{"id":"https://openalex.org/W2145708132","doi":null,"title":"Beneficial Antipsychotic Effects of Omega-3 Fatty Acids Add-On Therapy for the Pharmacological Management of Patients With Schizophrenia","display_name":"Beneficial Antipsychotic Effects of Omega-3 Fatty Acids Add-On Therapy for the Pharmacological Management of Patients With Schizophrenia","publication_year":2008,"publication_date":"2008-07-31","ids":{"openalex":"https://openalex.org/W2145708132","mag":"2145708132"},"language":"en","primary_location":{"id":"mag:2145708132","doi":null,"is_oa":false,"landing_page_url":"http://ijpbs.neoscriber.org/cdn/dl/8eb44ff0-e707-11e6-9e28-d32ade97c239","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050890055","display_name":"Ali Manteghiy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ali Manteghiy","raw_affiliation_strings":["Ibn-E-Sina Psychiatric Hospital, Bue Ali square, Ameli Ave., Mashhad University of Medical Science and Health Services, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ibn-E-Sina Psychiatric Hospital, Bue Ali square, Ameli Ave., Mashhad University of Medical Science and Health Services, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000759080","display_name":"Mohammad Taghi Shakeri","orcid":"https://orcid.org/0000-0002-8287-9594","observed_orcids":["https://orcid.org/0000-0002-8287-9594"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mohammad Taghi Shakeri","raw_affiliation_strings":["Mashhad University of Medical Sciences and Health Services, Mashhad, Iran"],"raw_orcid":"https://orcid.org/0000-0002-8287-9594","affiliations":[{"raw_affiliation_string":"Mashhad University of Medical Sciences and Health Services, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048904844","display_name":"Laleh Koohestani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Laleh Koohestani","raw_affiliation_strings":["Mashhad University of Medical Sciences and Health Services, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mashhad University of Medical Sciences and Health Services, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"last","author":{"id":null,"display_name":"Elham Salari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Elham Salari","raw_affiliation_strings":["Mashhad University of Medical Sciences and Health Services, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mashhad University of Medical Sciences and Health Services, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165560825"],"apc_list":null,"apc_paid":null,"fwci":0.2038,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.58374599,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"2","issue":"2","first_page":"35","last_page":"40"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.7832000255584717,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10387","display_name":"Fatty Acid Research and Health","score":0.21230000257492065,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omega-3-fatty-acids","display_name":"omega-3 fatty acids","score":0.9950000047683716},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/risperidone","display_name":"risperidone","score":0.9599999785423279},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.859000027179718},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.8159999847412109},{"id":"https://openalex.org/keywords/positive-and-negative-symptoms","display_name":"positive and negative symptoms","score":0.7689999938011169},{"id":"https://openalex.org/keywords/omega-3-fatty-acid-deficiency","display_name":"omega-3 deficiency","score":0.5830000042915344},{"id":"https://openalex.org/keywords/hospitalized-patients","display_name":"hospitalized patients","score":0.4169999957084656}],"concepts":[{"id":"https://openalex.org/C2780057945","wikidata":"https://www.wikidata.org/wiki/Q412443","display_name":"Risperidone","level":3,"score":0.8938779830932617},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.7421017289161682},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.730576753616333},{"id":"https://openalex.org/C2780494398","wikidata":"https://www.wikidata.org/wiki/Q208144","display_name":"Antipsychotic","level":3,"score":0.6094360947608948},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5522388219833374},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5133832693099976},{"id":"https://openalex.org/C2780135775","wikidata":"https://www.wikidata.org/wiki/Q7233251","display_name":"Positive and Negative Syndrome Scale","level":3,"score":0.486405611038208},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4746066927909851},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.44090718030929565},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.37692564725875854},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3565751016139984},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.25870150327682495},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2145708132","doi":null,"is_oa":false,"landing_page_url":"http://ijpbs.neoscriber.org/cdn/dl/8eb44ff0-e707-11e6-9e28-d32ade97c239","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W607947957","https://openalex.org/W972265609","https://openalex.org/W1556485502","https://openalex.org/W1688754235","https://openalex.org/W1963651433","https://openalex.org/W1973929440","https://openalex.org/W1986482524","https://openalex.org/W1993401922","https://openalex.org/W2027225253","https://openalex.org/W2034194523","https://openalex.org/W2066902809","https://openalex.org/W2099170374","https://openalex.org/W2117752152","https://openalex.org/W2122634210","https://openalex.org/W2130279922","https://openalex.org/W2131417790","https://openalex.org/W2138506253","https://openalex.org/W2262793543","https://openalex.org/W4367485085"],"related_works":["https://openalex.org/W2049727618","https://openalex.org/W2252894397","https://openalex.org/W4312812949","https://openalex.org/W7220553130","https://openalex.org/W3132681180","https://openalex.org/W4416122410","https://openalex.org/W2960627740","https://openalex.org/W7219904368","https://openalex.org/W7029486156","https://openalex.org/W1970622627"],"abstract_inverted_index":{"Objective:":[0],"It":[1],"has":[2],"been":[3,49],"shown":[4],"that":[5,219],"serum":[6],"and":[7,109,131,148,166,177,179,203],"red":[8],"blood":[9],"cells\u2019":[10],"level":[11],"of":[12,32,38,43,65,68,105,117,146,151,164,184,206,214,234,238,247],"Omega-3":[13,91,118,191,240],"fatty":[14,192,241],"acids":[15,193,242],"are":[16,225],"low":[17],"in":[18,35,141,161,199,227,243],"people":[19],"with":[20,83],"schizophrenia.":[21,207,248],"Many":[22],"studies":[23,46],"have,":[24],"therefore,":[25],"attempted":[26],"to":[27,58,87,197,210,229],"explore":[28],"the":[29,36,41,44,66,69,149,162,181,185,201,235,239,244],"beneficial":[30],"effects":[31,237],"these":[33],"substances":[34],"management":[37,246],"Schizophrenia.":[39],"However,":[40,208],"outcomes":[42],"previous":[45,70,152],"have":[47],"not":[48],"clear":[50],"cut.":[51],"The":[52,122],"present":[53],"study":[54],"is":[55],"an":[56],"attempt":[57],"retest":[59],"this":[60],"hypothesis":[61],"by":[62,127],"eliminating":[63],"some":[64],"limitations":[67],"studies.":[71],"Methods:":[72],"In":[73,188],"a":[74,97,211,231],"prospective":[75],"double":[76],"blind":[77],"placebo-controlled":[78],"clinical":[79,223],"trial,":[80],"85":[81],"inpatients":[82],"schizophrenia":[84],"randomly":[85],"assigned":[86],"either":[88],"risperidone":[89,93,106,113],"plus":[90,94,107,114],"or":[92],"placebo.":[95],"After":[96],"washout":[98],"period,":[99],"44":[100],"patients":[101,111],"received":[102,112],"2-8":[103],"mg/day":[104],"placebo":[108,198],"43":[110],"3":[115,176],"gr/day":[116],"for":[119,180],"6":[120,178],"weeks.":[121],"treatment":[123],"effect":[124],"was":[125],"calculated":[126],"Friedman,":[128],"Mann":[129],"Whitney":[130],"t":[132],"test.":[133],"There":[134,155],"were":[135,156],"no":[136,157,195],"significant":[137,159],"differences":[138,160],"between":[139,170],"groups":[140,172],"age,":[142],"sex,":[143],"education,":[144],"duration":[145,183,213],"illness":[147],"number":[150],"hospitalizations.":[153],"Results:":[154],"statistically":[158],"scores":[163],"Positive":[165],"Negative":[167],"Syndrome":[168],"Scale":[169],"two":[171],"at":[173],"weeks":[174],"0,":[175],"whole":[182],"study.":[186],"Conclusion:":[187],"our":[189,215],"study,":[190,216],"had":[194],"superiority":[196],"reducing":[200],"positive":[202],"negative":[204],"symptoms":[205],"due":[209],"short":[212],"we":[217],"recommend":[218],"more":[220],"long":[221],"term":[222],"trials":[224],"needed":[226],"order":[228],"develop":[230],"better":[232],"understanding":[233],"therapeutic":[236],"pharmacological":[245]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}