{"id":"https://openalex.org/W2145690342","doi":"https://doi.org/10.2337/db08-0872","title":"Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes","display_name":"Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W2145690342","doi":"https://doi.org/10.2337/db08-0872","mag":"2145690342","pmid":"https://pubmed.ncbi.nlm.nih.gov/18829989","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2584129"},"language":"en","primary_location":{"id":"doi:10.2337/db08-0872","doi":"https://doi.org/10.2337/db08-0872","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db08-0872","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.2337/db08-0872","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024258221","display_name":"Carey Nien-Kai Lumeng","orcid":"https://orcid.org/0000-0003-0303-6204","observed_orcids":["https://orcid.org/0000-0003-0303-6204"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carey N. Lumeng","raw_affiliation_strings":["Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan","Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan","Life Sciences Institute, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112046933","display_name":"Jennifer B. DelProposto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer B. DelProposto","raw_affiliation_strings":["Life Sciences Institute, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076251668","display_name":"Daniel J. Westcott","orcid":"https://orcid.org/0000-0002-1828-2582","observed_orcids":["https://orcid.org/0000-0002-1828-2582"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Westcott","raw_affiliation_strings":["Life Sciences Institute, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018176504","display_name":"Alan R. Saltiel","orcid":"https://orcid.org/0000-0002-9726-9828","observed_orcids":["https://orcid.org/0000-0002-9726-9828"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan R. Saltiel","raw_affiliation_strings":["Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan","Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan","Life Sciences Institute, University of Michigan, Ann Arbor, Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":21.6911,"has_fulltext":true,"cited_by_count":951,"citation_normalized_percentile":{"value":0.99671231,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"57","issue":"12","first_page":"3239","last_page":"3246"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-tissue-macrophages","display_name":"adipose tissue macrophages","score":0.9980000257492065},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7860000133514404},{"id":"https://openalex.org/keywords/m2a-macrophages","display_name":"M2a macrophages","score":0.8529999852180481},{"id":"https://openalex.org/keywords/m1-macrophages","display_name":"M1 macrophages","score":0.996999979019165},{"id":"https://openalex.org/keywords/ccr2","display_name":"CCR2","score":0.8399999737739563},{"id":"https://openalex.org/keywords/macrophage-recruitment","display_name":"macrophage recruitment","score":0.8180000185966492},{"id":"https://openalex.org/keywords/adipose-tissue-inflammation","display_name":"adipose tissue inflammation","score":0.6539999842643738},{"id":"https://openalex.org/keywords/adipogenic-differentiation","display_name":"adipogenesis","score":0.7900000214576721},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8640000224113464},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.8080000281333923}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6695880889892578},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6428446769714355},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5946498513221741},{"id":"https://openalex.org/C17675752","wikidata":"https://www.wikidata.org/wiki/Q12898553","display_name":"Adipose tissue macrophages","level":4,"score":0.5562409162521362},{"id":"https://openalex.org/C122927707","wikidata":"https://www.wikidata.org/wiki/Q2824461","display_name":"Adipogenesis","level":3,"score":0.5545665621757507},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5517615079879761},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.507569432258606},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.45594465732574463},{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.447394996881485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44018369913101196},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.439972460269928},{"id":"https://openalex.org/C2776175234","wikidata":"https://www.wikidata.org/wiki/Q357519","display_name":"Adipocyte","level":3,"score":0.4216794967651367},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.4125567376613617},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.405588299036026},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.36661434173583984},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34654176235198975},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27799201011657715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2370358407497406},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18564465641975403},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18061912059783936},{"id":"https://openalex.org/C151955695","wikidata":"https://www.wikidata.org/wiki/Q654528","display_name":"White adipose tissue","level":3,"score":0.11041736602783203},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09718888998031616},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.0890464186668396},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001212","descriptor_name":"Asialoglycoproteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D001212","descriptor_name":"Asialoglycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001212","descriptor_name":"Asialoglycoproteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054390","descriptor_name":"Receptors, CCR2","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D054390","descriptor_name":"Receptors, CCR2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054390","descriptor_name":"Receptors, CCR2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.2337/db08-0872","doi":"https://doi.org/10.2337/db08-0872","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db08-0872","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2584129","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2584129","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Text"},{"id":"pmid:18829989","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18829989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6w74w20b","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/6w74w20b","pdf_url":"https://escholarship.org/content/qt6w74w20b/qt6w74w20b.pdf","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, vol 57, iss 12","raw_type":"article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.278.1617","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.278.1617","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/96/ce/Diabetes_2008_Dec_57(12)_3239-3246.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.623.4306","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.623.4306","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://diabetes.diabetesjournals.org/content/57/12/3239.full.pdf","raw_type":"text"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt6w74w20b","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6w74w20b","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diabetes, vol 57, iss 12","raw_type":"article"}],"best_oa_location":{"id":"doi:10.2337/db08-0872","doi":"https://doi.org/10.2337/db08-0872","is_oa":true,"landing_page_url":"https://doi.org/10.2337/db08-0872","pdf_url":null,"source":{"id":"https://openalex.org/S129060628","display_name":"Diabetes","issn_l":"0012-1797","issn":["0012-1797","1939-327X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320274","host_organization_name":"American Diabetes Association","host_organization_lineage":["https://openalex.org/P4310320274"],"host_organization_lineage_names":["American Diabetes Association"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2201854337","display_name":"Michigan Diabetes Research and Training Center","funder_award_id":"P60DK020572","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3823198395","display_name":null,"funder_award_id":"HD028820","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6904411972","display_name":"Signaling Pathways in Insulin Action","funder_award_id":"R01DK060591","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7738382678","display_name":"Adipose tissue macrophage polarization and its influence on adipocyte function","funder_award_id":"K08DK078851","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000888561","display_name":"Advancing Child Health Through Cellular and Molecular Biology","funder_award_id":"K12HD028820","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145690342.pdf","grobid_xml":"https://content.openalex.org/works/W2145690342.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W164884863","https://openalex.org/W1764140709","https://openalex.org/W1976844022","https://openalex.org/W1985929369","https://openalex.org/W1991401793","https://openalex.org/W1993067007","https://openalex.org/W2009170266","https://openalex.org/W2010472544","https://openalex.org/W2020744745","https://openalex.org/W2084622089","https://openalex.org/W2086073611","https://openalex.org/W2093705034","https://openalex.org/W2112004869","https://openalex.org/W2114360920","https://openalex.org/W2114412752","https://openalex.org/W2121438383","https://openalex.org/W2128553223","https://openalex.org/W2131598118","https://openalex.org/W2134046076","https://openalex.org/W2139716106","https://openalex.org/W2139833921","https://openalex.org/W2141189887","https://openalex.org/W2145441493","https://openalex.org/W2145697808","https://openalex.org/W2150252938","https://openalex.org/W2150586369","https://openalex.org/W2152037832","https://openalex.org/W2155654730","https://openalex.org/W2158380859","https://openalex.org/W2165202791","https://openalex.org/W2167485774","https://openalex.org/W2620406790","https://openalex.org/W4250725029","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7099185402","https://openalex.org/W2145697808","https://openalex.org/W3045131948","https://openalex.org/W2222894597","https://openalex.org/W1971434116","https://openalex.org/W2023655124","https://openalex.org/W2152037832","https://openalex.org/W2106466636","https://openalex.org/W2804734969","https://openalex.org/W1970757590"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"establish":[2],"the":[3,6,64,80,136,182,194,210,222,227],"mechanism":[4],"of":[5,9,45,59,67,98,114,138,140,152,196,213,229],"phenotypic":[7],"switch":[8,202],"adipose":[10],"tissue":[11],"macrophages":[12,142,166,232],"(ATMs)":[13],"from":[14,32,221],"an":[15,214],"alternatively":[16],"activated":[17,22],"(M2a)":[18],"to":[19,69,92,127,143,209,218,226,233],"a":[20,43,112],"classically":[21],"(M1)":[23],"phenotype":[24],"with":[25,61,117],"obesity.":[26],"RESEARCH":[27],"DESIGN":[28],"AND":[29],"METHODS:":[30],"ATMs":[31,60,68,75,106,116,235],"lean":[33,77],"and":[34,49,54,90,100,120,164,172,190,224],"obese":[35],"(high-fat":[36],"diet-fed)":[37],"C57Bl/6":[38],"mice":[39,78],"were":[40],"analyzed":[41],"by":[42,188],"combination":[44],"flow":[46],"cytometry,":[47],"immunofluorescence,":[48],"expression":[50,124],"analysis":[51],"for":[52],"M2a":[53,81,122,231],"M1":[55,119,234],"genes.":[56],"Pulse":[57,132],"labeling":[58,133],"PKH26":[62],"assessed":[63],"recruitment":[65,139,157,195,212],"rate":[66,137],"spatially":[70],"distinct":[71,197],"regions.":[72],"RESULTS:":[73],"Resident":[74],"in":[76,108,160,176,181,193,203,236],"express":[79],"marker":[82],"macrophage":[83,219],"galactose":[84],"N-acetyl-galactosamine":[85],"specific":[86],"lectin":[87],"1":[88],"(MGL1)":[89],"localize":[91],"interstitial":[93,109,153],"spaces":[94],"between":[95],"adipocytes":[96],"independent":[97],"CCR2":[99],"CCL2.":[101],"With":[102],"diet-induced":[103],"obesity,":[104],"MGL1(+)":[105,154],"remain":[107],"spaces,":[110],"whereas":[111],"population":[113],"MGL1(-)CCR2(+)":[115],"high":[118],"low":[121],"gene":[123],"is":[125,147,158,186,207],"recruited":[126],"clusters":[128,146,220],"surrounding":[129],"necrotic":[130],"adipocytes.":[131],"showed":[134],"that":[135,151],"new":[141],"MGL1(-)":[144],"ATM":[145,184,198,204,216],"significantly":[148],"faster":[149],"than":[150],"ATMs.":[155],"This":[156],"attenuated":[159],"Ccr2(-/-)":[161],"mice.":[162],"M2a-":[163],"M1-polarized":[165],"produced":[167],"different":[168],"effects":[169],"on":[170],"adipogenesis":[171],"adipocyte":[173],"insulin":[174],"sensitivity":[175],"vitro.":[177],"CONCLUSIONS:":[178],"The":[179,200],"shift":[180],"M2a/M1":[183],"balance":[185],"generated":[187],"spatial":[189],"temporal":[191],"differences":[192],"subtypes.":[199],"obesity-induced":[201],"activation":[205],"state":[206],"coupled":[208],"localized":[211],"inflammatory":[215],"subtype":[217],"circulation":[223],"not":[225],"conversion":[228],"resident":[230],"situ.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":20},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":55},{"year":2023,"cited_by_count":47},{"year":2022,"cited_by_count":49},{"year":2021,"cited_by_count":71},{"year":2020,"cited_by_count":77},{"year":2019,"cited_by_count":63},{"year":2018,"cited_by_count":65},{"year":2017,"cited_by_count":76},{"year":2016,"cited_by_count":56},{"year":2015,"cited_by_count":63},{"year":2014,"cited_by_count":60},{"year":2013,"cited_by_count":63},{"year":2012,"cited_by_count":45}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}