{"id":"https://openalex.org/W2145504663","doi":"https://doi.org/10.1172/jci109888","title":"Analysis of factors regulating erythrocyte deformability.","display_name":"Analysis of factors regulating erythrocyte deformability.","publication_year":1980,"publication_date":"1980-09-01","ids":{"openalex":"https://openalex.org/W2145504663","doi":"https://doi.org/10.1172/jci109888","mag":"2145504663","pmid":"https://pubmed.ncbi.nlm.nih.gov/6156955","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/371685"},"language":"en","primary_location":{"id":"doi:10.1172/jci109888","doi":"https://doi.org/10.1172/jci109888","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109888","pdf_url":"http://www.jci.org/articles/view/109888/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/109888/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034746599","display_name":"Narla Mohandas","orcid":"https://orcid.org/0000-0003-2271-5296","observed_orcids":["https://orcid.org/0000-0003-2271-5296"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N Mohandas","raw_affiliation_strings":["Cancer Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110015911","display_name":"Margaret R. Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M R Clark","raw_affiliation_strings":["Cancer Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081414993","display_name":"Mark S. Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M S Jacobs","raw_affiliation_strings":["Cancer Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067233184","display_name":"Simon Shohet","orcid":"https://orcid.org/0009-0003-0901-5233","observed_orcids":["https://orcid.org/0009-0003-0901-5233"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S B Shohet","raw_affiliation_strings":["Cancer Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California 94143"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Institute and the Departments of Laboratory Medicine and Medicine, University of California, San Francisco, California 94143","institution_ids":["https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I180670191"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":9.3255,"has_fulltext":true,"cited_by_count":388,"citation_normalized_percentile":{"value":0.98477509,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"66","issue":"3","first_page":"563","last_page":"573"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.6342999935150146,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.358599990606308,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythrocyte-deformability","display_name":"erythrocyte deformability","score":1.0},{"id":"https://openalex.org/keywords/osmolality","display_name":"osmolality","score":0.8769999742507935},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.9390000104904175},{"id":"https://openalex.org/keywords/internal-viscosity","display_name":"internal viscosity","score":0.9129999876022339},{"id":"https://openalex.org/keywords/surface-to-volume-ratio","display_name":"surface-to-volume ratio","score":0.9929999709129333},{"id":"https://openalex.org/keywords/membrane-viscoelasticity","display_name":"membrane viscoelasticity","score":0.9440000057220459},{"id":"https://openalex.org/keywords/membrane-flexibility","display_name":"membrane flexibility","score":0.9330000281333923},{"id":"https://openalex.org/keywords/hereditary-spherocytosis","display_name":"hereditary spherocytosis","score":0.968999981880188},{"id":"https://openalex.org/keywords/hereditary-pyropoikilocytosis","display_name":"hereditary pyropoikilocytosis","score":0.9860000014305115},{"id":"https://openalex.org/keywords/laser-diffraction","display_name":"laser diffraction","score":0.847000002861023}],"concepts":[{"id":"https://openalex.org/C2776185378","wikidata":"https://www.wikidata.org/wiki/Q5396464","display_name":"Erythrocyte deformability","level":3,"score":0.7169210910797119},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.575547456741333},{"id":"https://openalex.org/C2776952295","wikidata":"https://www.wikidata.org/wiki/Q541244","display_name":"Hereditary spherocytosis","level":2,"score":0.5587467551231384},{"id":"https://openalex.org/C127172972","wikidata":"https://www.wikidata.org/wiki/Q128709","display_name":"Viscosity","level":2,"score":0.5197564959526062},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5000414848327637},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.46104568243026733},{"id":"https://openalex.org/C21141959","wikidata":"https://www.wikidata.org/wiki/Q657936","display_name":"Shear stress","level":2,"score":0.45191603899002075},{"id":"https://openalex.org/C186541917","wikidata":"https://www.wikidata.org/wiki/Q910483","display_name":"Viscoelasticity","level":2,"score":0.4446674585342407},{"id":"https://openalex.org/C2994203641","wikidata":"https://www.wikidata.org/wiki/Q5712543","display_name":"Blood viscosity","level":2,"score":0.435323566198349},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.41175058484077454},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.4103524088859558},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.3861185610294342},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.37265390157699585},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25494152307510376},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.18070369958877563},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16029790043830872},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1432068645954132},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11420410871505737},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0705585777759552},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000745","descriptor_name":"Anemia, Hemolytic, Congenital","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001809","descriptor_name":"Blood Viscosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004905","descriptor_name":"Erythrocyte Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006445","descriptor_name":"Hemoglobin C Disease","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008244","descriptor_name":"Lysophosphatidylcholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011312","descriptor_name":"Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013103","descriptor_name":"Spherocytosis, Hereditary","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci109888","doi":"https://doi.org/10.1172/jci109888","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109888","pdf_url":"http://www.jci.org/articles/view/109888/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmid:6156955","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6156955","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:371685","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC371685/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1172/jci109888","doi":"https://doi.org/10.1172/jci109888","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci109888","pdf_url":"http://www.jci.org/articles/view/109888/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145504663.pdf","grobid_xml":"https://content.openalex.org/works/W2145504663.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W115584207","https://openalex.org/W118689326","https://openalex.org/W1557793783","https://openalex.org/W1607126357","https://openalex.org/W1979443037","https://openalex.org/W1994733396","https://openalex.org/W2023150271","https://openalex.org/W2057202370","https://openalex.org/W2074187633","https://openalex.org/W2082104044","https://openalex.org/W2097980168","https://openalex.org/W2102715003","https://openalex.org/W2103537552","https://openalex.org/W2121132978","https://openalex.org/W2156010457","https://openalex.org/W2247127371","https://openalex.org/W2399287609","https://openalex.org/W2399784954","https://openalex.org/W2406698868","https://openalex.org/W2407359885","https://openalex.org/W2411807328","https://openalex.org/W2416244328","https://openalex.org/W2418076301","https://openalex.org/W2441309328","https://openalex.org/W4239647872"],"related_works":["https://openalex.org/W2400311789","https://openalex.org/W2947196840","https://openalex.org/W115584207","https://openalex.org/W2247127371","https://openalex.org/W2312198801","https://openalex.org/W2055527371","https://openalex.org/W1987968783","https://openalex.org/W224056403","https://openalex.org/W2425402802","https://openalex.org/W2006348849"],"abstract_inverted_index":{"Using":[0],"a":[1,71],"laser":[2],"diffraction":[3],"technique,":[4],"we":[5],"have":[6],"studied":[7],"factors":[8],"that":[9],"influence":[10],"the":[11,28,45,80,93,153,161,175,188,197],"deformability":[12,34,69,97,114],"of":[13,35,44,68,73,79,92,134,155,164,177,190],"erythrocytes.":[14],"Variations":[15],"in":[16,52,58,64,96,113,196,207],"suspending":[17],"medium":[18,74,99],"osmolality":[19,75,100,116],"and":[20,41,147,168],"applied":[21,137],"shear":[22,130,199],"stress":[23],"were":[24,56,136],"employed":[25],"to":[26,31,60,138,151],"isolate":[27],"individual":[29],"contributions":[30],"whole":[32],"cell":[33],"internal":[36,106,170,192],"viscosity,":[37],"surface":[38,84,166,180],"area-to-volume":[39,85,181],"ratio,":[40],"viscoelastic":[42],"properties":[43],"membrane.":[46],"An":[47,194],"experimental":[48],"system":[49],"was":[50,87,101,108,117,123,204],"devised":[51],"which":[53],"normal":[54,94],"cells":[55,139,185],"modified":[57,81],"vitro":[59],"induce":[61],"specific":[62],"alterations":[63],"each":[65],"factor.":[66],"Measurements":[67],"as":[70,98,115],"function":[72],"showed":[76,160,186],"characteristic":[77],"behavior":[78],"cells.":[82],"Reduced":[83],"ratio":[86],"detected":[88,109,124],"by":[89,110,125],"an":[90,111],"exaggeration":[91],"decrease":[95],"decreased.":[102,118],"In":[103],"contrast,":[104],"increased":[105,169],"viscosity":[107],"increase":[112,195],"Finally,":[119],"decreased":[120],"membrane":[121,198,202],"flexibility":[122],"reduced":[126,156,165,179],"deformation":[127],"at":[128],"low":[129],"stress.":[131],"These":[132],"methods":[133],"analysis":[135],"from":[140],"patients":[141],"with":[142],"hereditary":[143,145],"spherocytosis,":[144],"pyropoikilocytosis,":[146],"hemoglobin":[148],"CC":[149,184],"disease":[150],"define":[152],"basis":[154],"deformability.":[157],"Hereditary":[158,172],"spherocytes":[159],"combined":[162],"effects":[163,176,189],"area":[167],"viscosity.":[171,193],"pyropoikilocytes":[173],"revealed":[174],"severely":[178],"ratio.":[182],"Hemoglobin":[183],"only":[187],"high":[191],"modulus":[200],"(decreased":[201],"deformability)":[203],"not":[205],"evident":[206],"these":[208],"disorders.":[209]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":11}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
