{"id":"https://openalex.org/W2145478309","doi":"https://doi.org/10.1084/jem.20020619","title":"A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis","display_name":"A Point Mutation of Tyr-759 in Interleukin 6 Family Cytokine Receptor Subunit gp130 Causes Autoimmune Arthritis","publication_year":2002,"publication_date":"2002-09-30","ids":{"openalex":"https://openalex.org/W2145478309","doi":"https://doi.org/10.1084/jem.20020619","mag":"2145478309","pmid":"https://pubmed.ncbi.nlm.nih.gov/12370259","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2194024"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20020619","doi":"https://doi.org/10.1084/jem.20020619","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.20020619","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2194024","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063756074","display_name":"Toru Atsumi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toru Atsumi","raw_affiliation_strings":["1Department of Molecular Oncology (C7), Graduate School of Medicine","5Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI), Yokohama, Kanagawa 230-0045, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Oncology (C7), Graduate School of Medicine","institution_ids":[]},{"raw_affiliation_string":"5Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI), Yokohama, Kanagawa 230-0045, Japan","institution_ids":["https://openalex.org/I4210110652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059064018","display_name":"Katsuhiko Ishihara","orcid":"https://orcid.org/0000-0002-2826-5188","observed_orcids":["https://orcid.org/0000-0002-2826-5188"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuhiko Ishihara","raw_affiliation_strings":["1Department of Molecular Oncology (C7), Graduate School of Medicine","4Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Oncology (C7), Graduate School of Medicine","institution_ids":[]},{"raw_affiliation_string":"4Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063407770","display_name":"Daisuke Kamimura","orcid":"https://orcid.org/0000-0003-1022-4430","observed_orcids":["https://orcid.org/0000-0003-1022-4430","https://orcid.org/0000-0003-1607-0970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daisuke Kamimura","raw_affiliation_strings":["1Department of Molecular Oncology (C7), Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Oncology (C7), Graduate School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002179551","display_name":"Hideto Ikushima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hideto Ikushima","raw_affiliation_strings":["1Department of Molecular Oncology (C7), Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Oncology (C7), Graduate School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057458035","display_name":"Takuya Ohtani","orcid":"https://orcid.org/0009-0006-3876-4630","observed_orcids":["https://orcid.org/0009-0006-3876-4630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takuya Ohtani","raw_affiliation_strings":["1Department of Molecular Oncology (C7), Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Oncology (C7), Graduate School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028737176","display_name":"Seiichi Hirota","orcid":"https://orcid.org/0000-0002-5000-9631","observed_orcids":["https://orcid.org/0000-0002-5000-9631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seiichi Hirota","raw_affiliation_strings":["2Department of Pathology (C2), Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology (C2), Graduate School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020287062","display_name":"Hideyuki Kobayashi","orcid":"https://orcid.org/0000-0003-1381-1665","observed_orcids":["https://orcid.org/0000-0003-1381-1665","https://orcid.org/0000-0002-3711-5683"]},"institutions":[{"id":"https://openalex.org/I4210088742","display_name":"Kowa (Japan)","ror":"https://ror.org/009z2z347","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210088742"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideyuki Kobayashi","raw_affiliation_strings":["6Tokyo Research Laboratories, Kowa Co., Ltd, Higashi-murayama, Tokyo 189-0022, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"6Tokyo Research Laboratories, Kowa Co., Ltd, Higashi-murayama, Tokyo 189-0022, Japan","institution_ids":["https://openalex.org/I4210088742"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023645791","display_name":"Sung\u2010Joo Park","orcid":"https://orcid.org/0000-0002-6227-6681","observed_orcids":["https://orcid.org/0000-0002-6227-6681"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sung-Joo Park","raw_affiliation_strings":["1Department of Molecular Oncology (C7), Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Oncology (C7), Graduate School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086977819","display_name":"Yukihiko Saeki","orcid":"https://orcid.org/0000-0003-3870-0275","observed_orcids":["https://orcid.org/0000-0003-3870-0275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukihiko Saeki","raw_affiliation_strings":["3Department of Molecular Medicine (C4), Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Department of Molecular Medicine (C4), Graduate School of Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111447872","display_name":"Yukihiko Kitamura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukihiko Kitamura","raw_affiliation_strings":["2Department of Pathology (C2), Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pathology (C2), Graduate School of Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100809847","display_name":"Toshio Hirano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110652","display_name":"RIKEN","ror":"https://ror.org/01sjwvz98","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210110652"]},{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshio Hirano","raw_affiliation_strings":["1Department of Molecular Oncology (C7), Graduate School of Medicine","4Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan","5Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI), Yokohama, Kanagawa 230-0045, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Molecular Oncology (C7), Graduate School of Medicine","institution_ids":[]},{"raw_affiliation_string":"4Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"5Laboratory for Cytokine Signaling, RIKEN Research Center for Allergy and Immunology (RCAI), Yokohama, Kanagawa 230-0045, Japan","institution_ids":["https://openalex.org/I4210110652"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5324,"has_fulltext":false,"cited_by_count":224,"citation_normalized_percentile":{"value":0.95573525,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"196","issue":"7","first_page":"979","last_page":"990"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.4805000126361847,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.4805000126361847,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.45680001378059387,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.03880000114440918,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gp130","display_name":"gp130","score":0.9879999756813049},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.800000011920929},{"id":"https://openalex.org/keywords/autoimmune-arthritis","display_name":"autoimmune arthritis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.7200000286102295},{"id":"https://openalex.org/keywords/thymocyte-selection","display_name":"thymic selection","score":0.9319999814033508},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.8700000047683716},{"id":"https://openalex.org/keywords/activation-induced-cell-death","display_name":"activation-induced cell death","score":0.9850000143051147},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.8309999704360962}],"concepts":[{"id":"https://openalex.org/C126037660","wikidata":"https://www.wikidata.org/wiki/Q21116066","display_name":"Glycoprotein 130","level":4,"score":0.687811017036438},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.579426646232605},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5651480555534363},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.5519372224807739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49736765027046204},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43331441283226013},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.411375492811203},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2597673237323761},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.24208977818489075},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18989989161491394},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1655464768409729}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D001169","descriptor_name":"Arthritis, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008198","descriptor_name":"Lymph Nodes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018089","descriptor_name":"Superantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019943","descriptor_name":"Amino Acid Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1084/jem.20020619","doi":"https://doi.org/10.1084/jem.20020619","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.20020619","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2194024","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2194024","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},{"id":"pmid:12370259","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12370259","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.283.2211","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.283.2211","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/eb/b1/J_Exp_Med_2002_Oct_7_196(7)_979-990.tar.gz","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.328.5451","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.328.5451","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jem.rupress.org/content/196/7/979.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2194024","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2194024","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W132781887","https://openalex.org/W1496109170","https://openalex.org/W1564482286","https://openalex.org/W1579900509","https://openalex.org/W1723158139","https://openalex.org/W1979347549","https://openalex.org/W1980264776","https://openalex.org/W1986543207","https://openalex.org/W1988917700","https://openalex.org/W1995997868","https://openalex.org/W2002076761","https://openalex.org/W2004751481","https://openalex.org/W2005260135","https://openalex.org/W2012677567","https://openalex.org/W2023585051","https://openalex.org/W2025117799","https://openalex.org/W2026891958","https://openalex.org/W2029599607","https://openalex.org/W2032848182","https://openalex.org/W2036368914","https://openalex.org/W2038106655","https://openalex.org/W2038468714","https://openalex.org/W2041669657","https://openalex.org/W2044578185","https://openalex.org/W2045590518","https://openalex.org/W2047547740","https://openalex.org/W2063051740","https://openalex.org/W2072479885","https://openalex.org/W2076269825","https://openalex.org/W2080565933","https://openalex.org/W2098840577","https://openalex.org/W2101617873","https://openalex.org/W2101840353","https://openalex.org/W2105676640","https://openalex.org/W2109971798","https://openalex.org/W2111034338","https://openalex.org/W2117439999","https://openalex.org/W2119733834","https://openalex.org/W2125415295","https://openalex.org/W2128822995","https://openalex.org/W2130859575","https://openalex.org/W2133703099","https://openalex.org/W2134341159","https://openalex.org/W2135392289","https://openalex.org/W2137530456","https://openalex.org/W2167978531","https://openalex.org/W2326775643","https://openalex.org/W4236183098","https://openalex.org/W4313347835"],"related_works":["https://openalex.org/W7100999849","https://openalex.org/W2123253747","https://openalex.org/W2133947803","https://openalex.org/W2059454672","https://openalex.org/W7144556390","https://openalex.org/W2019466258","https://openalex.org/W2089146793","https://openalex.org/W2951451700","https://openalex.org/W7095946067","https://openalex.org/W3037489280"],"abstract_inverted_index":{"We":[0],"generated":[1],"a":[2,90,124,128],"mouse":[3],"line":[4],"in":[5,85,89],"which":[6],"the":[7,52,55,94,132],"src":[8],"homology":[9],"2":[10],"domain-bearing":[11],"protein":[12],"tyrosine":[13,20,95],"phosphatase":[14],"(SHP)-2":[15],"binding":[16],"site":[17],"of":[18,72,97,105,127],"gp130,":[19],"759,":[21],"was":[22,38,83,115],"mutated":[23],"to":[24,134],"phenylalanine":[25],"(gp130(F759/F759)).":[26],"The":[27,36,69],"gp130(F759/F759)":[28,86],"mice":[29],"developed":[30],"rheumatoid":[31],"arthritis":[32],"(RA)-like":[33],"joint":[34],"disease.":[35,137],"disease":[37,53,113],"accompanied":[39],"by":[40],"autoantibody":[41],"production":[42],"and":[43,48,60,63,103],"accumulated":[44],"memory/activated":[45],"T":[46,56,87],"cells":[47,57,88],"myeloid":[49],"cells.":[50],"Before":[51],"onset,":[54],"were":[58,67],"hyperresponsive":[59],"thymic":[61],"selection":[62],"peripheral":[64],"clonal":[65],"deletion":[66],"impaired.":[68],"inhibitory":[70],"effect":[71],"IL-6":[73],"on":[74,93,117],"Fas":[75],"ligand":[76],"expression":[77],"during":[78],"activation-induced":[79],"cell":[80],"death":[81],"(AICD)":[82],"augmented":[84],"manner":[91],"dependent":[92,116],"residues":[96],"gp130":[98],"required":[99],"for":[100],"signal":[101],"transducer":[102],"activator":[104],"transcription":[106],"3":[107],"activation.":[108],"Finally,":[109],"we":[110],"showed":[111],"that":[112,123],"development":[114],"lymphocytes.":[118],"These":[119],"results":[120],"provide":[121],"evidence":[122],"point":[125],"mutation":[126],"cytokine":[129],"receptor":[130],"has":[131],"potential":[133],"induce":[135],"autoimmune":[136]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":12},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}