2098544382","https://openalex.org/W2098785293","https://openalex.org/W2099056476","https://openalex.org/W2100490225","https://openalex.org/W2100589633","https://openalex.org/W2101055270","https://openalex.org/W2101276992","https://openalex.org/W2103013933","https://openalex.org/W2103229964","https://openalex.org/W2103796073","https://openalex.org/W2105026490","https://openalex.org/W2105261759","https://openalex.org/W2107015590","https://openalex.org/W2107693250","https://openalex.org/W2109242805","https://openalex.org/W2111631361","https://openalex.org/W2113230030","https://openalex.org/W2114048774","https://openalex.org/W2114255370","https://openalex.org/W2114383061","https://openalex.org/W2117825789","https://openalex.org/W2119281341","https://openalex.org/W2119351872","https://openalex.org/W2121389354","https://openalex.org/W2122730895","https://openalex.org/W2124084216","https://openalex.org/W2124196948","https://openalex.org/W2126277347","https://openalex.org/W2129787264","https://openalex.org/W2129936304","https://openalex.org/W2130244550","https://openalex.org/W2131413118","https://openalex.org/W2133508691","https://openalex.org/W2134630203","https://openalex.org/W2135051816","https://openalex.org/W2137487800","https://openalex.org/W2138797825","https://openalex.org/W2139910235","https://openalex.org/W2140407529","https://openalex.org/W2141127904","https://openalex.org/W2143546230","https://openalex.org/W2144262617","https://openalex.org/W2144264656","https://openalex.org/W2144831154","https://openalex.org/W2146012957","https://openalex.org/W2147326962","https://openalex.org/W2148000330","https://openalex.org/W2148537111","https://openalex.org/W2148802162","https://openalex.org/W2149032069","https://openalex.org/W2149530900","https://openalex.org/W2149931147","https://openalex.org/W2149942973","https://openalex.org/W2150696691","https://openalex.org/W2154834163","https://openalex.org/W2155008672","https://openalex.org/W2155523608","https://openalex.org/W2156382022","https://openalex.org/W2156647409","https://openalex.org/W2160605524","https://openalex.org/W2161000665","https://openalex.org/W2161959587","https://openalex.org/W2164687768","https://openalex.org/W2164837623","https://openalex.org/W2167539263","https://openalex.org/W2168106779","https://openalex.org/W2168479321","https://openalex.org/W2168586185","https://openalex.org/W2168752603","https://openalex.org/W2170542243","https://openalex.org/W2171313739","https://openalex.org/W2398518093","https://openalex.org/W2561540427","https://openalex.org/W2617635878","https://openalex.org/W4241530587"],"related_works":["https://openalex.org/W2323661500","https://openalex.org/W2058578594","https://openalex.org/W4412713766","https://openalex.org/W2791297317","https://openalex.org/W2789493946","https://openalex.org/W2030440427","https://openalex.org/W1513282104","https://openalex.org/W4404814472","https://openalex.org/W4296129731","https://openalex.org/W2158694435"],"abstract_inverted_index":{"In":[0],"recent":[1],"years,":[2],"tyrosine":[3,48,102],"kinases":[4],"(TKs)":[5],"have":[6,36],"been":[7,37,61],"recognized":[8],"as":[9],"central":[10],"players":[11],"and":[12,19,21,45,63,133],"regulators":[13],"of":[14,54,109,116],"cancer":[15,78,139],"cell":[16],"proliferation,":[17],"apoptosis,":[18],"angiogenesis,":[20],"are":[22,67,80],"therefore":[23],"considered":[24],"suitable":[25],"potential":[26],"targets":[27],"for":[28,33],"anti-cancer":[29],"therapies.":[30],"Several":[31],"strategies":[32],"targeting":[34],"TKs":[35],"developed,":[38],"the":[39,73,91,107,114],"most":[40,92],"successful":[41],"being":[42],"monoclonal":[43],"antibodies":[44],"small":[46],"molecule":[47],"kinase":[49,103],"inhibitors.":[50],"However,":[51],"increasing":[52],"evidence":[53],"acquired":[55,99],"resistance":[56,100,135],"to":[57,69,71,82,89,101,127,136],"these":[58,123],"drugs":[59],"has":[60],"documented,":[62],"extensive":[64],"preclinical":[65],"studies":[66,124],"ongoing":[68],"try":[70],"understand":[72],"molecular":[74,95],"mechanisms":[75,96],"by":[76],"which":[77],"cells":[79],"able":[81],"bypass":[83],"their":[84],"inhibitory":[85],"activity.This":[86],"review":[87],"intends":[88],"present":[90],"recently":[93],"identified":[94,105],"that":[97,131],"mediate":[98],"inhibitors,":[104],"through":[106],"use":[108],"in":[110,138],"vitro":[111],"models":[112],"or":[113],"analysis":[115],"patient":[117],"samples.":[118],"The":[119],"knowledge":[120],"obtained":[121],"from":[122],"will":[125],"help":[126],"design":[128],"better":[129],"therapies":[130],"prevent":[132],"overcome":[134],"treatment":[137],"patients.":[140]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":18},{"year":2016,"cited_by_count":24},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":32},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}