{"id":"https://openalex.org/W2145493241","doi":null,"title":"Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma.","display_name":"Small cell lung carcinoma exhibits greater phospholipase C-beta1 expression and edelfosine resistance compared with non-small cell lung carcinoma.","publication_year":2000,"publication_date":"2000-05-15","ids":{"openalex":"https://openalex.org/W2145493241","mag":"2145493241","pmid":"https://pubmed.ncbi.nlm.nih.gov/10825148"},"language":"en","primary_location":{"id":"pmid:10825148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10825148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008514790","display_name":"Derek Strassheim","orcid":"https://orcid.org/0000-0001-5264-6792","observed_orcids":["https://orcid.org/0000-0001-5264-6792"]},"institutions":[{"id":"https://openalex.org/I4210087537","display_name":"Guthrie Foundation","ror":"https://ror.org/004wh0w58","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Strassheim","raw_affiliation_strings":["Molecular Pharmacology Laboratory, Guthrie Research Institute, Syre, Pennsylvania 18840, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology Laboratory, Guthrie Research Institute, Syre, Pennsylvania 18840, USA","institution_ids":["https://openalex.org/I4210087537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029298252","display_name":"Shulamith H. Shafer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087537","display_name":"Guthrie Foundation","ror":"https://ror.org/004wh0w58","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S H Shafer","raw_affiliation_strings":["Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, Pennsylvania 18840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, Pennsylvania 18840","institution_ids":["https://openalex.org/I4210087537"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026345396","display_name":"Scott H. Phelps","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087537","display_name":"Guthrie Foundation","ror":"https://ror.org/004wh0w58","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S H Phelps","raw_affiliation_strings":["Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, Pennsylvania 18840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, Pennsylvania 18840","institution_ids":["https://openalex.org/I4210087537"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081449694","display_name":"Carol L. Williams","orcid":"https://orcid.org/0009-0007-0748-2371","observed_orcids":["https://orcid.org/0009-0007-0748-2371"]},"institutions":[{"id":"https://openalex.org/I4210087537","display_name":"Guthrie Foundation","ror":"https://ror.org/004wh0w58","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210087537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C L Williams","raw_affiliation_strings":["Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, Pennsylvania 18840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, Pennsylvania 18840","institution_ids":["https://openalex.org/I4210087537"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210087537"],"apc_list":null,"apc_paid":null,"fwci":1.5573,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.81999593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"60","issue":"10","first_page":"2730","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":1.0},{"id":"https://openalex.org/keywords/phospholipase-c-beta-1","display_name":"PLCB1","score":0.984000027179718},{"id":"https://openalex.org/keywords/edelfosine","display_name":"edelfosine","score":0.906000018119812},{"id":"https://openalex.org/keywords/neurotensin-receptor","display_name":"neurotensin receptor","score":0.7139999866485596},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.8379999995231628},{"id":"https://openalex.org/keywords/neuropeptide-signaling","display_name":"neuropeptide signaling","score":0.7770000100135803},{"id":"https://openalex.org/keywords/calcium-mobilization","display_name":"calcium mobilization","score":0.8489999771118164},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.5839999914169312},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.634992778301239},{"id":"https://openalex.org/C2909444961","wikidata":"https://www.wikidata.org/wiki/Q738170","display_name":"Small Cell Lung Carcinoma","level":4,"score":0.5984033942222595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5906228423118591},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5835354924201965},{"id":"https://openalex.org/C2778976297","wikidata":"https://www.wikidata.org/wiki/Q419576","display_name":"Neurotensin","level":4,"score":0.5739808678627014},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.573269248008728},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5420755743980408},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5115652680397034},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4896450638771057},{"id":"https://openalex.org/C2777307743","wikidata":"https://www.wikidata.org/wiki/Q24782815","display_name":"Neurotensin receptor","level":5,"score":0.4672536551952362},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42678698897361755},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.40116673707962036},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38465163111686707},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.27954569458961487},{"id":"https://openalex.org/C2779292878","wikidata":"https://www.wikidata.org/wiki/Q738170","display_name":"Small-cell carcinoma","level":3,"score":0.2658142149448395},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24438875913619995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2232080101966858},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11496764421463013},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010726","descriptor_name":"Phosphodiesterase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010742","descriptor_name":"Phospholipid Ethers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010742","descriptor_name":"Phospholipid Ethers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016244","descriptor_name":"Guanosine 5'-O-(3-Thiotriphosphate)","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043802","descriptor_name":"GTP-Binding Protein alpha Subunits, Gq-G11","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054799","descriptor_name":"Phospholipase C beta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10825148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10825148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Comparative Study"},{"id":"mag:2145493241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10825148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W94846272","https://openalex.org/W1500958160","https://openalex.org/W1511598709","https://openalex.org/W1516229395","https://openalex.org/W1539287293","https://openalex.org/W1579641819","https://openalex.org/W1592087407","https://openalex.org/W1849452663","https://openalex.org/W1964037924","https://openalex.org/W1964445130","https://openalex.org/W1964584856","https://openalex.org/W1967097978","https://openalex.org/W1972368443","https://openalex.org/W1976128207","https://openalex.org/W1977560897","https://openalex.org/W1981182586","https://openalex.org/W1991702084","https://openalex.org/W1992893445","https://openalex.org/W1998936982","https://openalex.org/W2001523114","https://openalex.org/W2007368806","https://openalex.org/W2009966516","https://openalex.org/W2014294294","https://openalex.org/W2031956553","https://openalex.org/W2035006492","https://openalex.org/W2037294918","https://openalex.org/W2039758929","https://openalex.org/W2045716547","https://openalex.org/W2053520635","https://openalex.org/W2055718756","https://openalex.org/W2063592572","https://openalex.org/W2074571303","https://openalex.org/W2076460438","https://openalex.org/W2080558320","https://openalex.org/W2080634852","https://openalex.org/W2084918247","https://openalex.org/W2089817854","https://openalex.org/W2093779834","https://openalex.org/W2100540045","https://openalex.org/W2116153676","https://openalex.org/W2138014015","https://openalex.org/W2151312020","https://openalex.org/W2169052646","https://openalex.org/W2169184778","https://openalex.org/W2245909646","https://openalex.org/W2265371507","https://openalex.org/W2323478681","https://openalex.org/W2409182939","https://openalex.org/W2416789205","https://openalex.org/W2417493447","https://openalex.org/W3142144633","https://openalex.org/W4406790788"],"related_works":["https://openalex.org/W2117284676","https://openalex.org/W2169184778","https://openalex.org/W2038993474","https://openalex.org/W2175767930","https://openalex.org/W2161063110","https://openalex.org/W7077986376","https://openalex.org/W125824572","https://openalex.org/W4393093523","https://openalex.org/W2897378436","https://openalex.org/W1869710310"],"abstract_inverted_index":{"Aberrant":[0],"signal":[1],"transduction":[2],"pathways":[3],"involved":[4],"in":[5,14,65,77,97,100,180,276,282],"the":[6,119,127,136,144,163,254,283],"development":[7,284],"of":[8,36,40,52,63,107,118,126,139,174,178,202,224,230,256,269,285],"metastatic":[9],"disease":[10],"are":[11,34,131],"poorly":[12],"defined":[13],"both":[15,270],"small":[16],"cell":[17,23,32,81,87,108,155,165],"lung":[18,24],"carcinoma":[19,25],"(SCLC)":[20],"and":[21,47,75,83,272,288],"non-small":[22],"(NSCLC).":[26],"Neuropeptide-driven":[27],"positive":[28],"feedback":[29],"loops":[30],"stimulating":[31],"proliferation":[33],"characteristic":[35],"SCLC.":[37],"The":[38,61,152,176,222],"activation":[39,201,250],"phospholipase":[41],"C":[42],"(PLC)-beta1":[43],"is":[44,93,159,187,207,217,235,265],"an":[45,266],"early":[46],"common":[48],"response":[49],"to":[50,70,135,167,226],"stimulation":[51],"G":[53],"protein-coupled":[54],"receptors":[55,186,216],"by":[56,104,149,182,189,209,214,220,238],"these":[57],"neuroendocrine":[58],"growth":[59,184],"factors.":[60],"importance":[62],"PLC-beta":[64,72,264],"neuropeptide":[66],"signaling":[67,181],"prompted":[68],"us":[69],"compare":[71],"isoform":[73],"expression":[74,278],"activity":[76],"four":[78,84],"independent":[79,85],"SCLC":[80,98,111,145,154,183,231,271],"lines":[82,112,121,130,166],"NSCLC":[86,120,129,164,273],"lines.":[88],"We":[89],"found":[90],"that":[91,158,192,243,263],"PLC-beta1":[92,179,193,277],"more":[94,133],"highly":[95],"expressed":[96],"than":[99],"NSCLC,":[101],"as":[102,147,160,162],"indicated":[103,148,188],"Western":[105],"blotting":[106],"lysates.":[109],"All":[110],"studied":[113],"express":[114],"PLC-beta1;":[115],"only":[116,153],"one":[117],"investigated":[122],"showed":[123],"detectable":[124],"levels":[125,173],"enzyme.":[128],"significantly":[132],"sensitive":[134,161],"antiproliferative":[137],"effects":[138],"ET-18-OCH3":[140,168,244],"(edelfosine)":[141],"compared":[142],"with":[143,198,233,248,258],"lines,":[146],"[3H]thymidine":[150],"uptake.":[151],"line":[156],"(NCI-H345)":[157],"also":[169,218],"expresses":[170],"uniquely":[171],"low":[172],"PLC-beta1.":[175,259],"participation":[177],"factor":[185],"our":[190],"finding":[191],"(but":[194],"not":[195,236,246],"PLC-beta3)":[196],"coimnunoprecipitates":[197],"G(alpha)q/11":[199,227,249,257],"upon":[200,228],"neurotensin":[203,215,234],"receptors;":[204],"this":[205],"association":[206,255],"inhibited":[208,219,237],"ET-18-OCH3.":[210,221,239],"Ca2+":[211],"mobilization":[212],"mediated":[213],"binding":[223],"GTPgammaS":[225],"treatment":[229],"cells":[232],"These":[240],"findings":[241],"indicate":[242],"does":[245],"interfere":[247],"but":[251],"rather":[252],"inhibits":[253],"Our":[260],"data":[261],"suggest":[262],"important":[267],"mediator":[268],"proliferation.":[274],"Differences":[275],"may":[279],"be":[280],"exploitable":[281],"effective":[286],"diagnostic":[287],"therapeutic":[289],"tools.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
