{"id":"https://openalex.org/W2145453216","doi":"https://doi.org/10.1111/j.1742-4658.2008.06404.x","title":"An alternative transcript from the death\u2010associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing","display_name":"An alternative transcript from the death\u2010associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing","publication_year":2008,"publication_date":"2008-04-16","ids":{"openalex":"https://openalex.org/W2145453216","doi":"https://doi.org/10.1111/j.1742-4658.2008.06404.x","mag":"2145453216","pmid":"https://pubmed.ncbi.nlm.nih.gov/18422656"},"language":"en","primary_location":{"id":"doi:10.1111/j.1742-4658.2008.06404.x","doi":"https://doi.org/10.1111/j.1742-4658.2008.06404.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1742-4658.2008.06404.x","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://napier-repository.worktribe.com/output/328374","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051411280","display_name":"Yao Lin","orcid":"https://orcid.org/0000-0002-0493-0155","observed_orcids":["https://orcid.org/0000-0002-0493-0155","https://orcid.org/0009-0006-6431-4641"]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yao Lin","raw_affiliation_strings":["Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066785239","display_name":"Craig Stevens","orcid":"https://orcid.org/0000-0003-0372-6299","observed_orcids":["https://orcid.org/0000-0003-0372-6299"]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Craig Stevens","raw_affiliation_strings":["Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034601455","display_name":"Roman Hrstka","orcid":"https://orcid.org/0000-0002-6139-2664","observed_orcids":["https://orcid.org/0000-0002-6139-2664"]},"institutions":[{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Roman Hrstka","raw_affiliation_strings":["Masaryk Memorial Cancer Institute, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masaryk Memorial Cancer Institute, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060935645","display_name":"Benjamin J. Harrison","orcid":"https://orcid.org/0000-0002-6078-5060","observed_orcids":["https://orcid.org/0000-0002-6078-5060"]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ben Harrison","raw_affiliation_strings":["Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087242132","display_name":"Argyro Fourtouna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Argyro Fourtouna","raw_affiliation_strings":["Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056776541","display_name":"Suresh Pathuri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Suresh Pathuri","raw_affiliation_strings":["Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Borek Vojtesek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115043","display_name":"Masaryk Memorial Cancer Institute","ror":"https://ror.org/0270ceh40","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210115043"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Borek Vojtesek","raw_affiliation_strings":["Masaryk Memorial Cancer Institute, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Masaryk Memorial Cancer Institute, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210115043"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082767643","display_name":"Ted R. Hupp","orcid":"https://orcid.org/0000-0003-0391-0352","observed_orcids":["https://orcid.org/0000-0003-0391-0352"]},"institutions":[{"id":"https://openalex.org/I4210158898","display_name":"Institute of Genetics and Cancer","ror":"https://ror.org/05hygey35","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210087105","https://openalex.org/I4210158898","https://openalex.org/I90344618","https://openalex.org/I98677209"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ted Hupp","raw_affiliation_strings":["Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics and Molecular Medicine, Cell Signalling Unit, CRUK p53 Signal Transduction Group, University of Edinburgh, UK","institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5082767643"],"corresponding_institution_ids":["https://openalex.org/I4210158898","https://openalex.org/I98677209"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.274,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.58353195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"275","issue":"10","first_page":"2574","last_page":"2584"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.8378999829292297,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.12540000677108765,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dapk1","display_name":"DAPK1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/splice-variants","display_name":"splice variants","score":0.7639999985694885},{"id":"https://openalex.org/keywords/membrane-blebbing","display_name":"membrane blebbing","score":0.9169999957084656},{"id":"https://openalex.org/keywords/proteolytic-processing","display_name":"proteolytic processing","score":0.9810000061988831},{"id":"https://openalex.org/keywords/ankyrin-repeat-domain","display_name":"ankyrin repeat domain","score":0.7630000114440918},{"id":"https://openalex.org/keywords/protein-kinases","display_name":"protein kinases","score":0.4699999988079071},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8330000042915344},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6179999709129333},{"id":"https://openalex.org/keywords/protein-localization","display_name":"protein localization","score":0.5400000214576721},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.6036461591720581},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5920418500900269},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5771365165710449},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5407010316848755},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4739658534526825},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4103175699710846},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38179588317871094},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36708614230155945},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14800861477851868}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022081","descriptor_name":"Cell Surface Extensions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051017","descriptor_name":"Apoptosis Regulatory Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D064550","descriptor_name":"Death-Associated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1742-4658.2008.06404.x","doi":"https://doi.org/10.1111/j.1742-4658.2008.06404.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1742-4658.2008.06404.x","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:18422656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18422656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"},{"id":"pmh:oai:napier-surface.worktribe.com:328374","doi":null,"is_oa":false,"landing_page_url":"http://researchrepository.napier.ac.uk/Output/328374","pdf_url":null,"source":{"id":"https://openalex.org/S4306402591","display_name":"Edinburgh Napier Research Repository (Edinburgh Napier University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I251738","host_organization_name":"Edinburgh Napier University","host_organization_lineage":["https://openalex.org/I251738"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:repository@napier.ac.uk:328374","doi":null,"is_oa":true,"landing_page_url":"https://napier-repository.worktribe.com/output/328374","pdf_url":null,"source":{"id":"https://openalex.org/S4306402591","display_name":"Edinburgh Napier Research Repository (Edinburgh Napier University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I251738","host_organization_name":"Edinburgh Napier University","host_organization_lineage":["https://openalex.org/I251738"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:repository@napier.ac.uk:328374","doi":null,"is_oa":true,"landing_page_url":"https://napier-repository.worktribe.com/output/328374","pdf_url":null,"source":{"id":"https://openalex.org/S4306402591","display_name":"Edinburgh Napier Research Repository (Edinburgh Napier University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I251738","host_organization_name":"Edinburgh Napier University","host_organization_lineage":["https://openalex.org/I251738"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1493931678","https://openalex.org/W1966134982","https://openalex.org/W1981720385","https://openalex.org/W1990126127","https://openalex.org/W1995972219","https://openalex.org/W2010323640","https://openalex.org/W2018313026","https://openalex.org/W2030352564","https://openalex.org/W2047724911","https://openalex.org/W2057871351","https://openalex.org/W2063563698","https://openalex.org/W2109577572","https://openalex.org/W2116280927","https://openalex.org/W2145923454","https://openalex.org/W2148914027","https://openalex.org/W2149956571","https://openalex.org/W2152754848","https://openalex.org/W2161784983","https://openalex.org/W2171128065"],"related_works":["https://openalex.org/W2149826367","https://openalex.org/W2093207749","https://openalex.org/W1799955757","https://openalex.org/W1506358663","https://openalex.org/W1990126127","https://openalex.org/W2148359476","https://openalex.org/W2007318620","https://openalex.org/W1967340595","https://openalex.org/W2111233859","https://openalex.org/W2050558315"],"abstract_inverted_index":{"Death-associated":[0],"protein":[1,8,102,160,203,226,239],"kinase":[2,9,161],"1":[3],"(DAPK-1)":[4],"is":[5,142,270],"a":[6,25,37,60,76,106,113],"multidomain":[7],"with":[10,105],"diverse":[11],"roles":[12],"in":[13,67,75,93,145,157,179,195],"autophagic,":[14],"apoptotic":[15,165],"and":[16,59,112,233,259],"survival":[17],"pathways.":[18],"Bioinformatic":[19],"screens":[20],"were":[21],"used":[22],"to":[23,175,229,272],"identify":[24],"small":[26],"internal":[27],"mRNA":[28,72],"from":[29,227],"the":[30,45,48,53,123,133,139,169,180,199,205,213,222,225,249,256,265],"DAPK-1":[31,156,178,257],"locus":[32],"(named":[33],"s-DAPK-1).":[34],"This":[35],"encodes":[36],"295":[38],"amino":[39],"acid":[40],"polypeptide":[41],"encompassing":[42],"part":[43,51],"of":[44,52,57,70,78,109,116,122,127,132,171,182,208,212,216,224,251,255,264,268],"ankyrin-repeat":[46],"domain,":[47],"P-loop":[49],"motifs,":[50],"cytoskeletal":[54,228],"binding":[55],"domain":[56],"DAPK-1,":[58],"unique":[61],"C-terminal":[62,124,266],"'tail'":[63],"extension":[64,126,215],"not":[65],"present":[66],"DAPK-1.":[68],"Expression":[69],"s-DAPK-1":[71,95,128,150,172,217,238,269],"was":[73,173],"detected":[74],"panel":[77],"normal":[79],"human":[80],"tissues":[81],"as":[82,84,241],"well":[83],"primary":[85],"colorectal":[86],"cancers,":[87],"indicating":[88],"that":[89,138,261],"its":[90,219,275],"expression":[91],"occurs":[92],"vivo.":[94],"gene":[96,151],"transfection":[97,166,170],"into":[98],"cells":[99],"produces":[100],"two":[101],"products:":[103],"one":[104],"denatured":[107],"mass":[108],"44":[110,186],"kDa,":[111],"smaller":[114,140],"product":[115,141,254],"40":[117,134,200],"kDa.":[118],"Double":[119],"alanine":[120],"mutation":[121],"tail":[125,214,267],"(Gly296/Arg297)":[129],"prevented":[130],"production":[131],"kDa":[135,187,201],"fragment,":[136],"suggesting":[137],"generated":[143],"by":[144,243],"vivo":[146],"proteolytic":[147,262],"processing.":[148],"The":[149,185],"cannot":[152],"substitute":[153],"for":[154],"full-length":[155,177],"an":[158,252],"mitogen-activated":[159],"kinase/extracellular":[162],"signal-regulated":[163],"kinase-dependent":[164],"assay.":[167],"However,":[168],"able":[174],"mimic":[176],"induction":[181],"membrane":[183,196,209],"blebbing.":[184,210],"protease-resistant":[188],"mutant":[189],"s-DAPK-1G296A/R297A":[190],"had":[191],"very":[192],"low":[193],"activity":[194],"blebbing,":[197],"whereas":[198],"s-DAPK-1Deltatail":[202],"exhibited":[204],"highest":[206],"levels":[207],"Deletion":[211],"increased":[218],"half-life,":[220],"shifted":[221],"equilibrium":[223],"soluble":[230],"cytosolic":[231],"pools,":[232],"altered":[234],"green":[235],"fluorescent":[236],"protein-tagged":[237],"localization":[240],"observed":[242],"confocal":[244],"microscopy.":[245],"These":[246],"data":[247],"highlight":[248],"existence":[250],"alternative":[253],"locus,":[258],"suggest":[260],"removal":[263],"required":[271],"stimulate":[273],"maximally":[274],"membrane-blebbing":[276],"function.":[277]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}