{"id":"https://openalex.org/W2145476436","doi":"https://doi.org/10.4269/ajtmh.2001.65.442","title":"Elimination of lymphocytes, but not eosinophils, by Fas-mediated apoptosis in murine schistosomiasis.","display_name":"Elimination of lymphocytes, but not eosinophils, by Fas-mediated apoptosis in murine schistosomiasis.","publication_year":2001,"publication_date":"2001-11-01","ids":{"openalex":"https://openalex.org/W2145476436","doi":"https://doi.org/10.4269/ajtmh.2001.65.442","mag":"2145476436","pmid":"https://pubmed.ncbi.nlm.nih.gov/11716096"},"language":"en","primary_location":{"id":"doi:10.4269/ajtmh.2001.65.442","doi":"https://doi.org/10.4269/ajtmh.2001.65.442","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.2001.65.442","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006738105","display_name":"Catherine A. Rumbley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Rumbley","raw_affiliation_strings":["Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024585908","display_name":"Hiroko Sugaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Sugaya","raw_affiliation_strings":["Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010588525","display_name":"S. Ali Zekavat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S A Zekavat","raw_affiliation_strings":["Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023090654","display_name":"Peter James Perrin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P J Perrin","raw_affiliation_strings":["Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009905528","display_name":"S M Phillips","orcid":"https://orcid.org/0000-0002-3720-6470","observed_orcids":["https://orcid.org/0000-0002-3720-6470"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S M Phillips","raw_affiliation_strings":["Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary, Allergy and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia 19104-6160, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":1.7832,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.83174751,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"65","issue":"5","first_page":"442","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12234","display_name":"Mollusks and Parasites Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":0.9139999747276306},{"id":"https://openalex.org/keywords/schistosomiasis","display_name":"schistosomiasis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/fas-mediated-apoptosis","display_name":"Fas-mediated apoptosis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.890999972820282},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.8960000276565552},{"id":"https://openalex.org/keywords/granuloma","display_name":"granuloma","score":0.9330000281333923},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.7390000224113464},{"id":"https://openalex.org/keywords/bcl-2","display_name":"Bcl-2","score":0.7789999842643738},{"id":"https://openalex.org/keywords/bcl-xl","display_name":"Bcl-xL","score":0.9729999899864197},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9990000128746033},{"id":"https://openalex.org/keywords/antigen-concentration","display_name":"antigen concentration","score":0.6740000247955322},{"id":"https://openalex.org/keywords/helminth-infection","display_name":"helminthiasis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/splenocytes","display_name":"splenocytes","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.8543232679367065},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8101492524147034},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.7280490398406982},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.7055554389953613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.678756058216095},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6260672807693481},{"id":"https://openalex.org/C2780140890","wikidata":"https://www.wikidata.org/wiki/Q1129338","display_name":"Granuloma","level":2,"score":0.5270562171936035},{"id":"https://openalex.org/C3031857","wikidata":"https://www.wikidata.org/wiki/Q1649375","display_name":"Fas receptor","level":4,"score":0.43372052907943726},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4277694821357727},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.3473284840583801},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.19065532088279724},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.13651379942893982},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006099","descriptor_name":"Granuloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012555","descriptor_name":"Schistosomiasis mansoni","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019254","descriptor_name":"Genes, bcl-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4269/ajtmh.2001.65.442","doi":"https://doi.org/10.4269/ajtmh.2001.65.442","is_oa":false,"landing_page_url":"https://doi.org/10.4269/ajtmh.2001.65.442","pdf_url":null,"source":{"id":"https://openalex.org/S100045985","display_name":"American Journal of Tropical Medicine and Hygiene","issn_l":"0002-9637","issn":["0002-9637","1476-1645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315658","host_organization_name":"American Society of Tropical Medicine and Hygiene","host_organization_lineage":["https://openalex.org/P4310315658"],"host_organization_lineage_names":["American Society of Tropical Medicine and Hygiene"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"journal-article"},{"id":"pmid:11716096","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11716096","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of tropical medicine and hygiene","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.491.9700","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.491.9700","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://intl.ajtmh.org/content/65/5/442.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1474323980","display_name":null,"funder_award_id":"N01AI55270","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1828820569","display_name":null,"funder_award_id":"AI-46750","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G1996020343","display_name":"SUPPLY SCHISTOSOME INFECTED SNAILS &MAMMALS","funder_award_id":"n01ai055270-007","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5990806513","display_name":null,"funder_award_id":"AI 15193","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8065465668","display_name":"SUPPRESSION OF IMMUNOPATHOLOGY IN SCHISTOSMIASIS BY ANTI","funder_award_id":"1r01ai046750-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000909123","display_name":"Center for Molecular Studies in Digestive and Liver Diseases","funder_award_id":"P30DK050306","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W148065352","https://openalex.org/W1493729213","https://openalex.org/W1499855814","https://openalex.org/W1501703333","https://openalex.org/W1506095565","https://openalex.org/W1517827977","https://openalex.org/W1529680890","https://openalex.org/W1588051227","https://openalex.org/W1588446472","https://openalex.org/W1590434810","https://openalex.org/W1598719623","https://openalex.org/W1600555406","https://openalex.org/W1899841286","https://openalex.org/W1917039863","https://openalex.org/W1974001190","https://openalex.org/W1975154590","https://openalex.org/W1993348799","https://openalex.org/W2000820719","https://openalex.org/W2007498454","https://openalex.org/W2022325320","https://openalex.org/W2035468900","https://openalex.org/W2041770967","https://openalex.org/W2080986992","https://openalex.org/W2115130133","https://openalex.org/W2134947454","https://openalex.org/W2149699865","https://openalex.org/W2166622998","https://openalex.org/W2467450961","https://openalex.org/W4313377081"],"related_works":["https://openalex.org/W2156439850","https://openalex.org/W2115130133","https://openalex.org/W7098907274","https://openalex.org/W2134639738","https://openalex.org/W2070136642","https://openalex.org/W1568010615","https://openalex.org/W1917039863","https://openalex.org/W2109310212","https://openalex.org/W2112519321","https://openalex.org/W1994982942"],"abstract_inverted_index":{"Infection":[0],"with":[1,9,23],"the":[2,21,47,84,107,113,119,136,142],"helminth":[3],"parasite":[4,15],"Schistosoma":[5],"mansoni":[6],"is":[7,33],"associated":[8],"a":[10,132],"pathogenic":[11],"granulomatous":[12],"response":[13],"to":[14,66,78,94,130],"eggs.":[16],"Multiple":[17],"cell":[18],"types":[19],"constitute":[20],"granuloma":[22,61,85],"eosinophils":[24,82],"achieving":[25],"numerical":[26],"dominance.":[27],"We":[28,40,57],"hypothesize":[29],"that":[30,43,60],"eosinophil":[31,139],"dominance":[32],"achieved":[34],"by":[35,106],"selective":[36],"apoptosis":[37,68,74,95,105,140],"in":[38,96,101,112,135,141],"lymphocytes.":[39],"report":[41],"here":[42],"lymphocytes":[44,62,71],"from":[45,83,103],"both":[46],"spleens":[48,87],"and":[49,72,86,98,125],"granulomas":[50],"of":[51,88,109,115,138],"S.":[52,89],"mansoni-infected":[53,90],"mice":[54,91],"undergo":[55],"apoptosis.":[56],"also":[58],"show":[59],"are":[63,92,99],"more":[64],"susceptible":[65],"Fas-FasL-mediated":[67,104],"than":[69],"spleen":[70],"this":[73],"may":[75],"be":[76],"related":[77],"antigen":[79],"concentration.":[80],"Conversely,":[81],"resistant":[93],"vivo":[97],"protected":[100],"vitro":[102],"absence":[108],"FasL":[110],"expression":[111],"presence":[114],"Fas":[116],"expression.":[117],"Finally,":[118],"apoptotic":[120],"regulatory":[121],"molecules":[122],"Bcl-2,":[123],"Bcl-xL,":[124],"Bax,":[126],"do":[127],"not":[128],"appear":[129],"play":[131],"significant":[133],"role":[134],"regulation":[137],"schistosome":[143],"granuloma.":[144]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}