{"id":"https://openalex.org/W2145652748","doi":"https://doi.org/10.1128/jvi.01408-13","title":"A Two-Pronged Structural Analysis of Retroviral Maturation Indicates that Core Formation Proceeds by a Disassembly-Reassembly Pathway Rather than a Displacive Transition","display_name":"A Two-Pronged Structural Analysis of Retroviral Maturation Indicates that Core Formation Proceeds by a Disassembly-Reassembly Pathway Rather than a Displacive Transition","publication_year":2013,"publication_date":"2013-10-10","ids":{"openalex":"https://openalex.org/W2145652748","doi":"https://doi.org/10.1128/jvi.01408-13","mag":"2145652748","pmid":"https://pubmed.ncbi.nlm.nih.gov/24109217","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3838239"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01408-13","doi":"https://doi.org/10.1128/jvi.01408-13","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01408-13","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3838239","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038173012","display_name":"Paul W. Keller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul W. Keller","raw_affiliation_strings":["Laboratory of Structural Biology Research, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology Research, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001710213","display_name":"Rick K Huang","orcid":"https://orcid.org/0000-0002-3336-9635","observed_orcids":["https://orcid.org/0000-0002-3336-9635"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rick K. Huang","raw_affiliation_strings":["Laboratory of Structural Biology Research, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology Research, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088912734","display_name":"Matthew R. England","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew R. England","raw_affiliation_strings":["Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045580491","display_name":"Kayoko Waki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kayoko Waki","raw_affiliation_strings":["Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110034558","display_name":"Naiqian Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Naiqian Cheng","raw_affiliation_strings":["Laboratory of Structural Biology Research, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology Research, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041170594","display_name":"J. Bernard Heymann","orcid":"https://orcid.org/0000-0002-8872-5326","observed_orcids":["https://orcid.org/0000-0002-8872-5326"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Bernard Heymann","raw_affiliation_strings":["Laboratory of Structural Biology Research, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology Research, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111909316","display_name":"Rebecca C. Craven","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca C. Craven","raw_affiliation_strings":["Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054660762","display_name":"Eric O. Freed","orcid":"https://orcid.org/0000-0003-3345-022X","observed_orcids":["https://orcid.org/0000-0003-3345-022X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric O. Freed","raw_affiliation_strings":["Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, Maryland, USA","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090643634","display_name":"Alasdair C. Steven","orcid":"https://orcid.org/0000-0003-4104-6497","observed_orcids":["https://orcid.org/0000-0003-4104-6497"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210087962","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alasdair C. Steven","raw_affiliation_strings":["Laboratory of Structural Biology Research, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Structural Biology Research, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210087962"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1093,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.9560885,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"87","issue":"24","first_page":"13655","last_page":"13664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9169999957084656,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12159","display_name":"T-cell and Retrovirus Studies","score":0.031599998474121094,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.009999999776482582,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/capsid-assembly","display_name":"capsid assembly","score":0.7590000033378601},{"id":"https://openalex.org/keywords/gag-protein","display_name":"Gag protein","score":0.6930000185966492},{"id":"https://openalex.org/keywords/capsid-protein","display_name":"capsid protein","score":0.8090000152587891},{"id":"https://openalex.org/keywords/displacive-phase-transition","display_name":"displacive phase transition","score":0.968999981880188},{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.7239999771118164},{"id":"https://openalex.org/keywords/rous-sarcoma-virus","display_name":"Rous sarcoma virus","score":0.9800000190734863},{"id":"https://openalex.org/keywords/proteolytic-cleavage-sites","display_name":"proteolytic cleavage sites","score":0.6190000176429749},{"id":"https://openalex.org/keywords/core-formation","display_name":"core formation","score":0.5120000243186951},{"id":"https://openalex.org/keywords/cryo-electron-tomography","display_name":"cryo-electron tomography","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C202878990","wikidata":"https://www.wikidata.org/wiki/Q830465","display_name":"Capsid","level":3,"score":0.9119813442230225},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.7631429433822632},{"id":"https://openalex.org/C2777441520","wikidata":"https://www.wikidata.org/wiki/Q1444330","display_name":"Rous sarcoma virus","level":3,"score":0.6551873683929443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5301371812820435},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5184868574142456},{"id":"https://openalex.org/C2778431562","wikidata":"https://www.wikidata.org/wiki/Q189308","display_name":"Retrovirus","level":3,"score":0.4715331196784973},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.36916384100914},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3680296540260315},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35842564702033997},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.30156731605529785},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.22420936822891235},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002213","descriptor_name":"Capsid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015683","descriptor_name":"Gene Products, gag","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015683","descriptor_name":"Gene Products, gag","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015683","descriptor_name":"Gene Products, gag","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D052736","descriptor_name":"Rous sarcoma virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052736","descriptor_name":"Rous sarcoma virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D052736","descriptor_name":"Rous sarcoma virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054301","descriptor_name":"gag Gene Products, Human Immunodeficiency Virus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.01408-13","doi":"https://doi.org/10.1128/jvi.01408-13","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01408-13","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3838239","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3838239","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:24109217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24109217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3838239","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3838239","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3892671279","display_name":"Viruses and Cancer","funder_award_id":"T32CA060395","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7665878625","display_name":"Interactions of the CA Protein in the Retrovirus Core","funder_award_id":"R01CA100322","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W181778438","https://openalex.org/W1562103219","https://openalex.org/W1594514074","https://openalex.org/W1595806441","https://openalex.org/W1599995235","https://openalex.org/W1659719610","https://openalex.org/W1816747902","https://openalex.org/W1924577704","https://openalex.org/W1964022123","https://openalex.org/W1965723868","https://openalex.org/W1968718594","https://openalex.org/W1971637353","https://openalex.org/W1986015062","https://openalex.org/W1991485090","https://openalex.org/W1993452562","https://openalex.org/W1996586859","https://openalex.org/W1999148331","https://openalex.org/W2000218608","https://openalex.org/W2013652077","https://openalex.org/W2024814523","https://openalex.org/W2032146255","https://openalex.org/W2033236966","https://openalex.org/W2034606779","https://openalex.org/W2034897068","https://openalex.org/W2042354407","https://openalex.org/W2042938599","https://openalex.org/W2048107562","https://openalex.org/W2053607817","https://openalex.org/W2055643881","https://openalex.org/W2059244672","https://openalex.org/W2061714407","https://openalex.org/W2092609668","https://openalex.org/W2094692623","https://openalex.org/W2101208957","https://openalex.org/W2105175831","https://openalex.org/W2105529947","https://openalex.org/W2105974649","https://openalex.org/W2115382947","https://openalex.org/W2116262094","https://openalex.org/W2117091532","https://openalex.org/W2125419134","https://openalex.org/W2128286418","https://openalex.org/W2128580131","https://openalex.org/W2132629607","https://openalex.org/W2132762790","https://openalex.org/W2135035609","https://openalex.org/W2138792611","https://openalex.org/W2146667353","https://openalex.org/W2152539875","https://openalex.org/W2154413242","https://openalex.org/W2155921043","https://openalex.org/W2159772529","https://openalex.org/W2160176988","https://openalex.org/W2161840329","https://openalex.org/W2162004774","https://openalex.org/W2169408873","https://openalex.org/W2171446073","https://openalex.org/W2412256155","https://openalex.org/W2419224004"],"related_works":["https://openalex.org/W2152882014","https://openalex.org/W2283239154","https://openalex.org/W7095461297","https://openalex.org/W2074560169","https://openalex.org/W2094692623","https://openalex.org/W4407494111","https://openalex.org/W4407499270","https://openalex.org/W2562928209","https://openalex.org/W2128286418","https://openalex.org/W2955761623"],"abstract_inverted_index":{"Retrovirus":[0],"maturation":[1,135],"involves":[2],"sequential":[3],"cleavages":[4],"of":[5,18,44,59,72,79,90,134,154,204],"the":[6,41,50,60,70,88,132,140,151,155,186,192,196,202,213,245],"Gag":[7,157,187],"polyprotein,":[8],"initially":[9],"arrayed":[10],"in":[11,48,98,131],"a":[12,45,147,173,231],"spherical":[13],"shell,":[14],"leading":[15],"to":[16,96,126,176,185,195],"formation":[17],"capsids":[19,28],"with":[20,139,219],"polyhedral":[21],"or":[22,138],"conical":[23,237],"morphology.":[24],"Evidence":[25],"suggests":[26],"that":[27,117,149,180,225],"assemble":[29,97],"de":[30],"novo":[31],"inside":[32],"maturing":[33],"virions":[34,145],"from":[35,110],"dissociated":[36],"capsid":[37],"(CA)":[38],"protein,":[39],"but":[40,55,159,168,234],"possibility":[42],"persists":[43],"displacive":[46],"pathway":[47,247],"which":[49,208],"CA":[51,64,83,114,152,164],"shell":[52,148,158],"remains":[53],"assembled":[54,106],"is":[56,160,166],"remodeled.":[57],"Inhibition":[58],"final":[61],"cleavage":[62,198,211],"between":[63],"and":[65,107,200],"spacer":[66],"peptide":[67],"SP1/SP":[68],"blocks":[69],"production":[71],"mature":[73,174],"capsids.":[74,102],"We":[75,121,178],"investigated":[76],"whether":[77],"retention":[78],"SP":[80,118],"might":[81],"render":[82],"assembly":[84],"incompetent":[85],"by":[86,113],"testing":[87],"ability":[89],"Rous":[91],"sarcoma":[92],"virus":[93],"(RSV)":[94],"CA-SP":[95],"vitro":[99],"into":[100],"icosahedral":[101],"Capsids":[103],"were":[104,108],"indeed":[105],"indistinguishable":[109],"those":[111],"formed":[112],"alone,":[115],"indicating":[116],"was":[119],"disordered.":[120],"also":[122],"used":[123],"cryo-electron":[124],"tomography":[125],"characterize":[127],"HIV-1":[128],"particles":[129],"produced":[130],"presence":[133],"inhibitor":[136],"PF-46396":[137,183],"cleavage-blocking":[141],"CA5":[142,206],"mutation.":[143],"Inhibitor-treated":[144],"have":[146,216],"resembles":[150],"layer":[153],"immature":[156],"less":[161],"complete.":[162],"Some":[163],"protein":[165],"generated":[167],"usually":[169],"not":[170],"enough":[171],"for":[172,248],"core":[175,249],"assemble.":[177],"propose":[179],"inhibitors":[181],"like":[182],"bind":[184],"lattice":[188,227],"where":[189],"they":[190],"deny":[191],"protease":[193],"access":[194],"CA-SP1":[197,214],"site":[199],"prevent":[201],"release":[203],"CA.":[205],"particles,":[207],"exhibit":[209],"no":[210],"at":[212],"site,":[215],"spheroidal":[217],"shells":[218],"relatively":[220],"thin":[221],"walls.":[222],"It":[223],"appears":[224],"this":[226],"progresses":[228],"displacively":[229],"toward":[230],"mature-like":[232],"state":[233],"produces":[235],"neither":[236],"cores":[238],"nor":[239],"infectious":[240],"virions.":[241],"These":[242],"observations":[243],"support":[244],"disassembly-reassembly":[246],"formation.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}