{"id":"https://openalex.org/W2145754044","doi":"https://doi.org/10.1158/1078-0432.ccr-08-0358","title":"An Initial Report of a Radiation Dose-Escalation Trial in Patients with One to Five Sites of Metastatic Disease","display_name":"An Initial Report of a Radiation Dose-Escalation Trial in Patients with One to Five Sites of Metastatic Disease","publication_year":2008,"publication_date":"2008-08-12","ids":{"openalex":"https://openalex.org/W2145754044","doi":"https://doi.org/10.1158/1078-0432.ccr-08-0358","mag":"2145754044","pmid":"https://pubmed.ncbi.nlm.nih.gov/18698045"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-08-0358","doi":"https://doi.org/10.1158/1078-0432.ccr-08-0358","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-08-0358","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066986846","display_name":"Joseph Kamel Salama","orcid":"https://orcid.org/0000-0001-5159-4687","observed_orcids":["https://orcid.org/0000-0001-5159-4687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph K. Salama","raw_affiliation_strings":["1Department of Radiation and Cellular Oncology,","2Cancer Research Center,","3The Ludwig Center for Metastasis Research,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Radiation and Cellular Oncology,","institution_ids":[]},{"raw_affiliation_string":"2Cancer Research Center,","institution_ids":[]},{"raw_affiliation_string":"3The Ludwig Center for Metastasis Research,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055476105","display_name":"Steven J. Chmura","orcid":"https://orcid.org/0000-0001-8851-7108","observed_orcids":["https://orcid.org/0000-0001-8851-7108"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven J. Chmura","raw_affiliation_strings":["1Department of Radiation and Cellular Oncology,","2Cancer Research Center,","3The Ludwig Center for Metastasis Research,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Radiation and Cellular Oncology,","institution_ids":[]},{"raw_affiliation_string":"2Cancer Research Center,","institution_ids":[]},{"raw_affiliation_string":"3The Ludwig Center for Metastasis Research,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Neil Mehta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil Mehta","raw_affiliation_strings":["5SWC Oncology, Palos Height, Illinois"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5SWC Oncology, Palos Height, Illinois","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038523162","display_name":"Kamil M. Yenice","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamil M. Yenice","raw_affiliation_strings":["1Department of Radiation and Cellular Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Radiation and Cellular Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088131964","display_name":"Walter Michael Stadler","orcid":"https://orcid.org/0000-0002-0435-2527","observed_orcids":["https://orcid.org/0000-0002-0435-2527"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Walter M. Stadler","raw_affiliation_strings":["2Cancer Research Center,","4Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Cancer Research Center,","institution_ids":[]},{"raw_affiliation_string":"4Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois and","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063904421","display_name":"Everett E. Vokes","orcid":"https://orcid.org/0000-0002-8645-8068","observed_orcids":["https://orcid.org/0000-0002-8645-8068"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Everett E. Vokes","raw_affiliation_strings":["1Department of Radiation and Cellular Oncology,","2Cancer Research Center,","4Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Radiation and Cellular Oncology,","institution_ids":[]},{"raw_affiliation_string":"2Cancer Research Center,","institution_ids":[]},{"raw_affiliation_string":"4Section of Hematology/Oncology, The University of Chicago, Chicago, Illinois and","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038481817","display_name":"Daniel J. Haraf","orcid":"https://orcid.org/0000-0001-5184-1166","observed_orcids":["https://orcid.org/0000-0001-5184-1166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel J. Haraf","raw_affiliation_strings":["1Department of Radiation and Cellular Oncology,","2Cancer Research Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Radiation and Cellular Oncology,","institution_ids":[]},{"raw_affiliation_string":"2Cancer Research Center,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068338594","display_name":"Samuel Hellm\u00e4n","orcid":"https://orcid.org/0009-0003-8360-6306","observed_orcids":["https://orcid.org/0009-0003-8360-6306"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel Hellman","raw_affiliation_strings":["1Department of Radiation and Cellular Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Radiation and Cellular Oncology,","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054855052","display_name":"Ralph R. Weichselbaum","orcid":"https://orcid.org/0000-0002-5643-8939","observed_orcids":["https://orcid.org/0000-0002-5643-8939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph R. Weichselbaum","raw_affiliation_strings":["1Department of Radiation and Cellular Oncology,","2Cancer Research Center,","3The Ludwig Center for Metastasis Research,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Radiation and Cellular Oncology,","institution_ids":[]},{"raw_affiliation_string":"2Cancer Research Center,","institution_ids":[]},{"raw_affiliation_string":"3The Ludwig Center for Metastasis Research,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.425,"has_fulltext":false,"cited_by_count":89,"citation_normalized_percentile":{"value":0.97432213,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"16","first_page":"5255","last_page":"5259"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12108","display_name":"Management of metastatic bone disease","score":0.8442000150680542,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.0544000007212162,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.04560000076889992,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligometastatic-disease","display_name":"oligometastatic disease","score":0.9850000143051147},{"id":"https://openalex.org/keywords/metastatic-cancer","display_name":"metastatic cancer","score":0.9259999990463257},{"id":"https://openalex.org/keywords/hypofractionated-radiotherapy","display_name":"hypofractionated radiotherapy","score":0.8830000162124634},{"id":"https://openalex.org/keywords/radiotherapy-dose-escalation","display_name":"radiation dose escalation","score":0.906000018119812},{"id":"https://openalex.org/keywords/fdg-pet-response","display_name":"FDG-PET response","score":0.6330000162124634},{"id":"https://openalex.org/keywords/radiation-toxicity","display_name":"radiation toxicity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.4390000104904175}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9078214168548584},{"id":"https://openalex.org/C2777793932","wikidata":"https://www.wikidata.org/wiki/Q1116229","display_name":"Common Terminology Criteria for Adverse Events","level":3,"score":0.7713658809661865},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6885600090026855},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6353598833084106},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5399271845817566},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5035037398338318},{"id":"https://openalex.org/C2779524853","wikidata":"https://www.wikidata.org/wiki/Q1284347","display_name":"Pneumonitis","level":3,"score":0.4401783049106598},{"id":"https://openalex.org/C2778357063","wikidata":"https://www.wikidata.org/wiki/Q713102","display_name":"Pelvis","level":2,"score":0.43407750129699707},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.4289303421974182},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.42483627796173096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3829931914806366},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3441067337989807},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.14279711246490479}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D011881","descriptor_name":"Radiotherapy, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019583","descriptor_name":"Dose Fractionation, Radiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020266","descriptor_name":"Radiotherapy, Conformal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-08-0358","doi":"https://doi.org/10.1158/1078-0432.ccr-08-0358","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-08-0358","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:18698045","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18698045","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1583948349","https://openalex.org/W1979300931","https://openalex.org/W1984107964","https://openalex.org/W1999966467","https://openalex.org/W2002260386","https://openalex.org/W2022980644","https://openalex.org/W2030505692","https://openalex.org/W2034855589","https://openalex.org/W2042770658","https://openalex.org/W2045356660","https://openalex.org/W2067003626","https://openalex.org/W2080439368","https://openalex.org/W2082833890","https://openalex.org/W2091353570","https://openalex.org/W2091461365","https://openalex.org/W2092192760","https://openalex.org/W2097593062","https://openalex.org/W2120292596","https://openalex.org/W2125551462","https://openalex.org/W2145835533","https://openalex.org/W2157222268","https://openalex.org/W2157769714","https://openalex.org/W2162427240","https://openalex.org/W2327610290","https://openalex.org/W3041047318","https://openalex.org/W4240340450"],"related_works":["https://openalex.org/W1528207664","https://openalex.org/W3022844141","https://openalex.org/W2758911710","https://openalex.org/W3197881686","https://openalex.org/W7162675232","https://openalex.org/W3167186646","https://openalex.org/W2022441355","https://openalex.org/W3119069444","https://openalex.org/W1969931281","https://openalex.org/W1975452943"],"abstract_inverted_index":{"PURPOSE:":[0],"Previous":[1],"investigations":[2],"have":[3,208,219],"suggested":[4],"that":[5],"a":[6,14,69,171],"subset":[7],"of":[8,17,32,52,65,72,82,88,102,174,198,206,216,234],"patients":[9,28,157,178,199,207],"with":[10,29,55,60,68,90,98,110,158,170,238],"metastatic":[11,33,66,160,240],"cancer":[12,27,67,89,241],"in":[13,232],"limited":[15,30],"number":[16],"organs":[18],"may":[19,248],"benefit":[20,249],"from":[21,164,250],"local":[22,230],"treatment.":[23,213],"We":[24],"investigated":[25],"whether":[26],"sites":[31,51,64,87],"disease":[34,54],"(oligometastasis)":[35],"who":[36],"failed":[37],"standard":[38],"therapies":[39],"could":[40],"be":[41,243],"identified":[42],"and":[43,75,106,108,118,140,183,185,247],"safely":[44,245],"treated":[45,217],"at":[46,222],"one":[47,61,186],"to":[48,62,84,167,201,228],"five":[49,63],"known":[50,86],"low-volume":[53,239],"radiotherapy.":[56,251],"EXPERIMENTAL":[57],"DESIGN:":[58],"Patients":[59,94,237],"life":[70],"expectancy":[71],">3":[73],"months":[74],"good":[76],"performance":[77],"status":[78],"received":[79],"escalating":[80],"doses":[81],"radiation":[83,92],"all":[85],"hypofractionated":[91],"therapy.":[93,203],"were":[95,125,143,162],"followed":[96],"radiographically":[97],"computed":[99],"tomography":[100,113],"scans":[101],"the":[103,128,146],"chest,":[104],"abdomen,":[105],"pelvis":[107],"metabolically":[109],"[18F]fluorodeoxyglucose-positron":[111],"emission":[112],"1":[114],"month":[115],"following":[116,211],"treatment":[117],"then":[119],"every":[120],"3":[121],"months.":[122,176],"Acute":[123],"toxicities":[124,142],"scored":[126,144],"using":[127,145],"National":[129],"Cancer":[130],"Institute":[131],"Common":[132],"Terminology":[133],"Criteria":[134],"for":[135],"Adverse":[136],"Events":[137],"version":[138],"3.0":[139],"late":[141,151],"Radiation":[147],"Therapy":[148],"Oncology":[149],"Group":[150],"toxicity":[152],"scoring":[153],"system.":[154],"RESULTS:":[155],"Twenty-nine":[156],"56":[159],"lesions":[161,218],"enrolled":[163],"November":[165],"2004":[166],"March":[168],"2007,":[169],"median":[172],"follow-up":[173],"14.9":[175],"Two":[177],"experienced":[179,187],"acute":[180],"(radiation":[181],"pneumonitis":[182],"nausea)":[184],"chronic":[188],"(gastrointestinal":[189],"hemorrhage)":[190],"grade":[191],">":[192],"or":[193],"=3":[194],"toxicity.":[195],"Fifty-nine":[196],"percent":[197,205,215],"responded":[200],"protocol":[202,212],"Twenty-one":[204],"not":[209,220],"progressed":[210,221],"Fifty-seven":[214],"last":[223],"follow-up.":[224],"Progression":[225],"was":[226],"amenable":[227],"further":[229],"therapy":[231],"48%":[233],"patients.":[235],"CONCLUSIONS:":[236],"can":[242],"identified,":[244],"treated,":[246]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}