{"id":"https://openalex.org/W2145662009","doi":"https://doi.org/10.1021/jp509789m","title":"Electroporation Threshold of POPC Lipid Bilayers with Incorporated Polyoxyethylene Glycol (C12E8)","display_name":"Electroporation Threshold of POPC Lipid Bilayers with Incorporated Polyoxyethylene Glycol (C12E8)","publication_year":2014,"publication_date":"2014-12-15","ids":{"openalex":"https://openalex.org/W2145662009","doi":"https://doi.org/10.1021/jp509789m","mag":"2145662009","pmid":"https://pubmed.ncbi.nlm.nih.gov/25495217"},"language":"en","primary_location":{"id":"doi:10.1021/jp509789m","doi":"https://doi.org/10.1021/jp509789m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp509789m","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070743591","display_name":"Andra\u017e Polak","orcid":"https://orcid.org/0009-0009-7324-4675","observed_orcids":["https://orcid.org/0009-0009-7324-4675"]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Andra\u017e Polak","raw_affiliation_strings":["University of Ljubljana, Faculty of Electrical Engineering, Tr\u017ea\u0161ka cesta 25, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ljubljana, Faculty of Electrical Engineering, Tr\u017ea\u0161ka cesta 25, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080094105","display_name":"Alja\u017e Velikonja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Alja\u017e Velikonja","raw_affiliation_strings":["SMARTEH Research and Development of Electronic Controlling and Regulating Systems, Poljubinj 114, SI-5220 Tolmin, Slovenia","University of Ljubljana, Faculty of Electrical Engineering, Tr\u017ea\u0161ka cesta 25, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SMARTEH Research and Development of Electronic Controlling and Regulating Systems, Poljubinj 114, SI-5220 Tolmin, Slovenia","institution_ids":[]},{"raw_affiliation_string":"University of Ljubljana, Faculty of Electrical Engineering, Tr\u017ea\u0161ka cesta 25, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059187233","display_name":"Peter Kramar","orcid":"https://orcid.org/0000-0002-3341-0052","observed_orcids":["https://orcid.org/0000-0002-3341-0052"]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Peter Kramar","raw_affiliation_strings":["University of Ljubljana, Faculty of Electrical Engineering, Tr\u017ea\u0161ka cesta 25, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ljubljana, Faculty of Electrical Engineering, Tr\u017ea\u0161ka cesta 25, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012712063","display_name":"Mounir Tarek","orcid":"https://orcid.org/0000-0002-9451-3215","observed_orcids":["https://orcid.org/0000-0002-9451-3215"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I90183372","display_name":"Universit\u00e9 de Lorraine","ror":"https://ror.org/04vfs2w97","country_code":"FR","type":"education","lineage":["https://openalex.org/I90183372"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Mounir Tarek","raw_affiliation_strings":["CNRS, UMR 7565, F-54506 Vandoeuvre-l\u00e8s-Nancy, France","Universit\u00e9 de Lorraine, UMR 7565, F-54506 Vandoeuvre-l\u00e8s-Nancy, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS, UMR 7565, F-54506 Vandoeuvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"Universit\u00e9 de Lorraine, UMR 7565, F-54506 Vandoeuvre-l\u00e8s-Nancy, France","institution_ids":["https://openalex.org/I90183372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071211846","display_name":"Damijan Miklav\u010di\u010d","orcid":"https://orcid.org/0000-0003-3506-9449","observed_orcids":["https://orcid.org/0000-0003-3506-9449"]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Damijan Miklav\u010di\u010d","raw_affiliation_strings":["University of Ljubljana, Faculty of Electrical Engineering, Tr\u017ea\u0161ka cesta 25, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ljubljana, Faculty of Electrical Engineering, Tr\u017ea\u0161ka cesta 25, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5012712063","https://openalex.org/A5071211846"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I153976015","https://openalex.org/I90183372"],"apc_list":null,"apc_paid":null,"fwci":0.833,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.67038892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"119","issue":"1","first_page":"192","last_page":"200"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.6147000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.3659999966621399,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12274","display_name":"Electrostatics and Colloid Interactions","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electroporation","display_name":"electroporation","score":0.8849999904632568},{"id":"https://openalex.org/keywords/popc-bilayer","display_name":"POPC bilayer","score":0.8809999823570251},{"id":"https://openalex.org/keywords/polyethylene-glycol","display_name":"polyethylene glycol","score":0.8560000061988831},{"id":"https://openalex.org/keywords/electroporation-threshold","display_name":"electroporation threshold","score":0.8700000047683716},{"id":"https://openalex.org/keywords/voltage-breakdown","display_name":"voltage breakdown","score":0.734000027179718},{"id":"https://openalex.org/keywords/membrane-capacitance","display_name":"membrane capacitance","score":0.8769999742507935},{"id":"https://openalex.org/keywords/hydrophilic-pores","display_name":"hydrophilic pores","score":0.8579999804496765},{"id":"https://openalex.org/keywords/water-wires","display_name":"water wires","score":0.8420000076293945},{"id":"https://openalex.org/keywords/ion-channels","display_name":"ion channels","score":0.6420000195503235},{"id":"https://openalex.org/keywords/membrane-permeabilization","display_name":"membrane permeabilization","score":0.8009999990463257},{"id":"https://openalex.org/keywords/model-membranes","display_name":"model membranes","score":0.4779999852180481}],"concepts":[{"id":"https://openalex.org/C2780943371","wikidata":"https://www.wikidata.org/wiki/Q10860475","display_name":"POPC","level":4,"score":0.9681951999664307},{"id":"https://openalex.org/C186852380","wikidata":"https://www.wikidata.org/wiki/Q1142521","display_name":"Electroporation","level":3,"score":0.7735519409179688},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.7429758906364441},{"id":"https://openalex.org/C192157962","wikidata":"https://www.wikidata.org/wiki/Q4087243","display_name":"Bilayer","level":3,"score":0.7397968769073486},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.6691258549690247},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6078820824623108},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.47381746768951416},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.4165780544281006},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.41640377044677734},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3666650652885437},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3261515498161316},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15443336963653564},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.14941257238388062},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06383159756660461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D008051","descriptor_name":"Lipid Bilayers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018274","descriptor_name":"Electroporation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/jp509789m","doi":"https://doi.org/10.1021/jp509789m","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jp509789m","pdf_url":null,"source":{"id":"https://openalex.org/S185621672","display_name":"The Journal of Physical Chemistry B","issn_l":"1520-5207","issn":["1520-5207","1520-6106"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physical Chemistry B","raw_type":"journal-article"},{"id":"pmid:25495217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25495217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of physical chemistry. B","raw_type":"Journal Article"},{"id":"mag:2913789441","doi":null,"is_oa":false,"landing_page_url":"https://dissem.in/p/21464558/polyoxyethylene-glycol-c12e8-decreases-the-electroporation-threshold-of-popc-lipid-bilayers","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322554","display_name":"Javna Agencija za Raziskovalno Dejavnost RS","ror":"https://ror.org/059bp8k51"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W94464194","https://openalex.org/W601267216","https://openalex.org/W1508486720","https://openalex.org/W1605166042","https://openalex.org/W1963650692","https://openalex.org/W1967905520","https://openalex.org/W1968142235","https://openalex.org/W1970370189","https://openalex.org/W1972800394","https://openalex.org/W1972913617","https://openalex.org/W1977680394","https://openalex.org/W1980450411","https://openalex.org/W1984093518","https://openalex.org/W1984138433","https://openalex.org/W1988901585","https://openalex.org/W1997665328","https://openalex.org/W2004754106","https://openalex.org/W2005638969","https://openalex.org/W2005820308","https://openalex.org/W2005839003","https://openalex.org/W2007750502","https://openalex.org/W2012715898","https://openalex.org/W2015392719","https://openalex.org/W2017312383","https://openalex.org/W2020188774","https://openalex.org/W2028984555","https://openalex.org/W2032062499","https://openalex.org/W2033080732","https://openalex.org/W2035687084","https://openalex.org/W2036004272","https://openalex.org/W2036379364","https://openalex.org/W2037152236","https://openalex.org/W2042621142","https://openalex.org/W2045558911","https://openalex.org/W2048623371","https://openalex.org/W2049962926","https://openalex.org/W2053658650","https://openalex.org/W2056491293","https://openalex.org/W2062803251","https://openalex.org/W2064451603","https://openalex.org/W2065464482","https://openalex.org/W2066414494","https://openalex.org/W2067970128","https://openalex.org/W2068067779","https://openalex.org/W2070669688","https://openalex.org/W2079416519","https://openalex.org/W2079530087","https://openalex.org/W2080015784","https://openalex.org/W2089717693","https://openalex.org/W2096546953","https://openalex.org/W2099769636","https://openalex.org/W2100062287","https://openalex.org/W2100473454","https://openalex.org/W2103815459","https://openalex.org/W2122387392","https://openalex.org/W2122698968","https://openalex.org/W2138045682","https://openalex.org/W2138450226","https://openalex.org/W2146676040","https://openalex.org/W2158319581","https://openalex.org/W2159442951","https://openalex.org/W2170173864","https://openalex.org/W2171689657","https://openalex.org/W2397876963","https://openalex.org/W4254021855","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2913789441","https://openalex.org/W2158319581","https://openalex.org/W2100473454","https://openalex.org/W2037581262","https://openalex.org/W7099972736","https://openalex.org/W2067970128","https://openalex.org/W2057999340","https://openalex.org/W98797074","https://openalex.org/W1605166042","https://openalex.org/W7098657637"],"abstract_inverted_index":{"Electroporation":[0],"relates":[1],"to":[2,14,91],"a":[3,30,51,73,80,113],"phenomenon":[4],"in":[5,116,122,138],"which":[6,144],"cell":[7],"membranes":[8],"are":[9,135],"permeabilized":[10],"after":[11],"being":[12],"exposed":[13],"high":[15],"electric":[16],"fields.":[17],"On":[18],"the":[19,22,48,77,84,101,108,117,123,126,133,139,142,157,162,170,181,184],"molecular":[20,36],"level,":[21],"mechanism":[23],"is":[24],"not":[25],"yet":[26],"fully":[27],"elucidated,":[28],"although":[29],"considerable":[31],"body":[32],"of":[33,50,57,59,76,83,89,119,132,141,147,186],"experiments":[34],"and":[35,54,79],"dynamic":[37],"(MD)":[38],"simulations":[39],"were":[40,97],"performed":[41],"on":[42],"model":[43],"membranes.":[44],"Here":[45],"we":[46],"present":[47],"results":[49,71,96],"combined":[52],"theoretical":[53],"experimental":[55,70],"investigation":[56],"electroporation":[58,127],"palmitoy-oleoyl-phosphatidylcholine":[60],"(POPC)":[61],"bilayers":[62,124],"with":[63],"incorporated":[64],"polyoxyethylene":[65,109],"glycol":[66,110],"(C12E8)":[67],"surfactants.":[68],"The":[69,129],"show":[72],"slight":[74],"increase":[75],"capacitance":[78],"22%":[81],"decrease":[82],"voltage":[85],"breakdown":[86],"upon":[87],"addition":[88],"C12E8":[90,171],"pure":[92],"POPC":[93],"bilayers.":[94],"These":[95,174],"qualitatively":[98],"confirmed":[99],"by":[100,169],"MD":[102],"simulations.":[103],"They":[104],"later":[105],"revealed":[106],"that":[107,150],"molecules":[111],"play":[112],"major":[114,187],"role":[115],"formation":[118,146],"hydrophilic":[120,175],"pores":[121],"above":[125],"threshold.":[128],"headgroup":[130],"moieties":[131],"latter":[134],"indeed":[136],"embedded":[137],"interior":[140],"bilayer,":[143,164],"favors":[145],"water":[148,158],"wires":[149,159],"protrude":[151],"into":[152],"its":[153],"hydrophobic":[154],"core.":[155],"When":[156],"extend":[160],"across":[161,180],"whole":[163],"they":[165],"form":[166],"channels":[167,176],"stabilized":[168],"head":[172],"groups.":[173],"can":[177],"transport":[178],"ions":[179],"membrane":[182],"without":[183],"need":[185],"lipid":[188],"head-group":[189],"rearrangements.":[190]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}