{"id":"https://openalex.org/W2145709103","doi":null,"title":"Difluoromethylornithine chemoprevention of epidermal carcinogenesis in K14-HPV16 transgenic mice.","display_name":"Difluoromethylornithine chemoprevention of epidermal carcinogenesis in K14-HPV16 transgenic mice.","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W2145709103","mag":"2145709103","pmid":"https://pubmed.ncbi.nlm.nih.gov/10446971"},"language":"en","primary_location":{"id":"pmid:10446971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10446971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108521588","display_name":"Jeffery M. Arbeit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J M Arbeit","raw_affiliation_strings":["UCSF Cancer Center, San Francisco, California 94143, USA. arbeit@cc.ucsf.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCSF Cancer Center, San Francisco, California 94143, USA. arbeit@cc.ucsf.edu","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028693815","display_name":"Rebeccah R. Riley","orcid":"https://orcid.org/0000-0002-5870-6837","observed_orcids":["https://orcid.org/0000-0002-5870-6837"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R R Riley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051117934","display_name":"Bing Huey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Huey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"C Porter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C Porter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048308941","display_name":"Gary J. Kelloff","orcid":"https://orcid.org/0000-0002-5656-4900","observed_orcids":["https://orcid.org/0000-0002-5656-4900"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Kelloff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111500448","display_name":"Ron Lubet","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Lubet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056561546","display_name":"J M Ward","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Ward","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111957391","display_name":"Daniel Pinkel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Pinkel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2454,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.76354865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"59","issue":"15","first_page":"3610","last_page":"20"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11924","display_name":"Polyamine Metabolism and Applications","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/difluoromethylornithine","display_name":"difluoromethylornithine","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.9259999990463257},{"id":"https://openalex.org/keywords/epidermal-carcinogenesis","display_name":"epidermal carcinogenesis","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ornithine-decarboxylase-inhibition","display_name":"ornithine decarboxylase inhibition","score":0.8600000143051147},{"id":"https://openalex.org/keywords/polyamine-metabolism","display_name":"polyamine metabolism","score":0.9470000267028809},{"id":"https://openalex.org/keywords/putrescine","display_name":"putrescine","score":0.8970000147819519},{"id":"https://openalex.org/keywords/ear-cancer","display_name":"ear cancer","score":0.3569999933242798},{"id":"https://openalex.org/keywords/precancerous-lesions","display_name":"precancerous lesions","score":0.7979999780654907},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6714290976524353},{"id":"https://openalex.org/C121289238","wikidata":"https://www.wikidata.org/wiki/Q931579","display_name":"Ornithine decarboxylase","level":3,"score":0.6652425527572632},{"id":"https://openalex.org/C2780115381","wikidata":"https://www.wikidata.org/wiki/Q421959","display_name":"Polyamine","level":2,"score":0.609765887260437},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.5807027220726013},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5608794093132019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44698596000671387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4155122637748718},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3846595287322998},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38355132937431335},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.36493736505508423},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3629630506038666},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06269174814224243},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06053522229194641},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000518","descriptor_name":"Eflornithine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000518","descriptor_name":"Eflornithine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000518","descriptor_name":"Eflornithine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004423","descriptor_name":"Ear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007633","descriptor_name":"Keratins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011700","descriptor_name":"Putrescine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012871","descriptor_name":"Skin Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013909","descriptor_name":"Thorax","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016588","descriptor_name":"Anticarcinogenic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019076","descriptor_name":"Transgenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D027383","descriptor_name":"Papillomaviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053547","descriptor_name":"Keratin-14","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065108","descriptor_name":"Ornithine Decarboxylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10446971","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10446971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2145709103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10446971","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3972355017","display_name":"PRECLINICAL EVALUATIONS OF INTERMEDIATE ENDPOINTS","funder_award_id":"n01cn055183-002","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W43017604","https://openalex.org/W47953737","https://openalex.org/W1484020898","https://openalex.org/W1487217102","https://openalex.org/W1529419844","https://openalex.org/W1556279087","https://openalex.org/W1556848075","https://openalex.org/W1562563770","https://openalex.org/W1567178433","https://openalex.org/W1569924715","https://openalex.org/W1576015926","https://openalex.org/W1596365792","https://openalex.org/W1608358877","https://openalex.org/W1609254428","https://openalex.org/W1687775674","https://openalex.org/W1868796410","https://openalex.org/W1963903539","https://openalex.org/W1968506175","https://openalex.org/W1980332250","https://openalex.org/W1982172428","https://openalex.org/W1985386774","https://openalex.org/W1986833613","https://openalex.org/W2000330422","https://openalex.org/W2000530321","https://openalex.org/W2005740472","https://openalex.org/W2007705990","https://openalex.org/W2008266758","https://openalex.org/W2010153946","https://openalex.org/W2013436237","https://openalex.org/W2014091897","https://openalex.org/W2014418134","https://openalex.org/W2017773116","https://openalex.org/W2018208300","https://openalex.org/W2023321396","https://openalex.org/W2024575518","https://openalex.org/W2026644829","https://openalex.org/W2029031988","https://openalex.org/W2029917964","https://openalex.org/W2039249065","https://openalex.org/W2039323907","https://openalex.org/W2041144325","https://openalex.org/W2041460044","https://openalex.org/W2049761824","https://openalex.org/W2051686420","https://openalex.org/W2059928759","https://openalex.org/W2074101255","https://openalex.org/W2077044260","https://openalex.org/W2080628861","https://openalex.org/W2101005249","https://openalex.org/W2109338704","https://openalex.org/W2117304898","https://openalex.org/W2135991192","https://openalex.org/W2137254784","https://openalex.org/W2138664843","https://openalex.org/W2145344972","https://openalex.org/W2145925849","https://openalex.org/W2147822352","https://openalex.org/W2148459495","https://openalex.org/W2161356660","https://openalex.org/W2177441133","https://openalex.org/W2184431203","https://openalex.org/W2223029678","https://openalex.org/W2334245459","https://openalex.org/W2397256054","https://openalex.org/W2404671200","https://openalex.org/W2414509775","https://openalex.org/W3015374474"],"related_works":["https://openalex.org/W2011047085","https://openalex.org/W2125928562","https://openalex.org/W2113731575","https://openalex.org/W7095309250","https://openalex.org/W1986312202","https://openalex.org/W2188102195","https://openalex.org/W52119757","https://openalex.org/W1612038793","https://openalex.org/W2168886093","https://openalex.org/W7099169517"],"abstract_inverted_index":{"To":[0],"be":[1],"informative":[2],"for":[3,326],"chemoprevention,":[4],"animal":[5],"models":[6],"must":[7],"both":[8,157,209,325],"closely":[9],"emulate":[10],"human":[11],"disease":[12],"and":[13,28,41,46,110,128,135,144,189,211,214,221,227,273,302,333,341],"possess":[14],"surrogate":[15,30],"endpoint":[16,31],"biomarkers":[17,32],"that":[18,43,118,150,290],"facilitate":[19],"rapid":[20],"drug":[21],"screening.":[22],"This":[23],"study":[24,313,328],"elucidated":[25],"site-specific":[26],"histopathological":[27],"biochemical":[29],"of":[33,48,64,78,106,120,156,159,167,186,194,206,219,247,255,263,270,277,293,317,329],"spontaneous":[34],"epidermal":[35,66,191,319],"carcinogenesis":[36,320],"in":[37,68,88,94,104,142,169,173,182,190,197,237,250,284,289,321],"K14-HPV16":[38,322],"transgenic":[39,71,108,256,323],"mice":[40,72,109,257,324],"demonstrated":[42],"the":[44,54,83,95,170,174,183,198,217,282,291,315,327,330],"incidence":[45,63,218,299],"severity":[47,292],"these":[49,248,309],"markers":[50],"were":[51,102,111,119,139,231,287,305],"decreased":[52,216],"by":[53,75,234],"ornithine":[55],"decarboxylase":[56],"(ODC)":[57],"inhibitor":[58],"difluoromethylornithine":[59],"(DFMO).":[60],"The":[61],"cumulative":[62],"visible":[65,210],"cancers":[67,304],"127":[69],"untreated":[70],"was":[73,152,178,242,265,300],"42%":[74],"52":[76],"weeks":[77,166,205,262],"age,":[79],"most":[80],"frequently":[81],"affecting":[82],"chest":[84,131,145,220,251,285,294],"as":[85,97,162,164,334],"flat":[86],"lesions":[87,117],"association":[89],"with":[90,267],"chronic":[91],"ulcers,":[92],"or":[93],"ear":[96,126,143,222,238,271],"protuberant":[98],"masses.":[99],"Microscopic":[100],"malignancies":[101,213],"detected":[103],"39%":[105],"32-week-old":[107],"found":[112],"to":[113,203,260],"emerge":[114],"from":[115,201,258],"precursor":[116,223],"two":[121],"distinct":[122],"types:":[123],"dysplastic":[124,278],"sessile":[125],"papillomas":[127],"hyperproliferative":[129],"follicular/interfollicular":[130],"dysplasias.":[132],"ODC":[133,225],"activity":[134,226],"tissue":[136,228],"polyamine":[137,160,176],"contents":[138],"differentially":[140],"elevated":[141],"skin":[146,286],"during":[147],"carcinogenesis,":[148],"such":[149],"there":[151,241],"a":[153,243,274,335],"marked":[154,275],"elevation":[155],"parameters":[158,249],"metabolism":[161,177],"early":[163],"4":[165,202],"age":[168,207,264],"ear,":[171],"whereas":[172,240],"chest,":[175],"increased":[179],"significantly":[180,215],"only":[181],"late":[184],"stages":[185],"neoplastic":[187],"progression":[188],"cancers.":[192],"Administration":[193],"1.0%":[195],"DFMO":[196,235,253],"drinking":[199],"water":[200],"32":[204,261],"prevented":[208],"microscopic":[212,303],"lesions.":[224,310],"putrescine":[229],"content":[230],"markedly":[232],"diminished":[233],"chemoprevention":[236],"skin,":[239],"more":[244],"modest":[245],"decline":[246],"skin.":[252],"treatment":[254],"28":[259],"associated":[266],"an":[268],"absence":[269],"cancer":[272],"regression":[276],"papillomas.":[279],"In":[280],"contrast,":[281],"results":[283],"complex":[288],"precursors":[295],"diminished,":[296],"but":[297],"their":[298],"unchanged,":[301],"still":[306],"detectable":[307],"within":[308],"Collectively,":[311],"this":[312],"highlights":[314],"utility":[316],"multistage":[318],"biology":[331],"of,":[332],"screening":[336],"tool":[337],"for,":[338],"novel":[339],"drugs":[340],"chemopreventive":[342],"regimens.":[343]},"counts_by_year":[{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
