{"id":"https://openalex.org/W2145483967","doi":"https://doi.org/10.1017/s0007114514000750","title":"LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies","display_name":"LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies","publication_year":2014,"publication_date":"2014-04-29","ids":{"openalex":"https://openalex.org/W2145483967","doi":"https://doi.org/10.1017/s0007114514000750","mag":"2145483967","pmid":"https://pubmed.ncbi.nlm.nih.gov/24780090","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4071994"},"language":"en","primary_location":{"id":"doi:10.1017/s0007114514000750","doi":"https://doi.org/10.1017/s0007114514000750","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114514000750","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/E4EDEF178C21BAAED1E64035CD950E12/S0007114514000750a.pdf/div-class-title-ldl-cholesterol-lowering-effect-of-plant-sterols-and-stanols-across-different-dose-ranges-a-meta-analysis-of-randomised-controlled-studies-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/E4EDEF178C21BAAED1E64035CD950E12/S0007114514000750a.pdf/div-class-title-ldl-cholesterol-lowering-effect-of-plant-sterols-and-stanols-across-different-dose-ranges-a-meta-analysis-of-randomised-controlled-studies-div.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110576133","display_name":"Rouyanne T. Ras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281337","display_name":"Unilever Research and Development Vlaardingen","ror":"https://ror.org/047hzsk31","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1342131907","https://openalex.org/I4210113155","https://openalex.org/I4405281337"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Rouyanne T. Ras","raw_affiliation_strings":["Unilever R&D Vlaardingen,Olivier van Noortlaan 120, PO Box 114,3130 ACVlaardingen,The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unilever R&D Vlaardingen,Olivier van Noortlaan 120, PO Box 114,3130 ACVlaardingen,The Netherlands","institution_ids":["https://openalex.org/I4405281337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024313662","display_name":"Johanna Marianne Geleijnse","orcid":"https://orcid.org/0000-0001-7638-0589","observed_orcids":["https://orcid.org/0000-0001-7638-0589"]},"institutions":[{"id":"https://openalex.org/I913481162","display_name":"Wageningen University & Research","ror":"https://ror.org/04qw24q55","country_code":"NL","type":"education","lineage":["https://openalex.org/I913481162"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Johanna M. Geleijnse","raw_affiliation_strings":["Division of Human Nutrition, Wageningen University,Bomenweg 2,6703 HDWageningen,The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Nutrition, Wageningen University,Bomenweg 2,6703 HDWageningen,The Netherlands","institution_ids":["https://openalex.org/I913481162"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111824127","display_name":"Elke A. Trautwein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405281337","display_name":"Unilever Research and Development Vlaardingen","ror":"https://ror.org/047hzsk31","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1342131907","https://openalex.org/I4210113155","https://openalex.org/I4405281337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Elke A. Trautwein","raw_affiliation_strings":["Unilever R&D Vlaardingen,Olivier van Noortlaan 120, PO Box 114,3130 ACVlaardingen,The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unilever R&D Vlaardingen,Olivier van Noortlaan 120, PO Box 114,3130 ACVlaardingen,The Netherlands","institution_ids":["https://openalex.org/I4405281337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110576133"],"corresponding_institution_ids":["https://openalex.org/I4405281337"],"apc_list":{"value":3550,"currency":"USD","value_usd":3550},"apc_paid":{"value":3550,"currency":"USD","value_usd":3550},"fwci":5.639,"has_fulltext":true,"cited_by_count":381,"citation_normalized_percentile":{"value":0.98582398,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"112","issue":"2","first_page":"214","last_page":"219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.611299991607666,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.28760001063346863,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.06780000030994415,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phytosterols","display_name":"phytosterols","score":0.9480000138282776},{"id":"https://openalex.org/keywords/plant-stanols","display_name":"plant stanols","score":0.9620000123977661},{"id":"https://openalex.org/keywords/ldl-cholesterol","display_name":"LDL cholesterol","score":0.5720000267028809},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.9330000281333923},{"id":"https://openalex.org/keywords/cholesterol-lowering-effect","display_name":"cholesterol-lowering effect","score":0.8309999704360962},{"id":"https://openalex.org/keywords/dietary-supplementation","display_name":"dietary supplementation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.7329999804496765},{"id":"https://openalex.org/keywords/dose-range","display_name":"dose range","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.6919527053833008},{"id":"https://openalex.org/C2779718769","wikidata":"https://www.wikidata.org/wiki/Q412457","display_name":"Phytosterol","level":2,"score":0.6446645259857178},{"id":"https://openalex.org/C2909892341","wikidata":"https://www.wikidata.org/wiki/Q412457","display_name":"Plant sterols","level":4,"score":0.5824098587036133},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.4423104226589203},{"id":"https://openalex.org/C2778718757","wikidata":"https://www.wikidata.org/wiki/Q143623","display_name":"Sterol","level":3,"score":0.37882328033447266},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.35272306203842163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33152711391448975},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3301357924938202},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32576557993888855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32381802797317505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2780963182449341}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D008078","descriptor_name":"Cholesterol, LDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010840","descriptor_name":"Phytosterols","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010840","descriptor_name":"Phytosterols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D010840","descriptor_name":"Phytosterols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019317","descriptor_name":"Evidence-Based Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019587","descriptor_name":"Dietary Supplements","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D055951","descriptor_name":"Functional Food","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1017/s0007114514000750","doi":"https://doi.org/10.1017/s0007114514000750","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114514000750","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/E4EDEF178C21BAAED1E64035CD950E12/S0007114514000750a.pdf/div-class-title-ldl-cholesterol-lowering-effect-of-plant-sterols-and-stanols-across-different-dose-ranges-a-meta-analysis-of-randomised-controlled-studies-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3043684","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4071994","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4071994/pdf/S0007114514000750a.pdf","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4071994","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4071994","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Nutr","raw_type":"Text"},{"id":"pmid:24780090","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24780090","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The British journal of nutrition","raw_type":"Comparative Study"},{"id":"pmh:oai:library.wur.nl:wurpubs/490173","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/ldl-cholesterol-lowering-effect-of-plant-sterols-and-stanols-acro","pdf_url":null,"source":{"id":"https://openalex.org/S4210201231","display_name":"Socio-Environmental Systems Modeling","issn_l":"2663-3027","issn":["2663-3027"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"ISSN: 0007-1145","raw_type":"Article/Letter to editor"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.803.4899","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.803.4899","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/43/6a/S0007114514000750a.PMC4071994.pdf","raw_type":"text"},{"id":"pmh:wur:oai:library.wur.nl:wurpubs/490173","doi":null,"is_oa":true,"landing_page_url":"https://research.wur.nl/en/publications/ldl-cholesterol-lowering-effect-of-plant-sterols-and-stanols-acro","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"British Journal of Nutrition, 112(2), 214 - 219","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1017/s0007114514000750","doi":"https://doi.org/10.1017/s0007114514000750","is_oa":true,"landing_page_url":"https://doi.org/10.1017/s0007114514000750","pdf_url":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/E4EDEF178C21BAAED1E64035CD950E12/S0007114514000750a.pdf/div-class-title-ldl-cholesterol-lowering-effect-of-plant-sterols-and-stanols-across-different-dose-ranges-a-meta-analysis-of-randomised-controlled-studies-div.pdf","source":{"id":"https://openalex.org/S4218381","display_name":"British Journal Of Nutrition","issn_l":"0007-1145","issn":["0007-1145","1475-2662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2145483967.pdf","grobid_xml":"https://content.openalex.org/works/W2145483967.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W69403367","https://openalex.org/W1892892846","https://openalex.org/W1978030963","https://openalex.org/W1981578249","https://openalex.org/W1982648903","https://openalex.org/W1994415887","https://openalex.org/W1995309830","https://openalex.org/W2013160324","https://openalex.org/W2014733253","https://openalex.org/W2015928244","https://openalex.org/W2016231128","https://openalex.org/W2018421950","https://openalex.org/W2019260035","https://openalex.org/W2025282311","https://openalex.org/W2030199905","https://openalex.org/W2044266401","https://openalex.org/W2062160470","https://openalex.org/W2076594116","https://openalex.org/W2081902805","https://openalex.org/W2090484954","https://openalex.org/W2091911287","https://openalex.org/W2107328434","https://openalex.org/W2107365071","https://openalex.org/W2113519471","https://openalex.org/W2131828349","https://openalex.org/W2134306662","https://openalex.org/W2134675186","https://openalex.org/W2136833176","https://openalex.org/W2159156200","https://openalex.org/W2161516242","https://openalex.org/W2764517945"],"related_works":["https://openalex.org/W2310648559","https://openalex.org/W1982648903","https://openalex.org/W2076594116","https://openalex.org/W2159156200","https://openalex.org/W2044266401","https://openalex.org/W2094099724","https://openalex.org/W2021321646","https://openalex.org/W2081902805","https://openalex.org/W2159005521","https://openalex.org/W2014733253"],"abstract_inverted_index":{"Phytosterols":[0],"(PS,":[1],"comprising":[2],"plant":[3,6,61,81,130,190,235],"sterols":[4,62,82,131,146,191,236],"and":[5,44,63,77,83,94,132,135,147,153,192,198,220,237],"stanols)":[7],"have":[8,42],"been":[9,22,58],"proven":[10],"to":[11,73,116,180,240,243,249],"lower":[12],"LDL-cholesterol":[13,105,183],"concentrations.":[14],"The":[15,66,164],"dose-response":[16,38,200],"relationship":[17],"for":[18,30,52,60,129],"this":[19],"effect":[20,232,252],"has":[21,56],"evaluated":[23],"in":[24,151],"several":[25],"meta-analyses":[26],"by":[27,35,113],"calculating":[28],"averages":[29,51],"different":[31,53,88],"dose":[32,54,89,167],"ranges":[33,55],"or":[34],"applying":[36],"continuous":[37],"functions.":[39],"Both":[40],"approaches":[41],"advantages":[43],"disadvantages.":[45],"So":[46],"far,":[47],"the":[48,69,75,121,157,230],"calculation":[49],"of":[50,68,80,162,175,226,233,245,253],"not":[57,214],"done":[59,128],"stanols":[64,84,133,148,193,238],"separately.":[65,136],"objective":[67],"present":[70],"meta-analysis":[71],"was":[72,127,168],"investigate":[74],"combined":[76,134],"separate":[78],"effects":[79,106],"when":[85,109],"classified":[86],"into":[87],"ranges.":[90],"Studies":[91,204],"were":[92,102,107,111,143,149,178,194,202,213,218],"searched":[93],"selected":[95],"based":[96],"on":[97,186],"predefined":[98],"criteria.":[99],"Relevant":[100],"data":[101],"extracted.":[103],"Average":[104],"calculated":[108],"studies":[110,140],"categorised":[112],"dose,":[114],"according":[115],"random-effects":[117],"models":[118],"while":[119],"using":[120],"variance":[122],"as":[123,216],"weighing":[124],"factor.":[125],"This":[126],"In":[137,228],"total,":[138],"124":[139],"(201":[141],"strata)":[142],"included.":[144],"Plant":[145],"administered":[150],"129":[152],"fifty-nine":[154],"strata,":[155],"respectively;":[156],"remaining":[158],"used":[159],"a":[160,223],"mix":[161],"both.":[163],"average":[165,251],"PS":[166,173,208],"2.1":[169],"(range":[170],"0.2-9.0)":[171],"g/d.":[172],"intakes":[174,244],"0.6-3.3":[176],"g/d":[177,212,248],"found":[179],"gradually":[181],"reduce":[182],"concentrations":[184],"by,":[185],"average,":[187],"6-12%.":[188],"When":[189],"analysed":[195],"separately,":[196],"clear":[197],"comparable":[199],"relationships":[201],"observed.":[203],"carried":[205],"out":[206],"with":[207],"doses":[209],"exceeding":[210],"4":[211],"pooled,":[215],"these":[217],"scarce":[219],"scattered":[221],"across":[222],"wide":[224],"range":[225],"doses.":[227],"conclusion,":[229],"LDL-cholesterol-lowering":[231],"both":[234],"continues":[239],"increase":[241],"up":[242],"approximately":[246],"3":[247],"an":[250],"12%.":[254]},"counts_by_year":[{"year":2026,"cited_by_count":25},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":36},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":41},{"year":2020,"cited_by_count":43},{"year":2019,"cited_by_count":41},{"year":2018,"cited_by_count":34},{"year":2017,"cited_by_count":32},{"year":2016,"cited_by_count":31},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}