{"id":"https://openalex.org/W2145478479","doi":"https://doi.org/10.1128/jvi.79.19.12382-12393.2005","title":"Identification of Complement Regulatory Domains in Vaccinia Virus Complement Control Protein","display_name":"Identification of Complement Regulatory Domains in Vaccinia Virus Complement Control Protein","publication_year":2005,"publication_date":"2005-09-14","ids":{"openalex":"https://openalex.org/W2145478479","doi":"https://doi.org/10.1128/jvi.79.19.12382-12393.2005","mag":"2145478479","pmid":"https://pubmed.ncbi.nlm.nih.gov/16160165","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1211521"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.79.19.12382-12393.2005","doi":"https://doi.org/10.1128/jvi.79.19.12382-12393.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.79.19.12382-12393.2005","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1211521/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019489765","display_name":"Jayati Mullick","orcid":"https://orcid.org/0000-0002-8572-2867","observed_orcids":["https://orcid.org/0000-0002-8572-2867"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jayati Mullick","raw_affiliation_strings":["National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India","institution_ids":["https://openalex.org/I4210104670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111953773","display_name":"John Bernet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"John Bernet","raw_affiliation_strings":["National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India","institution_ids":["https://openalex.org/I4210104670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012178413","display_name":"Yogesh Panse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yogesh Panse","raw_affiliation_strings":["National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India","institution_ids":["https://openalex.org/I4210104670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040738231","display_name":"Sharanabasava Hallihosur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sharanabasava Hallihosur","raw_affiliation_strings":["National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India","institution_ids":["https://openalex.org/I4210104670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042512506","display_name":"Akhilesh K. Singh","orcid":"https://orcid.org/0000-0001-6739-6079","observed_orcids":["https://orcid.org/0000-0001-6739-6079"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Akhilesh K. Singh","raw_affiliation_strings":["National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India","institution_ids":["https://openalex.org/I4210104670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029043252","display_name":"Arvind Sahu","orcid":"https://orcid.org/0000-0003-1664-2422","observed_orcids":["https://orcid.org/0000-0003-1664-2422","https://orcid.org/0009-0001-2801-5429"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Arvind Sahu","raw_affiliation_strings":["National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Pune University Campus, Ganeshkhind, Pune 411007, India","institution_ids":["https://openalex.org/I4210104670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210104670"],"apc_list":null,"apc_paid":null,"fwci":1.4767,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.8040353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"79","issue":"19","first_page":"12382","last_page":"12393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.8057000041007996,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11767","display_name":"Poxvirus research and outbreaks","score":0.1907999962568283,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/complement-regulatory-proteins","display_name":"complement regulatory proteins","score":0.765999972820282},{"id":"https://openalex.org/keywords/complement-control-protein-domains","display_name":"complement control protein domains","score":0.8259999752044678},{"id":"https://openalex.org/keywords/c3b","display_name":"C3b","score":0.6769999861717224},{"id":"https://openalex.org/keywords/c4b","display_name":"C4b","score":0.9990000128746033},{"id":"https://openalex.org/keywords/c3-convertase","display_name":"C3 convertase","score":0.7760000228881836},{"id":"https://openalex.org/keywords/classical-pathway","display_name":"classical pathway","score":0.4650000035762787},{"id":"https://openalex.org/keywords/alternative-pathway","display_name":"alternative pathway","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cofactor-activity","display_name":"cofactor activity","score":0.9760000109672546},{"id":"https://openalex.org/keywords/factor-i","display_name":"factor I","score":0.8600000143051147},{"id":"https://openalex.org/keywords/protein-protein-binding","display_name":"protein-protein binding","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C138873322","wikidata":"https://www.wikidata.org/wiki/Q83130456","display_name":"Complement control protein","level":5,"score":0.9118137359619141},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7509639263153076},{"id":"https://openalex.org/C2781356689","wikidata":"https://www.wikidata.org/wiki/Q1986297","display_name":"Vaccinia","level":4,"score":0.6724175810813904},{"id":"https://openalex.org/C92731135","wikidata":"https://www.wikidata.org/wiki/Q4035579","display_name":"CD46","level":4,"score":0.6408929228782654},{"id":"https://openalex.org/C9478725","wikidata":"https://www.wikidata.org/wiki/Q5008114","display_name":"C3-convertase","level":5,"score":0.5802821516990662},{"id":"https://openalex.org/C189446657","wikidata":"https://www.wikidata.org/wiki/Q4736500","display_name":"Alternative complement pathway","level":4,"score":0.5788899660110474},{"id":"https://openalex.org/C171279029","wikidata":"https://www.wikidata.org/wiki/Q5128320","display_name":"Classical complement pathway","level":4,"score":0.5687907934188843},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5174130201339722},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.4775027632713318},{"id":"https://openalex.org/C179369057","wikidata":"https://www.wikidata.org/wiki/Q20970075","display_name":"Complement factor I","level":4,"score":0.44620344042778015},{"id":"https://openalex.org/C14356644","wikidata":"https://www.wikidata.org/wiki/Q14911975","display_name":"Factor H","level":4,"score":0.4404410719871521},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4392551779747009},{"id":"https://openalex.org/C8487232","wikidata":"https://www.wikidata.org/wiki/Q5248822","display_name":"Decay-accelerating factor","level":4,"score":0.4234296381473541},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.29242241382598877},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2680608928203583},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18537044525146484},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18420416116714478},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1733451783657074},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.13288137316703796}],"mesh":[{"descriptor_ui":"D003170","descriptor_name":"Complement Pathway, Alternative","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003171","descriptor_name":"Complement Pathway, Classical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003179","descriptor_name":"Complement C3b","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010449","descriptor_name":"Peptide Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014616","descriptor_name":"Vaccinia virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014616","descriptor_name":"Vaccinia virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015935","descriptor_name":"Complement C4b","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017384","descriptor_name":"Sequence Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018958","descriptor_name":"CD55 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.79.19.12382-12393.2005","doi":"https://doi.org/10.1128/jvi.79.19.12382-12393.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.79.19.12382-12393.2005","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmid:16160165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16160165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1211521","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1211521/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1211521","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1211521/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W131315550","https://openalex.org/W1492385697","https://openalex.org/W1502671196","https://openalex.org/W1513100518","https://openalex.org/W1544744127","https://openalex.org/W1569686393","https://openalex.org/W1571520344","https://openalex.org/W1580023435","https://openalex.org/W1595283955","https://openalex.org/W1653032956","https://openalex.org/W1659710835","https://openalex.org/W1756973693","https://openalex.org/W1895100616","https://openalex.org/W1910602244","https://openalex.org/W1936615645","https://openalex.org/W1970276449","https://openalex.org/W1977609475","https://openalex.org/W1980219722","https://openalex.org/W1980548993","https://openalex.org/W1980853864","https://openalex.org/W1985498833","https://openalex.org/W1989186015","https://openalex.org/W1989222495","https://openalex.org/W1992918473","https://openalex.org/W1997481878","https://openalex.org/W2001408411","https://openalex.org/W2018118709","https://openalex.org/W2018958370","https://openalex.org/W2022739407","https://openalex.org/W2030700009","https://openalex.org/W2030868383","https://openalex.org/W2036268056","https://openalex.org/W2036729671","https://openalex.org/W2042439640","https://openalex.org/W2055874010","https://openalex.org/W2055978589","https://openalex.org/W2058655889","https://openalex.org/W2058992020","https://openalex.org/W2061501964","https://openalex.org/W2076353777","https://openalex.org/W2077207597","https://openalex.org/W2080663504","https://openalex.org/W2085279345","https://openalex.org/W2089328798","https://openalex.org/W2092392556","https://openalex.org/W2114697705","https://openalex.org/W2115668602","https://openalex.org/W2132414631","https://openalex.org/W2143518294","https://openalex.org/W2150945217","https://openalex.org/W2154160642","https://openalex.org/W2156732183","https://openalex.org/W2158357718","https://openalex.org/W2160208086","https://openalex.org/W2164858718","https://openalex.org/W2419625176","https://openalex.org/W2477936151","https://openalex.org/W2491588459"],"related_works":["https://openalex.org/W2163705347","https://openalex.org/W2114697705","https://openalex.org/W2093407180","https://openalex.org/W2055874010","https://openalex.org/W2164858718","https://openalex.org/W2063766381","https://openalex.org/W2788069699","https://openalex.org/W160732716","https://openalex.org/W2241605527","https://openalex.org/W2737993645"],"abstract_inverted_index":{"Vaccinia":[0],"virus":[1,12],"encodes":[2],"a":[3,61,113],"homolog":[4],"of":[5,20,53,78,84,96,115,203,222,238],"the":[6,42,51,54,64,74,93,108,121,143,155,167,182,201,207,211,219,223,235],"human":[7],"complement":[8,13,23],"regulators":[9],"named":[10],"vaccinia":[11],"control":[14,24],"protein":[15,25,224],"(VCP).":[16],"It":[17],"is":[18,225,241],"composed":[19],"four":[21,168],"contiguous":[22],"(CCP)":[26],"domains.":[27],"Previously,":[28],"VCP":[29,97],"has":[30],"been":[31],"shown":[32],"to":[33,35,40,107,126,142,149,153,179,190,196],"bind":[34],"C3b":[36,79,134,197],"and":[37,39,44,59,80,105,135,165,198,232],"C4b":[38,81],"inactivate":[41],"classical":[43,55,156],"alternative":[45,65,183],"pathway":[46,56,66,157,184],"C3":[47,57,67,85],"convertases":[48],"by":[49,72,111],"accelerating":[50],"decay":[52],"convertase":[58],"(to":[60],"limited":[62],"extent)":[63],"convertase,":[68],"as":[69,71],"well":[70],"supporting":[73],"factor":[75],"I-mediated":[76],"inactivation":[77],"(the":[82],"subunits":[83],"convertases).":[86],"In":[87],"this":[88],"study,":[89],"we":[90],"have":[91],"mapped":[92],"CCP":[94,138,204,240],"domains":[95],"important":[98],"for":[99,130,133,172,194,209,227],"its":[100,173],"cofactor":[101,131],"activities,":[102,104],"decay-accelerating":[103,158,185],"binding":[106,195],"target":[109,212],"proteins":[110],"utilizing":[112],"series":[114],"deletion":[116],"mutants.":[117],"Our":[118],"data":[119],"indicate":[120],"following.":[122],"(i)":[123],"CCPs":[124,147,169,177,188],"1":[125,148,189],"3":[127,191],"are":[128,151,170,192],"essential":[129],"activity":[132,159],"C4b;":[136],"however,":[137],"4":[139,180,205],"also":[140],"contributes":[141],"optimal":[144],"activity.":[145,175,186],"(ii)":[146],"2":[150,178],"enough":[152],"mediate":[154,181],"but":[160,200],"show":[161],"very":[162],"minimal":[163],"activity,":[164],"all":[166],"necessary":[171],"efficient":[174],"(iii)":[176],"(iv)":[187],"required":[193,226],"C4b,":[199],"presence":[202],"enhances":[206],"affinity":[208],"both":[210],"proteins.":[213],"These":[214],"results":[215],"together":[216],"demonstrate":[217],"that":[218],"entire":[220],"length":[221],"VCP's":[228],"various":[229],"functional":[230],"activities":[231],"suggests":[233],"why":[234],"four-domain":[236],"structure":[237],"viral":[239],"conserved":[242],"in":[243],"poxviruses.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
