{"id":"https://openalex.org/W2145677283","doi":"https://doi.org/10.1192/bjp.139.5.417","title":"Diazepam, Propranolol and their Combination in the Management of Chronic Anxiety","display_name":"Diazepam, Propranolol and their Combination in the Management of Chronic Anxiety","publication_year":1981,"publication_date":"1981-11-01","ids":{"openalex":"https://openalex.org/W2145677283","doi":"https://doi.org/10.1192/bjp.139.5.417","mag":"2145677283","pmid":"https://pubmed.ncbi.nlm.nih.gov/7037093"},"language":"en","primary_location":{"id":"doi:10.1192/bjp.139.5.417","doi":"https://doi.org/10.1192/bjp.139.5.417","is_oa":false,"landing_page_url":"https://doi.org/10.1192/bjp.139.5.417","pdf_url":null,"source":{"id":"https://openalex.org/S127936299","display_name":"The British Journal of Psychiatry","issn_l":"0007-1250","issn":["0007-1250","1472-1465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045182016","display_name":"Cosmo Hallstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Hallstrom","raw_affiliation_strings":["Institute of Psychiatry, Department of Pharmacology, De Crespigny Park, Denmark Hill, London SE5 8AF"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry, Department of Pharmacology, De Crespigny Park, Denmark Hill, London SE5 8AF","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112679501","display_name":"Ian H. Treasaden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801859090","display_name":"Royal South Hants Hospital","ror":"https://ror.org/01zbzxe52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800602287","https://openalex.org/I2801859090","https://openalex.org/I2802965805"]},{"id":"https://openalex.org/I43439940","display_name":"University of Southampton","ror":"https://ror.org/01ryk1543","country_code":"GB","type":"education","lineage":["https://openalex.org/I43439940"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I. Treasaden","raw_affiliation_strings":["University of Southampton Medical School, Royal South Hants Hospital, Southampton SO9 4PE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Southampton Medical School, Royal South Hants Hospital, Southampton SO9 4PE","institution_ids":["https://openalex.org/I2801859090","https://openalex.org/I43439940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111844650","display_name":"J. Guy Edwards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801859090","display_name":"Royal South Hants Hospital","ror":"https://ror.org/01zbzxe52","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800602287","https://openalex.org/I2801859090","https://openalex.org/I2802965805"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. Guy Edwards","raw_affiliation_strings":["Royal South Hants Hospital, Southampton SO9 4PE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Royal South Hants Hospital, Southampton SO9 4PE","institution_ids":["https://openalex.org/I2801859090"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108285762","display_name":"MALCOLM H. LADER","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Lader","raw_affiliation_strings":["Institute of Psychiatry, Department of Pharmacology, De Crespigny Park, Denmark Hill, London SE5 8AF"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Psychiatry, Department of Pharmacology, De Crespigny Park, Denmark Hill, London SE5 8AF","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4920,"currency":"USD","value_usd":4920},"apc_paid":null,"fwci":4.5618,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.95552605,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"139","issue":"5","first_page":"417","last_page":"421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10853","display_name":"Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13118","display_name":"Psychological Treatments and Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diazepam","display_name":"diazepam","score":0.953000009059906},{"id":"https://openalex.org/keywords/propranolol","display_name":"propranolol","score":1.0},{"id":"https://openalex.org/keywords/chronic-anxiety","display_name":"chronic anxiety","score":0.8840000033378601},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7829999923706055},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.6700000166893005},{"id":"https://openalex.org/keywords/benzodiazepines","display_name":"benzodiazepines","score":0.9290000200271606},{"id":"https://openalex.org/keywords/resting-heart-rate","display_name":"resting heart rate","score":0.8100000023841858},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.7049999833106995},{"id":"https://openalex.org/keywords/outpatients","display_name":"outpatients","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2778151854","wikidata":"https://www.wikidata.org/wiki/Q423364","display_name":"Propranolol","level":2,"score":0.8633695840835571},{"id":"https://openalex.org/C2776175493","wikidata":"https://www.wikidata.org/wiki/Q210402","display_name":"Diazepam","level":2,"score":0.8330197334289551},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.6599429845809937},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.46970269083976746},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43816107511520386},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.39046767354011536},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.3360903263092041},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3135525584220886}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001008","descriptor_name":"Anxiety Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011433","descriptor_name":"Propranolol","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011674","descriptor_name":"Pulse","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1192/bjp.139.5.417","doi":"https://doi.org/10.1192/bjp.139.5.417","is_oa":false,"landing_page_url":"https://doi.org/10.1192/bjp.139.5.417","pdf_url":null,"source":{"id":"https://openalex.org/S127936299","display_name":"The British Journal of Psychiatry","issn_l":"0007-1250","issn":["0007-1250","1472-1465"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Psychiatry","raw_type":"journal-article"},{"id":"pmid:7037093","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7037093","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of psychiatry : the journal of mental science","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W2009030095","https://openalex.org/W2021378306","https://openalex.org/W2025021427","https://openalex.org/W2032950654","https://openalex.org/W2081209440","https://openalex.org/W2153141790","https://openalex.org/W2160070901","https://openalex.org/W2254619986","https://openalex.org/W2418562842"],"related_works":["https://openalex.org/W2047925202","https://openalex.org/W2021378306","https://openalex.org/W2465339190","https://openalex.org/W1995043837","https://openalex.org/W156528118","https://openalex.org/W2010209230","https://openalex.org/W2032599404","https://openalex.org/W2032762820","https://openalex.org/W4407815550","https://openalex.org/W2146190387"],"abstract_inverted_index":{"The":[0,27],"therapeutic":[1,63],"benefit":[2,99],"of":[3,10,52,74],"combining":[4],"propranolol":[5,51],"with":[6,22],"diazepam":[7],"over":[8],"either":[9],"these":[11],"drugs":[12],"given":[13],"alone":[14,68],"was":[15,29,36],"tested":[16],"in":[17,45,60,70,82,89],"a":[18,61],"placebo-controlled":[19],"crossover":[20],"study":[21],"twenty-four":[23],"chronically":[24],"anxious":[25,94],"out-patients.":[26],"combination":[28],"generally":[30,96],"more":[31,37,53],"effective":[32,38],"than":[33,39,54],"diazepam.":[34],"Diazepam":[35],"placebo":[40],"or":[41],"propranolol.":[42],"A":[43],"reduction":[44],"the":[46],"resting":[47],"pulse":[48],"rate":[49],"by":[50],"7.5":[55],"beats":[56],"per":[57],"minute":[58],"resulted":[59],"greater":[62],"response":[64],"to":[65,78,86],"this":[66],"drug,":[67],"and":[69],"combination.":[71],"Lesser":[72],"degrees":[73],"pathology":[75],"responded":[76],"better":[77],"treatment.":[79,103],"Psychological":[80],"factors":[81],"treatment":[83],"showed":[84],"themselves":[85],"be":[87],"important":[88],"moderating":[90],"pharmacological":[91],"response.":[92],"Chronically":[93],"patients":[95],"derived":[97],"little":[98],"from":[100],"continued":[101],"anti-anxiety":[102]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
