{"id":"https://openalex.org/W2145666748","doi":"https://doi.org/10.1016/j.cbpa.2005.12.016","title":"A biological approach to computational models of proteomic networks","display_name":"A biological approach to computational models of proteomic networks","publication_year":2006,"publication_date":"2006-01-07","ids":{"openalex":"https://openalex.org/W2145666748","doi":"https://doi.org/10.1016/j.cbpa.2005.12.016","mag":"2145666748","pmid":"https://pubmed.ncbi.nlm.nih.gov/16406679"},"language":"en","primary_location":{"id":"doi:10.1016/j.cbpa.2005.12.016","doi":"https://doi.org/10.1016/j.cbpa.2005.12.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2005.12.016","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027602726","display_name":"Kevin A. Janes","orcid":"https://orcid.org/0000-0002-8028-6138","observed_orcids":["https://orcid.org/0000-0002-8028-6138"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kevin A Janes","raw_affiliation_strings":["Biological Engineering Division and Cell Decision Processes Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. kjanes@mit.edu","Biological Engineering Division and Cell Decision Processes Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Engineering Division and Cell Decision Processes Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. kjanes@mit.edu","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Biological Engineering Division and Cell Decision Processes Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060106170","display_name":"Douglas A. Lauffenburger","orcid":"https://orcid.org/0000-0002-0050-989X","observed_orcids":["https://orcid.org/0000-0002-0050-989X"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas A Lauffenburger","raw_affiliation_strings":["Biological Engineering Division and Cell Decision Processes Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biological Engineering Division and Cell Decision Processes Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027602726"],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":4510,"currency":"USD","value_usd":4510},"apc_paid":null,"fwci":1.1723,"has_fulltext":false,"cited_by_count":115,"citation_normalized_percentile":{"value":0.74314997,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"73","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proteomic-networks","display_name":"proteomic networks","score":0.9950000047683716},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.6769999861717224},{"id":"https://openalex.org/keywords/computational-modeling","display_name":"computational modeling","score":0.5770000219345093},{"id":"https://openalex.org/keywords/network-inference","display_name":"network inference","score":0.550000011920929},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8050000071525574},{"id":"https://openalex.org/keywords/network-functions","display_name":"network functions","score":0.4050000011920929},{"id":"https://openalex.org/keywords/cell-behavior","display_name":"cell behavior","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6927124261856079},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.6481902003288269},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.5987327098846436},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.5021858215332031},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4989359378814697},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4666801691055298},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4567311108112335},{"id":"https://openalex.org/C137866125","wikidata":"https://www.wikidata.org/wiki/Q4299308","display_name":"Modelling biological systems","level":3,"score":0.441101610660553},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4393315315246582},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.31852054595947266},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20776233077049255},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0769490897655487},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.cbpa.2005.12.016","doi":"https://doi.org/10.1016/j.cbpa.2005.12.016","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.cbpa.2005.12.016","pdf_url":null,"source":{"id":"https://openalex.org/S35563517","display_name":"Current Opinion in Chemical Biology","issn_l":"1367-5931","issn":["1367-5931","1879-0402"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Opinion in Chemical Biology","raw_type":"journal-article"},{"id":"pmid:16406679","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16406679","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current opinion in chemical biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1540996371","display_name":null,"funder_award_id":"P50 GM68762","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2540146617","display_name":"Cell Migration Consortium","funder_award_id":"5u54gm064346-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G408263369","display_name":"Systems Biology of cell Decision Processes","funder_award_id":"5p50gm068762-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G752532097","display_name":null,"funder_award_id":"U54 GM 64346","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W1641228030","https://openalex.org/W1964037688","https://openalex.org/W1965942536","https://openalex.org/W1968365965","https://openalex.org/W1977290213","https://openalex.org/W1978254752","https://openalex.org/W1979955019","https://openalex.org/W1984871500","https://openalex.org/W1985572262","https://openalex.org/W1989053944","https://openalex.org/W1989262356","https://openalex.org/W1992282800","https://openalex.org/W1994147843","https://openalex.org/W1996984755","https://openalex.org/W1997526378","https://openalex.org/W2007875429","https://openalex.org/W2012667119","https://openalex.org/W2015556811","https://openalex.org/W2022619825","https://openalex.org/W2023096047","https://openalex.org/W2025166348","https://openalex.org/W2027202090","https://openalex.org/W2036924431","https://openalex.org/W2049265952","https://openalex.org/W2055519466","https://openalex.org/W2066580949","https://openalex.org/W2073307618","https://openalex.org/W2074097004","https://openalex.org/W2075161553","https://openalex.org/W2083752219","https://openalex.org/W2098630467","https://openalex.org/W2101803429","https://openalex.org/W2107919289","https://openalex.org/W2112078820","https://openalex.org/W2113330225","https://openalex.org/W2115260641","https://openalex.org/W2116271446","https://openalex.org/W2116875795","https://openalex.org/W2120909504","https://openalex.org/W2126448555","https://openalex.org/W2130515775","https://openalex.org/W2132997183","https://openalex.org/W2133258252","https://openalex.org/W2138582489","https://openalex.org/W2142333178","https://openalex.org/W2143894094","https://openalex.org/W2147207778","https://openalex.org/W2150317682","https://openalex.org/W2152262831","https://openalex.org/W2155443196","https://openalex.org/W2161682775","https://openalex.org/W2169228855","https://openalex.org/W2169805130","https://openalex.org/W2171228793","https://openalex.org/W2398236422","https://openalex.org/W2579553565"],"related_works":["https://openalex.org/W2139924741","https://openalex.org/W4244039304","https://openalex.org/W2022693294","https://openalex.org/W7097477222","https://openalex.org/W2932100867","https://openalex.org/W7100654859","https://openalex.org/W2138397600","https://openalex.org/W1488788979","https://openalex.org/W1967568262","https://openalex.org/W2146883006"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}